Drug & supplement interaction

Poria Mushroom + Hydroxyurea

Hydroxyurea brand names: Droxia, Hydrea, Siklos, Xromi.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Poria Mushroom and Hydroxyurea in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Poria Mushroom and Hydroxyurea

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydroxyurea and Poria Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poria Mushroom safety at a glance

Poria Mushroom overall Use caution Generally well tolerated in traditional use, but human safety data are limited.

Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid No reliable safety data while breastfeeding, so avoidance is recommended.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydroxyurea and Poria Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Hydroxyurea

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hydroxyurea is filed under 2 classifications — antineoplastics, oral drugs. Poria Mushroom has documented interactions with 3 drug classes — the most serious being anticholinergic drugs (moderate), cholinergic drugs (moderate) and cns depressants (moderate) — and none of Hydroxyurea’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Poria Mushroom Does Interact With Other Medications

Poria Mushroom has 417 moderate known drug interactions in our database — Hydroxyurea isn’t one of them. If you take anything else, check it against the full list below.

Moderate 417 No known interaction 2,413 (incl. Hydroxyurea)

Taking anything else?

Check Another of Your Medications Against Poria Mushroom

Covers the 2,830 medications we’ve checked against Poria Mushroom. Pick one to open its full report.

What to actually watch for

What Poria Mushroom Itself Has Been Linked To

This is not an interaction — nothing below involves Hydroxyurea. It is the side-effect record for Poria Mushroom on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Poria Mushroom, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

Wheezing / An allergic reaction Worth acting on Additional detail
“Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma (12).”

Poria Mushroom · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
1 source cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
A stuffy or runny nose Additional detail

Recorded for Poria Mushroom in the same Natural Medicines adverse-effect record shown under Wheezing / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Poria Mushroom — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Hydroxyurea’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Hydroxyurea column appears here.

Overlapping uses

What Hydroxyurea Is Prescribed For, and What Poria Mushroom Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Hydroxyurea is a prescription medicine with approved uses on its FDA label. Poria Mushroom is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Hydroxyurea is prescribed for: Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults. Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.

Poria Mushroom has been studied for:

Cancer studied, not established Poria Mushroom has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Poria Mushroom for cancer

Although there is interest in using oral poria mushroom for cancer, there is insufficient reliable information about the clinical effects of poria mushroom for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Hydroxyurea on your own; if you are taking Poria Mushroom for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Poria Mushroom or Hydroxyurea

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Poria Mushroom or Hydroxyurea, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydroxyurea

This page covers Poria Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyurea page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 10 minor.

From our pharmacist’s overview on the Hydroxyurea page

“People take hydroxyurea (Droxia, Hydrea, Siklos, Xromi) for serious reasons, most often sickle cell disease or certain blood cancers, and it only works if a steady dose reaches the bloodstream. That is exactly what nearly all 18 supplements listed here can undermine, so this page earns real vigilance rather than a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Hydroxyurea interaction page

One more smart check

Taking Poria Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,303 real supplement products containing Poria Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Poria Mushroom. Even though Poria Mushroom itself has no known interaction with Hydroxyurea, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Poria Mushroom and Hydroxyurea Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poria Mushroom

Top 25%

#190 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Hydroxyurea

Top 5%

#38 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poria Mushroom reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Poria Mushroom and Hydroxyurea records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Poria Mushroom

What is Poria Mushroom?

Fluid retention and swelling
Digestive complaints
Sleep and calming support
General wellness and immune support
Urinary support

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited, so its benefits are not well proven. It is generally considered well tolerated, but talk with your pharmacist or doctor before using it, and avoid it in pregnancy and breastfeeding due to a lack of safety data.

Wolfiporia extensa · Polyporaceae · Dried fungus body (sclerotium) · Dried slices, powder, capsules, teas, and ingredient in traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Poria Mushroom is a good idea for someone in your situation. Here is what our Poria Mushroom record says about it on its own.

Poria Mushroom: dosing

There is no official, standardized dose of poria mushroom for any health condition. Do not exceed the recommended amount, and start low to see how you tolerate it.

From our Poria Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poria Mushroom monograph & all interactions

Medication

About Hydroxyurea

What Is Hydroxyurea Used For?

Brand names: Droxia, Hydrea, Siklos, Xromi

Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults.

Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.

Most-Reported Side Effects for Hydroxyurea

From FAERS, the FDA’s public side-effect reporting system (21,027 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,548 reports

Sickle cell anaemia with crisis 1,486 reports

Diarrhea 1,408 reports

Nausea 1,306 reports

Headache 1,068 reports

See full Hydroxyurea drug information

Keep checking

Other Drugs & Poria Mushroom

Browse every other medication we’ve checked against Poria Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

417Moderate

0Minor

2,412No known interaction

417 Moderate 2,412 No interaction

Moderate

417 interactions

Showing 60 of 417 moderate interactions — see all 417 on the Poria Mushroom page.

No interaction 2,412 drugs checked — show the list

We also checked Poria Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,412 medications checked with no known interaction — see the full Poria Mushroom list.

See the full Poria Mushroom interactions page

See every supplement checked against Hydroxyurea, ranked by severity

Evidence & sources

Poria Mushroom References

The 3 references that drive our Poria Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poria Mushroom and Hydroxyurea Together: Common Questions

Is it safe to take Poria Mushroom with Hydroxyurea?

We do not list a known interaction between Poria Mushroom and Hydroxyurea. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Poria Mushroom and Hydroxyurea used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Poria Mushroom in each. That is a conversation for your prescriber, especially if Hydroxyurea is being adjusted to a target.

How was the Poria Mushroom and Hydroxyurea combination checked?

Interactions in our licensed database are recorded against drug classes. Hydroxyurea is filed under 2 classifications, and Poria Mushroom has documented interactions with 3 drug classes — none of Hydroxyurea's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Poria Mushroom interact with any other medications?

Yes. Poria Mushroom has 417 documented drug interactions in our database — Hydroxyurea is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Hydroxyurea interact with any supplements?

Yes. Hydroxyurea has documented interactions with 18 supplements in our database — Poria Mushroom is not one of them. The Hydroxyurea interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poria Mushroom monograph Uses, safety profile, and every drug interaction in one place Hydroxyurea drug information The full plain-English guide to this medication Hydroxyurea supplement interactions Every supplement checked against Hydroxyurea, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydroxyurea and Poria Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.