Iboga + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide
Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide brand names: Rhinogesic JR, Rhinogesic.
Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide falls into 3 drug categories that Iboga can interact with; the most serious is rated moderate. Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drugs.
Read the full interaction reportIboga and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Iboga interacts with whole categories of medication. Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide falls into 3 of those categories, so it can interact with Iboga in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
SEROTONERGIC DRUGS
1 of 3Why this applies to Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide
Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide falls under SEROTONERGIC DRUGS — the group Iboga interacts with.
Ibogaine, a constituent in iboga, has serotonergic effects. Theoretically, combining serotonergic drugs with iboga might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using iboga with serotonergic drugs.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This cold and sinus combo (Rhinogesic) mixes a fever reducer, an antihistamine, a decongestant, and a pain reliever. The piece that matters here is chlorpheniramine, which gently nudges serotonin levels in the brain. Iboga (through ibogaine) also pushes serotonin upward. Put them together and, in theory, you could stack too much serotonin activity.
Honestly, this concern is theoretical and based on how these drugs work, not on real cases with this product. Still, with high serotonin you might feel agitated, sweaty, shaky, or have a racing heart. Iboga also carries serious heart rhythm risks on its own, which is the bigger worry. We do not recommend Iboga outside of research. Please check with your pharmacist or doctor before combining them.
- Glick SD, Maisonneuve IS. Mechanisms of antiaddictive actions of ibogaine. Ann N Y Acad Sci 1998;844:214-26.
- Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
- Litjens RP, Brunt TM. How toxic is ibogaine? Clin Toxicol (Phila). 2016;54(4):297-302. PubMed
ANTICHOLINERGIC DRUGS
2 of 3Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide also falls under ANTICHOLINERGIC DRUGS.
In vitro research shows that iboga can inhibit acetylcholinesterase and might increase acetylcholine levels. However, the constituent ibogaine does not appear to have this effect.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
The piece of this combo product that matters here is chlorpheniramine, the antihistamine. It works partly by blocking acetylcholine, one of your body's nerve signaling chemicals. In lab dish studies, iboga seemed to raise acetylcholine levels, which could in theory push back against chlorpheniramine and make it work a little less well (for example, less relief from a runny nose or sneezing). Worth knowing: ibogaine, the main active compound in iboga, did not show this effect, so this is a weak, theoretical concern only.
Honestly, my bigger worry is iboga itself, which is illegal in the U.S. and linked to dangerous heart rhythm problems. I would not combine these. Please check with your pharmacist or doctor before using either one.
- Alper K, Reith ME, Sershen H. Ibogaine and the inhibition of acetylcholinesterase. J Ethnopharmacol. 2012;139(3):879-82. PubMed
CYTOCHROME P450 2D6 (CYP2D6) INHIBITORS
3 of 3Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide also falls under CYTOCHROME P450 2D6 (CYP2D6) INHIBITORS.
Ibogaine, the active constituent of iboga, is a substrate of CYP2D6. One pharmacokinetic study shows that taking the CYP2D6 inhibitor paroxetine prior to taking ibogaine 20 mg increases the exposure to ibogaine and its metabolite noribogaine by 2-fold when compared with ibogaine alone.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to understand about this combo product (the one with acetaminophen, chlorpheniramine, phenylephrine, and salicylamide). The concern isn't that Iboga changes how your cold medicine works. It's the other direction. One of the ingredients here, chlorpheniramine, can mildly block an enzyme called CYP2D6. That same enzyme is what your body uses to clear ibogaine, the active part of Iboga. So blocking it can let ibogaine build up to higher levels in your blood.
Why does that matter? Ibogaine can cause dangerous heart rhythm changes and has been linked to deaths, so pushing its levels up is risky. This is based on limited research and is mostly theoretical, but I'd treat it seriously. Honestly, Iboga is illegal in the U.S. and not something I'd recommend at all. Please talk with your pharmacist or doctor before mixing anything like this.
- Henstra M, Wong L, Chahbouni A, et al. Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine. Clin Toxicol (Phila). 2017;55(6):600-602. PubMed
- Glue P, Winter H, Garbe K, et al. Influence of CYP2D6 activity on the pharmacokinetics and pharmacodynamics of a single 20?mg dose of ibogaine in healthy volunteers. J Clin Pharmacol. 2015;55(6):680-7. PubMed
- Rodriguez P, Urbanavicius J, Prieto JP, et al. A single administration of the atypical psychedelic ibogaine or its metabolite noribogaine induces an antidepressant-like effect in rats. ACS Chem Neurosci 2020;11(11):1661-1672. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Iboga Also Interacts With Other Medications
Iboga has 1 major, 500 moderate known drug interactions in our database — the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Iboga
We haven’t checked that one against Iboga yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Iboga. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide
This page covers Iboga only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide page lists 292 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 14 major · 232 moderate · 46 minor.
