Drug & supplement interaction

Wine + Dextromethorphan

Dextromethorphan brand names: Hold, Benylin Adult, Benylin Pediatric, Theraflu Thin Strips Long Acting Cough, Neo Citran Thin Strips Cough.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Wine and Dextromethorphan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Wine and Dextromethorphan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan and Wine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wine safety at a glance

Wine overall Use caution Wine contains alcohol, which can harm health and become habit-forming even in moderate amounts.

Pregnancy Likely Unsafe When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developm... Read the full pregnancy detail

Breastfeeding Likely Unsafe When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcoho... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan and Wine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Dextromethorphan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextromethorphan is filed under 6 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 2d6 (cyp2d6) substrates. Wine has documented interactions with 37 drug classes — the most serious being aspirin (major), cisapride (propulsid) (major) and cns depressants (major) — and none of Dextromethorphan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wine Does Interact With Other Medications

Wine has 656 major, 270 moderate known drug interactions in our database — Dextromethorphan isn’t one of them. If you take anything else, check it against the full list below.

Major 656 Moderate 270 No known interaction 1,904 (incl. Dextromethorphan)

Taking anything else?

Check Another of Your Medications Against Wine

Covers the 2,830 medications we’ve checked against Wine. Pick one to open its full report.

What to actually watch for

What Wine Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan. It is the side-effect record for Wine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Wine, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

Low magnesium / Low blood sugar Worth acting on Additional detail

“Orally, the side effects of wine depend on the amount of alcohol ingested and can vary among individuals.

Most Common Adverse Effects:

Orally: Most adverse effects are associated with alcohol content and include abdominal pain, aggression, blackouts, central nervous system (CNS) depression, confusion, diarrhea, drowsiness, emotional lability, flushing, hypoglycemia, hypothermia, indigestion, lack of coordination and…”

Wine · Natural Medicines adverse-effect record, reported in cancer.
Dependence or withdrawal symptoms / Unsteadiness / Hallucinations Worth acting on Additional detail
“Orally, wine can cause a variety of side effects which depend on the amount of alcohol ingested and can vary among individuals. Some common side effects include blackouts, central nervous system (CNS) depression, drowsiness, lack of coordination and trouble walking, migraines, neuropathies, and perceptual and sensational disturbances.”

Wine · Natural Medicines adverse-effect record, reported in dementia.
6 sources cited

6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.

8972. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

34055. Bechetoille, A., Ebran, J. M., Allain, P., and Mauras, Y. [Therapeutic affect of zinc sulfate on central scotoma due to optic neuropathy of alcohol and tobacco abuse]. J Fr.Ophtalmol. 1983;6(3):237-242.

34068. Leira, R. and Rodriguez, R. [Diet and migraine]. Rev Neurol. 1996;24(129):534-538.

8651. Mukamal KJ, Longstreth WT, Mittleman MA. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke 2001;32:1939-46. PubMed
A stroke or mini-stroke / Muscle weakness / A heart attack Worth acting on Additional detail
“Orally, chronic heavy alcohol ingestion of three or more drinks daily is associated with an increased risk of all-cause mortality, atrial fibrillation, cardiac myopathy, hypertension, ischemic stroke, and myocardial infarction (MI). Consumption of any amount of alcohol can increase the risk of hemorrhagic stroke.”

Wine · Natural Medicines adverse-effect record, reported in atrial fibrillation.
6 sources cited

2261. Pearson TA. Alcohol and heart disease. Circulation 1996;94:3023-5. PubMed

6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.

6892. Goldberg I, Mosca L, Piano MR, Fisher EA. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the America

8102. Thadhani R, Camargo CA, Stampfer MJ, et al. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med 2002;162:569-74. PubMed

9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

33984. Seiler, C. [Alcohol, the heart and cardiovascular system]. Ther Umsch. 2000;57(4):200-204.
Memory problems Worth acting on Additional detail
“Orally, wine can cause a variety of side effects which depend on the amount of alcohol ingested and can vary among individuals. Some common side effects include aggression, confusion, and emotional lability. Chronic heavy alcohol ingestion (three or more drinks daily) can lead to dementia, physical amnesia, and somnolence.”

