Drug & supplement interaction

Japanese Persimmon + Rifabutin

Rifabutin brand name: Mycobutin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Japanese Persimmon and Rifabutin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Rifabutin states a food rule worth keeping to.

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Interaction report

Japanese Persimmon and Rifabutin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rifabutin and Japanese Persimmon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Japanese Persimmon safety at a glance

Japanese Persimmon overall Use caution The fruit is safe as food, but eating large amounts of unripe persimmons may cause hard masses (bezoars) in the stomach.
Pregnancy Use caution Eating the fruit as food is likely fine, but concentrated leaf or calyx supplements have not been well studied, so avoid those.
Breastfeeding Use caution The fruit as food is likely fine, but there is not enough data on concentrated supplements, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rifabutin and Japanese Persimmon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Rifabutin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Rifabutin is filed under 4 classifications — including cytochrome p450 3a4 (cyp3a4) inducers, antibiotic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Japanese Persimmon has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Rifabutin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Japanese Persimmon Does Interact With Other Medications

Japanese Persimmon has 289 moderate known drug interactions in our database — Rifabutin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Rifabutin)
Taking anything else?

Check Another of Your Medications Against Japanese Persimmon

Covers the 2,830 medications we’ve checked against Japanese Persimmon. Pick one to open its full report.

What to actually watch for

What Rifabutin’s Own FDA Label Lists

This is not an interaction — none of it involves Japanese Persimmon. These are the most notable effects listed in the ADVERSE REACTIONS section of Rifabutin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 4.1% of FDA reports for Rifabutin
  • Chest pain Worth acting on
  • Anemia Worth acting on
  • Bloating or gas
  • Fever mentioned in 5.6% of FDA reports for Rifabutin
  • Reduced appetite
  • Muscle pain
  • Trouble sleeping
  • Stomach upset
  • Stomach pain

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Rifabutin. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,836 voluntary FDA FAERS reports for Rifabutin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Japanese Persimmon’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Japanese Persimmon side to compare — that is a limit of the record, not a statement that Japanese Persimmon has no side effects.

How to take them

Some Rifabutin Products Have a Food Rule — Japanese Persimmon Should Not Break It

At least one FDA label for a product containing Rifabutin says to take it with food. If you take Japanese Persimmon on an empty stomach out of habit, keep them separate — and take Rifabutin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Rifabutin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For those patients with propensity to nausea, vomiting, or other gastrointestinal upset, administration of rifabutin at doses of 150 mg twice daily taken with food may be useful.

From the Dosage and Administration section of the FDA label we read for Rifabutin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Japanese Persimmon or Rifabutin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Japanese Persimmon or Rifabutin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Rifabutin

This page covers Japanese Persimmon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rifabutin page lists 180 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 136 moderate · 41 minor.

From our pharmacist’s overview on the Rifabutin page

“Most people on rifabutin (Mycobutin) are treating or preventing serious mycobacterial infections like MAC or tuberculosis, often for months at a time, and this list deserves a careful read before adding a single capsule. Of the 180 supplements with an interaction on file, three carry a major rating, and all three can shift rifabutin's…”

Reviewed by 2 · Jul 18, 2026

Open the Rifabutin interaction page

One more smart check

Taking Japanese Persimmon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Japanese Persimmon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Japanese Persimmon. Even though Japanese Persimmon itself has no known interaction with Rifabutin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Japanese Persimmon and Rifabutin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Japanese Persimmon
Steady interest

#1,448 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rifabutin
Steady interest

#2,668 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Japanese Persimmon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Japanese Persimmon and Rifabutin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Japanese Persimmon

What is Japanese Persimmon?

  • High blood pressure
  • Cough and hiccups (traditional use)
  • Antioxidant support
  • Digestive health and fiber
  • Skin and general wellness

Japanese persimmon is a nutritious fruit rich in fiber, vitamins, and antioxidant plant compounds, and its leaves and calyx are used in traditional medicine. While eating the fruit as food is generally safe and healthy, the evidence for concentrated supplements or leaf extracts treating specific conditions is limited. Talk to your pharmacist or doctor before using persimmon products medicinally.

Diospyros kaki · Ebenaceae · Fruit, leaves, and the dried fruit calyx (persimmon stalk) · Fresh or dried fruit, tea (often from leaves), powder, capsules, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Japanese Persimmon is a good idea for someone in your situation. Here is what our Japanese Persimmon record says about it on its own.

Japanese Persimmon: dosing

There is no standardized or proven medicinal dose for persimmon supplements. As a food, persimmon is simply eaten as a fresh or dried fruit. For leaf teas, powders, and capsules, the right amount varies by product.If you choose to use a persimmon supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Japanese Persimmon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Japanese Persimmon monograph & all interactions
Medication

About Rifabutin

What Is Rifabutin Used For?

Brand name: Mycobutin

Rifabutin capsules are used to prevent disseminated MAC (Mycobacterium avium complex) disease — a serious bacterial infection that can spread throughout the body — in adults with advanced HIV infection.

It is not approved as a treatment for active tuberculosis (TB), and it should not be used alone for MAC prophylaxis in anyone who has active TB.

See full Rifabutin drug information
Keep checking

Other Drugs & Japanese Persimmon

Browse every other medication we’ve checked against Japanese Persimmon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
289Moderate
0Minor
2,540No known interaction
289 Moderate 2,540 No interaction
Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Japanese Persimmon page.

No interaction 2,540 drugs checked — show the list

We also checked Japanese Persimmon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Japanese Persimmon list.

See the full Japanese Persimmon interactions page
See every supplement checked against Rifabutin, ranked by severity
Evidence & sources

Japanese Persimmon References

The 6 references that drive our Japanese Persimmon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. .
  2. Akdoğan RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4.
  3. Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. PubMed
  4. Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475. PubMed
  5. Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74.
  6. Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Japanese Persimmon and Rifabutin Together: Common Questions

Is it safe to take Japanese Persimmon with Rifabutin?
We do not list a known interaction between Japanese Persimmon and Rifabutin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Japanese Persimmon and Rifabutin at the same time of day?
At least one FDA label for a product containing Rifabutin says to take it with food. If you take Japanese Persimmon on an empty stomach out of habit, keep them separate and take Rifabutin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Rifabutin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Japanese Persimmon and Rifabutin combination checked?
Interactions in our licensed database are recorded against drug classes. Rifabutin is filed under 4 classifications, and Japanese Persimmon has documented interactions with 2 drug classes — none of Rifabutin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Japanese Persimmon interact with any other medications?
Yes. Japanese Persimmon has 289 documented drug interactions in our database — Rifabutin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Rifabutin interact with any supplements?
Yes. Rifabutin has documented interactions with 180 supplements in our database — Japanese Persimmon is not one of them. The Rifabutin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Japanese Persimmon monograph Uses, safety profile, and every drug interaction in one place Rifabutin drug information The full plain-English guide to this medication Rifabutin supplement interactions Every supplement checked against Rifabutin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rifabutin and Japanese Persimmon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.