Herb & supplement monograph

Rice Protein Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Rice Protein interacts with medications. The heart of this page is the interaction list — every drug Rice Protein is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Rice Protein is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Rice Protein

23 medications have a known interaction with Rice Protein, graded by severity. Select any drug for the full evidence-based detail.

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Tell us the medications you take and we’ll check each one against Rice Protein using our pharmacist-reviewed interaction data.

AI summaries are generated from our Rice Protein interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Rice Protein combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Rice Protein affects

Every type of medication (drug category) Rice Protein is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Rice Protein interacts with

Ace Inhibitors (aceis)

Ace Inhibitors (Aceis)

In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE). In animal research, the inhibition of ACE is correlated with a reduction in systolic blood pressure. So far, this effect has not been shown in humans. Theoretically, concomitant use of rice protein and ACE inhibitors may increase the risk of blood pressure becoming too low. Use with caution. ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik).

Likelihood Possible Evidence D

Monograph

Rice Protein: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Rice protein is a plant-based protein powder made from rice that offers an easy way to add protein to your diet, especially if you avoid dairy or animal products. It is generally considered safe and well tolerated, though on its own it is lower in the amino acid lysine and is often blended with pea protein for a more complete amino acid profile. Talk to your pharmacist or doctor before using it if you have kidney problems or other health conditions.

Scientific name: Oryza sativa
Family: Poaceae
Part used: Seed (grain/endosperm and bran)
Common forms: Powder, protein shakes, capsules, blended plant-protein products

People commonly use it for

Building and maintaining muscle
Post-workout recovery
Plant-based protein source
Meal replacement and shakes
Weight management support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallLikely safe

Rice protein is generally considered safe for most healthy adults when used as a food.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than those found in food.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than those found in food.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rice protein is a powder made by separating the protein from rice grains, usually brown rice. Rice naturally contains starch (carbohydrate) along with some protein. To make rice protein, the starch and fiber are removed, leaving a concentrated protein powder.

Rice (Oryza sativa) is one of the most widely grown grains in the world. Rice protein has become popular as a plant-based, dairy-free, and often hypoallergenic alternative to whey or soy protein.

People most often use rice protein in shakes, smoothies, and protein bars to add protein to their diet, support exercise recovery, or as part of a vegan or vegetarian eating plan.

How it works

Protein supplies amino acids, the building blocks your body uses to build and repair muscle and other tissues. After exercise or to meet daily needs, getting enough protein helps support this process.

Rice protein contains all of the essential amino acids, but it is naturally lower in one called lysine. Because of this, manufacturers often blend rice protein with pea protein to create a more balanced, "complete" amino acid profile.

Rice protein is also a good source of certain amino acids like cysteine and methionine. These mechanisms are based on basic nutrition science and studies of protein in general.

Effectiveness

Does Rice Protein work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 3 uses evaluated

1 Possibly effective 2 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Possibly Effective Food allergies

Rating & evidence shown verbatim from Natural Medicines

Clinical research in infants 1 month of age and older with IgE-mediated allergy to cow's milk protein shows that administering either a partially hydrolyzed rice protein formula supplemented with lysine and threonine or a hydrolyzed cow's milk formula until age 24 months results in similar overall growth. Hydrolyzed rice protein formula is also similarly effective to hydrolyzed cow's milk formula for improving the rate of tolerance to cow's milk.

Sources Ref 97798

Also studied for 2 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Exercise-induced muscle soreness

Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that taking rice protein isolate (Oryzatein rice protein, Axiom Foods) 48 grams in water immediately after resistance training three times weekly for 8 weeks is as effective for reducing muscle soreness and increasing perceived recovery as taking whey protein isolate 48 hours after each individual session. The validity of this finding is limited by the lack of a placebo comparator group.

Sources Ref 95674

Insufficient Reliable Evidence To Rate Muscle strength

Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that taking rice protein isolate (Oryzatein rice protein, Axiom Foods) 48 grams in water immediately after resistance training three times weekly for 8 weeks is as effective for increasing muscle mass and muscle strength as taking whey protein isolate 48 hours after each individual session. The validity of this finding is limited by the lack of a placebo comparator group.

Sources Ref 95674

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Rice protein is generally safe and well tolerated for most healthy adults when used as directed. It is a common choice for people who cannot tolerate dairy or soy.

If you have kidney disease or any condition where you have been told to limit protein, talk to your doctor before using any protein supplement. People with rare metabolic conditions affecting protein should also check first.

One concern with rice-based products is that rice can take up arsenic from soil and water. Reputable brands test for heavy metals, so choose products that are third-party tested when possible.

For pregnancy and breastfeeding, eating rice as food is fine, but concentrated protein supplements have not been well studied during these times. To be safe, talk with your pharmacist or doctor before using rice protein powder.

Side effects

Rice protein is usually well tolerated. The most common complaints are mild digestive issues, such as bloating, gas, or stomach discomfort, especially with large servings.

Some people find the taste or gritty texture less pleasant than other protein powders. True allergic reactions to rice are uncommon but possible. Stop use and seek care if you have signs of an allergic reaction like rash, swelling, or trouble breathing.

As mentioned, the main long-term concern is potential heavy metal (arsenic) exposure from rice, which is why choosing tested products matters.