Wine · Natural Medicines adverse-effect record, reported in dementia.
4 sources cited

6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.

9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

34040. Bushman, B. J. and Cooper, H. M. Effects of alcohol on human aggression: an integrative research review. Psychol.Bull 1990;107(3):341-354.

8972. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
Pancreatitis Worth acting on Additional detail
“Orally, wine can cause a variety of side effects which depend on the amount of alcohol ingested and can vary among individuals. Some common side effects include abdominal pain, diarrhea, indigestion, nausea, and vomiting.. Chronic alcohol use is also associated with pancreatitis.”

Wine · Natural Medicines adverse-effect record, reported in diarrhea.
5 sources cited

6843. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.

8972. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

9004. Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed

34013. Bode, C. and Bode, J. C. Alcohol's role in gastrointestinal tract disorders. Alcohol Health Res World 1997;21(1):76-83.

34031. Pehl, C., Wendl, B., and Pfeiffer, A. White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Aliment.Pharmacol Ther 6-1-2006;23(11):1581-1586. PubMed

Showing the 10 most notable of 26 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Wine — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan.

Special populations

Wine in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; alcohol is a teratogen. Use during pregnancy is associated with significant risk of spontaneous abortion, fetal alcohol syndrome, and developmental and behavioral dysfunction in infants and children exposed to alcohol in utero; avoid using.

Lactation Likely Unsafe

When used orally. Alcohol is secreted in breast milk. Chronic use can cause abnormal psychomotor development and disrupt the infant's sleep-wake pattern. Alcohol also seems to reduce milk production; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Wine or Dextromethorphan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wine or Dextromethorphan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dextromethorphan

This page covers Wine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 125 moderate · 42 minor.

From our pharmacist’s overview on the Dextromethorphan page

“A glass of grapefruit juice can push dextromethorphan (Benylin, Hold, and other cough medicines) to higher levels than intended, one of four major-rated entries among the 171 supplements and herbs on file, and the list as a whole warrants real care. Most interactions trace back to the liver enzymes (CYP3A4 and CYP2D6) that clear dextro…”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan interaction page

One more smart check

Taking Wine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Wine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wine. Even though Wine itself has no known interaction with Dextromethorphan, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wine and Dextromethorphan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wine

Top half

#619 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Dextromethorphan

Top 5%

#80 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wine reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Wine and Dextromethorphan records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Wine

What is Wine?

Social and relaxation use
Heart health (popular belief)
Antioxidant intake
Aiding digestion (traditional use)
Culinary flavoring

Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine. Despite popular claims about heart benefits, the alcohol it contains carries real health risks, and no amount of drinking can be recommended to improve health. If you drink, do so in moderation, and avoid alcohol entirely during pregnancy or if you have certain medical conditions.

Fermented grapes (or other fruit) · Red wine, white wine, rosé, sparkling wine, fortified wine

An interaction check asks whether these two react with each other — it does not ask whether Wine is a good idea for someone in your situation. Here is what our Wine record says about it on its own.

Wine: dosing

There is no medicinal or supplement "dose" for wine, and no amount is recommended to improve health. If a person chooses to drink, public health guidelines generally define moderate drinking as up to one standard drink per day for women and up to two for men, with a standard drink being about 5 ounces of wine.Less is always better when it comes to alcohol, and not drinking at all is the safest choice.

From our Wine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wine monograph & all interactions

Medication

About Dextromethorphan

What Is Dextromethorphan Used For?

Brand names: Hold, Benylin Adult, Benylin Pediatric, Theraflu Thin Strips Long Acting Cough, Neo Citran Thin Strips Cough

Dextromethorphan temporarily relieves cough due to minor throat and bronchial irritation, such as the kind that comes with the common cold or breathing in irritants. It also helps reduce the urge to cough so you — or your child — can get to sleep.

Some products, including CVS Long Acting Cough and Premier Value Tussin Cough oral liquids, are also indicated to help loosen phlegm (mucus) and thin bronchial secretions to help drain the airways.

