Hyperimmune Egg + Colesevelam
Colesevelam brand names: WelChol, Lodalis.
We found no known interaction between Hyperimmune Egg and Colesevelam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Colesevelam states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Hyperimmune Egg and Colesevelam
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Colesevelam and Hyperimmune Egg in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Hyperimmune Egg at all — not against Colesevelam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Hyperimmune Egg safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Colesevelam Products Have a Food Rule — Hyperimmune Egg Should Not Break It
At least one FDA label for a product containing Colesevelam says to take it with food. If you take Hyperimmune Egg on an empty stomach out of habit, keep them separate — and take Colesevelam with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Colesevelam products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Colesevelam hydrochloride should be taken as follows ( 2.2 , 2.4 ): Tablets Take 6 tablets once daily or 3 tablets twice daily with a meal and liquid.
From the Dosage and Administration section of the FDA label we read for Colesevelam — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Colesevelam Is Prescribed For, and What Hyperimmune Egg Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Colesevelam is a prescription medicine with approved uses on its FDA label. Hyperimmune Egg is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Colesevelam is prescribed for: Colesevelam is used alongside diet and exercise to reduce high LDL cholesterol (the "bad" cholesterol) in adults with primary hyperlipidemia (high cholesterol). It is also approved to lower LDL cholesterol in boys and girls aged 10–17 who have heterozygous familial hypercholesterolemia (HeFH) — an inherited condition that causes very high cholesterol — when diet and lifestyle changes alone haven't worked. Colesevelam tablets and oral suspension (Welchol and colesevelam hydrochloride products) are also used to improve blood sugar control in adults with type 2 diabetes, as an add-on to diet and exercise. Colesevelam is not for type 1 diabetes or diabetic ketoacidosis.
Hyperimmune Egg has been studied for:
-
Hyperlipidemia studied, not established Hyperimmune Egg has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Hyperimmune Egg for hyperlipidemia
Preliminary clinical research shows that taking a specific hyperimmune egg powder formulation (Immune26, Legacy for Life) for 26 weeks does not significantly lower cholesterol when compared with baseline. The validity of this finding is limited by the lack of a comparator group.
1 source cited
- 13213. Karge WH, Deluca JP, Marchitelli LJ, et al. Pilot study on the effect of hyperimmune egg protein on elevated cholesterol levels and cardiovascular risk factors. J Med Food 1999;2:51-63. PubMed
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Colesevelam on your own; if you are taking Hyperimmune Egg for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Hyperimmune Egg or Colesevelam
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hyperimmune Egg or Colesevelam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Colesevelam
This page covers Hyperimmune Egg only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Colesevelam page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Colesevelam page
“Colesevelam (WelChol, Lodalis) lowers cholesterol by binding bile acids in your gut, and every one of the 17 supplements on this list can interfere with how oral medicines are absorbed in that same territory. I would treat this list with genuine care, and the place to start is activated charcoal, the only major-rated entry.”
Reviewed by 2 · Jul 18, 2026
Where Hyperimmune Egg and Colesevelam Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#696 of 1,452 supplements looked up here in the last 7 days
#2,013 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hyperimmune Egg reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hyperimmune Egg and Colesevelam records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Hyperimmune Egg
What is Hyperimmune Egg?
- Immune support
- Digestive health
- Diarrhea prevention
- Joint comfort
- General wellness
Hyperimmune egg is a dried egg product from hens vaccinated against common germs, so the eggs contain extra antibodies (mainly IgY). Some small studies suggest possible benefits for gut health and immune support, but the overall evidence is limited and not strong. People with egg allergy should avoid it, and pregnant or breastfeeding women should check with a doctor first.
Whole eggs (and egg powder) from hens immunized against specific microbes · Powder, capsules, tablets, protein shakes/drink mixes
An interaction check asks whether these two react with each other — it does not ask whether Hyperimmune Egg is a good idea for someone in your situation. Here is what our Hyperimmune Egg record says about it on its own.
Hyperimmune Egg: dosing
There is no official or standardized dose for hyperimmune egg. Products vary widely in strength and form, from powders to capsules.The best advice is to follow the directions on the product label and not exceed the recommended amount.
From our Hyperimmune Egg monograph — the full record covers uses, side effects and every documented interaction.
About Colesevelam
What Is Colesevelam Used For?
Brand names: WelChol, Lodalis
Colesevelam is used alongside diet and exercise to reduce high LDL cholesterol (the "bad" cholesterol) in adults with primary hyperlipidemia (high cholesterol). It is also approved to lower LDL cholesterol in boys and girls aged 10–17 who have heterozygous familial hypercholesterolemia (HeFH) — an inherited condition that causes very high cholesterol — when diet and lifestyle changes alone haven't worked.
Colesevelam tablets and oral suspension (Welchol and colesevelam hydrochloride products) are also used to improve blood sugar control in adults with type 2 diabetes, as an add-on to diet and exercise. Colesevelam is not for type 1 diabetes or diabetic ketoacidosis.
Most-Reported Side Effects for Colesevelam
From FAERS, the FDA’s public side-effect reporting system (2,014 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Hyperimmune Egg
Browse every other medication we’ve checked against Hyperimmune Egg — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Hyperimmune Egg against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hyperimmune Egg list.
Hyperimmune Egg References
The 10 references that drive our Hyperimmune Egg monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Sarker SA, Casswall TH, Juneja LR, et al. Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea. J Pediatr Gastroenterol Nutr 2001;32:19-25. DOI
- Greenblatt HC, Adalsteinsson O, Kagen L. Administration to arthritis patients of a dietary supplement containing immune egg: An open-label pilot study. J Med Food 1998;1:171-9. DOI
- Karge WH, Deluca JP, Marchitelli LJ, et al. Pilot study on the effect of hyperimmune egg protein on elevated cholesterol levels and cardiovascular risk factors. J Med Food 1999;2:51-63. PubMed
- Nguyen SV, Nguyen MTH, Tran BC, Ho MTQ, Umeda K, Rahman S. Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlle
- Scheett TM, Martin TD, Carr BM, Webster MJ. A Comparison of Hyperimmune Egg Protein and Placebo for Efficacy and Safety Among Healthy Young Adults (poster). J Int Soc Sport Nutr 2009;6(S1):P8. DOI
- Scheett TM, Martin TD, Carr BM, et al. Hyperimmune Egg Protein Decreases Submaximal Heart Rate and Increases Peak Power (poster). Medicine & Science in Sports Medicine & Exercise 2007;39(5):S365. https://insights.ovid.com/medicine-science-sports-exercise/ DOI
- Kollberg H, Carlander D, Olesen H, Wejaker PE, Johannesson M, Larsson A. Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase 1 feasibility study. Pediatr Pulmonol 20
- Nilsson E, Larsson A, Olesen HV, Wejaker PE, Kollberg H. Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatr Pulmonol 2008;43(9):892-9.
- Suzuki H, Nomura S, Masaoka T, et al. Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. Aliment Pharmacol Ther 2004;20 suppl 1:185-92. PubMed
- Horie K, Horie N, Abdou AM, et al. Suppressive effect of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans. J Dairy Sci 2004;87(12):4073-9. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Hyperimmune Egg and Colesevelam Together: Common Questions
Is it safe to take Hyperimmune Egg with Colesevelam?
Do Hyperimmune Egg and Colesevelam have any of the same side effects?
Should I take Hyperimmune Egg and Colesevelam at the same time of day?
Are Hyperimmune Egg and Colesevelam used for the same thing?
Does Colesevelam interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.