Drug & supplement interaction

Huperzine A + Levothyroxine Sodium

Levothyroxine Sodium brand names: Tirosint-Sol, Thyquidity, Ermez.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Huperzine A and Levothyroxine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Levothyroxine Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Huperzine A and Levothyroxine Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levothyroxine Sodium and Huperzine A in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Huperzine A safety at a glance

Huperzine A overall Use caution It is a pharmacologically active compound that can cause real side effects, so use it with care and medical guidance.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levothyroxine Sodium and Huperzine A? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levothyroxine Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levothyroxine Sodium is filed under 3 classifications — including thyroid hormone, oral drugs. Huperzine A has documented interactions with 2 drug classes — the most serious being anticholinergic drugs (moderate) and cholinergic drugs (moderate) — and none of Levothyroxine Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Huperzine A Does Interact With Other Medications

Huperzine A has 219 moderate known drug interactions in our database — Levothyroxine Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 219 No known interaction 2,611 (incl. Levothyroxine Sodium)
Taking anything else?

Check Another of Your Medications Against Huperzine A

Covers the 2,830 medications we’ve checked against Huperzine A. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Huperzine A and Levothyroxine Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Sweating / Trouble sleeping Additional detail

    Huperzine A

    “Orally, huperzine A can cause cholinergic side effects such as dizziness and sweating. Huperzine A can also cause hyperactivity and insomnia. Fainting has also been reported. In two case reports, consumption of a tea mistakenly brewed from Lycopodium selago, a source of huperzine A, has resulted in significant cholinergic toxicity, including sweating and slurred speech.”

    Huperzine A · Natural Medicines adverse-effect record, reported in insomnia.

    6 sources cited
    1. 3140. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
    2. 55613. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
    3. 93481. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
    4. 93482. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
    5. 3138. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
    6. 4624. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.

    Levothyroxine Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium. Read the label on DailyMed ›

  • Diarrhea / Nausea / Vomiting reported in 7.2% of FDA reports for Levothyroxine Sodium Additional detail

    Huperzine A

    “Orally, huperzine A can cause cholinergic side effects such as nausea, vomiting, diarrhea, and anorexia. Constipation and thirst have also been reported. In two case reports, consumption of a tea mistakenly brewed from Lycopodium selago, a source of huperzine A, has resulted in significant cholinergic toxicity, including vomiting and diarrhea.”

    Huperzine A · Natural Medicines adverse-effect record, reported in anorexia.

    5 sources cited
    1. 93480. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
    2. 93481. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
    3. 93482. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
    4. 93483. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed
    5. 13193. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed

    Levothyroxine Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Huperzine A but not commonly for Levothyroxine Sodium: a slow heartbeat, blurred vision, constipation and raised blood pressure.

Effects for Levothyroxine Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Huperzine A come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 312,551 voluntary FDA FAERS reports for Levothyroxine Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Levothyroxine Sodium Products Have a Food Rule — Huperzine A Should Not Break It

At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach. Most supplements — Huperzine A included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine Sodium on its own and move Huperzine A to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Levothyroxine Sodium

This page covers Huperzine A only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine Sodium page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

Open the Levothyroxine Sodium interaction page

One more smart check

Taking Huperzine A as Part of a Dietary Supplement Product? Check It for Interactions

We hold 86 real supplement products containing Huperzine A, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Huperzine A. Even though Huperzine A itself has no known interaction with Levothyroxine Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Huperzine A and Levothyroxine Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Huperzine A
Steady interest

#781 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levothyroxine Sodium
Top 5%

#132 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Huperzine A reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Huperzine A and Levothyroxine Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Huperzine A

What is Huperzine A?

Huperzine A
  • Memory and cognitive support
  • Alzheimer's disease and dementia
  • Age-related memory decline
  • Focus and mental performance
  • Myasthenia gravis (traditional/older use)

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies suggest it may modestly help memory in people with dementia, but the evidence is limited and the quality is uncertain. Because it is biologically active and not well standardized, talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Huperzia serrata · Lycopodiaceae · Whole plant (clubmoss), from which the compound huperzine A is extracted · Capsules, tablets, and as an ingredient in nootropic or 'brain health' supplement blends

An interaction check asks whether these two react with each other — it does not ask whether Huperzine A is a good idea for someone in your situation. Here is what our Huperzine A record says about it on its own.

Huperzine A: dosing

There is no official, well-established standard dose of huperzine A for supplement use. Studied amounts are very small and are usually measured in micrograms, not milligrams, which makes accurate dosing difficult with over-the-counter products.The safest approach is to follow the directions on the product label and not to exceed them.

From our Huperzine A monograph — the full record covers uses, side effects and every documented interaction.

Read the full Huperzine A monograph & all interactions
Medication

About Levothyroxine Sodium

Most-Reported Side Effects for Levothyroxine Sodium

From FAERS, the FDA’s public side-effect reporting system (312,551 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 26,585 reports
Nausea 22,605 reports
Headache 19,408 reports
Diarrhea 18,759 reports
Dyspnea 16,717 reports
Keep checking

Other Drugs & Huperzine A

Browse every other medication we’ve checked against Huperzine A — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
219Moderate
0Minor
2,610No known interaction
219 Moderate 2,610 No interaction
Moderate

219 interactions

Showing 60 of 219 moderate interactions — see all 219 on the Huperzine A page.

No interaction 2,610 drugs checked — show the list

We also checked Huperzine A against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,610 medications checked with no known interaction — see the full Huperzine A list.

See the full Huperzine A interactions page
See every supplement checked against Levothyroxine Sodium, ranked by severity
Evidence & sources

Huperzine A References

The 13 references that drive our Huperzine A monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Huperzine A and Levothyroxine Sodium Together: Common Questions

Is it safe to take Huperzine A with Levothyroxine Sodium?
We do not list a known interaction between Huperzine A and Levothyroxine Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Huperzine A and Levothyroxine Sodium have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Huperzine A and Levothyroxine Sodium at the same time of day?
At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Levothyroxine Sodium on its own and move Huperzine A to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Huperzine A and Levothyroxine Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Levothyroxine Sodium is filed under 3 classifications, and Huperzine A has documented interactions with 2 drug classes — none of Levothyroxine Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Huperzine A interact with any other medications?
Yes. Huperzine A has 219 documented drug interactions in our database — Levothyroxine Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levothyroxine Sodium interact with any supplements?
Yes. Levothyroxine Sodium has documented interactions with 50 supplements in our database — Huperzine A is not one of them. The Levothyroxine Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Huperzine A monograph Uses, safety profile, and every drug interaction in one place Levothyroxine Sodium supplement interactions Every supplement checked against Levothyroxine Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.