Drug & supplement interaction

Wheatgrass + Dapagliflozin Propanediol, Metformin

Dapagliflozin Propanediol, Metformin brand name: Xigduo XR.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Wheatgrass has a moderate interaction with Dapagliflozin Propanediol, Metformin. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Wheatgrass and Dapagliflozin Propanediol, Metformin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Dapagliflozin Propanediol, Metformin

Dapagliflozin Propanediol, Metformin falls under ANTIDIABETES DRUGS — the group Wheatgrass interacts with.

Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Animal research shows that taking wheatgrass stimulates the release of insulin from beta-cells and lowers blood glucose.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Xigduo XR combines two diabetes medicines, dapagliflozin and metformin, that already work to lower your blood sugar. Wheatgrass may add a small extra nudge in that same direction. In animal studies it seemed to prompt the release of insulin and bring glucose down, so stacking it on top of your medication could, in theory, push your numbers a little lower than intended.

If your blood sugar dips too far, you might feel shaky, sweaty, lightheaded, hungry, or confused. I want to be honest, though: this concern comes only from lab and animal research, not human trials, so the real-world risk is likely small. If you'd like to add wheatgrass, just keep an eye on your readings and run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mohan Y, Jesuthankaraj GN1, Ramasamy Thangavelu N. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats. Adv Pharmacol Sci 2013;2013:716073.
  2. Shakya G, Randhi PK, Pajaniradje S, Mohankumar K, Rajagopalan R. Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats. Toxicol Ind Health 2016;32(6):1026-32. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Wheatgrass Also Interacts With Other Medications

Wheatgrass has 271 moderate known drug interactions in our database — the Dapagliflozin Propanediol, Metformin one above is one of them. If you take anything else, check it against the full list below.

Moderate 271 No known interaction 2,559 (incl. Dapagliflozin Propanediol, Metformin)
Taking anything else?

Check Another of Your Medications Against Wheatgrass

Covers the 2,830 medications we’ve checked against Wheatgrass. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dapagliflozin Propanediol, Metformin

This page covers Wheatgrass only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dapagliflozin Propanediol, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Dapagliflozin Propanediol, Metformin page

“Siberian cocklebur is the one supplement I would flat-out avoid with Xigduo XR (dapagliflozin plus metformin). It has caused severe and worsening low blood sugar in people, a dangerous match for two glucose-lowering medicines.”

Reviewed by 2 · Jul 18, 2026

Open the Dapagliflozin Propanediol, Metformin interaction page

One more smart check

Taking Wheatgrass as Part of a Dietary Supplement Product? Check It for Interactions

We hold 104 real supplement products containing Wheatgrass, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wheatgrass. Your product may carry other ingredients that interact with Dapagliflozin Propanediol, Metformin too, on top of Wheatgrass — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wheatgrass and Dapagliflozin Propanediol, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wheatgrass
Top half

#476 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dapagliflozin Propanediol, Metformin
Top 25%

#317 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Wheatgrass

What is Wheatgrass?

Wheatgrass
  • General nutrition support
  • Digestive health
  • Antioxidant support
  • Energy and wellness
  • Arthritis symptoms
  • Detox or cleansing routines

Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most health claims is limited, and it is best viewed as a nutritional add-on rather than a treatment. It is generally well tolerated, but people with celiac disease, wheat allergy, or who are pregnant should be cautious and check with a healthcare provider.

Read the full Wheatgrass monograph & all interactions
Keep checking

Other Drugs & Wheatgrass

Browse every other medication we’ve checked against Wheatgrass — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
271Moderate
0Minor
2,558No known interaction
271 Moderate 2,558 No interaction
Moderate

271 interactions

Showing 60 of 271 moderate interactions — see all 271 on the Wheatgrass page.

No interaction 2,558 drugs checked — show the list

We also checked Wheatgrass against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,558 medications checked with no known interaction — see the full Wheatgrass list.

See the full Wheatgrass interactions page
See every supplement checked against Dapagliflozin Propanediol, Metformin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Wheatgrass monograph › Uses, safety, and every drug interaction in one place Dapagliflozin Propanediol, Metformin supplement interactions › Every supplement checked against Dapagliflozin Propanediol, Metformin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Wheatgrass and Dapagliflozin Propanediol, Metformin Together: Common Questions

Can you take Wheatgrass with Dapagliflozin Propanediol, Metformin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Wheatgrass and Dapagliflozin Propanediol, Metformin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dapagliflozin Propanediol, Metformin and Wheatgrass?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.