Drug & supplement interaction

Indian Snakeroot + Vancomycin

Vancomycin brand names: Vancocin, Vancoled.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Indian Snakeroot and Vancomycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Indian Snakeroot and Vancomycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vancomycin and Indian Snakeroot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indian Snakeroot safety at a glance

Indian Snakeroot overall Use caution Contains potent alkaloids that can cause serious side effects and should only be used under medical supervision.
Pregnancy Avoid Avoid during pregnancy, as its alkaloids may harm the developing baby.
Breastfeeding Avoid Avoid while breastfeeding, since reserpine can pass into breast milk.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vancomycin and Indian Snakeroot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Vancomycin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vancomycin is filed under 2 classifications — antibiotic drugs, oral drugs. Indian Snakeroot has documented interactions with 13 drug classes — the most serious being antipsychotic drugs (major), beta-blockers (major) and digoxin (lanoxin) (major) — and none of Vancomycin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indian Snakeroot Does Interact With Other Medications

Indian Snakeroot has 83 major, 760 moderate known drug interactions in our database — Vancomycin isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Indian Snakeroot

Covers the 2,830 medications we’ve checked against Indian Snakeroot. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Indian Snakeroot and Vancomycin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 8 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on reported in 11.2% of FDA reports for Vancomycin Additional detail

    Indian Snakeroot

    “There is one report of a hypersensitivity reaction to yohimbine, a constituent of Indian snakeroot. Symptoms included fever, chills, malaise, itchy, scaly skin, progressive kidney failure, and a lupus-like syndrome.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed

    “Orally, Indian snakeroot may cause increased urination.

    Indian snakeroot contains small amounts of yohimbine and may theoretically cause some of the adverse effects associated with this constituent. A case of acute kidney failure related to yohimbine-induced systemic lupus erythematosus has been reported.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in kidney failure.

    2 sources cited
    1. 94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
    2. 6169. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Wheezing / Shortness of breath Worth acting on Additional detail

    Indian Snakeroot

    “Orally, Indian snakeroot can cause nasal stuffiness or congestion and shortness of breath. One study shows that Indian snakeroot may increase the risk for nasal congestion more than the constituent reserpine.. Reserpine is also associated with rare reports of allergic reactions that can precipitate asthma (15,94328).”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 94330. Lowinger P. Rauwolfia serpentina in the control of anxiety. Psychiatr Q. 1957 Jul;31(3):445-53. PubMed
    2. 94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
    3. 94438. Achor RW, Hanson NO, Gifford RW Jr. Hypertension treated with Rauwolfia serpentina (whole root) and with reserpine; controlled study disclosing occasional severe depression. J Am Med Assoc. 1955 Oct 29;159(9):841-5. PubMed
    4. 94440. Wilkins RW, Judson WE. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med. 1953 Jan 8;248(2):48-53.
    5. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    6. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • Chest pain Worth acting on Additional detail

    Indian Snakeroot

    “Orally, Indian snakeroot has been associated with reports of bradycardia and mild hypotension. These adverse effects are thought to be related to the constituent reserpine. Adverse reactions to reserpine also include angina-like symptoms.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 94331. Sheldon MB, Kotte JH. Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study. Circulation. 1957 Aug;16(2):200-6.
    2. 94440. Wilkins RW, Judson WE. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med. 1953 Jan 8;248(2):48-53.
    3. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.
    4. 3312. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
    5. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    6. 86801. Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • Low mood Worth acting on Additional detail

    Indian Snakeroot

    “Orally, Indian snakeroot can cause emotional upset or depression, especially in people with prior episodes. This appears to be related to the constituent reserpine. One study shows the rate of depressive episodes is similar for patients taking Indian snakeroot and those taking reserpine. Some research suggests that the risk of depression might increase with dose or the length of use.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
    2. 94438. Achor RW, Hanson NO, Gifford RW Jr. Hypertension treated with Rauwolfia serpentina (whole root) and with reserpine; controlled study disclosing occasional severe depression. J Am Med Assoc. 1955 Oct 29;159(9):841-5. PubMed
    3. 94330. Lowinger P. Rauwolfia serpentina in the control of anxiety. Psychiatr Q. 1957 Jul;31(3):445-53. PubMed
    4. 17465. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
    5. 86784. Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. PubMed
    6. 86810. Swann, A. C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol.Psichiatr.Soc. 2010;19(2):120-130.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • A low platelet count / A low white blood cell count Worth acting on Additional detail

    Indian Snakeroot

    “Indian snakeroot contains small amounts of reserpine and yohimbine and may theoretically cause some of the adverse effects associated with these constituents. A case of drug-induced agranulocytosis has been reported following prolonged use of oral yohimbine. Reserpine may cause thrombocytopenia.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    2 sources cited
    1. 86877. Siddiqui, M. A., More-O'Ferrall, D., Hammod, R. S., Baime, R. V., and Staddon, A. P. Agranulocytosis associated with yohimbine use. Arch.Intern.Med 6-10-1996;156(11):1235-1237.
    2. 275. Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Indian Snakeroot

    Recorded for Indian Snakeroot in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath above.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • Chills Additional detail

    Indian Snakeroot

    “Orally, Indian snakeroot may cause headaches, feeling cold, dizziness, drowsiness, nightmares, and mild sedation. Indian snakeroot contains small amounts of reserpine and yohimbine and may theoretically cause some of the adverse effects associated with these constituents. Doses of reserpine of greater than 0.5 mg daily can increase the risk of side effects.”

