Drug & supplement interaction

Manna + Apixaban

Apixaban brand name: Eliquis.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Manna and Apixaban in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Manna and Apixaban

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Apixaban and Manna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manna safety at a glance

Manna overall Use caution Generally mild but can cause loose stools, gas, and cramping, especially at higher amounts.

Pregnancy Use caution Not well studied in pregnancy; use only under medical supervision.

Breastfeeding Use caution Little safety information exists, so caution is advised while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Apixaban and Manna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Apixaban

Interactions in our licensed database are recorded against drug classes, not just single drug names. Apixaban is filed under 4 classifications — including anticoagulant/antiplatelet drugs, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Manna has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (moderate), diuretic drugs (moderate) and stimulant laxatives (moderate) — and none of Apixaban’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manna Does Interact With Other Medications

Manna has 99 moderate known drug interactions in our database — Apixaban isn’t one of them. If you take anything else, check it against the full list below.

Moderate 99 No known interaction 2,731 (incl. Apixaban)

Taking anything else?

Check Another of Your Medications Against Manna

Covers the 2,830 medications we’ve checked against Manna. Pick one to open its full report.

What to actually watch for

What Manna Itself Has Been Linked To

This is not an interaction — nothing below involves Apixaban. It is the side-effect record for Manna on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Manna, this list is the first place to look.

Bloating or gas / Nausea Additional detail
“Orally, manna has been reported to cause flatulence and nausea (2,18).”

Manna · Natural Medicines adverse-effect record, reported in flatulence.
2 sources cited

2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Manna — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Apixaban’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Apixaban column appears here.

From our Q&A

Questions About Manna or Apixaban

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Manna or Apixaban, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Apixaban

This page covers Manna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apixaban page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 240 moderate · 40 minor.

From our pharmacist’s overview on the Apixaban page

“St. John's wort can weaken apixaban (Eliquis), speeding how the body clears this blood thinner and leaving you less protected from the strokes and clots it is prescribed to prevent.”

Reviewed by 2 · Jul 18, 2026

Open the Apixaban interaction page

One more smart check

Taking Manna as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Manna, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manna. Even though Manna itself has no known interaction with Apixaban, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manna and Apixaban Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manna

Top half

#691 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Apixaban

Most looked up

#1 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manna reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Manna and Apixaban records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Manna

What is Manna?

Gentle constipation relief
Mild laxative for children and elderly
Natural sweetener
Occasional bowel softening

Manna is the dried, sweet sap of the flowering ash tree (Fraxinus ornus) and is best known as a gentle, mild laxative because it contains a sugar alcohol called mannitol. It is generally considered mild and is sometimes used for occasional constipation, but high-quality modern studies are limited, so talk with your pharmacist or doctor before using it.

Fraxinus ornus · Oleaceae · Dried sap (exudate) from the bark and stems · Dried flakes or pieces, syrup, powder, and as an ingredient in laxative products

An interaction check asks whether these two react with each other — it does not ask whether Manna is a good idea for someone in your situation. Here is what our Manna record says about it on its own.

Manna: dosing

There is no official standardized dose of manna for supplement use. Amounts have traditionally varied based on the person's age and how strong a laxative effect is needed, with smaller amounts used for children.If you choose to use a manna product, follow the directions on the label and start with the lowest amount.

From our Manna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manna monograph & all interactions

Medication

About Apixaban

What Is Apixaban Used For?

Brand name: Eliquis

Apixaban is used to reduce the risk of stroke and dangerous clots traveling through the body in adults with nonvalvular atrial fibrillation (an irregular heart rhythm not caused by a heart valve problem). It is also used to prevent deep vein thrombosis (DVT — a blood clot in the leg) in adults after hip or knee replacement surgery, and to treat DVT and pulmonary embolism (PE — a blood clot in the lungs) in adults, including reducing the risk of those clots coming back.

Eliquis (the brand-name tablet and kit) is additionally approved to treat venous thromboembolism (VTE — blood clots in the veins) and reduce the risk of recurrent VTE in pediatric patients from birth and older, after at least 5 days of initial anticoagulant treatment. The generic apixaban tablet carries the adult indications only.

See full Apixaban drug information

Keep checking

Other Drugs & Manna

Browse every other medication we’ve checked against Manna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

99Moderate

0Minor

2,730No known interaction

99 Moderate 2,730 No interaction

Moderate

99 interactions

Showing 60 of 99 moderate interactions — see all 99 on the Manna page.

No interaction 2,730 drugs checked — show the list

We also checked Manna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full Manna list.

See the full Manna interactions page

See every supplement checked against Apixaban, ranked by severity

Evidence & sources

Manna References

The 3 references that drive our Manna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manna and Apixaban Together: Common Questions

Is it safe to take Manna with Apixaban?

We do not list a known interaction between Manna and Apixaban. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Manna and Apixaban combination checked?

Interactions in our licensed database are recorded against drug classes. Apixaban is filed under 4 classifications, and Manna has documented interactions with 4 drug classes — none of Apixaban's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Manna interact with any other medications?

Yes. Manna has 99 documented drug interactions in our database — Apixaban is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Apixaban interact with any supplements?

Yes. Apixaban has documented interactions with 285 supplements in our database — Manna is not one of them. The Apixaban interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manna monograph Uses, safety profile, and every drug interaction in one place Apixaban drug information The full plain-English guide to this medication Apixaban supplement interactions Every supplement checked against Apixaban, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Apixaban and Manna?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.