Drug & supplement interaction

Oleander + Warfarin Sodium

Warfarin Sodium brand names: Coumadin, Panwarfin, Sofarin.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Oleander and Warfarin Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Oleander and Warfarin Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Warfarin Sodium and Oleander in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Oleander safety at a glance

Oleander overall Avoid Oleander is highly toxic and can be deadly even in small amounts.

Pregnancy Likely Unsafe When used orally. Oleander has been reported to have abortifacient properties. Also, maternal ingestion of oleander seeds during pregnancy has led to fetal toxi... Read the full pregnancy detail

Breastfeeding Likely Unsafe When used orally. Oleander has been reported to have abortifacient properties. Also, maternal ingestion of oleander seeds during pregnancy has led to fetal toxi... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Warfarin Sodium and Oleander? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Warfarin Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Warfarin Sodium is filed under 10 classifications — including cytochrome p450 2c8 (cyp2c8) substrates, cytochrome p450 2c19 (cyp2c19) substrates, cytochrome p450 2c9 (cyp2c9) substrates. Oleander has documented interactions with 7 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (major) and macrolide antibiotics (major) — and none of Warfarin Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Oleander Does Interact With Other Medications

Oleander has 133 major, 23 moderate known drug interactions in our database — Warfarin Sodium isn’t one of them. If you take anything else, check it against the full list below.

Major 133 Moderate 23 No known interaction 2,674 (incl. Warfarin Sodium)

Taking anything else?

Check Another of Your Medications Against Oleander

Covers the 2,830 medications we’ve checked against Oleander. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Oleander and Warfarin Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

Kidney problems Worth acting on Additional detail
Oleander
“Orally, oleander can cause acute kidney failure characterized by dark colored, scanty urine (less than 300 mL daily).”

Oleander · Natural Medicines adverse-effect record, reported in kidney failure.
3 sources cited

65417. Samal, K. K. Yellow oleander poisoning with jaundice and renal failure. J Assoc Physicians India 1990;38(10):821-822.

65420. Samal, K. K., Sahu, H. K., Kar, M. K., Palit, S. K., Kar, B. C., and Sahu, C. S. Yellow oleander (cerbera thevetia) poisoning with jaundice and renal failure. J Assoc Physicians India 1989;37(3):232-233.

106426. Corcoran J, Gray T, Bangh SA, Singh V, Cole JB. Fatal yellow oleander poisoning masquerading as benign candlenut ingestion taken for weight loss. J Emerg Med. 2020;59(6):e209-e212. PubMed
Warfarin Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Warfarin Sodium. Read the label on DailyMed ›
Liver problems Worth acting on Additional detail
Oleander
“Two cases of jaundice, increased bilirubin, and hepatosplenomegaly have been reported after oleander ingestion.

Intramuscularly, there is one case report of a patient with cancer who developed hepatotoxicity after receiving daily injections of a specific oleander extract (Anvirzel, Phoenix Biotech) 1.2 mL/m2 for 2 months. Other causes of hepatotoxicity were ruled out.”

Oleander · Natural Medicines adverse-effect record, reported in cancer.
2 sources cited

65420. Samal, K. K., Sahu, H. K., Kar, M. K., Palit, S. K., Kar, B. C., and Sahu, C. S. Yellow oleander (cerbera thevetia) poisoning with jaundice and renal failure. J Assoc Physicians India 1989;37(3):232-233.

94428. Altan E, Bitik B, Kalpakci Y, ET AL. Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. J Altern Complement Med 2009;15:113.
Warfarin Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Warfarin Sodium. Read the label on DailyMed ›
Stomach pain / Diarrhea / Vomiting / Nausea reported in 4.5% of FDA reports for Warfarin Sodium Additional detail
Oleander
“Orally, oleander leaves, flowers, and seeds have a bitter taste, and can cause a burning sensation in the mouth, nausea, vomiting, and diarrhea (17,18,3495,65395,65411,65419,65422,65423,65431,65437,94417,94430,94432,94435,94436,98220,103239,103241). Oleander can also cause mucous membrane irritation, increased salivation, abdominal pain and cramping, and buccal erythema.”

