Drug & supplement interaction

Wild Yam + Felodipine

Felodipine brand names: Plendil, Renedil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wild Yam and Felodipine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Felodipine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wild Yam and Felodipine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Felodipine and Wild Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wild Yam safety at a glance

Wild Yam overall Use caution Likely fine for short-term use in healthy adults, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Felodipine and Wild Yam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Felodipine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Felodipine is filed under 5 classifications — including calcium channel blockers, antihypertensive drugs, cytochrome p450 3a4 (cyp3a4) substrates. Wild Yam has documented interactions with 1 drug class — the most serious being estrogens (moderate) — and none of Felodipine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wild Yam Does Interact With Other Medications

Wild Yam has 41 moderate known drug interactions in our database — Felodipine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 No known interaction 2,789 (incl. Felodipine)
Taking anything else?

Check Another of Your Medications Against Wild Yam

Covers the 2,830 medications we’ve checked against Wild Yam. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wild Yam and Felodipine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Wild Yam

    “Orally, wild yam is generally well tolerated.

    Most Common Adverse Effects:

    Orally: Fever, headache, upset stomach, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Anaphylaxis.”

    Wild Yam · Natural Medicines adverse-effect record, reported in cluster headache.

    Felodipine

    Listed in the ADVERSE REACTIONS section of the FDA label for Felodipine. Read the label on DailyMed ›

  • Stomach upset / Vomiting Additional detail

    Wild Yam

    “Orally, wild yam can cause upset stomach and vomiting, especially at higher doses (12,86450).”

    Wild Yam · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Felodipine

    Listed in the ADVERSE REACTIONS section of the FDA label for Felodipine. Read the label on DailyMed ›

  • Headache reported in 7.8% of FDA reports for Felodipine Additional detail

    Wild Yam

    “Orally, wild yam can cause headache and fever, especially at higher doses.”

    Wild Yam · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Felodipine

    Listed in the ADVERSE REACTIONS section of the FDA label for Felodipine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Wild Yam but not commonly for Felodipine: loss of vision, blood clots and fever.

Effects for Felodipine come from the ADVERSE REACTIONS section of its FDA label; effects for Wild Yam come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 11,328 voluntary FDA FAERS reports for Felodipine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Felodipine Products Have a Food Rule — Wild Yam Should Not Break It

At least one FDA label for a product containing Felodipine says to take it on an empty stomach. Most supplements — Wild Yam included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Felodipine on its own and move Wild Yam to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Felodipine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Felodipine should regularly be taken either without food or with a light meal (see CLINICAL PHARMACOLOGY, Pharmacokinetics and Metabolism ).

From the Dosage and Administration section of the FDA label we read for Felodipine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Wild Yam or Felodipine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wild Yam or Felodipine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Felodipine

This page covers Wild Yam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Felodipine page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 8 major · 182 moderate · 42 minor.

From our pharmacist’s overview on the Felodipine page

“Felodipine (Plendil) is a blood pressure medicine broken down by the CYP3A4 enzyme, which is why 232 supplements and foods have an interaction on file, eight of them rated major. This list deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Felodipine interaction page

One more smart check

Taking Wild Yam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,014 real supplement products containing Wild Yam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Yam. Even though Wild Yam itself has no known interaction with Felodipine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Yam and Felodipine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Yam
Top 25%

#227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Felodipine
Top 25%

#585 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wild Yam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wild Yam and Felodipine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wild Yam

What is Wild Yam?

  • Menopausal symptoms
  • Menstrual cramps
  • Hormone balance (popular belief)
  • Digestive cramps
  • Joint and muscle discomfort

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular claims, your body cannot convert its compounds into hormones like progesterone, so creams marketed that way usually don't work as advertised. Talk with a pharmacist or doctor before using it.

Dioscorea villosa · Dioscoreaceae · Root and rhizome (underground stem) · Capsules, tablets, dried root, tinctures, topical creams, tea

An interaction check asks whether these two react with each other — it does not ask whether Wild Yam is a good idea for someone in your situation. Here is what our Wild Yam record says about it on its own.

Wild Yam: dosing

There is no well-established standard dose for wild yam. The amount can vary widely between products and forms (capsules, tinctures, teas, or creams).The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Wild Yam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wild Yam monograph & all interactions
Medication

About Felodipine

What Is Felodipine Used For?

Brand names: Plendil, Renedil

Felodipine extended-release tablets are used to treat high blood pressure (hypertension). Lowering blood pressure reduces the risk of serious events like stroke and heart attack. Felodipine may be used alone or combined with other blood pressure medicines.

Keeping blood pressure under control is part of a broader approach to heart health that can include managing cholesterol, blood sugar, and lifestyle factors like diet, exercise, and not smoking.

Most-Reported Side Effects for Felodipine

From FAERS, the FDA’s public side-effect reporting system (11,328 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,108 reports
Dyspnea 1,002 reports
Dizziness 1,000 reports
Diarrhea 887 reports
Nausea 887 reports
See full Felodipine drug information
Keep checking

Other Drugs & Wild Yam

Browse every other medication we’ve checked against Wild Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
0Minor
2,788No known interaction
41 Moderate 2,788 No interaction
Moderate

41 interactions

No interaction 2,788 drugs checked — show the list

We also checked Wild Yam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,788 medications checked with no known interaction — see the full Wild Yam list.

See the full Wild Yam interactions page
See every supplement checked against Felodipine, ranked by severity
Evidence & sources

Wild Yam References

The 7 references that drive our Wild Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wild Yam and Felodipine Together: Common Questions

Is it safe to take Wild Yam with Felodipine?
We do not list a known interaction between Wild Yam and Felodipine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wild Yam and Felodipine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Wild Yam and Felodipine at the same time of day?
At least one FDA label for a product containing Felodipine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Felodipine on its own and move Wild Yam to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Wild Yam and Felodipine combination checked?
Interactions in our licensed database are recorded against drug classes. Felodipine is filed under 5 classifications, and Wild Yam has documented interactions with 1 drug class — none of Felodipine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wild Yam interact with any other medications?
Yes. Wild Yam has 41 documented drug interactions in our database — Felodipine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Felodipine interact with any supplements?
Yes. Felodipine has documented interactions with 232 supplements in our database — Wild Yam is not one of them. The Felodipine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wild Yam monograph Uses, safety profile, and every drug interaction in one place Felodipine drug information The full plain-English guide to this medication Felodipine supplement interactions Every supplement checked against Felodipine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Felodipine and Wild Yam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.