Drug & supplement interaction

Pulsatilla + Oxcarbazepine

Oxcarbazepine brand names: Trileptal, Oxtellar XR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Pulsatilla and Oxcarbazepine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Pulsatilla and Oxcarbazepine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxcarbazepine and Pulsatilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pulsatilla at all — not against Oxcarbazepine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pulsatilla safety at a glance

Pulsatilla overall Use caution The fresh plant is toxic and irritating; only properly dried or highly diluted homeopathic forms are used, and evidence is limited.
Pregnancy Likely Unsafe When used orally. The fresh or dried above ground parts are contraindicated due to abortifacient and teratogenic effects. ...when the fresh above ground parts a... Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh above ground parts are used for oral or topical use. There is insufficient reliable information available about the safety of dried pulsatilla du... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxcarbazepine and Pulsatilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Pulsatilla and Oxcarbazepine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Pulsatilla

    “Orally, fresh pulsatilla is a toxic gastrointestinal irritant (4,19). It can also cause kidney and urinary tract irritation (2).

    Topically, contact with the fresh plant can cause skin irritation, mucous membrane irritation, itching, and pustule formation known as ranunculus dermatitis (2).”

    Pulsatilla · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 19. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
    3. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Oxcarbazepine

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxcarbazepine. Read the label on DailyMed ›

  • A skin rash Additional detail

    Pulsatilla

    “Topically, contact with the fresh plant can cause skin irritation, mucous membrane irritation, itching, and pustule formation known as ranunculus dermatitis (2).”

    Pulsatilla · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    Oxcarbazepine

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxcarbazepine. Read the label on DailyMed ›

Reported for Pulsatilla but not commonly for Oxcarbazepine: itching.

Effects for Oxcarbazepine come from the ADVERSE REACTIONS section of its FDA label; effects for Pulsatilla come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 32,322 voluntary FDA FAERS reports for Oxcarbazepine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Pulsatilla in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. The fresh or dried above ground parts are contraindicated due to abortifacient and teratogenic effects. ...when the fresh above ground parts are used topically. There is insufficient reliable information available about the safety of topical dried pulsatilla during pregnancy.

Lactation Likely Unsafe

When the fresh above ground parts are used for oral or topical use. There is insufficient reliable information available about the safety of dried pulsatilla during breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pulsatilla or Oxcarbazepine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pulsatilla or Oxcarbazepine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxcarbazepine

This page covers Pulsatilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxcarbazepine page lists 122 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 99 moderate · 16 minor.

From our pharmacist’s overview on the Oxcarbazepine page

“People take oxcarbazepine (Trileptal, Oxtellar XR) to keep seizures in check, and I want anyone on it to read the seven major-rated interactions below before adding any supplement. Of the 122 ingredients on file, 78 have sedative effects, so the calming and sleep aids many patients reach for, kava among them, can pile drowsiness on top…”

Reviewed by 2 · Jul 18, 2026

Open the Oxcarbazepine interaction page

One more smart check

Taking Pulsatilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 65 real supplement products containing Pulsatilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pulsatilla. Even though Pulsatilla itself has no known interaction with Oxcarbazepine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pulsatilla and Oxcarbazepine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pulsatilla
Steady interest

#1,051 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxcarbazepine
Steady interest

#1,622 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pulsatilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pulsatilla and Oxcarbazepine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pulsatilla

What is Pulsatilla?

  • Menstrual and PMS-related complaints
  • Anxiety, moodiness, and weepiness (traditional/homeopathic)
  • Earache and cold symptoms (homeopathic)
  • Eye irritation and sinus complaints
  • Sleep and restlessness

Pulsatilla is a flowering plant in the buttercup family that is most often used today in homeopathic (highly diluted) preparations. The fresh plant is toxic and irritating, so it must never be eaten raw, and high-quality human evidence for its benefits is lacking. Talk with your pharmacist or doctor before using any Pulsatilla product, and avoid it during pregnancy and breastfeeding.

Pulsatilla vulgaris · Ranunculaceae · Aerial parts (dried whole flowering plant); used dried, never fresh · Homeopathic pellets and liquid dilutions, dried herb, tincture

An interaction check asks whether these two react with each other — it does not ask whether Pulsatilla is a good idea for someone in your situation. Here is what our Pulsatilla record says about it on its own.

Pulsatilla: dosing

There is no well-established, standardized dose of Pulsatilla for any health condition. Homeopathic products come in different potencies (such as 6C or 30C) and are dosed according to the label or a practitioner's directions, not by milligrams.Because the raw plant is toxic, you should never make or take a homemade preparation.

From our Pulsatilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pulsatilla monograph & all interactions
Medication

About Oxcarbazepine

What Is Oxcarbazepine Used For?

Brand names: Trileptal, Oxtellar XR

Oxcarbazepine treats partial-onset seizures (seizures that start in one area of the brain). It can be used alone (monotherapy) or alongside other seizure medicines (adjunctive therapy).

For adults, oxcarbazepine tablets, film-coated tablets, and oral suspension are approved for both monotherapy and adjunctive therapy. Oxcarbazepine extended-release tablets are approved for partial-onset seizures in patients 6 years and older. In children, Trileptal and oxcarbazepine oral suspension are approved as monotherapy in children aged 4–16 and as adjunctive therapy in children aged 2–16.

Most-Reported Side Effects for Oxcarbazepine

From FAERS, the FDA’s public side-effect reporting system (32,322 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 2,923 reports
Fatigue 1,641 reports
Dizziness 1,558 reports
Convulsion 1,464 reports
Headache 1,462 reports
See full Oxcarbazepine drug information
Keep checking

Other Drugs & Pulsatilla

Browse every other medication we’ve checked against Pulsatilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pulsatilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pulsatilla list.

See the full Pulsatilla interactions page
See every supplement checked against Oxcarbazepine, ranked by severity
Evidence & sources

Pulsatilla References

The 3 references that drive our Pulsatilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pulsatilla and Oxcarbazepine Together: Common Questions

Is it safe to take Pulsatilla with Oxcarbazepine?
We do not list a known interaction between Pulsatilla and Oxcarbazepine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pulsatilla and Oxcarbazepine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Oxcarbazepine interact with any supplements?
Yes. Oxcarbazepine has documented interactions with 122 supplements in our database — Pulsatilla is not one of them. The Oxcarbazepine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pulsatilla monograph Uses, safety profile, and every drug interaction in one place Oxcarbazepine drug information The full plain-English guide to this medication Oxcarbazepine supplement interactions Every supplement checked against Oxcarbazepine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxcarbazepine and Pulsatilla?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.