Drug & supplement interaction

Job's Tears + Ixazomib Citrate

Ixazomib Citrate brand name: Ninlaro.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Job's Tears and Ixazomib Citrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ixazomib Citrate states a food rule worth keeping to.

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Interaction report

Job's Tears and Ixazomib Citrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ixazomib Citrate and Job's Tears in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Job's Tears safety at a glance

Job's Tears overall Use caution Generally safe as a cooked food, but concentrated supplement evidence is limited.

Pregnancy Avoid Traditionally avoided in pregnancy and human safety data are lacking.

Breastfeeding Use caution Not enough reliable data; use only ordinary food amounts and check with a clinician.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ixazomib Citrate and Job's Tears? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Ixazomib Citrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ixazomib Citrate is filed under 3 classifications — hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Job's Tears has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), chlorzoxazone (parafon forte, paraflex) (moderate) and dextromethorphan (robitussin dm, others) (moderate) — and none of Ixazomib Citrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Job's Tears Does Interact With Other Medications

Job's Tears has 128 moderate known drug interactions in our database — Ixazomib Citrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 128 No known interaction 2,702 (incl. Ixazomib Citrate)

Taking anything else?

Check Another of Your Medications Against Job's Tears

Covers the 2,830 medications we’ve checked against Job's Tears. Pick one to open its full report.

What to actually watch for

What Ixazomib Citrate’s Own FDA Label Lists

This is not an interaction — none of it involves Job's Tears. These are the most notable effects listed in the ADVERSE REACTIONS section of Ixazomib Citrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

A low platelet count Worth acting on
A low white blood cell count Worth acting on
Liver problems Worth acting on
Numbness or tingling
Constipation
Swelling
Diarrhea
A skin rash
Vomiting
Nausea

From the ADVERSE REACTIONS section of the FDA label for Ixazomib Citrate. Read the label on DailyMed › Job's Tears’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Job's Tears side to compare — that is a limit of the record, not a statement that Job's Tears has no side effects.

How to take them

Some Ixazomib Citrate Products Have a Food Rule — Job's Tears Should Not Break It

At least one FDA label for a product containing Ixazomib Citrate says to take it on an empty stomach. Most supplements — Job's Tears included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Ixazomib Citrate on its own and move Job's Tears to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ixazomib Citrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Dose should be taken at least one hour before or at least two hours after food.

From the Dosage and Administration section of the FDA label we read for Ixazomib Citrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ixazomib Citrate

This page covers Job's Tears only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ixazomib Citrate page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Ixazomib Citrate page

“Anyone taking ixazomib citrate (Ninlaro) for multiple myeloma should give this list real weight, because a supplement that shifts this chemotherapy's blood level can shift how well it works against the cancer. Of the 168 ingredients on file, 121 act on CYP3A4, the enzyme that clears ixazomib.”

Reviewed by 2 · Jul 18, 2026

Open the Ixazomib Citrate interaction page

One more smart check

Taking Job's Tears as Part of a Dietary Supplement Product? Check It for Interactions

We hold 111 real supplement products containing Job's Tears, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Job's Tears. Even though Job's Tears itself has no known interaction with Ixazomib Citrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Job's Tears and Ixazomib Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Job's Tears

Top half

#580 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Ixazomib Citrate

Steady interest

#1,491 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Job's Tears reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Job's Tears and Ixazomib Citrate records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Job's Tears

What is Job's Tears?

Digestive support
Skin health and smoothness
Mild swelling or water retention
General nourishing food/tonic
Joint discomfort (traditional use)

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on metabolism, inflammation, and immunity, strong human evidence for its health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy.

Coix lacryma-jobi · Poaceae · Seeds (grain/kernel), sometimes root · Whole grain, cooked food, tea, powder, capsules, flour

An interaction check asks whether these two react with each other — it does not ask whether Job's Tears is a good idea for someone in your situation. Here is what our Job's Tears record says about it on its own.

Job's Tears: dosing

There is no established standardized dose for Job's Tears as a supplement. As a food, it is simply cooked and eaten like other whole grains.For capsules, powders, or teas, follow the directions on the product label, since strengths vary widely between products.

From our Job's Tears monograph — the full record covers uses, side effects and every documented interaction.

Read the full Job's Tears monograph & all interactions

Medication

About Ixazomib

What Is Ixazomib Used For?

Brand name: Ninlaro

Ninlaro (ixazomib) is used to treat multiple myeloma — a cancer of plasma cells in the bone marrow. It is not used alone; it is always taken together with two other medicines, lenalidomide and dexamethasone. This combination is for adults who have already received at least one prior treatment for their myeloma.

Ninlaro is not recommended for use as maintenance therapy or in newly diagnosed multiple myeloma patients on a lenalidomide and dexamethasone regimen outside of controlled clinical trials.

See full Ixazomib drug information Ixazomib NDC codes and packages

Keep checking

Other Drugs & Job's Tears

Browse every other medication we’ve checked against Job's Tears — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

128Moderate

0Minor

2,701No known interaction

128 Moderate 2,701 No interaction

Moderate

128 interactions

Showing 60 of 128 moderate interactions — see all 128 on the Job's Tears page.

No interaction 2,701 drugs checked — show the list

We also checked Job's Tears against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Job's Tears list.

See the full Job's Tears interactions page

See every supplement checked against Ixazomib Citrate, ranked by severity

Evidence & sources

Job's Tears References

The 3 references that drive our Job's Tears monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed
Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 2004;27:802-5. PubMed
Yao HT, Lin JH, Liu YT, Li ML, Chiang W. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019;11(10):2473. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Job's Tears and Ixazomib Citrate Together: Common Questions

Is it safe to take Job's Tears with Ixazomib Citrate?

We do not list a known interaction between Job's Tears and Ixazomib Citrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Job's Tears and Ixazomib Citrate at the same time of day?

At least one FDA label for a product containing Ixazomib Citrate says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Ixazomib Citrate on its own and move Job's Tears to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Job's Tears and Ixazomib Citrate combination checked?

Interactions in our licensed database are recorded against drug classes. Ixazomib Citrate is filed under 3 classifications, and Job's Tears has documented interactions with 5 drug classes — none of Ixazomib Citrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Job's Tears interact with any other medications?

Yes. Job's Tears has 128 documented drug interactions in our database — Ixazomib Citrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Ixazomib Citrate interact with any supplements?

Yes. Ixazomib Citrate has documented interactions with 168 supplements in our database — Job's Tears is not one of them. The Ixazomib Citrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Job's Tears monograph Uses, safety profile, and every drug interaction in one place Ixazomib drug information The full plain-English guide to this medication Ixazomib Citrate supplement interactions Every supplement checked against Ixazomib Citrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ixazomib Citrate and Job's Tears?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.