Drug & supplement interaction

Phenibut + Mirtazapine

Mirtazapine brand name: Remeron.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Phenibut and Mirtazapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phenibut and Mirtazapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mirtazapine and Phenibut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenibut safety at a glance

Phenibut overall Avoid Phenibut carries a high risk of dependence, dangerous withdrawal, and overdose, and is not approved as a supplement or drug in the U.S.
Pregnancy Avoid There is no safety data in pregnancy and it is a CNS depressant, so it should be avoided.
Breastfeeding Avoid It is unknown whether phenibut passes into breast milk, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mirtazapine and Phenibut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mirtazapine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mirtazapine is filed under 9 classifications — including antidepressant drugs, serotonergic drugs, serotonergic drugs. Phenibut has documented interactions with 2 drug classes — the most serious being cns depressants (moderate) and pregabalin (lyrica) (moderate) — and none of Mirtazapine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenibut Does Interact With Other Medications

Phenibut has 248 moderate known drug interactions in our database — Mirtazapine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Mirtazapine)
Taking anything else?

Check Another of Your Medications Against Phenibut

Covers the 2,830 medications we’ve checked against Phenibut. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phenibut and Mirtazapine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 7 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms / Hallucinations / Confusion / Seizures / Low mood Worth acting on Additional detail

    Phenibut

    “Orally, phenibut has been associated with aggression, agitation, altered mental status, anxiety, sedation, hallucinations, insomnia, and coma in case reports and case series. Phenibut is often used concurrently with other addictive substances, including alcohol.

    Observational research and case reports have found that the use of phenibut can lead to the rapid development of tolerance within 3 days, and that use for 3…”

    Phenibut · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 96748. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
    2. 96750. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
    3. 96753. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
    4. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    5. 101109. Ahuja T, Mgbako O, Katzman C, Grossman A. Phenibut (β-Phenyl-γ-aminobutyric Acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case Rep Psychiatry. 2018;2018:9864285.
    6. 101110. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Severe muscle breakdown Worth acting on Additional detail

    Phenibut

    “Orally, phenibut has been associated with withdrawal symptoms, including one case report of rhabdomyolysis and acute kidney injury in a previously healthy 24-year-old male who was also using anabolic steroids. In other case reports, phenibut withdrawal was associated with muscle aches and clonus.”

    Phenibut · Natural Medicines adverse-effect record, reported in muscle breakdown.

    5 sources cited
    1. 96756. Li W, Madhira B. Phenibut (beta-phenyl-gamma-aminobutyric acid) psychosis. Am J Therapeut 2017;24(5):e639-640.
    2. 96751. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017 May/Jun;11(3):239-40. PubMed
    3. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    4. 101111. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed
    5. 112293. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Raised blood pressure Worth acting on Additional detail

    Phenibut

    “Orally, phenibut has been associated with withdrawal symptoms, including tachycardia, palpitations, and hypertension.”

    Phenibut · Natural Medicines adverse-effect record, reported in hypertension.

    6 sources cited
    1. 101108. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
    2. 101111. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed
    3. 104511. Tamarelli C, Hosanagar A. Phenibut use in a patient prescribed gabapentinoids (letter). Pain Med 2020; Aug 4:pnaa205. doi: 10.1093/pm/pnaa205. PubMed
    4. 106839. Esposito CM, Mandolini GM, Delvecchio G, Fiorentini A, Brambilla P. Psychomotor agitation non-responsive to treatment: a case report of phenibut withdrawal syndrome. Front Psychiatry 2021;12:688147. PubMed
    5. 112293. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed
    6. 112294. Morris M, Espinosa J, Lucerna A, Lahr R. A case of phenibut withdrawal and treatment with baclofen. World J Emerg Med 2023;14(4):338-340. PubMed

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Drowsiness / Anxiety or restlessness Additional detail

    Phenibut

    Recorded for Phenibut in the same Natural Medicines adverse-effect record shown under Dependence or withdrawal symptoms / Hallucinations / Confusion / Seizures / Low mood above.

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Reduced appetite Additional detail

    Phenibut

    “Orally, phenibut has been associated with nausea and vomiting. Regular phenibut use followed by abrupt discontinuation is associated with withdrawal symptoms, including decreased appetite and nausea.”

    Phenibut · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 96753. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
    2. 101110. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed
    3. 96754. Magsalin RM, Khan AY. Withdrawal symptoms after internet purchase of phenibut (beta-phenyl-gamma-aminobutyric acid HCl). J Clin Psychopharmacol. 2010 Oct;30(5):648-9.

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

Showing the 10 most notable of 15 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Phenibut but not commonly for Mirtazapine: kidney problems, a fast or pounding heartbeat, sweating and trouble sleeping.

Effects for Mirtazapine come from the ADVERSE REACTIONS section of its FDA label; effects for Phenibut come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Mirtazapine Is Prescribed For, and What Phenibut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mirtazapine is a prescription medicine with approved uses on its FDA label. Phenibut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Mirtazapine is prescribed for: Mirtazapine tablets, mirtazapine orally disintegrating tablets, Remeron, and RemeronsолTab are all indicated for the treatment of major depressive disorder (MDD) in adults. Major depressive disorder involves a persistently low or sad mood most days, often accompanied by loss of interest, sleep changes, fatigue, and difficulty concentrating. The effectiveness of mirtazapine tablets in maintaining a response for up to 40 weeks after an initial treatment period has also been demonstrated. Patients should be reassessed periodically to determine whether continued treatment is needed.