From our pharmacist’s overview on the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide page
“I would slow down before pairing supplements with Rhinogesic (acetaminophen, chlorpheniramine, phenylephrine, salicylamide). Each part of this cold remedy opens a different door to trouble, so supplements can collide with it from several directions at once.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction page
Where Iboga and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#670 of 1,452 supplements looked up here in the last 7 days
#43 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Iboga
What is Iboga?
- Drug and alcohol addiction
- Opioid withdrawal
- Spiritual and ceremonial rituals
- Fatigue and stimulant effects
- Mood and emotional issues
Iboga is a Central African shrub whose root bark contains ibogaine, a powerful hallucinogenic compound studied mainly for addiction. It carries serious safety risks, including dangerous heart rhythm changes and deaths, and ibogaine is illegal in the United States and many other countries. We do not recommend its use outside of tightly controlled research settings.
Other Drugs & Iboga
Browse every other medication we’ve checked against Iboga — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
500 interactions
- Metronidazole ›
- Diphenhydramine ›
- Methylphenidate ›
- Erythromycin ›
- Ranitidine ›
- Quinidine ›
- Glycopyrrolate ›
- Bupropion ›
- Chloroquine ›
- Fentanyl ›
- Oxybutynin ›
- Tacrolimus ›
- Carbamazepine ›
- Dextromethorphan ›
- Ipratropium ›
- Phenylephrine ›
- Procainamide ›
- Trimipramine ›
- Buprenorphine ›
- Dimenhydrinate ›
- Everolimus ›
- Lofepramine ›
- Nortriptyline ›
- Pilocarpine ›
- Procyclidine ›
- Propoxyphene ›
- Selegiline ›
- Sotalol ›
- Sumatriptan Succinate ›
- Amantadine ›
- Aripiprazole ›
- Azithromycin ›
- Cimetidine ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Edrophonium ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Fluphenazine ›
- Hydroxyzine ›
- Hyoscyamine ›
- Levofloxacin ›
- Meclizine ›
- Metoclopramide ›
- Nicardipine ›
- Phenobarbital ›
- Prucalopride ›
- Scopolamine ›
- Tramadol ›
- Trihexyphenidyl ›
- Trospium ›
- Valproic Acid ›
- Vortioxetine ›
- Abiraterone Acetate ›
- Almotriptan ›
- Amiodarone ›
- Aripiprazole Lauroxil ›
- Artemether ›
Showing 60 of 500 moderate interactions — see all 500 on the Iboga page.
No interaction 2,328 drugs checked — show the list
We also checked Iboga against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Amlodipine Besylate ›
- Docusate ›
- Metformin ›
- Prednisone ›
- Tadalafil ›
- Semaglutide ›
- Hydroxyurea ›
- Valacyclovir ›
- Amphetamine ›
- Propranolol ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Doxycycline ›
- Pregabalin ›
- Acetaminophen, Aspirin, Caffeine ›
- Gabapentin ›
- Lamotrigine ›
- Naproxen ›
- Bendamustine ›
- Clonazepam ›
- Acyclovir ›
- Omeprazole ›
- Letrozole ›
- Ciprofloxacin ›
- Acetaminophen, Codeine ›
- Candesartan Cilexetil ›
- Acetaminophen, Butalbital, Caffeine ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Amlodipine Besylate, Benazepril ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Perindopril Arginine, Amlodipine ›
- Insulin Degludec, Liraglutide ›
- Acetaminophen, Caffeine, Codeine ›
- Bisoprolol ›
- Acetaminophen, Aspirin ›
- Amlodipine Besilate ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aspirin, Caffeine, Orphenadrine ›
Showing the 60 most looked-up of 2,328 medications checked with no known interaction — see the full Iboga list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide as a medicine that can lower these. This is not an interaction with Iboga — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Iboga and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide Together: Common Questions
Can you take Iboga with Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide?
Why are there 3 interactions listed for Iboga and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide?
How serious is the Iboga and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.