Magnolia + Selpercatinib

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

• Tiredness / Headache reported in 4.6% of FDA reports for Selpercatinib Additional detail

  Magnolia

  “In a clinical trial of an oral combination product containing extracts of magnolia and phellodendron, one patient reported shaking hands and perilabial numbness. Another patient reported fatigue and headache. However, it's not known if these side effects are related to magnolia or some other factor.”

  Magnolia · Natural Medicines adverse-effect record, reported in cluster headache.

  1 source cited

  1. 14349. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.

  Selpercatinib

  Listed in the ADVERSE REACTIONS section of the FDA label for Selpercatinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

• A skin rash reported in 4.5% of FDA reports for Selpercatinib Additional detail

  Magnolia

  “Topically, magnolia bark has been associated with reports of allergic contact dermatitis. In several cases, the use of anti-aging facial creams containing magnolia bark extract was associated with allergic contact dermatitis of the face. In one case, the use of a vaginal gel containing magnolia bark extract was associated with allergic contact dermatitis of the vulva.”

  Magnolia · Natural Medicines adverse-effect record, reported in dermatitis.

  4 sources cited

  1. 92463. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  2. 92468. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  3. 95030. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  4. 110709. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

  Selpercatinib

  Listed in the ADVERSE REACTIONS section of the FDA label for Selpercatinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Magnolia but not commonly for Selpercatinib: erection problems, heartburn, numbness or tingling and tremor or shakiness.

Effects for Selpercatinib come from the ADVERSE REACTIONS section of its FDA label; effects for Magnolia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,250 voluntary FDA FAERS reports for Selpercatinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.