Drug & supplement interaction

Shilajit + Treprostinil

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Shilajit and Treprostinil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Shilajit and Treprostinil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Treprostinil and Shilajit in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Shilajit safety at a glance

Shilajit overall Use caution Unpurified products may contain heavy metals or other contaminants, so only use purified, tested brands.
Pregnancy Avoid Not enough safety data and contamination risk, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety is unknown while breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Treprostinil and Shilajit? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Treprostinil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Treprostinil is filed under 5 classifications — including vasodilators, cytochrome p450 2c8 (cyp2c8) substrates, anticoagulant/antiplatelet drugs. Shilajit has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Treprostinil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Shilajit Does Interact With Other Medications

Shilajit has 86 moderate known drug interactions in our database — Treprostinil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Treprostinil)
Taking anything else?

Check Another of Your Medications Against Shilajit

Covers the 2,830 medications we’ve checked against Shilajit. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Shilajit and Treprostinil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 13.7% of FDA reports for Treprostinil Additional detail

    Shilajit

    “Orally, headache is reported rarely following shilajit intake in clinical research.”

    Shilajit · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 112616. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.

    Treprostinil

    Listed in the ADVERSE REACTIONS section of the FDA label for Treprostinil, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Swelling Additional detail

    Shilajit

    “Orally, a case of apparent mineralocorticoid excess, or pseudohyperaldosteronism, with edema, increased urinary potassium, calcium, and magnesium loss, hypokalemia, and metabolic alkalosis, is reported in a 37-year-old female following the use of shilajit for 6 months during pregnancy. Product discontinuation and treatment with intravenous and oral potassium led to restoration of potassium levels.”

    Shilajit · Natural Medicines adverse-effect record, reported in hypokalemia.

    1 source cited
    1. 112622. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed

    Treprostinil

    Listed in the ADVERSE REACTIONS section of the FDA label for Treprostinil. Read the label on DailyMed ›

Reported for Shilajit but not commonly for Treprostinil: raised blood pressure, low potassium, a severe allergic reaction and hives.

Effects for Treprostinil come from the ADVERSE REACTIONS section of its FDA label; effects for Shilajit come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 121,656 voluntary FDA FAERS reports for Treprostinil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Treprostinil Is Prescribed For, and What Shilajit Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Treprostinil is a prescription medicine with approved uses on its FDA label. Shilajit is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Treprostinil is prescribed for: Treprostinil treats pulmonary arterial hypertension (PAH; WHO Group 1) — high blood pressure in the arteries of the lungs. Depending on the product and route, it is used to improve exercise ability, delay disease progression, or reduce symptoms tied to physical activity. Remodulin and treprostinil injection products are also indicated for patients who need to transition away from another PAH medicine called epoprostenol. Tyvaso, Tyvaso DPI, and Yutrepia (inhaled forms) are additionally approved to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) — lung-pressure problems caused by scarring or inflammation in the lung tissue itself.

Read the rest of what Treprostinil is prescribed for

Orenitram (extended-release oral tablet) is specifically indicated to delay disease progression and improve exercise capacity in PAH.

Shilajit has been studied for:

  • Hypertension studied, not established Shilajit has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Shilajit for hypertension

    Although there is interest in using oral shilajit for hypertension, there is insufficient reliable information about the clinical effects of shilajit for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Treprostinil on your own; if you are taking Shilajit for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Shilajit or Treprostinil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Shilajit or Treprostinil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Treprostinil

This page covers Shilajit only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Treprostinil page lists 291 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).

By severity: 6 major · 258 moderate · 27 minor.

Open the Treprostinil interaction page

One more smart check

Taking Shilajit as Part of a Dietary Supplement Product? Check It for Interactions

We hold 525 real supplement products containing Shilajit, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Shilajit. Even though Shilajit itself has no known interaction with Treprostinil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Shilajit and Treprostinil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Shilajit
Top 25%

#304 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Treprostinil
Steady interest

#1,999 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Shilajit reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Shilajit and Treprostinil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Shilajit

What is Shilajit?

