What Supplements Interact with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine brand name: Colrex. Every interaction below applies to the brands too.
Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy
What is this page for?
One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.
This page covers supplement interactions only — to check Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy
What is this?
The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.Someone taking Colrex is usually fighting a miserable cold, and cold season is also when people reach for herbal sleep aids and energy boosters, which is exactly where this list bites hardest. Colrex combines acetaminophen, chlorpheniramine, codeine, and phenylephrine, and 18 of its 338 supplement interactions rate major, enough to warrant real care before adding anything herbal. The most serious pairings deepen sedation on top of the codeine and antihistamine, alcohol and kava chief among them, or add stimulant effects like ephedra does, raising blood pressure alongside the decongestant.
Most of the 275 moderate entries come down to herbs shifting the liver enzymes that process these four ingredients, meaning effects can run stronger or weaker than expected rather than becoming emergencies. The acetaminophen also gives the list a liver dimension that drinking makes worse. Start with the major entries below, and screen anything sedating or stimulating before it goes in the cart.
This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine: Top Interactions at a Glance
The Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.
Showing the 12 highest-ranked of 338 interacting ingredients — plus 1,114 more checked with no known interaction. See the complete ranked list.
The Most-Checked Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine Combinations Today
The Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineiVitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full interaction Moderate Likelihood Possible Ginger + Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineiGinger might increase or decrease the levels of CYP3A4 substrates.
Read the full interaction Moderate Likelihood Possible Ashwagandha + Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineiTheoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full interaction Moderate Likelihood Possible Black Pepper + Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineiTheoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full interaction Moderate Likelihood Possible Turmeric + Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineiTheoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full interactionEvery Supplement Checked Against Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine
All 1,452 ingredients in our database, ranked by severity — 338 with a Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction on file and 1,114 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.
Looking for an interaction with a specific supplement product? Search products instead ↓
No ingredients match “”.
Beer Likely
What it is: Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health suppl...
Concomitant use may increase sedative and other adverse effects.
Read the full Beer + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGrapefruitCitrus Paradisi Likely
What it is: Grapefruit is a nutritious citrus fruit rich in vitamin C and other nutrients, and it is generally safe to eat.
Grapefruit juice can increase levels of drugs metabolized by CYP3A4.
Read the full Grapefruit + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSiberian Cocklebur Likely
What it is: Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and al...
Siberian cocklebur can adversely affect the kidney.
Read the full Siberian Cocklebur + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWine Likely
What it is: Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine.
Concomitant use may increase sedative and other adverse effects.
Read the full Wine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction1,4-butanediolOne Comma Four, one Four Bdo, one Four Bee, +1 more Probable
What it is: 1,4-butanediol is a toxic industrial chemical, not a safe dietary supplement.
Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.
Read the full 1,4-butanediol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionActivated CharcoalActivated Carbon, animal Charcoal, carbo Vegetabilis, +13 more Probable
What it is: Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some...
Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full Activated Charcoal + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEphedraEphedra Distachya, belcho, cao Mahuang, +13 more Probable
What it is: Ephedra (ma huang) contains powerful stimulants like ephedrine that affect the heart and nervous system.
Theoretically, concomitant use might increase the risk for serious adverse effects.
Read the full Ephedra + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGamma-hydroxybutyrate (ghb) Probable
What it is: GHB (gamma-hydroxybutyrate) is a powerful central nervous system depressant that is NOT a safe dietary supplement.
GHB may increase the risk of serious CNS and respiratory depression.
Read the full Gamma-hydroxybutyrate (ghb) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHenbaneHyoscyamus Niger, beleño, devil's Eye, +11 more Probable
What it is: Henbane is a highly poisonous plant containing potent alkaloids like hyoscyamine and scopolamine, and even small amounts can cause serious o...
Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscyamine, phenothiazines, procainamide, scopolamine, and tricyclic antidepressants.
Read the full Henbane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKavaPiper Methysticum, ava Pepper, ava Root, +20 more Probable
What it is: Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety.