See full Dextromethorphan drug information

Keep checking

Other Drugs & Wine

Browse every other medication we’ve checked against Wine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

656Major

270Moderate

0Minor

1,903No known interaction

656 Major 270 Moderate 1,903 No interaction

Major

656 interactions

Showing 60 of 656 major interactions — see all 656 on the Wine page.

Moderate

270 interactions

Showing 60 of 270 moderate interactions — see all 270 on the Wine page.

No interaction 1,903 drugs checked — show the list

We also checked Wine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,903 medications checked with no known interaction — see the full Wine list.

See the full Wine interactions page

See every supplement checked against Dextromethorphan, ranked by severity

Evidence & sources

Wine References

The 73 references that drive our Wine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Hart CL, Smith GD, Hole DJ, Hawthorne VM. Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. BMJ 1999;318:1725-9. PubMed
Offman EM, Freeman DJ, Dresser GK, et al. Cisapride interaction with grapefruit juice and red wine. Clin Pharmacol Ther 2000;67:110 (abstract PI-83).
Tsunoda SM, Christians U, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) metabolites. Clin Pharmacol Ther 2000;67:150 (abstract PIII-35).
Tsunoda SM, Harris RZ, Velez RL, et al. Red wine (RW) effects on cyclosporine (CyA) Pharmacokinetics. Clin Pharmacol Ther 1998;65:159 (abstract PII-51). DOI
Pearson TA. Alcohol and heart disease. Circulation 1996;94:3023-5. PubMed
Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Stampfer MJ, Colditz GA, Willett WC, et al. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 1988;319:267-73. PubMed
Vally H, de Klerk N, Thompson PJ. Alcoholic drinks: important triggers for asthma. J Allergy Clin Immunol 2000;105:462-7. PubMed
Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997;337:1705-14.
Goldberg I, Mosca L, Piano MR, Fisher EA. AHA Science Advisory: Wine and your heart: a science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the America
Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-37.
Dufour MC. If you drink alcoholic beverages do so in moderation: what does this mean? J Nutr 2001;131:552S-61S. PubMed
Thadhani R, Camargo CA, Stampfer MJ, et al. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med 2002;162:569-74. PubMed
Mukamal KJ, Longstreth WT, Mittleman MA. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke 2001;32:1939-46. PubMed
Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 2001;286:2143-51. PubMed
Tsunoda SM, Harris RZ, Christians U, et al. Red wine decreases cyclosporine bioavailabity. Clin Pharmacol Ther 2001;70:462-7.
Bosetti C, La Vecchia C, Negri E, Franceschi S. Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr 2000;54:918-20. PubMed
Kato H, Yoshikawa M, Miyazaki T, et al. Expression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers. Cancer Lett 2001;167:65-72. PubMed
Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 2001;286:2143-51. PubMed
Duncan BB, Chambless LE, Schmidt MI, et al. Association of the waist-to-hip ratio is different with wine than with beer or hard liquor consumption. Am J Epidemiol 1995;142:1034-8. DOI
Bobak M, Skodova Z, Marmot M. Beer and obesity: a cross-sectional study. Eur J Clin Nutr 2003;57:1250-53. PubMed
Koh-Banerjee P, Chu N, Spiegelman D, et al. Prospective study of the association of changes in dietary intake, physicial activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. Am J Clin Nutr 2003;78:719-27..
Mennella J. Alcohol's effect on lactation. Alcohol Res Health 2001;25:230-4.
Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
Launoy, G., Milan, C., Day, N. E., Faivre, J., Pienkowski, P., and Gignoux, M. Oesophageal cancer in France: potential importance of hot alcoholic drinks. Int J Cancer 6-11-1997;71(6):917-923. DOI
Lijinsky, W. N-Nitroso compounds in the diet. Mutat.Res 7-15-1999;443(1-2):129-138. PubMed
Seiler, C. [Alcohol, the heart and cardiovascular system]. Ther Umsch. 2000;57(4):200-204.
Altieri, A., Bosetti, C., Gallus, S., Franceschi, S., Dal, Maso L., Talamini, R., Levi, F., Negri, E., Rodriguez, T., and La, Vecchia C. Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland. Oral PubMed
