Drug & supplement interaction

Poria Mushroom + Cladribine

Cladribine brand names: Leustatin, Mavenclad.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Poria Mushroom and Cladribine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Poria Mushroom and Cladribine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cladribine and Poria Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poria Mushroom safety at a glance

Poria Mushroom overall Use caution Generally well tolerated in traditional use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding, so avoidance is recommended.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cladribine and Poria Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cladribine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cladribine is filed under 2 classifications — immunosuppressants, oral drugs. Poria Mushroom has documented interactions with 3 drug classes — the most serious being anticholinergic drugs (moderate), cholinergic drugs (moderate) and cns depressants (moderate) — and none of Cladribine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Poria Mushroom Does Interact With Other Medications

Poria Mushroom has 417 moderate known drug interactions in our database — Cladribine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 417 No known interaction 2,413 (incl. Cladribine)
Taking anything else?

Check Another of Your Medications Against Poria Mushroom

Covers the 2,830 medications we’ve checked against Poria Mushroom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Poria Mushroom and Cladribine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Wheezing / An allergic reaction Worth acting on Additional detail

    Poria Mushroom

    “Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma (12).”

    Poria Mushroom · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Cladribine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cladribine. Read the label on DailyMed ›

Reported for Poria Mushroom but not commonly for Cladribine: a stuffy or runny nose.

Effects for Cladribine come from the ADVERSE REACTIONS section of its FDA label; effects for Poria Mushroom come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Cladribine

This page covers Poria Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cladribine page lists 70 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).

By severity: 1 major · 59 moderate · 10 minor.

From our pharmacist’s overview on the Cladribine page

“Cladribine (Leustatin, Mavenclad) treats hairy cell leukemia and relapsing multiple sclerosis by deliberately knocking down part of the immune system, so this list calls for real vigilance. Of the 70 supplements and herbs on file, 53 are immune stimulators, herbs like astragalus, ashwagandha, and ginseng that could push immunity back u…”

Reviewed by 2 · Jul 18, 2026

Open the Cladribine interaction page

One more smart check

Taking Poria Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,303 real supplement products containing Poria Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Poria Mushroom. Even though Poria Mushroom itself has no known interaction with Cladribine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Poria Mushroom and Cladribine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poria Mushroom
Top 25%

#176 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cladribine
Steady interest

#1,949 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poria Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Poria Mushroom and Cladribine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Poria Mushroom

What is Poria Mushroom?

  • Fluid retention and swelling
  • Digestive complaints
  • Sleep and calming support
  • General wellness and immune support
  • Urinary support

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited, so its benefits are not well proven. It is generally considered well tolerated, but talk with your pharmacist or doctor before using it, and avoid it in pregnancy and breastfeeding due to a lack of safety data.

Wolfiporia extensa · Polyporaceae · Dried fungus body (sclerotium) · Dried slices, powder, capsules, teas, and ingredient in traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Poria Mushroom is a good idea for someone in your situation. Here is what our Poria Mushroom record says about it on its own.

Poria Mushroom: dosing

There is no official, standardized dose of poria mushroom for any health condition. Do not exceed the recommended amount, and start low to see how you tolerate it.

From our Poria Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poria Mushroom monograph & all interactions
Medication

About Cladribine

What Is Cladribine Used For?

Brand names: Leustatin, Mavenclad

Cladribine has two different uses, depending on the product.

Cladribine tablets (including Mavenclad) treat relapsing forms of multiple sclerosis in adults. This includes relapsing-remitting disease and active secondary progressive disease. Because of its safety profile, it is generally used after another MS drug has not worked well enough or could not be tolerated. It is not recommended for clinically isolated syndrome (CIS).

Cladribine injection (intravenous) treats active hairy cell leukemia. That means disease with clinically significant anemia, neutropenia, thrombocytopenia or disease-related symptoms.

See full Cladribine drug information
Keep checking

Other Drugs & Poria Mushroom

Browse every other medication we’ve checked against Poria Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
417Moderate
0Minor
2,412No known interaction
417 Moderate 2,412 No interaction
Moderate

417 interactions

Showing 60 of 417 moderate interactions — see all 417 on the Poria Mushroom page.

No interaction 2,412 drugs checked — show the list

We also checked Poria Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,412 medications checked with no known interaction — see the full Poria Mushroom list.

See the full Poria Mushroom interactions page
See every supplement checked against Cladribine, ranked by severity
Evidence & sources

Poria Mushroom References

The 3 references that drive our Poria Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poria Mushroom and Cladribine Together: Common Questions

Is it safe to take Poria Mushroom with Cladribine?
We do not list a known interaction between Poria Mushroom and Cladribine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Poria Mushroom and Cladribine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Poria Mushroom and Cladribine combination checked?
Interactions in our licensed database are recorded against drug classes. Cladribine is filed under 2 classifications, and Poria Mushroom has documented interactions with 3 drug classes — none of Cladribine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Poria Mushroom interact with any other medications?
Yes. Poria Mushroom has 417 documented drug interactions in our database — Cladribine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cladribine interact with any supplements?
Yes. Cladribine has documented interactions with 70 supplements in our database — Poria Mushroom is not one of them. The Cladribine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poria Mushroom monograph Uses, safety profile, and every drug interaction in one place Cladribine drug information The full plain-English guide to this medication Cladribine supplement interactions Every supplement checked against Cladribine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cladribine and Poria Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.