Oleander · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

3495. Haynes BE, Bessen HA, Wightman WD. Oleander tea: herbal draught of death. Ann Emerg Med 1985;14:350-3. PubMed

65395. Bose, T. K., Basu, R. K., Biswas, B., De, J. N., Majumdar, B. C., and Datta, S. Cardiovascular effects of yellow oleander ingestion. J Indian Med Assoc. 1999;97(10):407-410.

65411. Camphausen, C., Haas, N. A., and Mattke, A. C. Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature. Z Kardiol. 2005;94(12):817-823. PubMed

65419. Brewster, D. Herbal poisoning: a case report of a fatal yellow oleander poisoning from the Solomon Islands. Ann.Trop.Paediatr. 1986;6(4):289-291. PubMed
Warfarin Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Warfarin Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
A skin rash Additional detail
Oleander
“Topically, the sap of freshly cut oleander leaves can cause contact dermatitis. In a case report, a 5-year-old child applied oleander leaves to the face and developed skin erythema, followed by blistering, swelling and partial thickness facial burns. The condition resolved with conservative management.”

Oleander · Natural Medicines adverse-effect record, reported in burns.
4 sources cited

5000. Langford SD, Boor PJ. Oleander toxicity: an examination of human and animal toxic exposures. Toxicology 1996;109:1-13. PubMed

65432. Apted, J. Oleander dermatitis. Contact Dermatitis 1983;9(4):321.

65448. Dorsey CS. Plant dermatitis in California. Calif Med 1962;96(6):412-413.

106425. van Oudtshoorn S, Gera S, Gera P. Paediatric facial burns from oleander leaves. Med J Aust. 2020 Sep;213(6):265-265.e1. Epub 2020 Aug 28. PubMed
Warfarin Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Warfarin Sodium. Read the label on DailyMed ›

Reported for Oleander but not commonly for Warfarin Sodium: yellowing of the skin or eyes, blurred vision, a low platelet count and a change in taste.

Effects for Warfarin Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Oleander come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 45,853 voluntary FDA FAERS reports for Warfarin Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Oleander in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally. Oleander has been reported to have abortifacient properties. Also, maternal ingestion of oleander seeds during pregnancy has led to fetal toxicity. There is insufficient reliable information available about the safety of topical use of oleander during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Oleander or Warfarin Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Oleander or Warfarin Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Warfarin Sodium

This page covers Oleander only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Warfarin Sodium page lists 361 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alfalfa (major), American Ginseng (major), Beer (major) and Cannabis (major).

Open the Warfarin Sodium interaction page

How much people look this up

Where Oleander and Warfarin Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oleander

Steady interest

#1,138 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Warfarin Sodium

Top 1%

#18 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Oleander reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Oleander and Warfarin Sodium records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Oleander

What is Oleander?

Heart failure (traditional)
Cancer (investigational)
Skin conditions
Asthma (folk use)
Pain relief (folk use)

Oleander is a highly poisonous ornamental plant, and every part of it can cause life-threatening heart and nervous system effects, even in small amounts. There is no proven safe dose for self-use, and serious poisonings and deaths have occurred from teas, extracts, and accidental ingestion. We strongly advise against using oleander as a supplement.

Nerium oleander · Apocynaceae · Leaves, flowers, stems, and seeds (all parts are toxic) · Extracts, teas, and historically tinctures (not recommended for self-use)

An interaction check asks whether these two react with each other — it does not ask whether Oleander is a good idea for someone in your situation. Here is what our Oleander record says about it on its own.

Oleander: dosing

There is no safe, established dose of oleander for self-use. Because the amount that might cause an effect is dangerously close to the amount that can poison or kill, no responsible dosing guidance can be given.We do not recommend taking oleander in any form. In nearly all cases, the safe answer is to avoid it entirely.

From our Oleander monograph — the full record covers uses, side effects and every documented interaction.

Read the full Oleander monograph & all interactions

Medication

About Warfarin

What Is Warfarin Used For?

Brand names: Coumadin, Panwarfin, Sofarin

Warfarin sodium tablets and Jantoven tablets are both used to prevent and treat venous thrombosis (blood clots in the veins) and pulmonary embolism (a clot in the lungs). They are also used to prevent clot-related complications in people with atrial fibrillation (an irregular heart rhythm) or who have had a heart valve replaced.