Bode, C. and Bode, J. C. Alcohol's role in gastrointestinal tract disorders. Alcohol Health Res World 1997;21(1):76-83.
Zilkens, R. R., Burke, V., Hodgson, J. M., Barden, A., Beilin, L. J., and Puddey, I. B. Red wine and beer elevate blood pressure in normotensive men. Hypertension 2005;45(5):874-879. PubMed
Mukamal, K. J., Maclure, M., Muller, J. E., and Mittleman, M. A. Binge drinking and mortality after acute myocardial infarction. Circulation 12-20-2005;112(25):3839-3845. PubMed
Pehl, C., Wendl, B., and Pfeiffer, A. White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Aliment.Pharmacol Ther 6-1-2006;23(11):1581-1586. PubMed
Chao, C. Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2007;16(11):2436-2447. PubMed
Bushman, B. J. and Cooper, H. M. Effects of alcohol on human aggression: an integrative research review. Psychol.Bull 1990;107(3):341-354.
Carstensen, J. M., Bygren, L. O., and Hatschek, T. Cancer incidence among Swedish brewery workers. Int J Cancer 3-15-1990;45(3):393-396. PubMed
Potter, J. F., Watson, R. D., Skan, W., and Beevers, D. G. The pressor and metabolic effects of alcohol in normotensive subjects. Hypertension 1986;8(7):625-631. PubMed
Puddey, I. B., Beilin, L. J., Vandongen, R., Rouse, I. L., and Rogers, P. Evidence for a direct effect of alcohol consumption on blood pressure in normotensive men. A randomized controlled trial. Hypertension 1985;7(5):707-713. PubMed
Puddey, I. B., Beilin, L. J., Vandongen, R., and Rouse, I. L. A randomized controlled trial of the effect of alcohol consumption on blood pressure. Clin Exp Pharmacol Physiol 1985;12(3):257-261. PubMed
Wellmann, K. F. ["Biere au cobalt". Remarks on the "Quebec myocardosis of beer drinker"]. Dtsch.Med Wochenschr. 3-15-1968;93(11):500-501.
Bechetoille, A., Ebran, J. M., Allain, P., and Mauras, Y. [Therapeutic affect of zinc sulfate on central scotoma due to optic neuropathy of alcohol and tobacco abuse]. J Fr.Ophtalmol. 1983;6(3):237-242.
Balazs, T. and Herman, E. H. Toxic cardiomyopathies. Ann Clin Lab Sci 1976;6(6):467-476.
Lauwerys, R. and Lison, D. Health risks associated with cobalt exposure--an overview. Sci Total Environ 6-30-1994;150(1-3):1-6. PubMed
Goldbohm, R. A., Van den Brandt, P. A., Van, 't, V, Dorant, E., Sturmans, F., and Hermus, R. J. Prospective study on alcohol consumption and the risk of cancer of the colon and rectum in the Netherlands. Cancer Causes Control 1994;5(2):95-104. PubMed
Anderson, P., Cremona, A., Paton, A., Turner, C., and Wallace, P. The risk of alcohol. Addiction 1993;88(11):1493-1508.
Leira, R. and Rodriguez, R. [Diet and migraine]. Rev Neurol. 1996;24(129):534-538.
Glynn, S. A., Albanes, D., Pietinen, P., Brown, C. C., Rautalahti, M., Tangrea, J. A., Taylor, P. R., and Virtamo, J. Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes Control 1996;7(2):214-223. PubMed
Ferraroni, M., Decarli, A., Franceschi, S., and La, Vecchia C. Alcohol consumption and risk of breast cancer: a multicentre Italian case-control study. Eur J Cancer 1998;34(9):1403-1409. PubMed
Chen JY, Zhu HC, Guo Q, et al. Dose-Dependent Associations between Wine Drinking and Breast Cancer Risk - Meta-Analysis Findings. Asian Pac J Cancer Prev. 2016;17(3):1221-33. PubMed
Miura K, Zens MS, Peart T, et al. Alcohol consumption and risk of melanoma among women: pooled analysis of eight case-control studies. Arch Dermatol Res. 2015;307(9):819-28. PubMed
Rivera A, Nan H, Li T, Qureshi A, Cho E. Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States. Cancer Epidemiol Biomarkers Prev. 2016;25(12):1550-1558. PubMed
Shufelt C, Merz CN, Yang Y, et al. Red versus white wine as a nutritional aromatase inhibitor in premenopausal women: a pilot study. J Womens Health (Larchmt). 2012;21(3):281-4. PubMed
VanDenBerg CM, Blob LF, Kemper EM, Azzaro AJ. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol. 2003;43(6):604-9. DOI
Peet M, Yates RA, Carroll JA, Middlemiss DN. The interaction of tyramine with a single dose of tranylcypromine in healthy volunteers. Br J Clin Pharmacol. 1981;11(2):212-4. PubMed
Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry. 2007;68 Suppl 8:42-6.
