Drug & supplement interaction

Japanese Persimmon + Oxycodone Hydrochloride

Oxycodone Hydrochloride brand names: Xtampza ER, Roxybond.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Japanese Persimmon and Oxycodone Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone Hydrochloride states a food rule worth keeping to.

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Interaction report

Japanese Persimmon and Oxycodone Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxycodone Hydrochloride and Japanese Persimmon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Persimmon safety at a glance

Japanese Persimmon overall Use caution The fruit is safe as food, but eating large amounts of unripe persimmons may cause hard masses (bezoars) in the stomach.

Pregnancy Use caution Eating the fruit as food is likely fine, but concentrated leaf or calyx supplements have not been well studied, so avoid those.

Breastfeeding Use caution The fruit as food is likely fine, but there is not enough data on concentrated supplements, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxycodone Hydrochloride and Japanese Persimmon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Oxycodone Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oxycodone Hydrochloride is filed under 6 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Japanese Persimmon has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Oxycodone Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Japanese Persimmon Does Interact With Other Medications

Japanese Persimmon has 289 moderate known drug interactions in our database — Oxycodone Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Oxycodone Hydrochloride)

Taking anything else?

Check Another of Your Medications Against Japanese Persimmon

Covers the 2,830 medications we’ve checked against Japanese Persimmon. Pick one to open its full report.

What to actually watch for

What Oxycodone Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Japanese Persimmon. These are the most notable effects listed in the ADVERSE REACTIONS section of Oxycodone Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Dependence or withdrawal symptoms Worth acting on mentioned in 49.2% of FDA reports for Oxycodone Hydrochloride
Serotonin syndrome Worth acting on
Thoughts of self-harm Worth acting on
A bowel blockage Worth acting on
Pain or burning when passing urine Worth acting on
Memory problems Worth acting on
Dehydration Worth acting on
Trouble swallowing Worth acting on
Trouble passing urine Worth acting on
Low sodium Worth acting on

Showing the 10 most notable of 66 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Oxycodone Hydrochloride. Read the label on DailyMed › Where a percentage is shown, it is the share of 283,386 voluntary FDA FAERS reports for Oxycodone Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Japanese Persimmon’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Japanese Persimmon side to compare — that is a limit of the record, not a statement that Japanese Persimmon has no side effects.

How to take them

Some Oxycodone Hydrochloride Products Have a Food Rule — Japanese Persimmon Should Not Break It

At least one FDA label for a product containing Oxycodone Hydrochloride says to take it with food. If you take Japanese Persimmon on an empty stomach out of habit, keep them separate — and take Oxycodone Hydrochloride with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .

From the Dosage and Administration section of the FDA label we read for Oxycodone Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Oxycodone Hydrochloride

This page covers Japanese Persimmon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone Hydrochloride page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

Open the Oxycodone Hydrochloride interaction page

One more smart check

Taking Japanese Persimmon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Japanese Persimmon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Persimmon. Even though Japanese Persimmon itself has no known interaction with Oxycodone Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Persimmon and Oxycodone Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Persimmon

Steady interest

#1,448 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Oxycodone Hydrochloride

Steady interest

#1,869 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Persimmon reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Japanese Persimmon and Oxycodone Hydrochloride records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Japanese Persimmon

What is Japanese Persimmon?

High blood pressure
Cough and hiccups (traditional use)
Antioxidant support
Digestive health and fiber
Skin and general wellness

Japanese persimmon is a nutritious fruit rich in fiber, vitamins, and antioxidant plant compounds, and its leaves and calyx are used in traditional medicine. While eating the fruit as food is generally safe and healthy, the evidence for concentrated supplements or leaf extracts treating specific conditions is limited. Talk to your pharmacist or doctor before using persimmon products medicinally.

Diospyros kaki · Ebenaceae · Fruit, leaves, and the dried fruit calyx (persimmon stalk) · Fresh or dried fruit, tea (often from leaves), powder, capsules, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Japanese Persimmon is a good idea for someone in your situation. Here is what our Japanese Persimmon record says about it on its own.

Japanese Persimmon: dosing

There is no standardized or proven medicinal dose for persimmon supplements. As a food, persimmon is simply eaten as a fresh or dried fruit. For leaf teas, powders, and capsules, the right amount varies by product.If you choose to use a persimmon supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Japanese Persimmon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Persimmon monograph & all interactions

Medication

About Oxycodone Hydrochloride

Most-Reported Side Effects for Oxycodone Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (283,386 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug dependence 101,882 reports

Overdose 56,283 reports

Emotional distress 49,398 reports

Drug withdrawal syndrome 37,426 reports

Dependence 20,302 reports

Keep checking

Other Drugs & Japanese Persimmon

Browse every other medication we’ve checked against Japanese Persimmon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

289Moderate

0Minor

2,540No known interaction

289 Moderate 2,540 No interaction

Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Japanese Persimmon page.

No interaction 2,540 drugs checked — show the list

We also checked Japanese Persimmon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Japanese Persimmon list.

See the full Japanese Persimmon interactions page

See every supplement checked against Oxycodone Hydrochloride, ranked by severity

Evidence & sources

Japanese Persimmon References

The 6 references that drive our Japanese Persimmon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. .
Akdo&gbreve;an RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4.
Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. PubMed
Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475. PubMed
Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74.
Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Persimmon and Oxycodone Hydrochloride Together: Common Questions

Is it safe to take Japanese Persimmon with Oxycodone Hydrochloride?

We do not list a known interaction between Japanese Persimmon and Oxycodone Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Japanese Persimmon and Oxycodone Hydrochloride at the same time of day?

At least one FDA label for a product containing Oxycodone Hydrochloride says to take it with food. If you take Japanese Persimmon on an empty stomach out of habit, keep them separate and take Oxycodone Hydrochloride with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Oxycodone Hydrochloride products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Japanese Persimmon and Oxycodone Hydrochloride combination checked?

Interactions in our licensed database are recorded against drug classes. Oxycodone Hydrochloride is filed under 6 classifications, and Japanese Persimmon has documented interactions with 2 drug classes — none of Oxycodone Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Japanese Persimmon interact with any other medications?

Yes. Japanese Persimmon has 289 documented drug interactions in our database — Oxycodone Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Oxycodone Hydrochloride interact with any supplements?

Yes. Oxycodone Hydrochloride has documented interactions with 145 supplements in our database — Japanese Persimmon is not one of them. The Oxycodone Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Persimmon monograph Uses, safety profile, and every drug interaction in one place Oxycodone Hydrochloride supplement interactions Every supplement checked against Oxycodone Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxycodone Hydrochloride and Japanese Persimmon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.