Rice Protein: Reported Adverse Effects

Documented safety reports on Rice Protein from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, rice protein seems to be generally well tolerated. Enterocolitis associated with rice protein has been rarely reported in young children. Although rice protein is considered hypoallergenic, allergies to the proteins in rice have been reported when used topically and orally.

Reports by condition

Allergic rhinitis (hay fever) Immunologic

Orally, rice protein has been rarely reported to cause enterocolitis. These symptoms have been possibly associated with an allergy to rice protein. In one case report of allergic enterocolitis, boiling did not adequately degrade the proteins involved in the IgE-mediated response. However, processing at high temperatures in a retort pouch allowed for adequate degradation.

Hydrolysis of rice protein with enzymatic decomposition, typically used for oral consumption, reduces dermatologic allergic symptoms in most people.

Allergic rhinitis (hay fever) Gastrointestinal

Orally, rice protein has been rarely reported to cause enterocolitis symptoms of vomiting, diarrhea, and dehydration, possibly leading to acidosis and lethargy, in infants and young children. Rarely, enterocolitis symptoms are associated with an allergy to rice protein.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for rice protein. Serving sizes are usually based on how much protein you want to add to your diet, commonly around 20 to 30 grams of protein per scoop, but this varies by product.

Always follow the directions on the product label and consider your total daily protein needs from all foods. If you are unsure how much protein is right for you, or you have a health condition such as kidney disease, check with a pharmacist, doctor, or registered dietitian.

Pregnancy & Breastfeeding

Rice Protein & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than those found in food.

Rice Protein & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using in amounts greater than those found in food.

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 6 references that drive our Rice Protein monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J 2013;12:86. PubMed
Li GH, Qu MR, Wan JZ, You JM. Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac J Clin Nutr. 2007;16 Suppl 1:275-80.
Reche M, Pascual C, Fiandor A, et al. The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577-85. PubMed
Amended final report on the safety assessment of Oryza sativa (rice) bran oil, Oryza sativa (rice) germ oil, rice bran acid, Oryza sativa (rice) bran wax, hydrogenated rice bran wax, Oryza sativa (rice) bran extract, Oryza sativa (rice) extract, Oryza sat
Yasutomi M, Kosaka T, Kawakita A, et al. Rice protein-induced enterocolitis syndrome with transient specific IgE to boiled rice but not to retort-processed rice. Pediatr Int. 2014;56(1):110-2.
Hojsak I, Kljaic-Turkalj M, Misak Z, Kolacek S. Rice protein-induced enterocolitis syndrome. Clin Nutr. 2006;25(3):533-6. PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Rice Protein

249 brands in our database make a supplement containing Rice Protein.

Sunwarrior Sport 14 products Swanson Certified Organic 10 products Swanson GreenFoods Formulas 36 products Synergistic Nutritional Compounds 23 products Systemic Formulas 23 products Terra Origin 82 products TerraVita Premium Collection 4,019 products The Cheat System Diet 17 products The Natural Citizen 6 products The Professional Series 20 products The Vitamin Shoppe 2,701 products Thorne 909 products Thorne FX 34 products Thorne Performance 12 products Thorne Research 758 products Total Eclipse 22 products Twinlab CleanSeries 5 products USANA 86 products Vade Nutrition 22 products Vega 8 products Vega Sport 13 products Vianda 20 products Vibrant Health 292 products Village Vitality 361 products

Product directory

Supplement products with Rice Protein

1,489 products in our database contain Rice Protein. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Rice Protein: Common Questions

What is Rice Protein used for, and does it work?

People use Rice Protein for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Rice Protein for Food allergies. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.

Does Rice Protein interact with prescription medications?

Yes. We list 23 medications with a known interaction with Rice Protein. Use the checker above to see how Rice Protein interacts with a specific drug.

How are Rice Protein interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Rice Protein with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Rice Protein interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Rice Protein used for?

It is mainly used as a plant-based, dairy-free protein source to add protein to your diet, support muscle and exercise recovery, and as a base for shakes or meal replacements.

Is Rice Protein a complete protein?

Rice Protein contains all essential amino acids but is naturally lower in lysine. It is often blended with pea protein to create a more complete amino acid profile.

Is Rice Protein safe?

It is generally safe and well tolerated for most healthy adults. Choose third-party tested products to limit possible heavy metal exposure, and check with your doctor if you have kidney problems.

How is Rice Protein different from whey protein?

Rice Protein is plant-based and dairy-free, making it a good option for people who are vegan or sensitive to dairy. Whey comes from milk and is naturally higher in some amino acids like leucine and lysine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Rice Protein

A rotating sample of real supplements in our database that list Rice Protein — open any to see its full ingredients and every drug interaction we check.

See all 1,489 products with Rice Protein →

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Rice Protein Drug Interactions, Uses, Effectiveness, Safety & More

Your Choice:

Drugs that interact with Rice Protein

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Rice Protein affects

Rice Protein: Uses, Safety & Side Effects

Overview

How it works

Does Rice Protein work?

Safety & precautions

Side effects

Rice Protein: Reported Adverse Effects

Dosing

Rice Protein & Pregnancy

Rice Protein & Breastfeeding

References & further reading

Brands that make products with Rice Protein

Supplement products with Rice Protein

Rice Protein: Common Questions

Related supplements & herbs

Products that contain Rice Protein

Have a question about Rice Protein?