  • Fatigue and low energy
  • Male fertility and testosterone support
  • General vitality and aging
  • Athletic performance
  • Cognitive support

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and mostly small or early-stage, so its real benefits are uncertain. Quality and purity vary widely, and contamination with heavy metals is a real concern, so choose tested products and talk to your pharmacist before use.

Mineral exudate (resin) from rock layers · Resin, capsules, powder, tablets

An interaction check asks whether these two react with each other — it does not ask whether Shilajit is a good idea for someone in your situation. Here is what our Shilajit record says about it on its own.

Shilajit: dosing

There is no well-established standard dose for shilajit, and products vary a lot in strength and form. Choose products that have been independently tested for heavy metals and contaminants.

From our Shilajit monograph — the full record covers uses, side effects and every documented interaction.

Read the full Shilajit monograph & all interactions
Medication

About Treprostinil

What Is Treprostinil Used For?

Treprostinil treats pulmonary arterial hypertension (PAH; WHO Group 1) — high blood pressure in the arteries of the lungs. Depending on the product and route, it is used to improve exercise ability, delay disease progression, or reduce symptoms tied to physical activity. Remodulin and treprostinil injection products are also indicated for patients who need to transition away from another PAH medicine called epoprostenol.

Tyvaso, Tyvaso DPI, and Yutrepia (inhaled forms) are additionally approved to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) — lung-pressure problems caused by scarring or inflammation in the lung tissue itself. Orenitram (extended-release oral tablet) is specifically indicated to delay disease progression and improve exercise capacity in PAH.

Most-Reported Side Effects for Treprostinil

From FAERS, the FDA’s public side-effect reporting system (124,758 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 21,361 reports
Headache 17,283 reports
Diarrhea 13,822 reports
Nausea 12,413 reports
Cough 11,659 reports
See full Treprostinil drug information
Keep checking

Other Drugs & Shilajit

Browse every other medication we’ve checked against Shilajit — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Shilajit page.

No interaction 2,743 drugs checked — show the list

We also checked Shilajit against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Shilajit list.

See the full Shilajit interactions page
See every supplement checked against Treprostinil, ranked by severity
Evidence & sources

Shilajit References

The 8 references that drive our Shilajit monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.
  2. Losa F, Deidda M, Firinu D, Martino MLD, Barca MP, Giacco SD. Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report. World J Clin Cases 2019;7(5):623-627. PubMed
  3. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010;42(1):48-56. PubMed
  4. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed
  5. Ghezelbash B, Shahrokhi N, Khaksari M, Ghaderi-Pakdel F, Asadikaram G. Hepatoprotective effects of shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. Horm Mol Biol Clin Investig 2020;41(1):/j/hmbci. PubMed
  6. Ghezelbash B, Shahrokhi N, Khaksari M, Asadikaram G, Shahrokhi M, Shirazpour S. Protective roles of shilajit in modulating resistin, adiponectin, and cytokines in rats with non-alcoholic fatty liver disease. Chin J Integr Med 2022;28(6):531-537. PubMed
  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
  8. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Ind. J. Pharmacol. 2004; 36(6):373-376.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Shilajit and Treprostinil Together: Common Questions

Is it safe to take Shilajit with Treprostinil?
We do not list a known interaction between Shilajit and Treprostinil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Shilajit and Treprostinil have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Shilajit and Treprostinil used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Shilajit in each. That is a conversation for your prescriber, especially if Treprostinil is being adjusted to a target.
How was the Shilajit and Treprostinil combination checked?
Interactions in our licensed database are recorded against drug classes. Treprostinil is filed under 5 classifications, and Shilajit has documented interactions with 1 drug class — none of Treprostinil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Shilajit interact with any other medications?
Yes. Shilajit has 86 documented drug interactions in our database — Treprostinil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Treprostinil interact with any supplements?
Yes. Treprostinil has documented interactions with 291 supplements in our database — Shilajit is not one of them. The Treprostinil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Shilajit monograph Uses, safety profile, and every drug interaction in one place Treprostinil drug information The full plain-English guide to this medication Treprostinil supplement interactions Every supplement checked against Treprostinil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Treprostinil and Shilajit?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.