Drug & supplement interaction

Wine + Aspirin, Codeine Phosphate, Methocarbamol

Aspirin, Codeine Phosphate, Methocarbamol brand name: Robaxisal C.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Aspirin, Codeine Phosphate, Methocarbamol falls into 4 drug categories that Wine can interact with; the most serious is rated major. Concomitant use may increase sedative and other adverse effects.

Read the full interaction report
SeverityMajor
LikelihoodLikely
Interactions4
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Wine and Aspirin, Codeine Phosphate, Methocarbamol

These two interact in 4 distinct ways. Each one is explained separately below.

Why Are There 4 Interactions?

Wine interacts with whole categories of medication. Aspirin, Codeine Phosphate, Methocarbamol falls into 4 of those categories, so it can interact with Wine in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

CNS DEPRESSANTS

1 of 4

Why this applies to Aspirin, Codeine Phosphate, Methocarbamol

Aspirin, Codeine Phosphate, Methocarbamol falls under CNS DEPRESSANTS — the group Wine interacts with.

Concomitant use may increase sedative and other adverse effects.
Concomitant use of alcohol with CNS depressants can increase sedative and other adverse effects, potentially through inhibition of the metabolism of certain CNS depressants.
Severity Major Likelihood Likely Evidence C

Well-controlled human studies have demonstrated the likely existence of this interaction.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill packs two ingredients that already slow down your brain and body: codeine (an opioid pain reliever) and methocarbamol (a muscle relaxant). Add wine on top, and the alcohol piles onto that same sedating effect. You can end up much more drowsy, dizzy, or foggy than you'd expect, with slowed breathing being the most serious worry. Alcohol may also slow how your body clears these medicines, so the effect lingers longer.

There's also the aspirin piece. Both aspirin and alcohol irritate the stomach lining, so mixing them raises your risk of stomach upset or bleeding. My honest advice: skip the wine while you're taking this, and check with your pharmacist or doctor before combining the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Major

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

2 of 4

Aspirin, Codeine Phosphate, Methocarbamol also falls under NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs).

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.
Concomitant use of NSAIDs with alcohol may increase the risk of GI bleeding.
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill (Robaxisal C) contains three things, and the one that matters most here is the aspirin. Aspirin is hard on the stomach lining and slows down how well your blood clots. Wine and other alcohol also irritate the stomach. Put them together and you raise the odds of bleeding in your stomach or gut, which can show up as stomach pain, black or tarry stools, or vomit that looks like coffee grounds.

There's also the codeine to think about. Both codeine and alcohol slow your breathing and make you drowsy, so mixing them adds to that sedating effect. This is a well-recognized concern, not just a theory. If you drink at all, please talk with your pharmacist or doctor first about whether it's safe with this medicine.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Major

ASPIRIN

3 of 4
Concomitant use may increase the risk of gastrointestinal (GI) bleeding.
Concomitant use of aspirin with alcohol may increase the risk of GI bleeding.
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product (Robaxisal C) contains aspirin, and that's the piece that worries me when wine enters the picture. Both aspirin and alcohol can irritate the stomach lining, and aspirin also makes platelets less able to clot. Put them together and you raise the chance of stomach bleeding, which can show up as stomach pain, dark or tarry stools, vomit that looks like coffee grounds, or feeling unusually weak and dizzy.

There's also the codeine to think about. Mixing alcohol with codeine can pile on the drowsiness, dizziness, and slowed breathing, so that's a second reason to be cautious. This is a well-recognized interaction, not just a theory. Please don't change anything on your own, but do check with your pharmacist or doctor about drinking while taking this.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Moderate

NARCOTIC DRUGS

4 of 4

Aspirin, Codeine Phosphate, Methocarbamol also falls under NARCOTIC DRUGS.

Concomitant use of large amounts of alcohol may decrease the metabolism of narcotic drugs.
Concomitant consumption of large amounts of alcohol can decrease the metabolism of narcotic drugs.
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill has three parts, and wine touches two of them in a real way. The codeine is a narcotic, and the methocarbamol is a muscle relaxant. Both already make you drowsy and slow your breathing. Drinking large amounts of alcohol can slow how your body clears the narcotic, so it can build up, and the sedating effects stack on top of each other. That means more grogginess, dizziness, slowed breathing, and a higher risk of falls or oversedation.

There's also the aspirin piece: alcohol and aspirin together can be rougher on your stomach lining and raise bleeding risk. A small splash now and then is different from heavy drinking, but please check with your pharmacist or doctor before mixing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Wine Also Interacts With Other Medications

Wine has 655 major, 270 moderate known drug interactions in our database — the Aspirin, Codeine Phosphate, Methocarbamol one above is among them. If you take anything else, check it against the full list below.

Major 655 Moderate 270 No known interaction 1,905 (incl. Aspirin, Codeine Phosphate, Methocarbamol)
Taking anything else?

Check Another of Your Medications Against Wine

Covers the 2,830 medications we’ve checked against Wine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Codeine Phosphate, Methocarbamol

This page covers Wine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Codeine Phosphate, Methocarbamol page lists 328 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 12 major · 282 moderate · 34 minor.

From our pharmacist’s overview on the Aspirin, Codeine Phosphate, Methocarbamol page

“Alcohol is the single riskiest thing to combine with Robaxisal C (aspirin, codeine phosphate, and methocarbamol). Beer and wine both carry major ratings backed by solid human evidence, because codeine and methocarbamol already slow breathing and reflexes, and alcohol deepens that sedation.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Codeine Phosphate, Methocarbamol interaction page

One more smart check

Taking Wine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Wine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wine. Your product may carry other ingredients that interact with Aspirin, Codeine Phosphate, Methocarbamol too, on top of Wine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wine and Aspirin, Codeine Phosphate, Methocarbamol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wine
Top half

#556 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Codeine Phosphate, Methocarbamol
Steady interest

#1,612 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Wine

What is Wine?

  • Social and relaxation use
  • Heart health (popular belief)
  • Antioxidant intake
  • Aiding digestion (traditional use)
  • Culinary flavoring

Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine. Despite popular claims about heart benefits, the alcohol it contains carries real health risks, and no amount of drinking can be recommended to improve health. If you drink, do so in moderation, and avoid alcohol entirely during pregnancy or if you have certain medical conditions.

Read the full Wine monograph & all interactions
Keep checking

Other Drugs & Wine

Browse every other medication we’ve checked against Wine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

655Major
270Moderate
0Minor
1,904No known interaction
655 Major 270 Moderate 1,904 No interaction
Major

655 interactions

Showing 60 of 655 major interactions — see all 655 on the Wine page.

Moderate

270 interactions

Showing 60 of 270 moderate interactions — see all 270 on the Wine page.

No interaction 1,904 drugs checked — show the list

We also checked Wine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,904 medications checked with no known interaction — see the full Wine list.

See the full Wine interactions page
See every supplement checked against Aspirin, Codeine Phosphate, Methocarbamol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Wine monograph › Uses, safety, and every drug interaction in one place Aspirin, Codeine Phosphate, Methocarbamol supplement interactions › Every supplement checked against Aspirin, Codeine Phosphate, Methocarbamol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Wine and Aspirin, Codeine Phosphate, Methocarbamol Together: Common Questions

Can you take Wine with Aspirin, Codeine Phosphate, Methocarbamol?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 4 interactions listed for Wine and Aspirin, Codeine Phosphate, Methocarbamol?
Aspirin, Codeine Phosphate, Methocarbamol belongs to more than one drug category, and Wine interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Wine and Aspirin, Codeine Phosphate, Methocarbamol interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Codeine Phosphate, Methocarbamol and Wine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.