In people who have had a heart attack, warfarin is used to reduce the risk of death, another heart attack, stroke, or other clotting events. It does not dissolve an existing clot, but it helps prevent the clot from growing and stops new dangerous clots from forming.

See full Warfarin drug information

Keep checking

Other Drugs & Oleander

Browse every other medication we’ve checked against Oleander — both the ones with a known interaction and the ones without. Select any drug for the full detail.

133Major

23Moderate

0Minor

2,673No known interaction

133 Major 23 Moderate 2,673 No interaction

Major

133 interactions

Showing 60 of 133 major interactions — see all 133 on the Oleander page.

Moderate

23 interactions

No interaction 2,673 drugs checked — show the list

We also checked Oleander against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,673 medications checked with no known interaction — see the full Oleander list.

See the full Oleander interactions page

See every supplement checked against Warfarin Sodium, ranked by severity

Evidence & sources

Oleander References

The 39 references that drive our Oleander monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Eddleston M, Rajapakse S, Rajakanthan K, et al. Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomized controlled trial. Lancet 2000;355:967-72.
Haynes BE, Bessen HA, Wightman WD. Oleander tea: herbal draught of death. Ann Emerg Med 1985;14:350-3. PubMed
Langford SD, Boor PJ. Oleander toxicity: an examination of human and animal toxic exposures. Toxicology 1996;109:1-13. PubMed
Bose, T. K., Basu, R. K., Biswas, B., De, J. N., Majumdar, B. C., and Datta, S. Cardiovascular effects of yellow oleander ingestion. J Indian Med Assoc. 1999;97(10):407-410.
Camphausen, C., Haas, N. A., and Mattke, A. C. Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child: case report and review of literature. Z Kardiol. 2005;94(12):817-823. PubMed
Samal, K. K. Yellow oleander poisoning with jaundice and renal failure. J Assoc Physicians India 1990;38(10):821-822.
Brewster, D. Herbal poisoning: a case report of a fatal yellow oleander poisoning from the Solomon Islands. Ann.Trop.Paediatr. 1986;6(4):289-291. PubMed
Samal, K. K., Sahu, H. K., Kar, M. K., Palit, S. K., Kar, B. C., and Sahu, C. S. Yellow oleander (cerbera thevetia) poisoning with jaundice and renal failure. J Assoc Physicians India 1989;37(3):232-233.
Saravanapavananthan, N. and Ganeshamoorthy, J. Yellow oleander poisoning--a study of 170 cases. Forensic Sci.Int 1988;36(3-4):247-250. PubMed
Blum, L. M. and Rieders, F. Oleandrin distribution in a fatality from rectal and oral Nerium oleander extract administration. J Anal.Toxicol. 1987;11(5):219-221. PubMed
Kaojarern, S., Sukhupunyarak, S., and Mokkhavesa, C. Oleander Yee tho poisoning. J Med Assoc.Thai. 1986;69(2):108-112.
Thilagar, S., Thirumalaikolundusubramanian, P., Gopalakrishnan, S., Lakshmikandan, R., Ayyappan, A., and Subramanian, R. Possible yellow oleander toxicity in a neonate. Indian Pediatr 1986;23(5):393.
Mallick, B. K. Cardiotoxicity in yellow oleander seed poisoning. J Indian Med Assoc. 1984;82(8):296-297.
Apted, J. Oleander dermatitis. Contact Dermatitis 1983;9(4):321.
Kakrani, A. L., Rajput, C. S., Khandare, S. K., and Redkar, V. E. Yellow oleander seed poisoning with cardiotoxicity. A case report. Indian Heart J 1981;33(1):31-33.
Nishioka, Sd and Resende, E. S. Transitory complete atrioventricular block associated to ingestion of Nerium oleander. Rev Assoc Med Bras 1995;41(1):60-62.
Ahlawat, S. K., Agarwal, A. K., and Wadhwa, S. Rare poisoning with cerebra thevetia (yellow oleander): a report of three cases. Trop.Doct. 1994;24(1):37-38. PubMed
Dasgupta, A. and Hart, A. P. Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Effect of treatment with digoxin-specific Fab antibody fragment (ovine). Am J Clin.Pathol. 1997;108(4):411-416.
Gupta, A., Joshi, P., Jortani, S. A., Valdes, R., Jr., Thorkelsson, T., Verjee, Z., and Shemie, S. A case of nondigitalis cardiac glycoside toxicity. Ther.Drug Monit. 1997;19(6):711-714. PubMed
