Herb & supplement monograph

Stereospermum Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Stereospermum interacts with medications. The heart of this page is the interaction list — every drug Stereospermum is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Stereospermum is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Stereospermum Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Stereospermum drug interaction appears low for most people, though those taking diabetes medications should be more careful. None of the listed interactions are rated major, and every one traces back to a single, unproven concern about blood sugar.

Interactions deserving the most attention

The only interaction that stands out involves diabetes medications such as glimepiride and glyburide. Animal research suggests Stereospermum may lower blood sugar, so combining it with these drugs could, in theory, push blood sugar too low. This effect has not been shown in humans, but because blood sugar control is closely monitored and low blood sugar can be serious, we think this combination deserves the most caution.

What the rest of the list means

Although the list of interacting medications looks long, it does not mean each combination is known to be harmful. Nearly all of these entries come from the same theoretical blood sugar concern, which so far rests on animal studies rather than human evidence. In other words, one unproven finding accounts for the entire list.

Check your medications against Stereospermum

Based on HelloPharmacist’s Stereospermum interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Stereospermum

86 medications have a known interaction with Stereospermum, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose› AcetohexamideDymelor› AlbiglutideTanzeum› AlogliptinNesina› Alogliptin, MetforminKazano› Alogliptin, PioglitazoneOseni› Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi› CanagliflozinInvokana› Canagliflozin, MetforminInvokamet› Canagliflozin, Metformin HydrochlorideInvokamet XR› ChlorpropamideChlorpropam, Diabinese› DapagliflozinFarxiga› Dapagliflozin Propanediol, MetforminXigduo XR› Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern› Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR› Dasiglucagon HydrochlorideZegalogue› DulaglutideTrulicity› EmpagliflozinJardiance› Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR› Empagliflozin, MetforminSynjardy› Empagliflozin, Metformin HydrochlorideSynjardy XR› ErtugliflozinSteglatro› Ertugliflozin, Metformin HydrochlorideSegluromet› ExenatideBydureon, Byetta› Exenatide SyntheticBydureon BCISE› GliclazideDiamicron› GlimepirideAmaryl› GlipizideGlucotrol, Glucotrol XL› Glipizide, MetforminMetaglip› GlucagonBaqsimi, Glucagon›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Stereospermum combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Stereospermum affects

Every type of medication (drug category) Stereospermum is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Stereospermum interacts with
Antidiabetes Drugs
Antidiabetes Drugs

Animal research suggests that stereospermum can have hypoglycemic effects. This has not been shown in humans. Until more is known, use cautiously in patients taking antidiabetes drugs. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Monograph

Stereospermum: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Stereospermum is a tree used in traditional Ayurvedic medicine, most notably as one of the herbs in the classic 'Dashamula' (ten-root) formula. There is very little high-quality human research to confirm its benefits, so its uses remain largely traditional. If you are considering it, talk with a pharmacist or doctor first, especially if you are pregnant, breastfeeding, or taking other medicines.

Scientific name
Stereospermum suaveolens
Family
Bignoniaceae
Part used
Root bark, stem bark, leaves, and flowers
Common forms
Powder (churna), decoction, capsules, and as part of traditional Ayurvedic herbal blends
People commonly use it for
  • Fever
  • Inflammation and pain
  • Digestive complaints
  • Respiratory issues
  • General tonic in Ayurveda

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLimited data

Human safety data are very limited, so its overall safety is not well established.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Stereospermum is a flowering tree in the Bignoniaceae family that grows in parts of India and other regions of South and Southeast Asia. Stereospermum suaveolens (sometimes listed under related species names) is the form most often mentioned in traditional medicine.

In Ayurveda, this plant is known by names such as Patala and is best known as one of the ten roots in the well-known Dashamula formula. The root bark, stem bark, leaves, and flowers have all been used in traditional preparations.

People have traditionally used it as a decoction, powder, or as part of multi-herb blends rather than as a standalone modern supplement.