Miraghajani M, Momenyan S, Arab A, Hasanpour Dehkordi A, Symonds ME. Blueberry and cardiovascular disease risk factors: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2020;53:102389. PubMed
German-Sanchez A, Alonso-Llamazares A, Garcia-Gonzalez F, Matala-Ahmed B, Bartolome-Zavala B, Antepara-Ercoreca I. Allergy to beer and wine caused by Saccharomyces cerevisiae in a patient sensitized to fungi. J Investig Allergol Clin Immunol 2021. PubMed
Glucophage XR (metformin) prescribing information. Bristol-Myers Squibb Company. Princeton, NJ, May 2018. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020357s034,021202s018lbl.pdf
Solosec (secnidazole) prescribing information. Lupin Pharmaceuticals, Inc. Baltimore, MD, January 2022. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/209363Orig1s014s016lbl.pdf
Tindamax (tinidazole) prescribing information. Mission Pharmaceutical Company. San Antonio, TX, December 2021. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/021618s008lbl.pdf
Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA. Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions. Antimicrob Agents Chemother. 2020;64(3):e02167-19. PubMed
Flagyl (metronidazole) prescribing information. Pfizer Labs. New York, NY, December 2021. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/012623s069lbl.pdf
Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187. PubMed
Flagyl (metronidazole) prescribing information [CANADA]. Odan Labs. Pointe-Claire, QC H9R 2Y6. January 2018. Available at: https://pdf.hres.ca/dpd_pm/00044072.PDF
Addyi (flibanserin) prescribing information. Sprout Pharmaceuticals, Inc. Raleigh, NC, September 2021. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022526s010lbl.pdf
Soriatane (Acitretin) prescribing information. Stiefl Laboratories, Inc. Research Triangle Park, NC, September 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019821s028lbl.pdf
Viberzi (Eluxadoline) prescribing information. Allergan USA, Inc. Irvine, CA, June 2020. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/206940s007lbl.pdf
Chantix (Varenicline) prescribing information. Pfizer Labs, Inc. New York, NY, February 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021928s048lbl.pdf
Zyrtec (Cetirizine) prescribing information. Pfizer Labs, Inc. New York, NY, October 2002. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/19835s15,%2020346s8lbl.pdf
Wellbutrin XL (Bupropion) prescribing information. GlaxoSmithKline LLC. Research Triangle Park, NC, March 2022. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/021515s044lbl.pdf
Fetzima (Levomilnacipran) prescribing information. Allergan USA, Inc. Madison, NJ, September 2021. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/204168s007lbl.pdf
Xyzal (Levocetirizine) prescribing information. UCB, Inc. April 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022064s038,022157s020lbl.pdf

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wine and Dextromethorphan Together: Common Questions

Is it safe to take Wine with Dextromethorphan?

We do not list a known interaction between Wine and Dextromethorphan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Wine and Dextromethorphan combination checked?

Interactions in our licensed database are recorded against drug classes. Dextromethorphan is filed under 6 classifications, and Wine has documented interactions with 37 drug classes — none of Dextromethorphan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Wine interact with any other medications?

Yes. Wine has 926 documented drug interactions in our database — Dextromethorphan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Dextromethorphan interact with any supplements?

Yes. Dextromethorphan has documented interactions with 171 supplements in our database — Wine is not one of them. The Dextromethorphan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wine monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan drug information The full plain-English guide to this medication Dextromethorphan supplement interactions Every supplement checked against Dextromethorphan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 73 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan and Wine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.