Drug & supplement interaction

Eleuthero + Pentobarbitone

Pentobarbitone brand name: Pentobarbitone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Eleuthero and Pentobarbitone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Eleuthero and Pentobarbitone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentobarbitone and Eleuthero in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Eleuthero safety at a glance

Eleuthero overall Use caution Often well tolerated for short-term use, but evidence on long-term safety is limited.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentobarbitone and Eleuthero? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pentobarbitone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentobarbitone is filed under 5 classifications — including barbiturates, anticonvulsants, cns depressants. Eleuthero has documented interactions with 10 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Pentobarbitone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Eleuthero Does Interact With Other Medications

Eleuthero has 679 moderate, 461 minor known drug interactions in our database — Pentobarbitone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 679 Minor 461 No known interaction 1,690 (incl. Pentobarbitone)
Taking anything else?

Check Another of Your Medications Against Eleuthero

Covers the 2,830 medications we’ve checked against Eleuthero. Pick one to open its full report.

What to actually watch for

What Eleuthero Itself Has Been Linked To

This is not an interaction — nothing below involves Pentobarbitone. It is the side-effect record for Eleuthero on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Eleuthero, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    “Orally, increased blood pressure has been reported in children with hypotension taking eleuthero in one clinical study. Eleuthero has been reported to cause tachycardia, hypertension, and pericardial pain in patients with rheumatic heart disease or atherosclerosis.”

    Eleuthero · Natural Medicines adverse-effect record, reported in atherosclerosis.

    4 sources cited
    1. 74980. Kaloeva, Z. D. [Effect of the glycosides of Eleutherococcus senticosus on the hemodynamic indices of children with hypotensive states]. Farmakol.Toksikol. 1986;49(5):73.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 797. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
    4. 6500. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  • Hives Worth acting on Additional detail

    “Orally, eleuthero root is generally well tolerated when used short-term.

    Most Common Adverse Effects:

    Orally: Diarrhea, dyspepsia, gastrointestinal upset, headache, nausea, and urticaria.”

    Eleuthero · Natural Medicines adverse-effect record, reported in cluster headache.

  • Bleeding or bruising Worth acting on Additional detail

    “Orally, mastalgia and uterine bleeding were reported in 7.3% of females taking eleuthero 2 grams daily in one clinical study. These adverse effects seem to be more likely with higher doses.”

    Eleuthero · Natural Medicines adverse-effect record, reported in mastalgia.

    2 sources cited
    1. 6500. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
    2. 11099. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed

    “Orally, headaches have been reported in 9.8% of people taking eleuthero in one clinical study.

    In one case report, a 53-year-old female developed spontaneous subarachnoid hemorrhage associated with the use of an herbal supplement containing red clover, dong quai, and eleuthero. It is unclear if this event was related to the use of eleuthero, the other ingredients, the combination, or another cause entirely.”

    Eleuthero · Natural Medicines adverse-effect record, reported in subarachnoid hemorrhage.

    2 sources cited
    1. 11099. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
    2. 70419. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  • Mood changes or irritability / Anxiety or restlessness Additional detail

    “Orally, nervousness has been reported in 7.3% of people taking eleuthero in one clinical study. Eleuthero has also been reported to cause slight anxiety, irritability, and melancholy in some patients. These adverse effects seem to be more likely to occur with higher doses.”

    Eleuthero · Natural Medicines adverse-effect record, reported in anxiety.

    2 sources cited
    1. 11099. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
    2. 6500. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  • A fast or pounding heartbeat / Low blood pressure Additional detail

    Recorded for Eleuthero in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

  • Stomach upset / Diarrhea Additional detail

    “Orally, eleuthero has been reported to cause dyspepsia, nausea, diarrhea, and gastrointestinal upset in some patients.”

    Eleuthero · Natural Medicines adverse-effect record, reported in diarrhea.