Uses & effectiveness

Stereospermum has a long history of traditional use, but modern scientific evidence is limited. Most studies so far are laboratory or animal experiments, not well-designed human trials.

Traditionally it has been used for:

  • Fever and inflammation
  • Pain
  • Digestive complaints
  • Respiratory problems such as cough
  • As a general restorative tonic

Some early laboratory and animal research suggests possible anti-inflammatory, antioxidant, and pain-relieving activity. However, these findings are preliminary and do not prove that the herb works in people. There is not enough reliable human evidence to recommend it for any specific health condition.

How it works

Researchers have identified several natural compounds in Stereospermum, including substances such as lapachol-type quinones, flavonoids, and other plant chemicals (phytochemicals). In laboratory and animal studies, some of these compounds have shown antioxidant and anti-inflammatory effects.

The idea is that these compounds may help reduce inflammation or neutralize harmful molecules called free radicals. However, it is important to understand that these are proposed mechanisms based mostly on test-tube and animal work. We do not have strong evidence on how it behaves in the human body.

Safety & precautions

The safety of Stereospermum in humans has not been well studied. Because reliable data are lacking, you should be cautious before using it.

Pregnancy and breastfeeding: There is not enough information to consider it safe. To be on the safe side, women who are pregnant or breastfeeding should avoid using it.

People with chronic health conditions, those taking prescription medicines, older adults, and children should speak with a healthcare professional before trying it. Quality and purity of herbal products can vary widely, so choose products from reputable manufacturers and always check with a pharmacist or doctor first.

Side effects

Because there is so little human research, the full side effect profile is not known. Traditional use has not clearly documented serious harm, but this is not the same as proof of safety.

As with many herbal products, possible reactions could include stomach upset, nausea, or allergic reactions in sensitive people. If you notice rash, swelling, trouble breathing, or any unusual symptoms, stop using it and seek medical care right away.

Dosing

There is no well-established standardized dose for Stereospermum. Traditional preparations vary, and it is often used as part of multi-herb formulas rather than alone.

If you choose to use a product that contains it, follow the directions on the product label and do not exceed the recommended amount. Because doses and product strengths differ, it is best to check with a pharmacist or doctor before starting.

Pregnancy & Breastfeeding

Stereospermum & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Stereospermum & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Stereospermum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Balasubramanian T, Lal MS, Sarkar M, Chatterjee TK. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. J Diet Suppl 2009;6(3):227-51.
  2. Balsubramanian T, Senthilkumar GP, Karthikeyan M, Chatterjee TK. Protective effect of ethyl acetate fraction of Stereospermum suaveolens against hepatic oxidative stress in STZ diabetic rats. J Tradit Complement Med 2013;3(3):175-81. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Stereospermum

6 brands in our database make a supplement containing Stereospermum.

Product directory

Supplement products with Stereospermum

34 products in our database contain Stereospermum. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Stereospermum: Common Questions

Does Stereospermum interact with prescription medications?
Yes. We list 86 medications with a known interaction with Stereospermum. Use the checker above to see how Stereospermum interacts with a specific drug.
How are Stereospermum interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Stereospermum with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Stereospermum interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Stereospermum used for?
It is used in traditional Ayurvedic medicine for fever, inflammation, pain, digestive complaints, and as a general tonic. These uses are traditional and not strongly proven by modern research.
Is Stereospermum safe to take?
Its safety in humans has not been well studied. Talk with a pharmacist or doctor before using it, especially if you have a health condition or take other medicines.
Can I take Stereospermum during pregnancy or while breastfeeding?
No reliable safety data exist for these situations, so it is best to avoid it during pregnancy and breastfeeding.
Is Stereospermum the same as Dashamula?
No. Dashamula is a traditional Ayurvedic blend of ten roots, and Stereospermum is one of those roots, not the whole formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Stereospermum

A rotating sample of real supplements in our database that list Stereospermum — open any to see its full ingredients and every drug interaction we check.

See all 34 products with Stereospermum →
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