Drug & supplement interaction

Ketogenic Diet + Abemaciclib

Abemaciclib brand name: Verzenio.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Ketogenic Diet and Abemaciclib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ketogenic Diet and Abemaciclib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Abemaciclib and Ketogenic Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Ketogenic Diet alongside specific medications may be limited.

Ketogenic Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ketogenic Diet safety at a glance

Ketogenic Diet overall Use caution Generally manageable for healthy adults short-term, but it can cause side effects and is not safe for everyone.

Pregnancy Use caution Strict keto is generally not recommended in pregnancy without medical supervision because of nutrient and growth concerns.

Breastfeeding Possibly Unsafe When used orally without medical supervision. While rare, there are several case reports of lactation ketoacidosis thought to be associated with adherence to ca... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Abemaciclib and Ketogenic Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Abemaciclib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Abemaciclib is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Ketogenic Diet has documented interactions with 6 drug classes — the most serious being anticonvulsants (moderate), antidiabetes drugs (moderate) and carbonic anhydrase inhibitors (moderate) — and none of Abemaciclib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ketogenic Diet Does Interact With Other Medications

Ketogenic Diet has 137 moderate, 122 minor known drug interactions in our database — Abemaciclib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 137 Minor 122 No known interaction 2,571 (incl. Abemaciclib)

Taking anything else?

Check Another of Your Medications Against Ketogenic Diet

Covers the 2,830 medications we’ve checked against Ketogenic Diet. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ketogenic Diet and Abemaciclib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so following Ketogenic Diet while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do. 6 of them are worth acting on rather than waiting out — marked below.

Blood clots Worth acting on Additional detail
Ketogenic Diet
“Orally, the ketogenic diet has been reported to increase levels of total cholesterol and triglycerides. The development of increased lipid levels can occur in as many as 60% of diet adherents. Plasma lipid levels usually normalize by 12 months, although hypercholesterolemia and hypertriglyceridemia have occurred in some patients. In very few cases, the ketogenic diet might need to be stopped.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in atherosclerosis.
6 sources cited

96903. Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: A meta-analysis of observational studies. Epilepsia Open. 2018;3(1):9-17. PubMed

96957. Martin-McGill KJ, Srikandarajah N, Marson AG, Tudur Smith C, Jenkinson MD. The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review. CNS Oncol. 2018;7(2):CNS17.

96966. Lima PA, de Brito Sampaio LP, Damasceno NR. Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress. Nutr Neurosci. 2015;18(8):337-44. PubMed

96968. Ulamek-Koziol M, Pluta R, Bogucka-Kocka A, Czuczwar SJ. To treat or not to treat drug-refractory epilepsy by the ketogenic diet? That is the question. Ann Agric Environ Med. 2016;23(4):533-536. PubMed

97639. Ashrafi MR, Hosseini SA, Zamani GR, et al. The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta Neurol Belg. 2017;117(1):175-182. PubMed

97647. Klepper J, Leiendecker B, Heussinger N, Lausch E, Bosch F. Severe hypertriglyceridemia in Glut1D on ketogenic Diet. Neuropediatrics. 2016;47(2):132-6. PubMed
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
A low platelet count / Bleeding or bruising Worth acting on Additional detail
Ketogenic Diet
“Hyperuricemia is a common mild and transient adverse effect related to a very low-calorie ketogenic diet in obese adults. It has also been reported with high-fat ketogenic diets in children with epilepsy and a few patients with cancer.

In a case report, hyponatremia thought to be related to the ketogenic diet occurred in an adult given the diet for super-refractory status epilepticus.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in anemia.
6 sources cited

96957. Martin-McGill KJ, Srikandarajah N, Marson AG, Tudur Smith C, Jenkinson MD. The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review. CNS Oncol. 2018;7(2):CNS17.

96970. Zahra A, Fath MA, Opat E, et al. Consuming a ketogenic diet while receiving radiation and chemotherapy for locally advanced lung cancer and pancreatic cancer: The University of Iowa experience of two phase 1 clinical trials. Radiat Res. 2017;187(6):743-75 PubMed

96978. Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: A systematic review. Crit Rev Oncol Hematol. 2017;112:41-58. PubMed

97650. Cai QY, Zhou ZJ, Luo R, et al. Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies. World J Pediatr. 2017;13(6):528-536. PubMed

98415. Cervenka MC, Hocker S, Koenig M, et al. Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus. Neurology. 2017;88(10):938-943. PubMed

100843. Chin A. Copper Deficiency Anemia and Neutropenia Due to Ketogenic Diet. Pediatrics. 2018;141(5). pii: e20173286. PubMed
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
Anemia / A low white blood cell count Worth acting on Additional detail

Ketogenic Diet

Recorded for Ketogenic Diet in the same Natural Medicines adverse-effect record shown under A low platelet count / Bleeding or bruising above.

Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
A higher chance of infection Worth acting on Additional detail
Ketogenic Diet
“Increased risk of infection has been reported rarely, possibly related to low protein intake. Anaphylaxis associated with the ketogenic diet has also been reported rarely. In one case, a 6-year-old male developed a new-onset egg allergy with an anaphylactic reaction following a previous consumption of 10-15 eggs daily for 6 months as part of the ketogenic diet for epilepsy.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
3 sources cited

98416. van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol. 2016;20(6):798-809. PubMed

96968. Ulamek-Koziol M, Pluta R, Bogucka-Kocka A, Czuczwar SJ. To treat or not to treat drug-refractory epilepsy by the ketogenic diet? That is the question. Ann Agric Environ Med. 2016;23(4):533-536. PubMed

97642. Levy Y, Peleg-Weiss L, Goldberg-Stern H. The modified Atkins diet for intractable epilepsy may be associated with late-onset egg-induced anaphylactic reaction: a case report. Nutrition. 2011;27(3):380-2.
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
Tiredness Additional detail
Ketogenic Diet
“Mild headaches, lethargy, and fatigue have been reported rarely, probably related to the reduction in carbohydrate intake. These symptoms are a part of a syndrome called the "keto flu" which sometimes occurs when initiating the ketogenic diet. In a few cases, seizures have worsened.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in epilepsy.
6 sources cited

96903. Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: A meta-analysis of observational studies. Epilepsia Open. 2018;3(1):9-17. PubMed

96954. Goday A, Bellido D, Sajoux I, et al. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutr Diabetes. 2016;6(9):e230. PubMed

96970. Zahra A, Fath MA, Opat E, et al. Consuming a ketogenic diet while receiving radiation and chemotherapy for locally advanced lung cancer and pancreatic cancer: The University of Iowa experience of two phase 1 clinical trials. Radiat Res. 2017;187(6):743-75 PubMed

96978. Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: A systematic review. Crit Rev Oncol Hematol. 2017;112:41-58. PubMed

97650. Cai QY, Zhou ZJ, Luo R, et al. Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies. World J Pediatr. 2017;13(6):528-536. PubMed

97651. Lin A, Turner Z, Doerrer SC, Stanfield A, Kossoff EH. Complications during ketogenic diet initiation: Prevalence, treatment, and influence on seizure outcomes. Pediatr Neurol. 2017;68:35-39.
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
Diarrhea Additional detail
Ketogenic Diet
“The most common adverse effect of the ketogenic diet is constipation, possibly requiring medication. Severe fecal impaction with a large stool bezoar that required a right hemicolectomy has been reported in a 6-week-old infant on ketogenic formula for refractory epilepsy. Other common mild adverse effects include vomiting, nausea, diarrhea, hunger, reflux, gas, and abdominal discomfort.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in constipation.
6 sources cited

98415. Cervenka MC, Hocker S, Koenig M, et al. Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus. Neurology. 2017;88(10):938-943. PubMed

98417. Kossoff EH, Zupec-Kania BA, Auvin S, et al. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018;3(2):175-192. PubMed

96903. Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: A meta-analysis of observational studies. Epilepsia Open. 2018;3(1):9-17. PubMed

96957. Martin-McGill KJ, Srikandarajah N, Marson AG, Tudur Smith C, Jenkinson MD. The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review. CNS Oncol. 2018;7(2):CNS17.

96978. Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: A systematic review. Crit Rev Oncol Hematol. 2017;112:41-58. PubMed

97639. Ashrafi MR, Hosseini SA, Zamani GR, et al. The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta Neurol Belg. 2017;117(1):175-182. PubMed
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
A skin rash Additional detail
Ketogenic Diet
“Orally, the ketogenic diet has been associated with reports of acne and balding, but these are rare. There are more than 20 reported cases of prurigo pigmentosa, commonly referred to as "keto rash", associated with following a ketogenic diet. Most individuals affected were females ages 16-29 years. The duration of diet prior to symptom onset has ranged from 4 to 160 days.”

