Drug & supplement interaction

Wheatgrass + Daratumumab

Daratumumab brand name: Darzalex.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Wheatgrass and Daratumumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Wheatgrass and Daratumumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Daratumumab and Wheatgrass in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wheatgrass safety at a glance

Wheatgrass overall Use caution Generally well tolerated as a food, but quality and contamination concerns mean caution is wise.

Pregnancy Avoid Safety is not established, and raw products may carry contamination risk, so avoid unless cleared by your doctor.

Breastfeeding Avoid There is not enough safety information, so avoid unless your doctor approves.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Daratumumab and Wheatgrass? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Wheatgrass Does Interact With Other Medications

Wheatgrass has 272 moderate known drug interactions in our database — Daratumumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 272 No known interaction 2,558 (incl. Daratumumab)

Taking anything else?

Check Another of Your Medications Against Wheatgrass

Covers the 2,830 medications we’ve checked against Wheatgrass. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wheatgrass and Daratumumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Constipation / Nausea Additional detail
Wheatgrass
“Orally, wheatgrass may cause nausea, anorexia, and constipation.”

Wheatgrass · Natural Medicines adverse-effect record, reported in anorexia.
1 source cited

11165. Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9.. PubMed
Daratumumab

Listed in the ADVERSE REACTIONS section of the FDA label for Daratumumab. Read the label on DailyMed ›

Reported for Wheatgrass but not commonly for Daratumumab: an allergic reaction and reduced appetite.

Effects for Daratumumab come from the ADVERSE REACTIONS section of its FDA label; effects for Wheatgrass come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 42,488 voluntary FDA FAERS reports for Daratumumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Daratumumab Is Prescribed For, and What Wheatgrass Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Daratumumab is a prescription medicine with approved uses on its FDA label. Wheatgrass is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Daratumumab is prescribed for: Darzalex is used to treat multiple myeloma (a cancer of plasma cells in the bone marrow) in adults. It can be used in newly diagnosed patients who are not eligible for a stem cell transplant, in patients who are eligible for a stem cell transplant, and in patients whose myeloma has returned or stopped responding to earlier treatments. Depending on how many prior treatments a patient has had, Darzalex may be given alone or in combination with other medicines such as lenalidomide, bortezomib, thalidomide, carfilzomib, pomalidomide, melphalan, dexamethasone, or prednisone. The specific combination used depends on the patient's situation and treatment history.

Wheatgrass has been studied for:

Cancer studied, not established Wheatgrass has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Wheatgrass for cancer

Although there has been interest in using oral wheatgrass for cancer, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Daratumumab on your own; if you are taking Wheatgrass for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Wheatgrass as Part of a Dietary Supplement Product? Check It for Interactions

We hold 104 real supplement products containing Wheatgrass, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wheatgrass. Even though Wheatgrass itself has no known interaction with Daratumumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wheatgrass and Daratumumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wheatgrass

Top half

#457 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Daratumumab

Steady interest

#1,854 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wheatgrass reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Wheatgrass and Daratumumab records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Wheatgrass

What is Wheatgrass?

General nutrition support
Digestive health
Antioxidant support
Energy and wellness
Arthritis symptoms
Detox or cleansing routines

Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most health claims is limited, and it is best viewed as a nutritional add-on rather than a treatment. It is generally well tolerated, but people with celiac disease, wheat allergy, or who are pregnant should be cautious and check with a healthcare provider.

Triticum aestivum · Poaceae · Young grass (leaves/shoots) of the wheat plant · Fresh juice, powder, tablets, capsules, and added to smoothies or health drinks

An interaction check asks whether these two react with each other — it does not ask whether Wheatgrass is a good idea for someone in your situation. Here is what our Wheatgrass record says about it on its own.

Wheatgrass: dosing

There is no official or standardized dose for wheatgrass. Amounts vary widely between fresh juice, powder, and tablets, so the right amount depends on the specific product.The safest approach is to follow the directions on the product label and start with a small amount to see how your body responds.

From our Wheatgrass monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wheatgrass monograph & all interactions

Medication

About Daratumumab Injection

What Is Daratumumab Injection Used For?

Brand name: Darzalex

Darzalex is used to treat multiple myeloma (a cancer of plasma cells in the bone marrow) in adults. It can be used in newly diagnosed patients who are not eligible for a stem cell transplant, in patients who are eligible for a stem cell transplant, and in patients whose myeloma has returned or stopped responding to earlier treatments.

Depending on how many prior treatments a patient has had, Darzalex may be given alone or in combination with other medicines such as lenalidomide, bortezomib, thalidomide, carfilzomib, pomalidomide, melphalan, dexamethasone, or prednisone. The specific combination used depends on the patient's situation and treatment history.

Most-Reported Side Effects for Daratumumab

From FAERS, the FDA’s public side-effect reporting system (42,488 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Plasma cell myeloma 3,971 reports

Infusion related reaction 2,703 reports

Pneumonia 2,104 reports

Neutropenia 2,097 reports

Fatigue 1,962 reports

See full Daratumumab Injection drug information

Keep checking

Other Drugs & Wheatgrass

Browse every other medication we’ve checked against Wheatgrass — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

272Moderate

0Minor

2,557No known interaction

272 Moderate 2,557 No interaction

Moderate

272 interactions

Showing 60 of 272 moderate interactions — see all 272 on the Wheatgrass page.

No interaction 2,557 drugs checked — show the list

We also checked Wheatgrass against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,557 medications checked with no known interaction — see the full Wheatgrass list.

See the full Wheatgrass interactions page

See every supplement checked against Daratumumab, ranked by severity

Evidence & sources

Wheatgrass References

The 5 references that drive our Wheatgrass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9.. PubMed
Mohan Y, Jesuthankaraj GN1, Ramasamy Thangavelu N. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats. Adv Pharmacol Sci 2013;2013:716073.
Shakya G, Randhi PK, Pajaniradje S, Mohankumar K, Rajagopalan R. Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats. Toxicol Ind Health 2016;32(6):1026-32. PubMed
Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wheatgrass and Daratumumab Together: Common Questions

Is it safe to take Wheatgrass with Daratumumab?

We do not list a known interaction between Wheatgrass and Daratumumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Wheatgrass and Daratumumab have any of the same side effects?

Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Wheatgrass and Daratumumab used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Wheatgrass in each. That is a conversation for your prescriber, especially if Daratumumab is being adjusted to a target.

Does Wheatgrass interact with any other medications?

Yes. Wheatgrass has 272 documented drug interactions in our database — Daratumumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wheatgrass monograph Uses, safety profile, and every drug interaction in one place Daratumumab Injection drug information The full plain-English guide to this medication Daratumumab supplement interactions Every supplement checked against Daratumumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Daratumumab and Wheatgrass?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.