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionL-tryptophanL-triptofano, l-trypt, l-tryptophane, +1 more Probable
What it is: L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood.
Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Read the full L-tryptophan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLithiumCarbonate De Lithium, citrate De Lithium, lithium Aspartate, +8 more Probable
What it is: Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment...
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPeyote Probable
What it is: Peyote is a small spineless cactus that contains mescaline, a powerful hallucinogen.
Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.
Read the full Peyote + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRauvolfia Vomitoria Probable
What it is: Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for hi...
Theoretically, concomitant use might cause additive effects.
Read the full Rauvolfia Vomitoria + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionScopoliaScopolia Carniolica, belladonna Scopola, escopolia, +6 more Probable
What it is: Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scop...
The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic drugs.
Read the full Scopolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSida CordifoliaAbutilon En Épi, bala, bariar, +15 more Probable
What it is: Sida cordifolia (bala or country mallow) is a traditional Ayurvedic plant that naturally contains ephedrine, a powerful stimulant.
Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.
Read the full Sida Cordifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSt. John's WortHypericum Perforatum, amber Touch-and-heal, barbe De Saint-jean, +13 more Probable
AsarabaccaAsarum Europaeum, asara, asari Herba, +12 more Possible
What it is: Asarabacca is a European woodland plant traditionally used to clear the nose, cause sweating, or trigger vomiting, but it is rarely used tod...
Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.
Read the full Asarabacca + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAyahuascaAppane, ayahoasca, caapi, +19 more Probable
What it is: Ayahuasca is a powerful psychoactive brew that combines a DMT-containing plant with a vine that allows the DMT to take effect, causing inten...
Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.
Read the full Ayahuasca + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBelladonna Probable
What it is: Belladonna is a highly toxic plant whose alkaloids (like atropine and scopolamine) are powerful medicines used only in carefully controlled,...
Belladonna may increase the risk of adverse effects when used concomitantly with anticholinergic drugs.
Read the full Belladonna + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBergamotCitrus Bergamia, aceite De Bergamota, bergamot, +8 more Probable
What it is: Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some...
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBetel Nut Probable
What it is: Betel nut is the seed of the areca palm and is chewed by millions of people across Asia and the Pacific as a stimulant.
In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.
Read the full Betel Nut + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack Tea Probable
What it is: Black tea is a popular caffeinated drink made from the fully oxidized leaves of the Camellia sinensis plant, and it contains caffeine and an...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Black Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBrussels Sprout Probable
What it is: Brussels sprouts are a nutritious cruciferous vegetable rich in fiber, vitamin C, vitamin K, and plant compounds called glucosinolates.
A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.
Read the full Brussels Sprout + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCabbageBrassica Oleracea, cabbage Leaf, chou, +13 more Probable
What it is: Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast en...
Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
Read the full Cabbage + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCaffeine Probable
What it is: Caffeine is a natural stimulant found in coffee, tea, and many other plants and products.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCannabidiol (cbd) Probable
What it is: CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorder...
Cannabidiol may increase levels of drugs metabolized by CYP1A2.
Read the full Cannabidiol (cbd) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChenopodium OilAceite De Paico, aceite De Quenopodio, american Wormseed, +15 more Probable
What it is: Chenopodium oil is a strong-smelling essential oil from the epazote plant that was historically used to treat intestinal worms.
Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.
Read the full Chenopodium Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChlorophyllChlorophylle, chlorophylle A, chlorophylle B, +3 more Probable
What it is: Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin.
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChlorophyllinChloresium, chlorophylline, chlorophylline De Cuivre Sodique, +6 more Probable
What it is: Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support woun...
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCocoaTheobroma Cacao, chocolat, chocolat Noir, +14 more Probable
What it is: Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate pro...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCoffee Probable
What it is: Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Coffee + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCoffee CharcoalCafé Arabica, café Carbonisé, café Robusta, +5 more Probable
What it is: Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarr...
Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Read the full Coffee Charcoal + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCola NutCola Acuminata, bissey Nut, bissy Nut, +10 more Probable
What it is: Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cola Nut + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDatura Wrightii Probable
What it is: Datura wrightii (sacred datura or jimsonweed relative) is a highly poisonous desert plant that has been used in some traditional and ceremon...
Datura wrightii contains atropine and scopolamine, as well as other tropane alkaloids with anticholinergic activity.
Read the full Datura Wrightii + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEuropean MandrakeMandragora Officinarum, alraunwurzel, mandragora, +7 more Probable
What it is: European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reli...
Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake.
Read the full European Mandrake + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEvodia Probable
What it is: Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain.
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Read the full Evodia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFever BarkAlstonia Constricta, alstonia Bark, australian Febrifuge, +10 more Probable
What it is: Fever bark is the bark of the Australian tree Alstonia constricta, used in traditional medicine for fever, diarrhea, and infections.
Theoretically, fever bark might increase or decrease the effects of stimulant drugs.
Read the full Fever Bark + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGarlicAllium Sativum, aged Black Garlic Extract, aged Garlic Extract, +16 more Probable
What it is: Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects...
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGlucomannanGlucomanano, glucomannane, konjac, +1 more Probable
What it is: Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipati...
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Glucomannan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGoldensealHydrastis Canadensis, chinese Goldenseal, eye Balm, +14 more Probable
What it is: Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects.
Goldenseal might increase serum levels of drugs metabolized by CYP2D6.
Read the full Goldenseal + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGreen CoffeeCoffea Arabica, coffea Canephora, coffea Bukobensis, +2 more Probable
What it is: Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Green Coffee + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGreen TeaCamellia Sinensis, green Sencha Tea, green Tea Extract, +17 more Probable
What it is: Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Green Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGuggulCommiphora Wightii, devadhupa, gomme Guggul, +17 more Probable
What it is: Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems.
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIlex Guayusa Probable
What it is: Ilex guayusa is a caffeine-containing holly leaf from the Amazon, traditionally brewed as a tea for energy and alertness, much like yerba ma...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Ilex Guayusa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMasterwortHeracleum Sphondylium, berce Commune, berce Laineuse, +9 more Probable
What it is: Masterwort (Heracleum sphondylium), a plant in the carrot family, has a long folk-medicine history for digestion, nerves, and skin.
The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effects.
Read the full Masterwort + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMelatoninN-acetyl-5-methoxytryptamine Probable
What it is: Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with...
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOolong Tea Probable
What it is: Oolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antio...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Oolong Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPsilocybin Probable
What it is: Psilocybin is a powerful psychedelic compound found in certain mushrooms and is being studied for hard-to-treat depression, anxiety, and add...
Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.
Read the full Psilocybin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPu-erh Tea Probable
What it is: Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Pu-erh Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionResveratrolExtrait De Vin, extrait De Vin Rouge, kojo-kon, +16 more Probable
What it is: Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant supp...
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSchisandraSchisandra Chinensis, bac Ngu Vi Tu, baie De Schisandra, +10 more Probable
What it is: Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support.
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSyrian Rue Probable
What it is: Syrian Rue (Peganum harmala) is a traditional plant whose seeds contain potent compounds called harmala alkaloids, including MAO-inhibiting...
Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Syrian Rue + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTree Turmeric Probable
What it is: Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content.
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Tree Turmeric + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWild CarrotDaucus Carota, beesnest Plant, bird's Nest Root, +10 more Probable
What it is: Wild carrot is a traditional herb (the wild ancestor of the garden carrot) used mostly for urinary, digestive, and menstrual complaints.
Theoretically, concomitant use might result in increased photosensitivity.
Read the full Wild Carrot + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionYerba MansaAnemopsis Californica, anemopsis De Californie, lizard's Tail, +3 more Probable
What it is: Yerba mansa is a traditional Southwestern and Mexican medicinal plant used for sore throats, skin problems, and infections.
Theoretically, concomitant use might cause additive or prolonged sedative effects.
Read the full Yerba Mansa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionYerba MateIlex Paraguariensis, chimarrao, green Mate, +14 more Probable
What it is: Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects.
Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.
Read the full Yerba Mate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionYohimbePausinystalia Yohimbe, 11-hydroxy Yohimbine, coryanthe Yohimbe, +7 more Probable
What it is: Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac.
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Yohimbe + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction1,3-dmaaDmaa, dimethylamylamine Possible
What it is: DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to seriou...
1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.
Read the full 1,3-dmaa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction1,3-dmba Possible
What it is: 1,3-DMBA is a synthetic stimulant chemically similar to the banned stimulant DMAA, and it is not a proven or safe dietary ingredient.
Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.
Read the full 1,3-dmba + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction1,4-dmaa Possible
What it is: 1,4-DMAA is a synthetic stimulant that the U.S.
1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.
Read the full 1,4-dmaa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction5-htp5 Hydroxy-tryptophan, 5 Hydroxy-tryptophane, 5-hydroxytryptophan, +9 more Possible
What it is: 5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches.
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full 5-htp + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcacia RigidulaVachellia Rigidula, acacia Rigidula, acaciopsis Rigidula, +3 more Possible
What it is: Acacia rigidula is a shrub from Texas and Mexico that is marketed in weight-loss and energy supplements.
Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 substrates.
Read the full Acacia Rigidula + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetyl-l-carnitineAcetil-l-carnitina, acetyl Carnitine, acétyl Carnitine, +6 more Possible
What it is: Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells.
Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Read the full Acetyl-l-carnitine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAconiteAconitum Napellus, aconitum, aconitum Angustifolium, +20 more Possible
What it is: Aconite is a highly poisonous plant, and even small amounts of the raw or improperly processed root can cause severe, life-threatening react...
Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovascular toxicity.
Read the full Aconite + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionActive Hexose Correlated Compound (ahcc) Possible
What it is: AHCC is a proprietary mushroom-derived supplement promoted mainly for immune support and to help people tolerate cancer treatment.
Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.
Read the full Active Hexose Correlated Compound (ahcc) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAdrafinilAdrafinilum, benzhydryl Sulfinyl Acetyl Hydroxamic Acid, crl-40028, +1 more Possible
What it is: Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug.
Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Adrafinil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAdrueCyperus Articulatus, chintul, cyperus, +5 more Possible
What it is: Adrue (Cyperus articulatus) is a sedge whose rhizome has long been used in traditional medicine for nausea and other stomach complaints, and...
Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold compared to the effects of the drugs alone.
Read the full Adrue + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAfrican Wild Potato Possible
What it is: African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflamm...
In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).
Read the full African Wild Potato + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAlbizia JulibrissinAlbizia Julibrissin, arbre De Sois, federbaum, +16 more Possible
What it is: Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming th...
Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice.
Read the full Albizia Julibrissin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAlfalfaMedicago Sativa, feuille De Luzerne, grand Trèfle, +9 more Possible
What it is: Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence f...
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAmerican ElderSambucus Canadensis, american Elderberry, common Elderberry, +9 more Possible
What it is: American elder is a North American plant whose cooked, ripe berries and flowers are used mainly for colds, flu, and general immune support.
Theoretically, taking American elder might increase levels of CYP3A4 substrates.
Read the full American Elder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAngel's TrumpetBrugmansia Species, devil's Trumpet, floripondio, +5 more Possible
What it is: Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine.
Concomitant use may increase anticholinergic effects and adverse effects.
Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAngelica ArchangelicaAmerican Angelica, angelicae Fructus, angelicae Herba, +12 more Possible
What it is: Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs.
Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.
Read the full Angelica Archangelica + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAnisePimpinella Anisum, anis, anís, +14 more Possible
What it is: Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs.
Theoretically, anise oil might increase the effects and adverse effects of codeine.
Read the full Anise + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAristolochiaAristolochia Auricularia, birthwort, guan Mu Tong, +15 more Possible
What it is: Aristolochia contains aristolochic acid, a potent toxin linked to severe kidney damage and cancer, and it is not safe to take.
Aristolochia is nephrotoxic.