    Indian Snakeroot · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 94331. Sheldon MB, Kotte JH. Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study. Circulation. 1957 Aug;16(2):200-6.
    2. 94332. Vakil RJ. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J. 1949 Oct;11(4):350-5. PubMed
    3. 94438. Achor RW, Hanson NO, Gifford RW Jr. Hypertension treated with Rauwolfia serpentina (whole root) and with reserpine; controlled study disclosing occasional severe depression. J Am Med Assoc. 1955 Oct 29;159(9):841-5. PubMed
    4. 94440. Wilkins RW, Judson WE. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med. 1953 Jan 8;248(2):48-53.
    5. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    6. 94328. Lobay D. Rauwolfia in the Treatment of Hypertension. Integr Med (Encinitas). 2015 Jun;14(3):40-6.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin. Read the label on DailyMed ›

  • Fever reported in 6.2% of FDA reports for Vancomycin Additional detail

    Indian Snakeroot

    Recorded for Indian Snakeroot in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Vancomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Vancomycin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Showing the 10 most notable of 20 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Indian Snakeroot but not commonly for Vancomycin: stomach upset, fainting, a heart attack and an irregular heartbeat.

Effects for Vancomycin come from the ADVERSE REACTIONS section of its FDA label; effects for Indian Snakeroot come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 64,480 voluntary FDA FAERS reports for Vancomycin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Indian Snakeroot or Vancomycin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Indian Snakeroot or Vancomycin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Vancomycin

This page covers Indian Snakeroot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vancomycin page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate) and Bifidobacterium Bifidum (moderate).

By severity: 1 major · 33 moderate · 10 minor.

From our pharmacist’s overview on the Vancomycin page

“Vancomycin (Vancocin) treats serious bacterial infections, and its oral form is a mainstay for C. diff in the gut, so read this list as a genuine safety check, not background noise.”

Reviewed by 2 · Jul 18, 2026

Open the Vancomycin interaction page

One more smart check

Taking Indian Snakeroot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 70 real supplement products containing Indian Snakeroot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indian Snakeroot. Even though Indian Snakeroot itself has no known interaction with Vancomycin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indian Snakeroot and Vancomycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indian Snakeroot
Top half

#375 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Vancomycin
Top 25%

#351 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indian Snakeroot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Indian Snakeroot and Vancomycin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indian Snakeroot

What is Indian Snakeroot?

Indian Snakeroot
  • High blood pressure
  • Anxiety and stress
  • Insomnia
  • Agitation
  • Fever (traditional use)

Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects. Because its potent alkaloids can cause serious side effects like depression and very low blood pressure, it should never be used without medical supervision. It is not a safe or simple home remedy, and many countries restrict its use.

Rauvolfia serpentina · Apocynaceae · Root · Powder, capsules, tablets, dried root, traditional preparations

An interaction check asks whether these two react with each other — it does not ask whether Indian Snakeroot is a good idea for someone in your situation. Here is what our Indian Snakeroot record says about it on its own.

Indian Snakeroot: dosing

There is no well-established safe dose of Indian snakeroot for self-care. The amount of active alkaloids in herbal products can vary widely, which makes safe dosing difficult.If a healthcare provider recommends a product, follow the label and their instructions exactly. Do not increase the dose on your own.

From our Indian Snakeroot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indian Snakeroot monograph & all interactions
Medication

About Vancomycin

What Is Vancomycin Used For?

Brand names: Vancocin, Vancoled

Vancomycin is used to fight serious bacterial infections caused by certain hard-to-treat bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). When given intravenously (by IV), it treats conditions like septicemia (a serious bloodstream infection), infective endocarditis (infection of the heart valves), skin and skin structure infections, bone infections, and lower respiratory tract infections.

When taken by mouth — as capsules or oral solution (brands include Vancocin and Firvanq) — vancomycin treats Clostridioides difficile-associated diarrhea (C. diff) and staphylococcal enterocolitis (a gut infection caused by Staphylococcus aureus). It's important to know that the oral form does not work for bloodstream or other serious infections, and the IV form does not work for C. diff or gut infections — each route has its own specific uses.

Most-Reported Side Effects for Vancomycin

From FAERS, the FDA’s public side-effect reporting system (65,520 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Acute kidney injury 4,892 reports
Fever 4,046 reports
Drug reaction with eosinophilia and systemic symptoms 2,695 reports
Renal failure 2,468 reports
Diarrhea 2,392 reports
See full Vancomycin drug information
Keep checking

Other Drugs & Indian Snakeroot

Browse every other medication we’ve checked against Indian Snakeroot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

83Major
760Moderate
0Minor
1,986No known interaction
Major

83 interactions

Showing 60 of 83 major interactions — see all 83 on the Indian Snakeroot page.

Moderate

760 interactions

Showing 60 of 760 moderate interactions — see all 760 on the Indian Snakeroot page.

No interaction 1,986 drugs checked — show the list
Evidence & sources

Indian Snakeroot References

The 43 references that drive our Indian Snakeroot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
  8. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  9. Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
  10. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
  11. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
  12. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
  13. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
  14. VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
  15. Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indian Snakeroot and Vancomycin Together: Common Questions

Is it safe to take Indian Snakeroot with Vancomycin?
We do not list a known interaction between Indian Snakeroot and Vancomycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Indian Snakeroot and Vancomycin have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Indian Snakeroot and Vancomycin combination checked?
Interactions in our licensed database are recorded against drug classes. Vancomycin is filed under 2 classifications, and Indian Snakeroot has documented interactions with 13 drug classes — none of Vancomycin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Indian Snakeroot interact with any other medications?
Yes. Indian Snakeroot has 843 documented drug interactions in our database — Vancomycin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Vancomycin interact with any supplements?
Yes. Vancomycin has documented interactions with 44 supplements in our database — Indian Snakeroot is not one of them. The Vancomycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Vancomycin and Indian Snakeroot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.