Ketogenic Diet · Natural Medicines adverse-effect record, reported in acne.
6 sources cited

96903. Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: A meta-analysis of observational studies. Epilepsia Open. 2018;3(1):9-17. PubMed

97644. Bertoli S, Trentani C, Ferraris C, De Giorgis V, Veggiotti P, Tagliabue A. Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series. Nutrition. 2014;30(6):726-8. PubMed

96962. Michaels JD, Hoss E, DiCaudo DJ, Price H. Prurigo pigmentosa after a strict ketogenic diet. Pediatr Dermatol. 2015;32(2):248-51. PubMed

102188. Alkeraye S, AlMuqrin A, AlQahtani SM, AlSwayyed M, Alhuzimi A. Twenty-five year-old female with sudden onset itchy skin eruption over her upper back and chest three weeks after starting a ketogenic diet. Ann Saudi Med. 2019;39(6):444-445. PubMed

105657. Lonowski S, Levins P. A unique case of prurigo pigmentosa related to ketogenic diet. Dermatol Online J 2020;26(2):13030/qt56p0z9rp. DOI

108216. Shahrigharahkoshan S, AlHalees Z, Pehr K. Ketogenic diet-induced prurigo pigmentosa: a rising association. Int J Dermatol 2022;61(7):779-782. PubMed
Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›
Vomiting Additional detail

Ketogenic Diet

Recorded for Ketogenic Diet in the same Natural Medicines adverse-effect record shown under Blood clots above.

Abemaciclib

Listed in the ADVERSE REACTIONS section of the FDA label for Abemaciclib. Read the label on DailyMed ›

Showing the 10 most notable of 12 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Ketogenic Diet but not commonly for Abemaciclib: stomach upset, a severe allergic reaction, bone thinning and kidney problems.

Effects for Abemaciclib come from the ADVERSE REACTIONS section of its FDA label; effects for Ketogenic Diet come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Ketogenic Diet in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally without medical supervision. While rare, there are several case reports of lactation ketoacidosis thought to be associated with adherence to calorie-restricted and non-calorie-restricted ketogenic diets. The increased metabolic demand of breastfeeding, especially if exclusively breastfeeding, may increase the risk of lactation ketoacidosis in these individuals. In addition to metabolic changes, symptoms included nausea, vomiting, dizziness, dyspnea, lethargy, epigastric pain, and chest pain. In one case, the lactation ketoacidosis was life-threatening and required treatment in the intensive care unit with non-invasive ventilatory support and dextrose and insulin infusions. In this case, the patient was following a calorie-restricted, ketogenic diet and had lost 19 pounds over 3 weeks.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Abemaciclib Is Prescribed For, and What Ketogenic Diet Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Abemaciclib is a prescription medicine with approved uses on its FDA label. Ketogenic Diet is an eating pattern: what follows is what researchers have looked at it for, and how strong that evidence is.

Abemaciclib is prescribed for: Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back. For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.

Ketogenic Diet has been studied for:

Breast cancer studied, not established Ketogenic Diet has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Ketogenic Diet for breast cancer

It is unclear if following the ketogenic diet is beneficial in patients with breast cancer.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Abemaciclib on your own; if you are taking Ketogenic Diet for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Abemaciclib

This page covers Ketogenic Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Abemaciclib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Abemaciclib page

“A daily pill for a common form of advanced breast cancer, abemaciclib (Verzenio) only helps when its blood level stays steady, so this list of 138 supplements deserves genuine care. Nearly all of them act on CYP3A4, the liver enzyme that clears abemaciclib, meaning a supplement can push its level up and intensify side effects, or drag…”

Reviewed by 2 · Jul 18, 2026

Open the Abemaciclib interaction page

How much people look this up

Where Ketogenic Diet and Abemaciclib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ketogenic Diet

Steady interest

#1,206 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Abemaciclib

Top 5%

#35 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ketogenic Diet reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ketogenic Diet and Abemaciclib records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Eating pattern

About Ketogenic Diet

What is Ketogenic Diet?

Weight loss
Type 2 diabetes and blood sugar control
Drug-resistant epilepsy (especially in children)
Reducing appetite
Athletic and metabolic interest

The ketogenic diet is a very low-carbohydrate, high-fat eating plan that shifts the body to burn fat for fuel. It has the strongest evidence as a medical therapy for hard-to-treat epilepsy and may help short-term weight loss and blood sugar, but it can be hard to sustain and is not right for everyone. Talk with a doctor or pharmacist before starting, especially if you have a medical condition or take medication.

Whole-food eating plan; sometimes paired with MCT oil or exogenous ketone supplements

An interaction check asks whether these two react with each other — it does not ask whether Ketogenic Diet is a good idea for someone in your situation. Here is what our Ketogenic Diet record says about it on its own.

