Drug & supplement interaction

Latilactobacillus Sakei + Cobicistat

Cobicistat brand name: Tybost.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Latilactobacillus Sakei and Cobicistat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cobicistat states a food rule worth keeping to.

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Interaction report

Latilactobacillus Sakei and Cobicistat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobicistat and Latilactobacillus Sakei in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Latilactobacillus Sakei safety at a glance

Latilactobacillus... overall Use caution Generally well tolerated in healthy people, but human safety data are limited.
Pregnancy Use caution Not enough safety data; avoid supplement forms unless cleared by your doctor.
Breastfeeding Use caution Not enough safety data; check with your doctor before using supplements.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobicistat and Latilactobacillus Sakei? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cobicistat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cobicistat is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, oral drugs. Latilactobacillus Sakei has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Cobicistat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Latilactobacillus Sakei Does Interact With Other Medications

Latilactobacillus Sakei has 182 moderate known drug interactions in our database — Cobicistat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Cobicistat)
Taking anything else?

Check Another of Your Medications Against Latilactobacillus Sakei

Covers the 2,830 medications we’ve checked against Latilactobacillus Sakei. Pick one to open its full report.

What to actually watch for

What Latilactobacillus Sakei Itself Has Been Linked To

This is not an interaction — nothing below involves Cobicistat. It is the side-effect record for Latilactobacillus Sakei on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Latilactobacillus Sakei, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    “Since Latilactobacillus sakei preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Some lactobacilli species have been isolated in cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis.”

    Latilactobacillus Sakei · Natural Medicines adverse-effect record, reported in sepsis.

    1 source cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Latilactobacillus Sakei — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Cobicistat’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Cobicistat column appears here.

How to take them

Some Cobicistat Products Have a Food Rule — Latilactobacillus Sakei Should Not Break It

At least one FDA label for a product containing Cobicistat says to take it with food. If you take Latilactobacillus Sakei on an empty stomach out of habit, keep them separate — and take Cobicistat with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cobicistat products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION TYBOST must be coadministered with atazanavir or darunavir at the same time, with food, and in combination with other HIV-1 antiretroviral agents.

From the Dosage and Administration section of the FDA label we read for Cobicistat — where that label names a specific product, the instruction is that product's. See the Cobicistat drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cobicistat

This page covers Latilactobacillus Sakei only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobicistat page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Cannabidiol (cbd) (moderate), Cannabinol (cbn) (moderate) and Cannabis (moderate).

By severity: 1 major · 19 moderate · 10 minor.

From our pharmacist’s overview on the Cobicistat page

“Activated charcoal is the one entry to understand first if you take cobicistat (Tybost). Charcoal soaks up drugs in the gut, and since cobicistat's entire job is boosting an HIV medicine to protective levels, blunting its absorption can put the whole regimen at risk.”

Reviewed by 2 · Jul 18, 2026

Open the Cobicistat interaction page

How much people look this up

Where Latilactobacillus Sakei and Cobicistat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Latilactobacillus Sakei
Steady interest

#1,258 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cobicistat
Steady interest

#1,552 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Latilactobacillus Sakei reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Latilactobacillus Sakei and Cobicistat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Latilactobacillus Sakei

What is Latilactobacillus Sakei?

  • Chronic rhinosinusitis and nasal congestion
  • Atopic dermatitis (eczema)
  • Allergies
  • Gut and immune support
  • Skin health

Latilactobacillus sakei is a probiotic bacterium found in fermented foods like kimchi and certain meats, studied mostly for nasal sinus problems and eczema. Early research looks interesting, but evidence is still limited, so it should not replace proven treatments. Talk with a pharmacist or doctor before using it, especially if you have a weakened immune system.

Latilactobacillus sakei · Lactobacillaceae · Whole bacterial cells (live or heat-killed) · Capsules, powders, nasal sprays, topical creams, fermented foods (kimchi, fermented sausage)

An interaction check asks whether these two react with each other — it does not ask whether Latilactobacillus Sakei is a good idea for someone in your situation. Here is what our Latilactobacillus Sakei record says about it on its own.

Latilactobacillus Sakei: dosing

There is no standard, well-established dose for Latilactobacillus sakei. Probiotic amounts are usually measured in CFUs (colony-forming units), and the right amount can vary by product, strain, and intended use.Because doses differ so much between products, the best advice is to follow the directions on the label of the specific product you buy. Do not assume more is better.A pharmacist can help you choose a reputable product and review whether it is appropriate for you.

From our Latilactobacillus Sakei monograph — the full record covers uses, side effects and every documented interaction.

Read the full Latilactobacillus Sakei monograph & all interactions
Medication

About Cobicistat

What Is Cobicistat Used For?

Brand name: Tybost

Tybost (cobicistat) is not itself an HIV treatment — it works by slowing the breakdown of certain HIV medicines so they stay active in your body long enough to work. Specifically, Tybost is used to boost the HIV medicines atazanavir or darunavir (once-daily dosing) as part of a complete HIV-1 treatment regimen in adults and in children weighing at least 14 kg (about 31 lbs).

Tybost is not interchangeable with ritonavir (another booster) for all HIV medicines. It is not recommended with darunavir twice-daily, fosamprenavir, saquinavir, or tipranavir.

Most-Reported Side Effects for Cobicistat

From FAERS, the FDA’s public side-effect reporting system (20,779 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Bone density decreased 8,112 reports
Chronic kidney disease 4,754 reports
Renal injury 4,577 reports
Tooth loss 4,186 reports
Bone loss 4,107 reports
See full Cobicistat drug information
Keep checking

Other Drugs & Latilactobacillus Sakei

Browse every other medication we’ve checked against Latilactobacillus Sakei — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Latilactobacillus Sakei page.

No interaction 2,647 drugs checked — show the list

We also checked Latilactobacillus Sakei against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Latilactobacillus Sakei list.

See the full Latilactobacillus Sakei interactions page
See every supplement checked against Cobicistat, ranked by severity
Evidence & sources

Latilactobacillus Sakei References

The 2 references that drive our Latilactobacillus Sakei monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Latilactobacillus Sakei and Cobicistat Together: Common Questions

Is it safe to take Latilactobacillus Sakei with Cobicistat?
We do not list a known interaction between Latilactobacillus Sakei and Cobicistat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Latilactobacillus Sakei and Cobicistat at the same time of day?
At least one FDA label for a product containing Cobicistat says to take it with food. If you take Latilactobacillus Sakei on an empty stomach out of habit, keep them separate and take Cobicistat with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cobicistat products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Latilactobacillus Sakei and Cobicistat combination checked?
Interactions in our licensed database are recorded against drug classes. Cobicistat is filed under 2 classifications, and Latilactobacillus Sakei has documented interactions with 1 drug class — none of Cobicistat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Latilactobacillus Sakei interact with any other medications?
Yes. Latilactobacillus Sakei has 182 documented drug interactions in our database — Cobicistat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cobicistat interact with any supplements?
Yes. Cobicistat has documented interactions with 30 supplements in our database — Latilactobacillus Sakei is not one of them. The Cobicistat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Latilactobacillus Sakei monograph Uses, safety profile, and every drug interaction in one place Cobicistat drug information The full plain-English guide to this medication Cobicistat supplement interactions Every supplement checked against Cobicistat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobicistat and Latilactobacillus Sakei?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.