Drug & supplement interaction

Phenibut + Mineral Oil

Mineral Oil brand name: Kondremul Plain.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Phenibut and Mineral Oil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mineral Oil states a food rule worth keeping to.

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Interaction report

Phenibut and Mineral Oil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mineral Oil and Phenibut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenibut safety at a glance

Phenibut overall Avoid Phenibut carries a high risk of dependence, dangerous withdrawal, and overdose, and is not approved as a supplement or drug in the U.S.
Pregnancy Avoid There is no safety data in pregnancy and it is a CNS depressant, so it should be avoided.
Breastfeeding Avoid It is unknown whether phenibut passes into breast milk, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mineral Oil and Phenibut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mineral Oil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mineral Oil is filed under a single classification — oral drugs. Phenibut has documented interactions with 2 drug classes — the most serious being cns depressants (moderate) and pregabalin (lyrica) (moderate) — and none of Mineral Oil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenibut Does Interact With Other Medications

Phenibut has 248 moderate known drug interactions in our database — Mineral Oil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Mineral Oil)
Taking anything else?

Check Another of Your Medications Against Phenibut

Covers the 2,830 medications we’ve checked against Phenibut. Pick one to open its full report.

What to actually watch for

What Phenibut Itself Has Been Linked To

This is not an interaction — nothing below involves Mineral Oil. It is the side-effect record for Phenibut on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Phenibut, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms / Hallucinations / Confusion / Seizures / Low mood Worth acting on Additional detail

    “Orally, phenibut has been associated with aggression, agitation, altered mental status, anxiety, sedation, hallucinations, insomnia, and coma in case reports and case series. Phenibut is often used concurrently with other addictive substances, including alcohol.

    Observational research and case reports have found that the use of phenibut can lead to the rapid development of tolerance within 3 days, and that use for 3…”

    Phenibut · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 96748. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
    2. 96750. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
    3. 96753. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
    4. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    5. 101109. Ahuja T, Mgbako O, Katzman C, Grossman A. Phenibut (β-Phenyl-γ-aminobutyric Acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case Rep Psychiatry. 2018;2018:9864285.
    6. 101110. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed
  • Severe muscle breakdown / Kidney problems Worth acting on Additional detail

    “Orally, phenibut has been associated with withdrawal symptoms, including one case report of rhabdomyolysis and acute kidney injury in a previously healthy 24-year-old male who was also using anabolic steroids. In other case reports, phenibut withdrawal was associated with muscle aches and clonus.”

    Phenibut · Natural Medicines adverse-effect record, reported in muscle breakdown.

    5 sources cited
    1. 96756. Li W, Madhira B. Phenibut (beta-phenyl-gamma-aminobutyric acid) psychosis. Am J Therapeut 2017;24(5):e639-640.
    2. 96751. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017 May/Jun;11(3):239-40. PubMed
    3. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    4. 101111. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed
    5. 112293. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed
  • Raised blood pressure Worth acting on Additional detail

    “Orally, phenibut has been associated with withdrawal symptoms, including tachycardia, palpitations, and hypertension.”

    Phenibut · Natural Medicines adverse-effect record, reported in hypertension.

    6 sources cited
    1. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    2. 101111. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed
    3. 104511. Tamarelli C, Hosanagar A. Phenibut use in a patient prescribed gabapentinoids (letter). Pain Med 2020; Aug 4:pnaa205. doi: 10.1093/pm/pnaa205. PubMed
    4. 106839. Esposito CM, Mandolini GM, Delvecchio G, Fiorentini A, Brambilla P. Psychomotor agitation non-responsive to treatment: a case report of phenibut withdrawal syndrome. Front Psychiatry 2021;12:688147. PubMed
    5. 112293. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed
    6. 112294. Morris M, Espinosa J, Lucerna A, Lahr R. A case of phenibut withdrawal and treatment with baclofen. World J Emerg Med 2023;14(4):338-340. PubMed
  • Sweating Additional detail

    “Orally, phenibut use has been associated with a hangover effect, dizziness, balance impairment, and electric shock symptoms in the limbs. Use of higher doses, ranging from 3 grams daily for 4 days to 25 grams in a single dose, has been associated with altered mental status, diminished consciousness, and sedation.”

    Phenibut · Natural Medicines adverse-effect record, reported in epilepsy.

    5 sources cited
    1. 96753. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
    2. 96748. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
    3. 96750. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
    4. 96752. Sankary S, Canino P, Jackson J. Phenibut overdose. AM J Emerg Med. 2017 Mar;35(3):516.e1-516.e2.
    5. 112293. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed
  • A fast or pounding heartbeat Additional detail

    Recorded for Phenibut in the same Natural Medicines adverse-effect record shown under Dependence or withdrawal symptoms / Hallucinations / Confusion / Seizures / Low mood above.

Showing the 10 most notable of 19 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Phenibut — expand a row for the licensed statement it rests on. We haven’t matched Mineral Oil to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Mineral Oil.

How to take them

Some Mineral Oil Products Have a Food Rule — Phenibut Should Not Break It

At least one FDA label for a product containing Mineral Oil says to take it with food. If you take Phenibut on an empty stomach out of habit, keep them separate — and take Mineral Oil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mineral Oil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions: * Do not take with meals.

