Drug & supplement interaction

Manna + Polyethylene Glycol 3350

Polyethylene Glycol 3350 brand names: Miralax, CoLyte, GoLytely, NuLytely, OCL, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Manna and Polyethylene Glycol 3350 in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Manna and Polyethylene Glycol 3350

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Polyethylene Glycol 3350 and Manna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manna safety at a glance

Manna overall Use caution Generally mild but can cause loose stools, gas, and cramping, especially at higher amounts.
Pregnancy Use caution Not well studied in pregnancy; use only under medical supervision.
Breastfeeding Use caution Little safety information exists, so caution is advised while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Polyethylene Glycol 3350 and Manna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Polyethylene Glycol 3350

Interactions in our licensed database are recorded against drug classes, not just single drug names. Polyethylene Glycol 3350 is filed under a single classification — oral drugs. Manna has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (moderate), diuretic drugs (moderate) and stimulant laxatives (moderate) — and none of Polyethylene Glycol 3350’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manna Does Interact With Other Medications

Manna has 99 moderate known drug interactions in our database — Polyethylene Glycol 3350 isn’t one of them. If you take anything else, check it against the full list below.

Moderate 99 No known interaction 2,731 (incl. Polyethylene Glycol 3350)
Taking anything else?

Check Another of Your Medications Against Manna

Covers the 2,830 medications we’ve checked against Manna. Pick one to open its full report.

What to actually watch for

What Manna Itself Has Been Linked To

This is not an interaction — nothing below involves Polyethylene Glycol 3350. It is the side-effect record for Manna on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Manna, this list is the first place to look.

  • Bloating or gas / Nausea Additional detail

    “Orally, manna has been reported to cause flatulence and nausea (2,18).”

    Manna · Natural Medicines adverse-effect record, reported in flatulence.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Manna — expand a row for the licensed statement it rests on. We haven’t matched Polyethylene Glycol 3350 to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Polyethylene Glycol 3350.

Overlapping uses

What Polyethylene Glycol 3350 Is Prescribed For, and What Manna Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Polyethylene Glycol 3350 is a prescription medicine with approved uses on its FDA label. Manna is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Polyethylene Glycol 3350 is prescribed for: Polyethylene Glycol 3350 relieves occasional constipation (irregularity). It generally produces a bowel movement within 1 to 3 days. This use is supported across multiple products including MiraLAX, Dulcolax, ClearLax, Basic Care ClearLax, and many other store-brand formulations.

Manna has been studied for:

  • Constipation studied, not established Manna has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Manna for constipation

    Although there has been interest in using oral manna for constipation, there is insufficient reliable information about the clinical effects of manna for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Polyethylene Glycol 3350 on your own; if you are taking Manna for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Manna or Polyethylene Glycol 3350

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Manna or Polyethylene Glycol 3350, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Polyethylene Glycol 3350

This page covers Manna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Polyethylene Glycol 3350 page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Polyethylene Glycol 3350 interaction page

One more smart check

Taking Manna as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Manna, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manna. Even though Manna itself has no known interaction with Polyethylene Glycol 3350, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manna and Polyethylene Glycol 3350 Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manna
Top half

#556 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Polyethylene Glycol 3350
Top half

#836 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manna reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Manna and Polyethylene Glycol 3350 records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manna

What is Manna?

Manna
  • Gentle constipation relief
  • Mild laxative for children and elderly
  • Natural sweetener
  • Occasional bowel softening

Manna is the dried, sweet sap of the flowering ash tree (Fraxinus ornus) and is best known as a gentle, mild laxative because it contains a sugar alcohol called mannitol. It is generally considered mild and is sometimes used for occasional constipation, but high-quality modern studies are limited, so talk with your pharmacist or doctor before using it.

Fraxinus ornus · Oleaceae · Dried sap (exudate) from the bark and stems · Dried flakes or pieces, syrup, powder, and as an ingredient in laxative products

An interaction check asks whether these two react with each other — it does not ask whether Manna is a good idea for someone in your situation. Here is what our Manna record says about it on its own.

Manna: dosing

There is no official standardized dose of manna for supplement use. Amounts have traditionally varied based on the person's age and how strong a laxative effect is needed, with smaller amounts used for children.If you choose to use a manna product, follow the directions on the label and start with the lowest amount.

From our Manna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manna monograph & all interactions
Medication

About Polyethylene Glycol 3350

What Is Polyethylene Glycol 3350 Used For?

Brand names: Miralax, CoLyte, GoLytely, NuLytely, OCL, Glycolax, PegLyte, Moviprep

Polyethylene Glycol 3350 relieves occasional constipation (irregularity). It generally produces a bowel movement within 1 to 3 days. This use is supported across multiple products including MiraLAX, Dulcolax, ClearLax, Basic Care ClearLax, and many other store-brand formulations.

Most-Reported Side Effects for Polyethylene Glycol 3350

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 7,484 reports
Nausea 6,227 reports
Constipation 5,524 reports
Fatigue 5,024 reports
Vomiting 4,309 reports
See full Polyethylene Glycol 3350 drug information
Keep checking

Other Drugs & Manna

Browse every other medication we’ve checked against Manna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
99Moderate
0Minor
2,730No known interaction
99 Moderate 2,730 No interaction
Moderate

99 interactions

Showing 60 of 99 moderate interactions — see all 99 on the Manna page.

No interaction 2,730 drugs checked — show the list

We also checked Manna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full Manna list.

See the full Manna interactions page
See every supplement checked against Polyethylene Glycol 3350, ranked by severity
Evidence & sources

Manna References

The 3 references that drive our Manna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manna and Polyethylene Glycol 3350 Together: Common Questions

Is it safe to take Manna with Polyethylene Glycol 3350?
We do not list a known interaction between Manna and Polyethylene Glycol 3350. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Manna and Polyethylene Glycol 3350 used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Manna in each. That is a conversation for your prescriber, especially if Polyethylene Glycol 3350 is being adjusted to a target.
How was the Manna and Polyethylene Glycol 3350 combination checked?
Interactions in our licensed database are recorded against drug classes. Polyethylene Glycol 3350 is filed under 1 classification, and Manna has documented interactions with 4 drug classes — none of Polyethylene Glycol 3350's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Manna interact with any other medications?
Yes. Manna has 99 documented drug interactions in our database — Polyethylene Glycol 3350 is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Polyethylene Glycol 3350 interact with any supplements?
Yes. Polyethylene Glycol 3350 has documented interactions with 17 supplements in our database — Manna is not one of them. The Polyethylene Glycol 3350 interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manna monograph Uses, safety profile, and every drug interaction in one place Polyethylene Glycol 3350 drug information The full plain-English guide to this medication Polyethylene Glycol 3350 supplement interactions Every supplement checked against Polyethylene Glycol 3350, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Polyethylene Glycol 3350 and Manna?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.