Dorsey CS. Plant dermatitis in California. Calif Med 1962;96(6):412-413.
Al B, Yarbil P, Dogan M, ET AL. A case of non-fatal oleander poisoning. BMJ Case Rep 2010;2010. pii: bcr02.2009.1573.
Altan E, Bitik B, Kalpakci Y, ET AL. Probable hepatotoxicity related to Nerium oleander extract in a patient with metastatic synovial sarcoma of the knee. J Altern Complement Med 2009;15:113.
Bavunoglu I, Balta M, Türkmen Z. Oleander Poisoning as an example of self-medication attempt. Balkan Med J 2016;33:559-562. PubMed
Boswell BR, Dorweiler MA, Erbs NC, Caplan JP. A case of Nerium oleander toxicity: a thorny predicament. Psychosomatics 2013;54:379-81. PubMed
Khan I, Kant C, Sanwaria A, Meena L. Acute cardiac toxicity of Nerium oleander/indicum poisoning (kaner) poisoning. Heart Views 2010;11:115-6. PubMed
Senthilkumaran S, Saravanakumar S, Thirumalaikolundusubramanian P. Cutaneous absorption of Oleander: Fact or fiction. J Emerg Trauma Shock 2009;2:43-5. PubMed
Tatlisu MA, Çekirdekçi EI, Akyüz S, Nurkalem Z. A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments. Turk Kardiyol Dern Ars 2015;43:648-50. PubMed
Vallé B, Lairez O, Gandia P, et al. Circuitous diagnosis in concealed self-poisoning with Nerium oleander. Clin Toxicol (Phila) 2012;50:228-9.
Zamani J, Aslani A. Cardiac findings in acute yellow oleander poisoning. J Cardiovasc Dis Res 2010;1:27-8. PubMed
Papi L, Luciani AB, Forni D, Giusiani M. Unexpected double lethal oleander poisoning. Am J Forensic Med Pathol 2012;33(1):93-7. doi: 10.1097/PAF.0b013e31822d33d4. PubMed
Karthik G, Iyadurai R, Ralph R, et al. Acute oleander poisoning: A study of clinical profile from a tertiary care center in South India. J Family Med Prim Care. 2020;9(1):136-40. PubMed
Anandhi D, Pandit VR, Kadhiravan T, Soundaravally R, Prakash Raju KNJ. Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow oleander (Cascabela thevetia) poisoning - a prospective study. Clin Toxicol (Phila).
Bataille C, Capaldo L, Courtois A, Seguy B, Lotiron C, Labadie M. Toxic thrombocytopenia during Nerium oleander poisoning. Clin Toxicol (Phila). 2018;56(11):1170-1.
van Oudtshoorn S, Gera S, Gera P. Paediatric facial burns from oleander leaves. Med J Aust. 2020 Sep;213(6):265-265.e1. Epub 2020 Aug 28. PubMed
Corcoran J, Gray T, Bangh SA, Singh V, Cole JB. Fatal yellow oleander poisoning masquerading as benign candlenut ingestion taken for weight loss. J Emerg Med. 2020;59(6):e209-e212. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Oleander and Warfarin Sodium Together: Common Questions

Is it safe to take Oleander with Warfarin Sodium?

We do not list a known interaction between Oleander and Warfarin Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Oleander and Warfarin Sodium have any of the same side effects?

Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Oleander and Warfarin Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Warfarin Sodium is filed under 10 classifications, and Oleander has documented interactions with 7 drug classes — none of Warfarin Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Oleander interact with any other medications?

Yes. Oleander has 156 documented drug interactions in our database — Warfarin Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Warfarin Sodium interact with any supplements?

Yes. Warfarin Sodium has documented interactions with 361 supplements in our database — Oleander is not one of them. The Warfarin Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Oleander monograph Uses, safety profile, and every drug interaction in one place Warfarin drug information The full plain-English guide to this medication Warfarin Sodium supplement interactions Every supplement checked against Warfarin Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 39 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Warfarin Sodium and Oleander?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.