Drug & supplement interaction

Oleander + Budesonide

Budesonide brand names: Entocort EC, Pulmicort, Uceris, Tarpeyo, Eohilia.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Oleander has a moderate interaction with Budesonide. Theoretically, using oleander with prolonged corticosteroid therapy can increase the risk of oleander toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Oleander and Budesonide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CORTICOSTEROIDS

Why this applies to Budesonide

Budesonide falls under CORTICOSTEROIDS — the group Oleander interacts with.

Theoretically, using oleander with prolonged corticosteroid therapy can increase the risk of oleander toxicity.
Oleander contains cardiac glycosides. Concomitant use of corticosteroids with oleander can increase the therapeutic and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First things first: I would not use oleander at all. It is a poisonous plant, and even tiny amounts can throw your heart rhythm dangerously off. So this is really a safety warning, not a 'how to combine them' tip.

Here is the concern with budesonide. It is a corticosteroid, and over the long haul steroids like it can lower your potassium. Oleander's heart-acting compounds become far more dangerous when potassium runs low. So the worry is that budesonide could quietly set the stage for worse oleander toxicity, meaning a higher chance of irregular or dangerous heartbeats. This link is theoretical, based on how the two work, but the risk from oleander itself is very real. Please talk with your pharmacist or doctor before combining anything like this.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Oleander Also Interacts With Other Medications

Oleander has 133 major, 22 moderate known drug interactions in our database — the Budesonide one above is one of them. If you take anything else, check it against the full list below.

Major 133 Moderate 22 No known interaction 2,675 (incl. Budesonide)
Taking anything else?

Check Another of Your Medications Against Oleander

Covers the 2,830 medications we’ve checked against Oleander. Pick one to open its full report.

From our Q&A

Questions About Oleander or Budesonide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Oleander or Budesonide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Budesonide

This page covers Oleander only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Budesonide page lists 154 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 110 moderate · 40 minor.

From our pharmacist’s overview on the Budesonide page

“Budesonide (Entocort EC, Pulmicort, Uceris) is a steroid designed to act locally in the gut or airways while the liver enzyme CYP3A4 clears most of what reaches the bloodstream. That design is exactly why this page warrants real care.”

Reviewed by 2 · Jul 18, 2026

Open the Budesonide interaction page

How much people look this up

Where Oleander and Budesonide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oleander
Top half

#710 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Budesonide
Top half

#1,392 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Oleander

What is Oleander?

  • Heart failure (traditional)
  • Cancer (investigational)
  • Skin conditions
  • Asthma (folk use)
  • Pain relief (folk use)

Oleander is a highly poisonous ornamental plant, and every part of it can cause life-threatening heart and nervous system effects, even in small amounts. There is no proven safe dose for self-use, and serious poisonings and deaths have occurred from teas, extracts, and accidental ingestion. We strongly advise against using oleander as a supplement.

Read the full Oleander monograph & all interactions
Medication

About Budesonide

What Is Budesonide Used For?

Brand names: Entocort EC, Pulmicort, Uceris, Tarpeyo, Eohilia

Budesonide calms inflammation. Which condition it treats depends on the product and how it is delivered.

  • Asthma: inhaled budesonide (Pulmicort Flexhaler for ages 6 and older; nebulized suspensions such as Pulmicort Respules for children 12 months to 8 years) is used for long-term control.
  • Crohn’s disease: budesonide delayed-release capsules treat mild to moderate active disease of the ileum and/or ascending colon (ages 8 and older). They also help maintain remission for up to 3 months in adults.
  • Ulcerative colitis: Uceris extended-release tablets and Uceris/budesonide rectal foam help bring on remission of mild to moderate disease.
  • Eosinophilic esophagitis (EoE): Eohilia oral suspension is used for 12 weeks in people 11 and older.
  • IgA nephropathy (IgAN): Tarpeyo is used in adults at risk of progression, to reduce loss of kidney function.

The inhaled products are not for sudden asthma attacks.

See full Budesonide drug information
Keep checking

Other Drugs & Oleander

Browse every other medication we’ve checked against Oleander — both the ones with a known interaction and the ones without. Select any drug for the full detail.

133Major
22Moderate
0Minor
2,674No known interaction
133 Major 22 Moderate 2,674 No interaction
Major

133 interactions

Showing 60 of 133 major interactions — see all 133 on the Oleander page.

Moderate

22 interactions

No interaction 2,674 drugs checked — show the list

We also checked Oleander against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,674 medications checked with no known interaction — see the full Oleander list.

See the full Oleander interactions page
See every supplement checked against Budesonide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Oleander monograph › Uses, safety, and every drug interaction in one place Budesonide supplement interactions › Every supplement checked against Budesonide, ranked by severity Budesonide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Oleander and Budesonide Together: Common Questions

Can you take Oleander with Budesonide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Oleander and Budesonide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Budesonide and Oleander?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.