Drug & supplement interaction

Sceletium + Linagliptin

Linagliptin brand name: Tradjenta.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sceletium and Linagliptin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Sceletium and Linagliptin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Linagliptin and Sceletium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sceletium safety at a glance

Sceletium overall Use caution It appears generally tolerable in small studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety data are lacking, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Linagliptin and Sceletium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Linagliptin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Linagliptin is filed under 4 classifications — including antidiabetes drugs, cytochrome p450 3a4 (cyp3a4) inhibitors, p-glycoprotein substrates. Sceletium has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Linagliptin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sceletium Does Interact With Other Medications

Sceletium has 248 moderate known drug interactions in our database — Linagliptin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Linagliptin)
Taking anything else?

Check Another of Your Medications Against Sceletium

Covers the 2,830 medications we’ve checked against Sceletium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sceletium and Linagliptin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache Additional detail

    Sceletium

    “Orally, a sceletium extract has been reported to cause anxiety, headache, insomnia, and irritability. There are also anecdotal reports that chewing sceletium can cause headache, depression, and listlessness. Additionally, anecdotal reports suggest that sceletium can cause euphoric effects when inhaled or taken orally in high doses.”

    Sceletium · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 106745. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed
    2. 17580. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
    3. 100649. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum

    Linagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Linagliptin. Read the label on DailyMed ›

Reported for Sceletium but not commonly for Linagliptin: reduced appetite, mood changes or irritability, raised blood pressure and low mood.

Effects for Linagliptin come from the ADVERSE REACTIONS section of its FDA label; effects for Sceletium come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Linagliptin

This page covers Sceletium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linagliptin page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), St. John's Wort (major), Acai (moderate) and Adrafinil (moderate).

By severity: 3 major · 240 moderate · 41 minor.

From our pharmacist’s overview on the Linagliptin page

“Linagliptin (Tradjenta) helps people with type 2 diabetes bring blood sugar down, so most of the 284 supplements and herbs on this page interact for one basic reason: they lower glucose too, and stacking them can drop you into hypoglycemia. I'd read this list with genuine care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Linagliptin interaction page

One more smart check

Taking Sceletium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 132 real supplement products containing Sceletium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sceletium. Even though Sceletium itself has no known interaction with Linagliptin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sceletium and Linagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sceletium
Top half

#392 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linagliptin
Top half

#1,200 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sceletium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sceletium and Linagliptin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sceletium

What is Sceletium?

  • Anxiety and stress
  • Low mood
  • Mental focus and cognition
  • Relaxation
  • Traditional use as a mood lifter

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk to your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Sceletium tortuosum · Aizoaceae · Aerial parts (leaves, stems, and flowers), often fermented · Capsules, tablets, powders, tinctures, chewed plant material, and tea

An interaction check asks whether these two react with each other — it does not ask whether Sceletium is a good idea for someone in your situation. Here is what our Sceletium record says about it on its own.

Sceletium: dosing

There is no official, well-established dose for Sceletium. Products differ greatly in their strength and in how they are prepared and standardized.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.

From our Sceletium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sceletium monograph & all interactions
Medication

About Linagliptin

What Is Linagliptin Used For?

Brand name: Tradjenta

Tradjenta (linagliptin) is used to help control blood sugar in adults with type 2 diabetes. It is meant to be used together with healthy eating and regular exercise, not as a replacement for them.

Linagliptin is not for type 1 diabetes, and it has not been studied in people with a history of pancreatitis.

See full Linagliptin drug information
Keep checking

Other Drugs & Sceletium

Browse every other medication we’ve checked against Sceletium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Sceletium page.

No interaction 2,581 drugs checked — show the list

We also checked Sceletium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Sceletium list.

See the full Sceletium interactions page
See every supplement checked against Linagliptin, ranked by severity
Evidence & sources

Sceletium References

The 3 references that drive our Sceletium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sceletium and Linagliptin Together: Common Questions

Is it safe to take Sceletium with Linagliptin?
We do not list a known interaction between Sceletium and Linagliptin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sceletium and Linagliptin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Sceletium and Linagliptin combination checked?
Interactions in our licensed database are recorded against drug classes. Linagliptin is filed under 4 classifications, and Sceletium has documented interactions with 1 drug class — none of Linagliptin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sceletium interact with any other medications?
Yes. Sceletium has 248 documented drug interactions in our database — Linagliptin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Linagliptin interact with any supplements?
Yes. Linagliptin has documented interactions with 284 supplements in our database — Sceletium is not one of them. The Linagliptin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sceletium monograph Uses, safety profile, and every drug interaction in one place Linagliptin drug information The full plain-English guide to this medication Linagliptin supplement interactions Every supplement checked against Linagliptin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Linagliptin and Sceletium?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.