Drug & supplement interaction

Laburnum + Enalapril Maleate

Enalapril Maleate brand names: Vasotec, Epaned.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Laburnum and Enalapril Maleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Laburnum and Enalapril Maleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Enalapril Maleate and Laburnum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Laburnum at all — not against Enalapril Maleate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Laburnum safety at a glance

Laburnum overall Avoid All parts of the plant are poisonous and ingestion can cause severe toxicity.
Pregnancy Unsafe When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Enalapril Maleate and Laburnum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Laburnum and Enalapril Maleate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Laburnum

    “Orally, the fatal adult dose of laburnum is estimated to be about 15-20 seeds or 3-4 unripe berries (18). Many cases of poisoning involve children who ingest small quantities of seeds and experience primarily gastrointestinal symptoms, with a relatively rapid recovery.”

    Laburnum · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    3. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
    4. 101222. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed

    “In the early phases of severe laburnum poisoning, hypertension and tachycardia occur, along with constriction of peripheral blood vessels leading to coldness in the limbs. In the later, delayed phase, hypotension, bradycardia, and cardiac arrhythmias are seen.”

    Laburnum · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 101220. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
    2. 101221. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed

    Enalapril Maleate

    Listed in the ADVERSE REACTIONS section of the FDA label for Enalapril Maleate. Read the label on DailyMed ›

Reported for Laburnum but not commonly for Enalapril Maleate: an irregular heartbeat, sweating, stomach pain and a fast or pounding heartbeat.

Effects for Enalapril Maleate come from the ADVERSE REACTIONS section of its FDA label; effects for Laburnum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Laburnum in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. All parts of the plant contain toxic alkaloids that are reported to cross the placenta and enter breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Laburnum or Enalapril Maleate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Laburnum or Enalapril Maleate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Enalapril Maleate

This page covers Laburnum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enalapril Maleate page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 136 moderate · 24 minor.

From our pharmacist’s overview on the Enalapril Maleate page

“Potassium is the supplement I worry about first with enalapril maleate (Vasotec, Epaned). This ACE inhibitor, used for high blood pressure and heart failure, already makes the body hold onto potassium, so adding more can raise blood levels too far, a problem called hyperkalemia.”

Reviewed by 2 · Jul 18, 2026

Open the Enalapril Maleate interaction page

One more smart check

Taking Laburnum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Laburnum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Laburnum. Even though Laburnum itself has no known interaction with Enalapril Maleate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Laburnum and Enalapril Maleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Laburnum
Steady interest

#1,111 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Enalapril Maleate
Top 5%

#60 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Laburnum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Laburnum and Enalapril Maleate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Laburnum

What is Laburnum?

  • Historically explored as a smoking-cessation aid (due to cytisine content)
  • Traditional folk use as a purgative or emetic
  • Ornamental garden plant
  • Source of the alkaloid cytisine

Laburnum is a poisonous ornamental tree, not a safe dietary supplement. All parts of the plant—especially the seeds—contain the toxic alkaloid cytisine and can cause serious poisoning. Do not eat or take any part of the Laburnum plant; consult a doctor or poison control immediately if ingestion is suspected.

Laburnum anagyroides · Fabaceae · Seeds, flowers, bark, and other plant parts (all considered toxic) · Not used as a commercial supplement; the plant is grown as an ornamental tree

An interaction check asks whether these two react with each other — it does not ask whether Laburnum is a good idea for someone in your situation. Here is what our Laburnum record says about it on its own.

Laburnum: dosing

There is no safe or established dose of Laburnum. It is not a dietary supplement, and no amount of the raw plant is considered safe to consume.Any information you may see about cytisine doses refers to purified, prescription-type products used under medical supervision in certain countries—not to the Laburnum plant. Do not attempt to make or take anything from this tree.

From our Laburnum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Laburnum monograph & all interactions
Medication

About Enalapril

What Is Enalapril Used For?

Brand names: Vasotec, Epaned

Enalapril treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks.

It also treats symptomatic heart failure. It is used for asymptomatic left ventricular dysfunction (a weak pumping chamber of the heart without symptoms) to slow the development of overt heart failure and reduce hospital stays for heart failure. Enalapril oral solution (including Epaned) is labeled for high blood pressure in adults and children older than one month.

See full Enalapril drug information
Keep checking

Other Drugs & Laburnum

Browse every other medication we’ve checked against Laburnum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Laburnum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Laburnum list.

See the full Laburnum interactions page
See every supplement checked against Enalapril Maleate, ranked by severity
Evidence & sources

Laburnum References

The 4 references that drive our Laburnum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Bramley A, Goulding R. Laburnum "poisoning". Br Med J (Clin Res Ed). 1981;283(6301):1220-1.
  3. Schep LJ, Slaughter RJ, Beasley DMG. Nicotinic plant poisoning. Clin Toxicol (Phila). 2009;47(8):771-81. doi: 10.1080/15563650903252186. PubMed
  4. Musshoff F, Madea B. Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS. Forensic Sci Int. 2009;186(1-3):e1-4. doi: 10.1016/j.forsciint.2009.01.011. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Laburnum and Enalapril Maleate Together: Common Questions

Is it safe to take Laburnum with Enalapril Maleate?
We do not list a known interaction between Laburnum and Enalapril Maleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Laburnum and Enalapril Maleate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Enalapril Maleate interact with any supplements?
Yes. Enalapril Maleate has documented interactions with 166 supplements in our database — Laburnum is not one of them. The Enalapril Maleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Laburnum monograph Uses, safety profile, and every drug interaction in one place Enalapril drug information The full plain-English guide to this medication Enalapril Maleate supplement interactions Every supplement checked against Enalapril Maleate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Enalapril Maleate and Laburnum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.