Ketogenic Diet: dosing

There is no single "dose" for a ketogenic diet. Instead, it is defined by how much of your calories come from fat, protein, and carbohydrates. Strict therapeutic versions used for epilepsy keep carbohydrates very low and are calculated carefully by a medical team. More relaxed low-carb versions allow somewhat more carbohydrate.If you try keto on your own, follow guidance from a reputable source and pay attention to food quality, hydration, and electrolytes. Children should only follow a medical ketogenic diet under specialist supervision.

From our Ketogenic Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ketogenic Diet monograph & all interactions

Medication

About Abemaciclib

What Is Abemaciclib Used For?

Brand name: Verzenio

Verzenio (abemaciclib) is used to treat HR-positive, HER2-negative breast cancer in adults. For early breast cancer at high risk of recurrence, Verzenio is taken alongside endocrine therapy (tamoxifen or an aromatase inhibitor) after surgery to help prevent the cancer from coming back.

For advanced or metastatic breast cancer (cancer that has spread), Verzenio can be used in combination with an aromatase inhibitor as a first hormonal treatment, in combination with fulvestrant after the cancer has progressed on endocrine therapy, or alone after prior endocrine therapy and chemotherapy have stopped working.

See full Abemaciclib drug information

Keep checking

Other Drugs & Ketogenic Diet

Browse every other medication we’ve checked against Ketogenic Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

137Moderate

122Minor

2,570No known interaction

137 Moderate 122 Minor 2,570 No interaction

Moderate

137 interactions

Showing 60 of 137 moderate interactions — see all 137 on the Ketogenic Diet page.

Minor

122 interactions

Showing 60 of 122 minor interactions — see all 122 on the Ketogenic Diet page.

No interaction 2,570 drugs checked — show the list

We also checked Ketogenic Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,570 medications checked with no known interaction — see the full Ketogenic Diet list.

