Drug & supplement interaction

Japanese Persimmon + Pemetrexed

Pemetrexed brand names: Alimta, Pemfexy.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Japanese Persimmon and Pemetrexed in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Japanese Persimmon and Pemetrexed

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pemetrexed and Japanese Persimmon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Persimmon safety at a glance

Japanese Persimmon overall Use caution The fruit is safe as food, but eating large amounts of unripe persimmons may cause hard masses (bezoars) in the stomach.

Pregnancy Use caution Eating the fruit as food is likely fine, but concentrated leaf or calyx supplements have not been well studied, so avoid those.

Breastfeeding Use caution The fruit as food is likely fine, but there is not enough data on concentrated supplements, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pemetrexed and Japanese Persimmon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Pemetrexed

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pemetrexed is filed under a single classification — organic anion transporter 3 (oat3) substrates. Japanese Persimmon has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Pemetrexed’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Japanese Persimmon Does Interact With Other Medications

Japanese Persimmon has 289 moderate known drug interactions in our database — Pemetrexed isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Pemetrexed)

Taking anything else?

Check Another of Your Medications Against Japanese Persimmon

Covers the 2,830 medications we’ve checked against Japanese Persimmon. Pick one to open its full report.

What to actually watch for

What Pemetrexed’s Own FDA Label Lists

This is not an interaction — none of it involves Japanese Persimmon. These are the most notable effects listed in the ADVERSE REACTIONS section of Pemetrexed’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

High potassium Worth acting on
Low sodium Worth acting on
Low potassium Worth acting on
High blood sugar Worth acting on
A low platelet count Worth acting on
Kidney problems Worth acting on
Anemia Worth acting on
Shortness of breath Worth acting on
A low white blood cell count Worth acting on
A higher chance of infection Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pemetrexed. Read the label on DailyMed › Japanese Persimmon’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Japanese Persimmon side to compare — that is a limit of the record, not a statement that Japanese Persimmon has no side effects.

Everything else you take

See Every Supplement That Interacts With Pemetrexed

This page covers Japanese Persimmon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pemetrexed page lists 4 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: African Wild Potato (moderate), Banderol (moderate), Caffeic Acid (moderate) and Quercetin (moderate).

By severity: 4 moderate.

From our pharmacist’s overview on the Pemetrexed page

“Every supplement on file for pemetrexed (Alimta, Pemfexy) works the same way. Each can slow how the kidneys pull the drug out of the blood, which would let it linger and build to higher levels than intended.”

Reviewed by 2 · Jul 18, 2026

Open the Pemetrexed interaction page

One more smart check

Taking Japanese Persimmon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Japanese Persimmon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Persimmon. Even though Japanese Persimmon itself has no known interaction with Pemetrexed, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Persimmon and Pemetrexed Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Persimmon

Steady interest

#1,448 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Pemetrexed

Steady interest

#1,496 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Persimmon reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Japanese Persimmon and Pemetrexed records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Japanese Persimmon

What is Japanese Persimmon?

High blood pressure
Cough and hiccups (traditional use)
Antioxidant support
Digestive health and fiber
Skin and general wellness

Japanese persimmon is a nutritious fruit rich in fiber, vitamins, and antioxidant plant compounds, and its leaves and calyx are used in traditional medicine. While eating the fruit as food is generally safe and healthy, the evidence for concentrated supplements or leaf extracts treating specific conditions is limited. Talk to your pharmacist or doctor before using persimmon products medicinally.

Diospyros kaki · Ebenaceae · Fruit, leaves, and the dried fruit calyx (persimmon stalk) · Fresh or dried fruit, tea (often from leaves), powder, capsules, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Japanese Persimmon is a good idea for someone in your situation. Here is what our Japanese Persimmon record says about it on its own.

Japanese Persimmon: dosing

There is no standardized or proven medicinal dose for persimmon supplements. As a food, persimmon is simply eaten as a fresh or dried fruit. For leaf teas, powders, and capsules, the right amount varies by product.If you choose to use a persimmon supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Japanese Persimmon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Persimmon monograph & all interactions

Medication

About Pemetrexed Injection

What Is Pemetrexed Injection Used For?

Brand names: Alimta, Pemfexy

Pemetrexed Injection is used for non-squamous non-small cell lung cancer (NSCLC) in several situations: as an initial treatment (combined with pembrolizumab and platinum chemotherapy, or with cisplatin alone), as a maintenance treatment after platinum-based chemotherapy, or as a single agent when the cancer has come back after prior chemotherapy. It is not used for squamous cell non-small cell lung cancer.

Pemetrexed Injection is also used, in combination with cisplatin, for the initial treatment of malignant pleural mesothelioma — a cancer of the lining of the lungs — in patients whose disease cannot be surgically removed or who are not good candidates for surgery.

Most-Reported Side Effects for Pemetrexed

From FAERS, the FDA’s public side-effect reporting system (37,889 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 3,095 reports

Anemia 2,134 reports

Nausea 1,906 reports

Diarrhea 1,824 reports

Pancytopenia 1,773 reports

See full Pemetrexed Injection drug information

Keep checking

Other Drugs & Japanese Persimmon

Browse every other medication we’ve checked against Japanese Persimmon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

289Moderate

0Minor

2,540No known interaction

289 Moderate 2,540 No interaction

Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Japanese Persimmon page.

No interaction 2,540 drugs checked — show the list

We also checked Japanese Persimmon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Japanese Persimmon list.

See the full Japanese Persimmon interactions page

See every supplement checked against Pemetrexed, ranked by severity

Evidence & sources

Japanese Persimmon References

The 6 references that drive our Japanese Persimmon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. .
Akdo&gbreve;an RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4.
Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. PubMed
Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475. PubMed
Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74.
Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Persimmon and Pemetrexed Together: Common Questions

Is it safe to take Japanese Persimmon with Pemetrexed?

We do not list a known interaction between Japanese Persimmon and Pemetrexed. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Japanese Persimmon and Pemetrexed combination checked?

Interactions in our licensed database are recorded against drug classes. Pemetrexed is filed under 1 classification, and Japanese Persimmon has documented interactions with 2 drug classes — none of Pemetrexed's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Japanese Persimmon interact with any other medications?

Yes. Japanese Persimmon has 289 documented drug interactions in our database — Pemetrexed is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Pemetrexed interact with any supplements?

Yes. Pemetrexed has documented interactions with 4 supplements in our database — Japanese Persimmon is not one of them. The Pemetrexed interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Persimmon monograph Uses, safety profile, and every drug interaction in one place Pemetrexed Injection drug information The full plain-English guide to this medication Pemetrexed supplement interactions Every supplement checked against Pemetrexed, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pemetrexed and Japanese Persimmon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.