Kudzu - Aspirin, Butalbital, Caffeine, Codeine Phosphate Interaction
Herbal: Kudzu
Also Known As: Pueraria montana, Bidarikand, Bilaikanda, Daidzein, Fen Ke, Fenge, Gange, Ge Gen, Gegen, Ghora-bel, Indian Kudzu, Isoflavones, Japanese Arrowroot, Kakkon, Kudsu, Nepalem, Pueraria, Vidarikand, Vigne Kudzu, Wa Yaka, White Indian Kudzu
Drug: Aspirin, Butalbital, Caffeine, Codeine Phosphate
Brand names:
Fiorinal w/ Codeine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Aspirin, Butalbital, Caffeine, Codeine Phosphate is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
- Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9.
Interaction Details
Aspirin, Butalbital, Caffeine, Codeine Phosphate is classified as belonging to the following category: Caffeine
Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246.
Kudzu Overview
Kudzu (Pueraria lobata) is a climbing vine native to Southeast Asia. It is known for its ability to grow rapidly and is considered an invasive species in some areas because it can overtake and smother native vegetation.
Kudzu has a long history of use in traditional Chinese medicine, where it is known as "ge gen." It is believed to have a number of medicinal properties, such as anti-inflammatory, antioxidant, and cholesterol-lowering effects.
Some studies have suggested that it may be helpful in reducing blood pressure and improving blood flow to the brain. Additionally, as a dietary supplement, it is often marketed for liver health and there is some evidence to suggest that kudzu may have potential benefits for people with alcoholism by helping to reduce alcohol cravings.
Kudzu - More Interactions
Kudzu interacts with 555 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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