Drug & supplement interaction

Poria Mushroom + Sargramostim

Sargramostim brand name: Leukine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Poria Mushroom and Sargramostim in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Poria Mushroom and Sargramostim

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sargramostim and Poria Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poria Mushroom safety at a glance

Poria Mushroom overall Use caution Generally well tolerated in traditional use, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding, so avoidance is recommended.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sargramostim and Poria Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Poria Mushroom Does Interact With Other Medications

Poria Mushroom has 417 moderate known drug interactions in our database — Sargramostim isn’t one of them. If you take anything else, check it against the full list below.

Moderate 417 No known interaction 2,413 (incl. Sargramostim)
Taking anything else?

Check Another of Your Medications Against Poria Mushroom

Covers the 2,830 medications we’ve checked against Poria Mushroom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Poria Mushroom and Sargramostim May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Poria Mushroom

    “Allergic reactions have been reported rarely, including allergic rhinitis and allergic asthma (12).”

    Poria Mushroom · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Sargramostim

    Listed in the ADVERSE REACTIONS section of the FDA label for Sargramostim. Read the label on DailyMed ›

  • A stuffy or runny nose Additional detail

    Poria Mushroom

    Recorded for Poria Mushroom in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Sargramostim

    Listed in the ADVERSE REACTIONS section of the FDA label for Sargramostim. Read the label on DailyMed ›

Reported for Poria Mushroom but not commonly for Sargramostim: wheezing.

Effects for Sargramostim come from the ADVERSE REACTIONS section of its FDA label; effects for Poria Mushroom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,675 voluntary FDA FAERS reports for Sargramostim that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Sargramostim Is Prescribed For, and What Poria Mushroom Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Sargramostim is a prescription medicine with approved uses on its FDA label. Poria Mushroom is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Sargramostim is prescribed for: Leukine (sargramostim) is used in several serious medical situations where the body's white blood cell production has been knocked down. It is approved to speed up the recovery of infection-fighting neutrophils after chemotherapy for acute myeloid leukemia (AML) in adults 55 and older, and to help bone marrow recover after autologous or allogeneic bone marrow transplants in adults and children aged 2 and older. Leukine is also used to mobilize stem cells from bone marrow into the bloodstream so they can be collected before an autologous transplant, and to treat delayed or failed bone marrow recovery after transplant. Additionally, Leukine is approved to improve survival in adults and children (from birth through age 17) who have been exposed to dangerously high doses of radiation (a condition called Hematopoietic Syndrome of Acute Radiation Syndrome, or H-ARS).

Poria Mushroom has been studied for:

  • Cancer studied, not established Poria Mushroom has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Poria Mushroom for cancer

    Although there is interest in using oral poria mushroom for cancer, there is insufficient reliable information about the clinical effects of poria mushroom for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sargramostim on your own; if you are taking Poria Mushroom for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Poria Mushroom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,303 real supplement products containing Poria Mushroom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Poria Mushroom. Even though Poria Mushroom itself has no known interaction with Sargramostim, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Poria Mushroom and Sargramostim Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poria Mushroom
Top 25%

#204 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sargramostim
Steady interest

#2,301 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poria Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Poria Mushroom and Sargramostim records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Poria Mushroom

What is Poria Mushroom?

  • Fluid retention and swelling
  • Digestive complaints
  • Sleep and calming support
  • General wellness and immune support
  • Urinary support

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited, so its benefits are not well proven. It is generally considered well tolerated, but talk with your pharmacist or doctor before using it, and avoid it in pregnancy and breastfeeding due to a lack of safety data.

Wolfiporia extensa · Polyporaceae · Dried fungus body (sclerotium) · Dried slices, powder, capsules, teas, and ingredient in traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Poria Mushroom is a good idea for someone in your situation. Here is what our Poria Mushroom record says about it on its own.

Poria Mushroom: dosing

There is no official, standardized dose of poria mushroom for any health condition. Do not exceed the recommended amount, and start low to see how you tolerate it.

From our Poria Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poria Mushroom monograph & all interactions
Medication

About Sargramostim

What Is Sargramostim Used For?

Brand name: Leukine

Leukine (sargramostim) is used in several serious medical situations where the body's white blood cell production has been knocked down. It is approved to speed up the recovery of infection-fighting neutrophils after chemotherapy for acute myeloid leukemia (AML) in adults 55 and older, and to help bone marrow recover after autologous or allogeneic bone marrow transplants in adults and children aged 2 and older.

Leukine is also used to mobilize stem cells from bone marrow into the bloodstream so they can be collected before an autologous transplant, and to treat delayed or failed bone marrow recovery after transplant. Additionally, Leukine is approved to improve survival in adults and children (from birth through age 17) who have been exposed to dangerously high doses of radiation (a condition called Hematopoietic Syndrome of Acute Radiation Syndrome, or H-ARS).

Most-Reported Side Effects for Sargramostim

From FAERS, the FDA’s public side-effect reporting system (1,675 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 153 reports
Nausea 118 reports
Dyspnea 110 reports
Hypotension 110 reports
Fatigue 94 reports
See full Sargramostim drug information
Keep checking

Other Drugs & Poria Mushroom

Browse every other medication we’ve checked against Poria Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
417Moderate
0Minor
2,412No known interaction
417 Moderate 2,412 No interaction
Moderate

417 interactions

Showing 60 of 417 moderate interactions — see all 417 on the Poria Mushroom page.

No interaction 2,412 drugs checked — show the list

We also checked Poria Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,412 medications checked with no known interaction — see the full Poria Mushroom list.

See the full Poria Mushroom interactions page
See every supplement checked against Sargramostim, ranked by severity
Evidence & sources

Poria Mushroom References

The 3 references that drive our Poria Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poria Mushroom and Sargramostim Together: Common Questions

Is it safe to take Poria Mushroom with Sargramostim?
We do not list a known interaction between Poria Mushroom and Sargramostim. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Poria Mushroom and Sargramostim have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Poria Mushroom and Sargramostim used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Poria Mushroom in each. That is a conversation for your prescriber, especially if Sargramostim is being adjusted to a target.
Does Poria Mushroom interact with any other medications?
Yes. Poria Mushroom has 417 documented drug interactions in our database — Sargramostim is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poria Mushroom monograph Uses, safety profile, and every drug interaction in one place Sargramostim drug information The full plain-English guide to this medication Sargramostim supplement interactions Every supplement checked against Sargramostim, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sargramostim and Poria Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.