Drug & supplement interaction

Jamaican Dogwood + Cobicistat

Cobicistat brand name: Tybost.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Jamaican Dogwood and Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cobicistat states a food rule worth keeping to.

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Interaction report

Jamaican Dogwood and Cobicistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobicistat and Jamaican Dogwood in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jamaican Dogwood safety at a glance

Jamaican Dogwood overall Use caution It can be toxic in higher doses and has limited safety data in humans.
Pregnancy Likely Unsafe When used orally; avoid using due to possible uterine depressant effects. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobicistat and Jamaican Dogwood? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cobicistat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cobicistat is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, oral drugs. Jamaican Dogwood has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Cobicistat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jamaican Dogwood Does Interact With Other Medications

Jamaican Dogwood has 248 moderate known drug interactions in our database — Cobicistat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Cobicistat)
Taking anything else?

Check Another of Your Medications Against Jamaican Dogwood

Covers the 2,830 medications we’ve checked against Jamaican Dogwood. Pick one to open its full report.

What to actually watch for

What Cobicistat’s Own FDA Label Lists

This is not an interaction — none of it involves Jamaican Dogwood. These are the most notable effects listed in the ADVERSE REACTIONS section of Cobicistat’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • Kidney stones Worth acting on
  • Severe muscle breakdown Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Low mood Worth acting on
  • Kidney problems Worth acting on
  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Vivid dreams or nightmares
  • Trouble sleeping
  • Itching

Showing the 10 most notable of 17 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cobicistat. Read the label on DailyMed › Jamaican Dogwood’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Jamaican Dogwood side to compare — that is a limit of the record, not a statement that Jamaican Dogwood has no side effects.

Special populations

Jamaican Dogwood in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; avoid using due to possible uterine depressant effects.

Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cobicistat Products Have a Food Rule — Jamaican Dogwood Should Not Break It

At least one FDA label for a product containing Cobicistat says to take it with food. If you take Jamaican Dogwood on an empty stomach out of habit, keep them separate — and take Cobicistat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION TYBOST must be coadministered with atazanavir or darunavir at the same time, with food, and in combination with other HIV-1 antiretroviral agents.

From the Dosage and Administration section of the FDA label we read for Cobicistat — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cobicistat

This page covers Jamaican Dogwood only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobicistat page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Cannabidiol (cbd) (moderate), Cannabinol (cbn) (moderate) and Cannabis (moderate).

By severity: 1 major · 19 moderate · 10 minor.

From our pharmacist’s overview on the Cobicistat page

“Activated charcoal is the one entry to understand first if you take cobicistat (Tybost). Charcoal soaks up drugs in the gut, and since cobicistat's entire job is boosting an HIV medicine to protective levels, blunting its absorption can put the whole regimen at risk.”

Reviewed by 2 · Jul 18, 2026

Open the Cobicistat interaction page

One more smart check

Taking Jamaican Dogwood as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Jamaican Dogwood, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jamaican Dogwood. Even though Jamaican Dogwood itself has no known interaction with Cobicistat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jamaican Dogwood and Cobicistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jamaican Dogwood
Top half

#573 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cobicistat
Top half

#1,170 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jamaican Dogwood reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Jamaican Dogwood and Cobicistat records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jamaican Dogwood

What is Jamaican Dogwood?

  • Insomnia and sleep trouble
  • Nerve pain
  • Anxiety and tension
  • Menstrual cramps
  • Muscle pain and spasms
  • Migraine and headaches

Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking. It can be toxic in larger amounts and should be used cautiously, if at all, and never during pregnancy or breastfeeding. Talk to a pharmacist or doctor before trying it.

Piscidia piscipula · Fabaceae · Bark of the root and stem · Dried bark, tinctures, liquid extracts, capsules, teas

An interaction check asks whether these two react with each other — it does not ask whether Jamaican Dogwood is a good idea for someone in your situation. Here is what our Jamaican Dogwood record says about it on its own.

Jamaican Dogwood: dosing

There is no well-established, standardized dose for Jamaican dogwood. Products vary widely in strength, and the bark's natural compounds can be potent, so there is no safe "recommended" amount we can confidently give.If you choose to use a product, follow the directions on the label exactly and do not exceed them. It is best to start any new supplement only after checking with a pharmacist or doctor, who can help you weigh the risks. Avoid using it long-term or in high amounts.

From our Jamaican Dogwood monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jamaican Dogwood monograph & all interactions
Medication

About Cobicistat

What Is Cobicistat Used For?

Brand name: Tybost

Cobicistat (sold as Tybost) is used to treat HIV-1 infection. It does not fight HIV by itself. It is taken together with atazanavir or darunavir, plus other HIV medicines.

Tybost is approved for adults and for children weighing at least 14 kg. It is used only with once-daily atazanavir or darunavir.

See full Cobicistat drug information Cobicistat NDC codes and packages
Keep checking

Other Drugs & Jamaican Dogwood

Browse every other medication we’ve checked against Jamaican Dogwood — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Jamaican Dogwood page.

No interaction 2,581 drugs checked — show the list

We also checked Jamaican Dogwood against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Jamaican Dogwood list.

See the full Jamaican Dogwood interactions page
See every supplement checked against Cobicistat, ranked by severity
Evidence & sources

Jamaican Dogwood References

The 2 references that drive our Jamaican Dogwood monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Della, Loggia R., Tubaro, A., and Redaelli, C. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. Riv.Neurol. 1981;51(5):297-310.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jamaican Dogwood and Cobicistat Together: Common Questions

Is it safe to take Jamaican Dogwood with Cobicistat?
We do not list a known interaction between Jamaican Dogwood and Cobicistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Jamaican Dogwood and Cobicistat at the same time of day?
At least one FDA label for a product containing Cobicistat says to take it with food. If you take Jamaican Dogwood on an empty stomach out of habit, keep them separate and take Cobicistat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cobicistat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Jamaican Dogwood and Cobicistat combination checked?
Interactions in our licensed database are recorded against drug classes. Cobicistat is filed under 2 classifications, and Jamaican Dogwood has documented interactions with 1 drug class — none of Cobicistat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jamaican Dogwood interact with any other medications?
Yes. Jamaican Dogwood has 248 documented drug interactions in our database — Cobicistat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cobicistat interact with any supplements?
Yes. Cobicistat has documented interactions with 30 supplements in our database — Jamaican Dogwood is not one of them. The Cobicistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jamaican Dogwood monograph Uses, safety profile, and every drug interaction in one place Cobicistat drug information The full plain-English guide to this medication Cobicistat supplement interactions Every supplement checked against Cobicistat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobicistat and Jamaican Dogwood?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.