From the Dosage and Administration section of the FDA label we read for Mineral Oil — where that label names a specific product, the instruction is that product's. See the Mineral Oil drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mineral Oil

This page covers Phenibut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mineral Oil page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Mineral Oil page

“Everything on record for mineral oil (Kondremul Plain) comes down to one theme, absorption in the gut, and it deserves genuine care, chiefly because of activated charcoal. Charcoal binds a wide array of medicines and can sharply cut how much of them the body actually takes in, and it carries this list's only major rating, so understand…”

Reviewed by 2 · Jul 18, 2026

Open the Mineral Oil interaction page

One more smart check

Taking Phenibut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 41 real supplement products containing Phenibut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenibut. Even though Phenibut itself has no known interaction with Mineral Oil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenibut and Mineral Oil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenibut
Top half

#566 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mineral Oil
Top 25%

#645 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenibut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phenibut and Mineral Oil records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenibut

What is Phenibut?

Phenibut
  • Anxiety and stress
  • Insomnia and sleep problems
  • Stress relief
  • Mood and focus
  • Reducing alcohol withdrawal symptoms (unproven)

Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it carries a serious risk of tolerance, dependence, and dangerous withdrawal. It is not an approved medication or dietary supplement in the United States, and we do not recommend its use. Talk to a doctor or pharmacist about safer, proven options for anxiety or sleep.

Synthetic compound (not a plant part) · Powder, capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Phenibut is a good idea for someone in your situation. Here is what our Phenibut record says about it on its own.

Phenibut: dosing

There is no established safe or standardized dose of phenibut for use as a supplement, and it is not approved as a medicine or supplement in the United States. Products sold online are unregulated, so the actual amount and purity can vary widely and be unpredictable.Because of the real risk of dependence, dangerous withdrawal, and overdose, we do not provide dosing guidance and do not recommend using phenibut. If you already use it regularly, do not stop suddenly—get medical help to taper safely.

From our Phenibut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenibut monograph & all interactions
Medication

About Mineral Oil

What Is Mineral Oil Used For?

Brand name: Kondremul Plain

Most mineral oil products are used to relieve occasional constipation. Rectal enema products — including Fleet, Leader Ready to Use Mineral Oil, Foster and Thrive Ready to Use Mineral oil, Enema, and Enema Mineral Oil — are also used for relief of fecal impaction (stool that is stuck and won't pass) and to remove residue left in the bowel after a barium procedure.

Humco Mineral Oil Light topical liquid is used to help treat and prevent diaper rash, protect chafed skin, and seal out wetness. HANHOO BlemishPatch is applied directly to skin concerns as a topical patch.

See full Mineral Oil drug information
Keep checking

Other Drugs & Phenibut

Browse every other medication we’ve checked against Phenibut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Phenibut page.

No interaction 2,581 drugs checked — show the list

We also checked Phenibut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Phenibut list.

See the full Phenibut interactions page
See every supplement checked against Mineral Oil, ranked by severity
Evidence & sources

Phenibut References

The 23 references that drive our Phenibut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
  2. Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J. Phenibut dependence. BMJ Case Rep. 2013 Feb 6;2013. Pii: bcr2012008381.
  3. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
  4. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017 May/Jun;11(3):239-40. PubMed
  5. Sankary S, Canino P, Jackson J. Phenibut overdose. AM J Emerg Med. 2017 Mar;35(3):516.e1-516.e2.
  6. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
  7. Magsalin RM, Khan AY. Withdrawal symptoms after internet purchase of phenibut (beta-phenyl-gamma-aminobutyric acid HCl). J Clin Psychopharmacol. 2010 Oct;30(5):648-9.
  8. Rod W, Kudryk A, Brunetti L, Sun N, Nguyen M. Phenibut withdrawal management in the setting of concomitant kratom and alcohol dependence. Critical Care Med 2018;46(1):451.
  9. Li W, Madhira B. Phenibut (beta-phenyl-gamma-aminobutyric acid) psychosis. Am J Therapeut 2017;24(5):e639-640.
  10. Joshi Y, Friend S, Jimenez B, Steiger L. Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report. J Clin Psychopharmacol 2017;37(4):478-80. PubMed
  11. Zheng KH, Khan A, Espiridion ED. Phenibut addiction in a patient with substance use disorder. Cureus. 2019;11(7):e5230. PubMed
  12. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
  13. Ahuja T, Mgbako O, Katzman C, Grossman A. Phenibut (β-Phenyl-γ-aminobutyric Acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case Rep Psychiatry. 2018;2018:9864285.
  14. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed
  15. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenibut and Mineral Oil Together: Common Questions

Is it safe to take Phenibut with Mineral Oil?
We do not list a known interaction between Phenibut and Mineral Oil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Phenibut and Mineral Oil at the same time of day?
At least one FDA label for a product containing Mineral Oil says to take it with food. If you take Phenibut on an empty stomach out of habit, keep them separate and take Mineral Oil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Mineral Oil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Phenibut and Mineral Oil combination checked?
Interactions in our licensed database are recorded against drug classes. Mineral Oil is filed under 1 classification, and Phenibut has documented interactions with 2 drug classes — none of Mineral Oil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenibut interact with any other medications?
Yes. Phenibut has 248 documented drug interactions in our database — Mineral Oil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mineral Oil interact with any supplements?
Yes. Mineral Oil has documented interactions with 17 supplements in our database — Phenibut is not one of them. The Mineral Oil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenibut monograph Uses, safety profile, and every drug interaction in one place Mineral Oil drug information The full plain-English guide to this medication Mineral Oil supplement interactions Every supplement checked against Mineral Oil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 23 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mineral Oil and Phenibut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.