Drug & supplement interaction

Maqui + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Maqui and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Maqui and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and Maqui in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maqui safety at a glance

Maqui overall Use caution Likely safe in food amounts, but supplement safety has not been well studied.
Pregnancy Avoid Not enough safety information, so it is best to avoid supplement amounts.
Breastfeeding Avoid Not enough safety information, so it is best to avoid supplement amounts.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and Maqui? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bupropion

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bupropion is filed under 6 classifications — including antidepressant drugs, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2d6 (cyp2d6) inhibitors. Maqui has documented interactions with 1 drug class — the most serious being antidiabetes drugs (minor) — and none of Bupropion’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maqui Does Interact With Other Medications

Maqui has 86 minor known drug interactions in our database — Bupropion isn’t one of them. If you take anything else, check it against the full list below.

Minor 86 No known interaction 2,744 (incl. Bupropion)
Taking anything else?

Check Another of Your Medications Against Maqui

Covers the 2,830 medications we’ve checked against Maqui. Pick one to open its full report.

What to actually watch for

What Bupropion’s Own FDA Label Lists

This is not an interaction — none of it involves Maqui. These are the most notable effects listed in the ADVERSE REACTIONS section of Bupropion’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Thoughts of self-harm Worth acting on
  • Trouble swallowing Worth acting on
  • Hallucinations Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 43 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed › Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Maqui’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Maqui side to compare — that is a limit of the record, not a statement that Maqui has no side effects.

From our Q&A

Questions About Maqui or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Maqui or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers Maqui only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

One more smart check

Taking Maqui as Part of a Dietary Supplement Product? Check It for Interactions

We hold 388 real supplement products containing Maqui, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maqui. Even though Maqui itself has no known interaction with Bupropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maqui and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maqui
Top half

#384 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maqui reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Maqui and Bupropion records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maqui

What is Maqui?

  • Antioxidant support
  • Blood sugar support
  • Eye health and dry eye
  • Anti-inflammatory support
  • Heart health

Maqui is a dark purple berry from Chile that is very rich in antioxidant plant pigments called anthocyanins. Early research suggests it may help with things like blood sugar, dry eye, and inflammation, but the human evidence is still limited and far from proven. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Aristotelia chilensis · Elaeocarpaceae · Berries (fruit); leaves are used traditionally · Capsules, powder, juice, extracts, dried berries

An interaction check asks whether these two react with each other — it does not ask whether Maqui is a good idea for someone in your situation. Here is what our Maqui record says about it on its own.

Maqui: dosing

There is no official or well-established dose for maqui. Doses used in research have varied widely depending on whether the product was a juice, powder, or standardized extract, so it is hard to recommend a single amount.The best approach is to follow the directions on the product label and not exceed them.

From our Maqui monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maqui monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & Maqui

Browse every other medication we’ve checked against Maqui — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
86Minor
2,743No known interaction
86 Minor 2,743 No interaction
Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Maqui page.

No interaction 2,743 drugs checked — show the list

We also checked Maqui against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Maqui list.

See the full Maqui interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

Maqui References

The 3 references that drive our Maqui monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Alvarado JL, Leschot A, Olivera-Nappa Á, et al. Delphinidin-rich maqui berry extract (Delphinol®) lowers fasting and postprandial glycemia and insulinemia in prediabetic individuals during oral glucose tolerance tests. Biomed Res Int. 2016;2016:9070537. PubMed
  2. Alvarado J, Schoenlau F, Leschot A, Salgad AM, Vigil Portales P. Delphinol® standardized maqui berry extract significantly lowers blood glucose and improves blood lipid profile in prediabetic individuals in three-month clinical trial. Panminerva Med. 2016
  3. Hidalgo J, Flores C, Hidalgo MA, et al. Delphinol® standardized maqui berry extract reduces postprandial blood glucose increase in individuals with impaired glucose regulation by novel mechanism of sodium glucose cotransporter inhibition. Panminerva Med.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maqui and Bupropion Together: Common Questions

Is it safe to take Maqui with Bupropion?
We do not list a known interaction between Maqui and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Maqui and Bupropion combination checked?
Interactions in our licensed database are recorded against drug classes. Bupropion is filed under 6 classifications, and Maqui has documented interactions with 1 drug class — none of Bupropion's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maqui interact with any other medications?
Yes. Maqui has 86 documented drug interactions in our database — Bupropion is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — Maqui is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maqui monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and Maqui?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.