Drug & supplement interaction

Phellodendron + Difluprednate

Difluprednate brand name: Durezol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Phellodendron and Difluprednate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phellodendron and Difluprednate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Difluprednate and Phellodendron in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phellodendron safety at a glance

Phellodendron overall Use caution Generally used short-term in traditional medicine, but human safety data are limited.
Pregnancy Avoid Berberine-containing herbs may not be safe in pregnancy, so avoid use.
Breastfeeding Likely Unsafe When used orally. The berberine constituent of phellodendron and other harmful constituents can be transferred to the infant through breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Difluprednate and Phellodendron? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Phellodendron Does Interact With Other Medications

Phellodendron has 1,160 moderate known drug interactions in our database — Difluprednate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,160 No known interaction 1,670 (incl. Difluprednate)
Taking anything else?

Check Another of Your Medications Against Phellodendron

Covers the 2,830 medications we’ve checked against Phellodendron. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phellodendron and Difluprednate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 3.6% of FDA reports for Difluprednate Additional detail

    Phellodendron

    “Orally, a combination product containing extracts of phellodendron plus magnolia has been associated with single reports of shaking hands, perilabial numbness, fatigue, and headache in clinical research. However, it is unknown if this is related to phellodendron or some other factor.”

    Phellodendron · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 14349. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
    2. 94901. Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary magnolia and phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.

    Difluprednate

    Listed in the ADVERSE REACTIONS section of the FDA label for Difluprednate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Phellodendron but not commonly for Difluprednate: erection problems, heartburn, numbness or tingling and tremor or shakiness.

Effects for Difluprednate come from the ADVERSE REACTIONS section of its FDA label; effects for Phellodendron come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 830 voluntary FDA FAERS reports for Difluprednate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Phellodendron in Pregnancy & Breastfeeding

Lactation Likely Unsafe

When used orally. The berberine constituent of phellodendron and other harmful constituents can be transferred to the infant through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

One more smart check

Taking Phellodendron as Part of a Dietary Supplement Product? Check It for Interactions

We hold 393 real supplement products containing Phellodendron, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phellodendron. Even though Phellodendron itself has no known interaction with Difluprednate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phellodendron and Difluprednate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phellodendron
Top 25%

#305 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Difluprednate
Top half

#1,228 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phellodendron reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phellodendron and Difluprednate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phellodendron

What is Phellodendron?

Phellodendron
  • Digestive complaints and diarrhea
  • Inflammation and joint discomfort
  • Stress and weight management (in combination products)
  • Skin conditions (topical, traditional)
  • Antimicrobial support

Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflammatory activity in lab studies. Human evidence for most uses is limited, and it is often sold in combination with other herbs, making its individual effects hard to judge. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Phellodendron amurense · Rutaceae · Bark (cortex) · Capsules, tablets, powders, tinctures, and dried bark used in teas or decoctions; often combined with other herbs

An interaction check asks whether these two react with each other — it does not ask whether Phellodendron is a good idea for someone in your situation. Here is what our Phellodendron record says about it on its own.

Phellodendron: dosing

There is no well-established, standardized dose of Phellodendron for any health condition. Products vary widely in strength and may contain other herbs, which makes general dosing advice difficult.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Phellodendron monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phellodendron monograph & all interactions
Medication

About Difluprednate Ophthalmic

What Is Difluprednate Ophthalmic Used For?

Brand name: Durezol

Difluprednate ophthalmic emulsion is used for two main purposes. First, it treats inflammation and pain that occur after ocular (eye) surgery. Second, it treats endogenous anterior uveitis — inflammation of the front part of the inside of the eye that originates from within the body rather than from an outside infection.

Most-Reported Side Effects for Difluprednate

From FAERS, the FDA’s public side-effect reporting system (830 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Eye pain 40 reports
Fatigue 31 reports
Diarrhea 30 reports
Headache 30 reports
Eye irritation 29 reports
See full Difluprednate Ophthalmic drug information
Keep checking

Other Drugs & Phellodendron

Browse every other medication we’ve checked against Phellodendron — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,160Moderate
0Minor
1,669No known interaction
1,160 Moderate 1,669 No interaction
Moderate

1,160 interactions

Showing 60 of 1,160 moderate interactions — see all 1,160 on the Phellodendron page.

No interaction 1,669 drugs checked — show the list

We also checked Phellodendron against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,669 medications checked with no known interaction — see the full Phellodendron list.

See the full Phellodendron interactions page
See every supplement checked against Difluprednate, ranked by severity
Evidence & sources

Phellodendron References

The 22 references that drive our Phellodendron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  3. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  14. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
  15. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phellodendron and Difluprednate Together: Common Questions

Is it safe to take Phellodendron with Difluprednate?
We do not list a known interaction between Phellodendron and Difluprednate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phellodendron and Difluprednate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Phellodendron interact with any other medications?
Yes. Phellodendron has 1,160 documented drug interactions in our database — Difluprednate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phellodendron monograph Uses, safety profile, and every drug interaction in one place Difluprednate Ophthalmic drug information The full plain-English guide to this medication Difluprednate supplement interactions Every supplement checked against Difluprednate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.