Phenibut has been studied for:

  • Depression studied, not established Phenibut has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Phenibut for depression

    Although there has been interest in using oral phenibut for depression, there is insufficient reliable information about the clinical effects of phenibut for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mirtazapine on your own; if you are taking Phenibut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Phenibut or Mirtazapine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Phenibut or Mirtazapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mirtazapine

This page covers Phenibut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mirtazapine page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 162 moderate · 46 minor.

From our pharmacist’s overview on the Mirtazapine page

“Depression and poor sleep tend to travel together, which is why people on mirtazapine (Remeron) so often eye herbal mood and sleep remedies, and that overlap is exactly where this list demands real care. Four of the 212 ingredients on file carry a major rating.”

Reviewed by 2 · Jul 18, 2026

Open the Mirtazapine interaction page

One more smart check

Taking Phenibut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 41 real supplement products containing Phenibut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenibut. Even though Phenibut itself has no known interaction with Mirtazapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenibut and Mirtazapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenibut
Top half

#653 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mirtazapine
Top 25%

#467 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenibut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phenibut and Mirtazapine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenibut

What is Phenibut?

Phenibut
  • Anxiety and stress
  • Insomnia and sleep problems
  • Stress relief
  • Mood and focus
  • Reducing alcohol withdrawal symptoms (unproven)

Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it carries a serious risk of tolerance, dependence, and dangerous withdrawal. It is not an approved medication or dietary supplement in the United States, and we do not recommend its use. Talk to a doctor or pharmacist about safer, proven options for anxiety or sleep.

Synthetic compound (not a plant part) · Powder, capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Phenibut is a good idea for someone in your situation. Here is what our Phenibut record says about it on its own.

Phenibut: dosing

There is no established safe or standardized dose of phenibut for use as a supplement, and it is not approved as a medicine or supplement in the United States. Products sold online are unregulated, so the actual amount and purity can vary widely and be unpredictable.Because of the real risk of dependence, dangerous withdrawal, and overdose, we do not provide dosing guidance and do not recommend using phenibut. If you already use it regularly, do not stop suddenly—get medical help to taper safely.

From our Phenibut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenibut monograph & all interactions
Medication

About Mirtazapine

What Is Mirtazapine Used For?

Brand name: Remeron

Mirtazapine tablets, mirtazapine orally disintegrating tablets, Remeron, and RemeronsолTab are all indicated for the treatment of major depressive disorder (MDD) in adults. Major depressive disorder involves a persistently low or sad mood most days, often accompanied by loss of interest, sleep changes, fatigue, and difficulty concentrating.

The effectiveness of mirtazapine tablets in maintaining a response for up to 40 weeks after an initial treatment period has also been demonstrated. Patients should be reassessed periodically to determine whether continued treatment is needed.

See full Mirtazapine drug information
Keep checking

Other Drugs & Phenibut

Browse every other medication we’ve checked against Phenibut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Phenibut page.

No interaction 2,581 drugs checked — show the list

We also checked Phenibut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Phenibut list.

See the full Phenibut interactions page
See every supplement checked against Mirtazapine, ranked by severity
Evidence & sources

Phenibut References

The 23 references that drive our Phenibut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
  2. Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J. Phenibut dependence. BMJ Case Rep. 2013 Feb 6;2013. Pii: bcr2012008381.
  3. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
  4. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017 May/Jun;11(3):239-40. PubMed
  5. Sankary S, Canino P, Jackson J. Phenibut overdose. AM J Emerg Med. 2017 Mar;35(3):516.e1-516.e2.
  6. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
  7. Magsalin RM, Khan AY. Withdrawal symptoms after internet purchase of phenibut (beta-phenyl-gamma-aminobutyric acid HCl). J Clin Psychopharmacol. 2010 Oct;30(5):648-9.
  8. Rod W, Kudryk A, Brunetti L, Sun N, Nguyen M. Phenibut withdrawal management in the setting of concomitant kratom and alcohol dependence. Critical Care Med 2018;46(1):451.
  9. Li W, Madhira B. Phenibut (beta-phenyl-gamma-aminobutyric acid) psychosis. Am J Therapeut 2017;24(5):e639-640.
  10. Joshi Y, Friend S, Jimenez B, Steiger L. Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report. J Clin Psychopharmacol 2017;37(4):478-80. PubMed
  11. Zheng KH, Khan A, Espiridion ED. Phenibut addiction in a patient with substance use disorder. Cureus. 2019;11(7):e5230. PubMed
  12. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
  13. Ahuja T, Mgbako O, Katzman C, Grossman A. Phenibut (β-Phenyl-γ-aminobutyric Acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case Rep Psychiatry. 2018;2018:9864285.
  14. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed
  15. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenibut and Mirtazapine Together: Common Questions

Is it safe to take Phenibut with Mirtazapine?
We do not list a known interaction between Phenibut and Mirtazapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phenibut and Mirtazapine have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Phenibut and Mirtazapine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Phenibut in each. That is a conversation for your prescriber, especially if Mirtazapine is being adjusted to a target.
How was the Phenibut and Mirtazapine combination checked?
Interactions in our licensed database are recorded against drug classes. Mirtazapine is filed under 9 classifications, and Phenibut has documented interactions with 2 drug classes — none of Mirtazapine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenibut interact with any other medications?
Yes. Phenibut has 248 documented drug interactions in our database — Mirtazapine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mirtazapine interact with any supplements?
Yes. Mirtazapine has documented interactions with 212 supplements in our database — Phenibut is not one of them. The Mirtazapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenibut monograph Uses, safety profile, and every drug interaction in one place Mirtazapine drug information The full plain-English guide to this medication Mirtazapine supplement interactions Every supplement checked against Mirtazapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 23 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mirtazapine and Phenibut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.