Drug & supplement interaction

Suma + Tramadol

Tramadol brand names: Ultram, Zytram XL, Qdolo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Suma and Tramadol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Suma and Tramadol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tramadol and Suma in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Suma at all — not against Tramadol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Suma safety at a glance

Suma overall Use caution Generally used in foods and supplements, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tramadol and Suma? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Suma Itself Has Been Linked To

This is not an interaction — nothing below involves Tramadol. It is the side-effect record for Suma on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Suma, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Orally, suma seems to be well tolerated (12). No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted. When inhaled, powdered suma root can cause occupational asthma.”

    Suma · Natural Medicines adverse-effect record, reported in asthma.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 515. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
    3. 76647. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

    “When inhaled, suma root powder has caused allergic asthma symptoms in a single patient.”

    Suma · Natural Medicines adverse-effect record, reported in asthma.

    1 source cited
    1. 76647. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Suma — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tramadol’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tramadol column appears here.

From our Q&A

Questions About Suma or Tramadol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Suma or Tramadol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tramadol

This page covers Suma only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tramadol page lists 223 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 10 major · 174 moderate · 39 minor.

From our pharmacist’s overview on the Tramadol page

“Tramadol (Ultram, Qdolo) is an opioid, and its supplement interactions worry me more than most because the worst of them compound the drug's most dangerous effects. Alcohol and dozens of calming herbs deepen its sedation, sometimes to the point of slowed breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Tramadol interaction page

One more smart check

Taking Suma as Part of a Dietary Supplement Product? Check It for Interactions

We hold 438 real supplement products containing Suma, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Suma. Even though Suma itself has no known interaction with Tramadol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Suma and Tramadol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Suma
Top half

#426 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tramadol
Top half

#1,397 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Suma reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Suma and Tramadol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Suma

What is Suma?

  • General energy and vitality
  • Adaptogen for stress
  • Sexual health and libido
  • Athletic performance
  • Immune support
  • Hormonal balance

Suma is a South American root often marketed as a 'Brazilian ginseng' and used as an adaptogen for energy, stamina, and stress. Human evidence is very limited, and most claims come from traditional use and lab or animal studies. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a hormone-sensitive condition.

Pfaffia paniculata · Amaranthaceae · Root · Capsules, powder, tablets, tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Suma is a good idea for someone in your situation. Here is what our Suma record says about it on its own.

Suma: dosing

There is no well-established standardized dose for Suma. Studies are too limited to recommend a specific amount, and product strengths vary widely.If you choose to use it, follow the dosing directions on the product label and do not exceed them. A pharmacist can help you review a product and decide whether it is appropriate for you.Start low, watch for any reactions, and stop if you notice side effects.

From our Suma monograph — the full record covers uses, side effects and every documented interaction.

Read the full Suma monograph & all interactions
Medication

About Tramadol

What Is Tramadol Used For?

Brand names: Ultram, Zytram XL, Qdolo

Tramadol is used in adults for pain that is severe enough to need an opioid-strength medication and where non-opioid treatments haven't been enough. It's typically reserved for situations where milder options have failed or aren't expected to work.

It is not meant for everyday or long-term use unless the pain remains severe and alternatives continue to fall short. Prescribers carefully weigh the benefits against the real risks before starting tramadol.

See full Tramadol drug information
Keep checking

Other Drugs & Suma

Browse every other medication we’ve checked against Suma — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Suma against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Suma list.

See the full Suma interactions page
See every supplement checked against Tramadol, ranked by severity
Evidence & sources

Suma References

The 3 references that drive our Suma monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
  3. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Suma and Tramadol Together: Common Questions

Is it safe to take Suma with Tramadol?
We do not list a known interaction between Suma and Tramadol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tramadol interact with any supplements?
Yes. Tramadol has documented interactions with 223 supplements in our database — Suma is not one of them. The Tramadol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Suma monograph Uses, safety profile, and every drug interaction in one place Tramadol drug information The full plain-English guide to this medication Tramadol supplement interactions Every supplement checked against Tramadol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tramadol and Suma?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.