See the full Ketogenic Diet interactions page

See every supplement checked against Abemaciclib, ranked by severity

Evidence & sources

Ketogenic Diet References

The 72 references that drive our Ketogenic Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Liu H, Yang Y, Wang Y, et al. Ketogenic diet for treatment of intractable epilepsy in adults: A meta-analysis of observational studies. Epilepsia Open. 2018;3(1):9-17. PubMed
Yancy WS Jr, Westman EC, McDuffie JR, et al. A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss. Arch Intern Med. 2010;170(2):136-45. PubMed
Goday A, Bellido D, Sajoux I, et al. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutr Diabetes. 2016;6(9):e230. PubMed
Saslow LR, Mason AE, Kim S, et al. An online intervention comparing a very low-carbohydrate ketogenic diet and lifestyle recommendations versus a plate method diet in overweight individuals with type 2 diabetes: A randomized controlled trial. J Med Intern
Hussain TA, Mathew TC, Dashti AA, Asfar S, Al-Zaid N, Dashti HM. Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes. Nutrition. 2012;28(10):1016-21. PubMed
Martin-McGill KJ, Srikandarajah N, Marson AG, Tudur Smith C, Jenkinson MD. The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review. CNS Oncol. 2018;7(2):CNS17.
Michaels JD, Hoss E, DiCaudo DJ, Price H. Prurigo pigmentosa after a strict ketogenic diet. Pediatr Dermatol. 2015;32(2):248-51. PubMed
Hawkes CP, Levine MA. Ketotic hypercalcemia: a case series and description of a novel entity. J Clin Endocrinol Metab. 2014;99(5):1531-6. PubMed
Lima PA, de Brito Sampaio LP, Damasceno NR. Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress. Nutr Neurosci. 2015;18(8):337-44. PubMed
Ulamek-Koziol M, Pluta R, Bogucka-Kocka A, Czuczwar SJ. To treat or not to treat drug-refractory epilepsy by the ketogenic diet? That is the question. Ann Agric Environ Med. 2016;23(4):533-536. PubMed
Zahra A, Fath MA, Opat E, et al. Consuming a ketogenic diet while receiving radiation and chemotherapy for locally advanced lung cancer and pancreatic cancer: The University of Iowa experience of two phase 1 clinical trials. Radiat Res. 2017;187(6):743-75 PubMed
Ahn WK, Park S, Kim HD. Protein-losing enteropathy as a complication of the ketogenic diet. Yonsei Med J. 2017;58(4):891-893. PubMed
Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: A systematic review. Crit Rev Oncol Hematol. 2017;112:41-58. PubMed
Kverneland M, Selmer KK, Nakken KO, Iversen PO, Taubøll E. A prospective study of the modified Atkins diet for adults with idiopathic generalized epilepsy. Epilepsy Behav. 2015;53:197-201. PubMed
Ashrafi MR, Hosseini SA, Zamani GR, et al. The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta Neurol Belg. 2017;117(1):175-182. PubMed
Levy Y, Peleg-Weiss L, Goldberg-Stern H. The modified Atkins diet for intractable epilepsy may be associated with late-onset egg-induced anaphylactic reaction: a case report. Nutrition. 2011;27(3):380-2.
Bertoli S, Trentani C, Ferraris C, De Giorgis V, Veggiotti P, Tagliabue A. Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series. Nutrition. 2014;30(6):726-8. PubMed
Desai AA, Thompson LM, Abdelmoity AT, Kayyali H, St Peter SD. Management of symptomatic cholelithiasis while on ketogenic diet: a case report. Pediatr Neurol. 2014;51(3):439-40. PubMed
Moriyama K, Watanabe M, Yamada Y, Shiihara T. Protein-losing enteropathy as a rare complication of the ketogenic diet. Pediatr Neurol. 2015;52(5):526-8. PubMed
Klepper J, Leiendecker B, Heussinger N, Lausch E, Bosch F. Severe hypertriglyceridemia in Glut1D on ketogenic Diet. Neuropediatrics. 2016;47(2):132-6. PubMed
Wing RR, Vazquez JA, Ryan CM. Cognitive effects of ketogenic weight-reducing diets. Int J Obes Relat Metab Disord. 1995;19(11):811-6.
Cai QY, Zhou ZJ, Luo R, et al. Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies. World J Pediatr. 2017;13(6):528-536. PubMed
Lin A, Turner Z, Doerrer SC, Stanfield A, Kossoff EH. Complications during ketogenic diet initiation: Prevalence, treatment, and influence on seizure outcomes. Pediatr Neurol. 2017;68:35-39.
Melchior RW, Dreher M, Ramsey E, Savoca M, Rosenthal T. Cardiopulmonary bypass considerations for pediatric patients on the ketogenic diet. Perfusion. 2015;30(5):423-6. PubMed
Kverneland M, Taubøll E, Selmer KK, Iversen PO, Nakken KO. Modified Atkins diet may reduce serum concentrations of antiepileptic drugs. Acta Neurol Scand. 2015;131(3):187-90. PubMed
Cervenka MC, Hocker S, Koenig M, et al. Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus. Neurology. 2017;88(10):938-943. PubMed
van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol. 2016;20(6):798-809. PubMed
Kossoff EH, Zupec-Kania BA, Auvin S, et al. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018;3(2):175-192. PubMed
Chin A. Copper Deficiency Anemia and Neutropenia Due to Ketogenic Diet. Pediatrics. 2018;141(5). pii: e20173286. PubMed
Alkeraye S, AlMuqrin A, AlQahtani SM, AlSwayyed M, Alhuzimi A. Twenty-five year-old female with sudden onset itchy skin eruption over her upper back and chest three weeks after starting a ketogenic diet. Ann Saudi Med. 2019;39(6):444-445. PubMed
Draaisma JMT, Hampsink BM, Janssen M, van Houdt NBM, Linders ETAM, Willemsen MA. The Ketogenic Diet and Its Effect on Bone Mineral Density: A Retrospective Observational Cohort Study. Neuropediatrics. 2019;50(6):353-358. PubMed
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Ketogenic Diet While Taking Abemaciclib: Common Questions

Is it safe to follow Ketogenic Diet while taking Abemaciclib?

We do not list a known interaction between Ketogenic Diet and Abemaciclib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Ketogenic Diet and Abemaciclib have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Ketogenic Diet and Abemaciclib used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ketogenic Diet in each. That is a conversation for your prescriber, especially if Abemaciclib is being adjusted to a target.

How was the Ketogenic Diet and Abemaciclib combination checked?

Interactions in our licensed database are recorded against drug classes. Abemaciclib is filed under 2 classifications, and Ketogenic Diet has documented interactions with 6 drug classes — none of Abemaciclib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Ketogenic Diet interact with any other medications?

Yes. Ketogenic Diet has 259 documented drug interactions in our database — Abemaciclib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Abemaciclib interact with any supplements?

Yes. Abemaciclib has documented interactions with 138 supplements in our database — Ketogenic Diet is not one of them. The Abemaciclib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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