Drug & supplement interaction

Stinging Nettle + Prednisone

Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Stinging Nettle and Prednisone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Prednisone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Stinging Nettle and Prednisone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prednisone and Stinging Nettle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stinging Nettle safety at a glance

Stinging Nettle overall Use caution Generally well tolerated for most adults when used as directed, but evidence and quality vary by product.
Pregnancy Likely Unsafe When used orally due to possible abortifacient and uterine-stimulant effects. Read the full pregnancy detail
Breastfeeding Avoid Safety during breastfeeding has not been established, so avoid until you talk with your doctor.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prednisone and Stinging Nettle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Prednisone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Prednisone is filed under 7 classifications — including corticosteroids, cytochrome p450 2c19 (cyp2c19) inducers, immunosuppressants. Stinging Nettle has documented interactions with 4 drug classes — the most serious being antidiabetes drugs (moderate), diuretic drugs (moderate) and lithium (moderate) — and none of Prednisone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Stinging Nettle Does Interact With Other Medications

Stinging Nettle has 164 moderate known drug interactions in our database — Prednisone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 164 No known interaction 2,666 (incl. Prednisone)
Taking anything else?

Check Another of Your Medications Against Stinging Nettle

Covers the 2,830 medications we’ve checked against Stinging Nettle. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Stinging Nettle and Prednisone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Hives Worth acting on Additional detail

    Stinging Nettle

    “Topically, fresh stinging nettle leaves and stalk can cause localized rash, itching, and stinging. Usually, short exposure to stinging nettle results in a transient urticarial reaction and a stinging sensation which may persist for more than 12 hours. In one report, a patient placed a fresh stinging nettle leaf on the tongue to suck out the sap of the leaf.”

    Stinging Nettle · Natural Medicines adverse-effect record, reported in common cold.

    6 sources cited
    1. 12490. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
    2. 76399. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
    3. 76412. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
    4. 76414. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
    5. 76417. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
    6. 76428. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Reduced appetite / Tiredness / Stomach pain / Nausea reported in 8.2% of FDA reports for Prednisone Additional detail

    Stinging Nettle

    “A case of idiosyncratic drug-induced liver disease (DILI) is reported in a 36-year-old female who presented with abdominal pain after 1 month of taking an herbal liver detox tea containing stinging nettle and other ingredients. Remarkable laboratory values included elevated liver enzymes, alkaline phosphatase, and total bilirubin.”

    Stinging Nettle · Natural Medicines adverse-effect record, reported in cirrhosis.

    2 sources cited
    1. 112178. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
    2. 112404. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Stomach upset Additional detail

    Stinging Nettle

    “Orally, stinging nettle root can cause gastrointestinal complaints, including diarrhea and constipation (1,7,11230). Stinging nettle above ground parts may cause mild gastrointestinal discomfort when taken on an empty stomach. Stinging nettle juice may cause diarrhea (1).”

    Stinging Nettle · Natural Medicines adverse-effect record, reported in constipation.

    5 sources cited
    1. 1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
    2. 7. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
    3. 11230. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
    4. 7035. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
    5. 70230. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • Constipation / Diarrhea reported in 5.7% of FDA reports for Prednisone Additional detail

    Stinging Nettle

    “Orally, stinging nettle seems to be generally well tolerated.

    Most Common Adverse Effects:

    Orally: Constipation, diarrhea.

    Topically: Contact with the raw plant causes itching, rash, and stinging.”

    Stinging Nettle · Natural Medicines adverse-effect record, reported in constipation.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Swelling Additional detail

    Stinging Nettle

    Recorded for Stinging Nettle in the same Natural Medicines adverse-effect record shown under Hives above.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

  • A skin rash Additional detail

    Stinging Nettle

    Recorded for Stinging Nettle in the same Natural Medicines adverse-effect record shown under Constipation / Diarrhea above.

    Prednisone

    Listed in the ADVERSE REACTIONS section of the FDA label for Prednisone. Read the label on DailyMed ›

Reported for Stinging Nettle but not commonly for Prednisone: liver problems, breast tenderness and itching.

Effects for Prednisone come from the ADVERSE REACTIONS section of its FDA label; effects for Stinging Nettle come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 491,135 voluntary FDA FAERS reports for Prednisone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Stinging Nettle in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally due to possible abortifacient and uterine-stimulant effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Prednisone Products Have a Food Rule — Stinging Nettle Should Not Break It

At least one FDA label for a product containing Prednisone says to take it with food. If you take Stinging Nettle on an empty stomach out of habit, keep them separate — and take Prednisone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Prednisone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk.

