Drug & supplement interaction

Jamaican Dogwood + Amitriptyline

Amitriptyline brand name: Elavil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Jamaican Dogwood has a moderate interaction with Amitriptyline. Jamaican dogwood may potentiate sedative effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jamaican Dogwood and Amitriptyline

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Amitriptyline

Amitriptyline falls under CNS DEPRESSANTS — the group Jamaican Dogwood interacts with.

Jamaican dogwood may potentiate sedative effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: amitriptyline already tends to make people pretty drowsy. It's one of the more sedating antidepressants, which is why doctors often have you take it at bedtime. Jamaican dogwood is traditionally used as a sleep aid and has its own calming, sedative-type effects. Put the two together and those effects can stack up, leaving you feeling extra groggy, foggy, dizzy, or unsteady on your feet.

To be fair, this concern is theoretical, based on how each one behaves rather than solid human studies. It isn't about your liver breaking the drug down differently, just two sedatives adding up. Still, falls and next-day drowsiness are real risks. Please check with your pharmacist or doctor before combining them, especially since Jamaican dogwood can be toxic in larger amounts.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Della, Loggia R., Tubaro, A., and Redaelli, C. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. Riv.Neurol. 1981;51(5):297-310.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jamaican Dogwood Also Interacts With Other Medications

Jamaican Dogwood has 247 moderate known drug interactions in our database — the Amitriptyline one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Amitriptyline)
Taking anything else?

Check Another of Your Medications Against Jamaican Dogwood

Covers the 2,830 medications we’ve checked against Jamaican Dogwood. Pick one to open its full report.

From our Q&A

Questions About Jamaican Dogwood or Amitriptyline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jamaican Dogwood or Amitriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amitriptyline

This page covers Jamaican Dogwood only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amitriptyline page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 17 major · 228 moderate · 51 minor.

From our pharmacist’s overview on the Amitriptyline page

“Amitriptyline (Elavil), an older antidepressant now often prescribed for nerve pain, migraines, and sleep, is one of the drugs I genuinely want patients to be careful with, and 17 of the 296 supplement and herbal ingredients on this list carry a major rating. Most of the serious ones deepen the drowsiness amitriptyline already causes,…”

Reviewed by 2 · Jul 18, 2026

Open the Amitriptyline interaction page

One more smart check

Taking Jamaican Dogwood as Part of a Dietary Supplement Product? Check It for Interactions

We hold 82 real supplement products containing Jamaican Dogwood, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jamaican Dogwood. Your product may carry other ingredients that interact with Amitriptyline too, on top of Jamaican Dogwood — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jamaican Dogwood and Amitriptyline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jamaican Dogwood
Top half

#681 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amitriptyline
Top 5%

#45 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jamaican Dogwood

What is Jamaican Dogwood?

  • Insomnia and sleep trouble
  • Nerve pain
  • Anxiety and tension
  • Menstrual cramps
  • Muscle pain and spasms
  • Migraine and headaches

Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking. It can be toxic in larger amounts and should be used cautiously, if at all, and never during pregnancy or breastfeeding. Talk to a pharmacist or doctor before trying it.

Read the full Jamaican Dogwood monograph & all interactions
Medication

About Amitriptyline

What Is Amitriptyline Used For?

Brand name: Elavil

Amitriptyline HCL and Amitriptyline Hydrochloride tablets are used to relieve symptoms of depression. Depression that originates from within the body (called endogenous depression) tends to respond better than other types of depression.

See full Amitriptyline drug information
Keep checking

Other Drugs & Jamaican Dogwood

Browse every other medication we’ve checked against Jamaican Dogwood — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Jamaican Dogwood page.

No interaction 2,582 drugs checked — show the list

We also checked Jamaican Dogwood against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Jamaican Dogwood list.

See the full Jamaican Dogwood interactions page
See every supplement checked against Amitriptyline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jamaican Dogwood monograph › Uses, safety, and every drug interaction in one place Amitriptyline supplement interactions › Every supplement checked against Amitriptyline, ranked by severity Amitriptyline drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jamaican Dogwood and Amitriptyline Together: Common Questions

Can you take Jamaican Dogwood with Amitriptyline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jamaican Dogwood and Amitriptyline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amitriptyline and Jamaican Dogwood?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.