  • Headache Additional detail

    Recorded for Eleuthero in the same Natural Medicines adverse-effect record shown under Hives above.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Eleuthero — expand a row for the licensed statement it rests on. We haven’t matched Pentobarbitone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Pentobarbitone.

From our Q&A

Questions About Eleuthero or Pentobarbitone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Eleuthero or Pentobarbitone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Pentobarbitone

This page covers Eleuthero only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentobarbitone page lists 127 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 103 moderate · 17 minor.

From our pharmacist’s overview on the Pentobarbitone page

“Pentobarbitone is a barbiturate, one of the older and heavier sedatives, and the gap between a dose that helps sleep and one that slows breathing too far is not a generous one. That is why I read this particular list with genuine concern.”

Reviewed by 2 · Jul 18, 2026

Open the Pentobarbitone interaction page

One more smart check

Taking Eleuthero as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,795 real supplement products containing Eleuthero, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Eleuthero. Even though Eleuthero itself has no known interaction with Pentobarbitone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Eleuthero and Pentobarbitone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Eleuthero
Top 5%

#69 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pentobarbitone
Top half

#1,322 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Eleuthero reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Eleuthero and Pentobarbitone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Eleuthero

What is Eleuthero?

Eleuthero
  • Fatigue and low energy
  • Physical and athletic performance
  • Stress resistance (adaptogen)
  • Immune support
  • Mental focus and alertness

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so it should not replace proven treatments. It is generally well tolerated short-term, but pregnant and breastfeeding people and those with certain conditions should avoid it or check with a healthcare provider first.

Eleutherococcus senticosus · Araliaceae · Root and rhizome (sometimes the stem bark) · Capsules, tablets, dried root powder, liquid extracts (tinctures), and teas

An interaction check asks whether these two react with each other — it does not ask whether Eleuthero is a good idea for someone in your situation. Here is what our Eleuthero record says about it on its own.

Eleuthero: dosing

There is no official standardized dose for eleuthero, and products differ widely in strength and form (dried root, extracts, tinctures, and teas).The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Eleuthero monograph — the full record covers uses, side effects and every documented interaction.

Read the full Eleuthero monograph & all interactions
Keep checking

Other Drugs & Eleuthero

Browse every other medication we’ve checked against Eleuthero — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
679Moderate
461Minor
1,689No known interaction
679 Moderate 461 Minor 1,689 No interaction
Moderate

679 interactions

Showing 60 of 679 moderate interactions — see all 679 on the Eleuthero page.

Minor

461 interactions

Showing 60 of 461 minor interactions — see all 461 on the Eleuthero page.

No interaction 1,689 drugs checked — show the list

We also checked Eleuthero against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,689 medications checked with no known interaction — see the full Eleuthero list.

See the full Eleuthero interactions page
See every supplement checked against Pentobarbitone, ranked by severity
Evidence & sources

Eleuthero References

The 24 references that drive our Eleuthero monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  5. Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
  7. Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
  8. Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
  9. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
  10. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
  11. Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
  12. Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
  13. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  14. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  15. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Eleuthero and Pentobarbitone Together: Common Questions

Is it safe to take Eleuthero with Pentobarbitone?
We do not list a known interaction between Eleuthero and Pentobarbitone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Eleuthero and Pentobarbitone combination checked?
Interactions in our licensed database are recorded against drug classes. Pentobarbitone is filed under 5 classifications, and Eleuthero has documented interactions with 10 drug classes — none of Pentobarbitone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Eleuthero interact with any other medications?
Yes. Eleuthero has 1,140 documented drug interactions in our database — Pentobarbitone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pentobarbitone interact with any supplements?
Yes. Pentobarbitone has documented interactions with 127 supplements in our database — Eleuthero is not one of them. The Pentobarbitone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Eleuthero monograph Uses, safety profile, and every drug interaction in one place Pentobarbitone supplement interactions Every supplement checked against Pentobarbitone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 24 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentobarbitone and Eleuthero?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.