From the Dosage and Administration section of the FDA label we read for Prednisone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Prednisone Is Prescribed For, and What Stinging Nettle Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Prednisone is a prescription medicine with approved uses on its FDA label. Stinging Nettle is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Prednisone is prescribed for: Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood. Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.

Stinging Nettle has been studied for:

  • Asthma studied, not established Stinging Nettle has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Stinging Nettle for asthma

    Although there is interest in using oral stinging nettle for asthma, there is insufficient reliable information about the clinical effects of stinging nettle for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Prednisone on your own; if you are taking Stinging Nettle for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Stinging Nettle or Prednisone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Stinging Nettle or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prednisone

This page covers Stinging Nettle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 168 moderate · 36 minor.

From our pharmacist’s overview on the Prednisone page

“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Prednisone interaction page

One more smart check

Taking Stinging Nettle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,276 real supplement products containing Stinging Nettle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stinging Nettle. Even though Stinging Nettle itself has no known interaction with Prednisone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stinging Nettle and Prednisone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stinging Nettle
Top 10%

#80 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prednisone
Top 1%

#22 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stinging Nettle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Stinging Nettle and Prednisone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stinging Nettle

What is Stinging Nettle?

Stinging Nettle
  • Enlarged prostate (BPH) symptoms
  • Seasonal allergies
  • Joint pain and arthritis
  • Urinary symptoms / mild diuretic
  • Blood sugar support

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it is best thought of as a supportive option rather than a proven treatment. It is generally well tolerated, but pregnant and breastfeeding people should avoid it and everyone should check with a pharmacist or doctor first.

Urtica dioica · Urticaceae · Leaves, roots, and seeds (aerial parts) · Tea, capsules, tablets, tinctures, liquid extracts, dried leaf, topical creams, and cooked greens

An interaction check asks whether these two react with each other — it does not ask whether Stinging Nettle is a good idea for someone in your situation. Here is what our Stinging Nettle record says about it on its own.

Stinging Nettle: dosing

There is no single official or proven dose of stinging nettle, and the right amount depends on the part of the plant (leaf, root, or seed) and the form (tea, capsule, tincture, or extract).The best approach is to follow the directions on the product label and not take more than recommended.

From our Stinging Nettle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stinging Nettle monograph & all interactions
Medication

About Prednisone

What Is Prednisone Used For?

Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos

Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood.

Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.

Most-Reported Side Effects for Prednisone

From FAERS, the FDA’s public side-effect reporting system (499,938 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 40,822 reports
Dyspnea 34,944 reports
Arthralgia 33,224 reports
Nausea 28,568 reports
Diarrhea 28,439 reports
See full Prednisone drug information
Keep checking

Other Drugs & Stinging Nettle

Browse every other medication we’ve checked against Stinging Nettle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
164Moderate
0Minor
2,665No known interaction
164 Moderate 2,665 No interaction
Moderate

164 interactions

Showing 60 of 164 moderate interactions — see all 164 on the Stinging Nettle page.

No interaction 2,665 drugs checked — show the list

We also checked Stinging Nettle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,665 medications checked with no known interaction — see the full Stinging Nettle list.

See the full Stinging Nettle interactions page
See every supplement checked against Prednisone, ranked by severity
Evidence & sources

Stinging Nettle References

The 23 references that drive our Stinging Nettle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stinging Nettle and Prednisone Together: Common Questions

Is it safe to take Stinging Nettle with Prednisone?
We do not list a known interaction between Stinging Nettle and Prednisone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Stinging Nettle and Prednisone have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Stinging Nettle and Prednisone at the same time of day?
At least one FDA label for a product containing Prednisone says to take it with food. If you take Stinging Nettle on an empty stomach out of habit, keep them separate and take Prednisone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Prednisone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Stinging Nettle and Prednisone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Stinging Nettle in each. That is a conversation for your prescriber, especially if Prednisone is being adjusted to a target.
How was the Stinging Nettle and Prednisone combination checked?
Interactions in our licensed database are recorded against drug classes. Prednisone is filed under 7 classifications, and Stinging Nettle has documented interactions with 4 drug classes — none of Prednisone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Stinging Nettle interact with any other medications?
Yes. Stinging Nettle has 164 documented drug interactions in our database — Prednisone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Prednisone interact with any supplements?
Yes. Prednisone has documented interactions with 208 supplements in our database — Stinging Nettle is not one of them. The Prednisone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stinging Nettle monograph Uses, safety profile, and every drug interaction in one place Prednisone drug information The full plain-English guide to this medication Prednisone supplement interactions Every supplement checked against Prednisone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 23 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Prednisone and Stinging Nettle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.