Read the full Aristolochia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionArrachChenopodium Vulvaria, arroche Puante, chénopode Fétide, +11 more Possible
What it is: Arrach (Chenopodium vulvaria) is a strong-smelling European herb that has been used in traditional folk medicine, mainly for menstrual and n...
Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photosensitivity.
Read the full Arrach + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAshitabaAngelica Keiskei, angelica, ashitaba Du Japon, +6 more Possible
What it is: Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benef...
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Ashitaba + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAshwagandhaWithania Somnifera, ajagandha, amangura, +17 more Possible
What it is: Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, thoug...
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Read the full Ashwagandha + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAstaxanthinAstaxanthine, astaxantina, dihydroxy-3, +6 more Possible
What it is: Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and...
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBacopaBacopa Monnieri, andri, brahmi, +11 more Possible
What it is: Bacopa is an Ayurvedic herb most often used for memory and thinking.
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBaikal SkullcapScutellaria Baicalensis, baikal Scullcap, baikal Skullcap Root, +16 more Possible
What it is: Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baica...
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Baikal Skullcap + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBay LeafLaurus Nobilis, bay, bay Laurel, +17 more Possible
What it is: Bay leaf is a common culinary herb that is safe in the small amounts used in cooking.
Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.
Read the full Bay Leaf + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBeetBeta Vulgaris, beet Greens, beet Juice, +19 more Possible
What it is: Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in...
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBerberineAlcaloïde De Berbérine, berberina, berbérine, +5 more Possible
What it is: Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of res...
Theoretically, berberine might increase the sedative effects of CNS depressants.
Read the full Berberine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBeta-methylphenethylamine (bmpea) Possible
What it is: Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and spo...
Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full Beta-methylphenethylamine (bmpea) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBilberryVaccinium Myrtillus, airelle, arándano, +16 more Possible
What it is: Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for...
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBiofeedback Possible
What it is: Biofeedback is a mind-body technique, not an herb or supplement.
There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.
Read the full Biofeedback + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBishop's WeedAmmi Majus, Élevé, ammi Inodore, +12 more Possible
What it is: Bishop's Weed (Ammi majus) is a flowering plant whose seeds contain natural light-sensitizing compounds called psoralens, which have been st...
Bishop's weed constituents seem to cause photosensitivity.
Read the full Bishop's Weed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBitter AlmondPrunus Amygdalus, almendra Amarga, almendro Amargo, +13 more Possible
What it is: Bitter almond is a variety of almond that contains amygdalin, a compound the body converts into cyanide, making it potentially poisonous.
Theoretically, bitter almond oil may have additive effects with other CNS depressants.
Read the full Bitter Almond + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBitter OrangeCitrus Aurantium, aurantii Fructus, aurantium, +17 more Possible
What it is: Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements.
Bitter orange might increase levels of drugs metabolized by CYP3A4.
Read the full Bitter Orange + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack CohoshActaea Racemosa, baie D'actée, baneberry, +10 more Possible
What it is: Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from s...
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Black Cohosh + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack Hoof MushroomPhellinus Linteus, black Hoof Fungus, mesima, +5 more Possible
What it is: Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support.
Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Black Hoof Mushroom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack PepperPiper Nigrum, black Peppercorn, extrait De Poivre, +23 more Possible
What it is: Black pepper is a common kitchen spice that is generally safe in the amounts used in food.
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Black Pepper + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack SeedNigella Sativa, black Caraway, black Cumin, +18 more Possible
What it is: Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure...
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Seed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBog Labrador TeaRhododendron Groenlandicum, bog Tea, continental Tea, +12 more Possible
What it is: Bog Labrador tea is a wetland shrub whose leaves have long been brewed as a traditional beverage and folk remedy, especially among Indigenou...
In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Bog Labrador Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBoldoPeumus Boldus, boldine, boldo Folium, +4 more Possible
What it is: Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is ver...
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBoswellia SerrataBoswellia Serrata, arbre à Oliban Indien, boswella, +10 more Possible
What it is: Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation.
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBoxwoodBuxus Sempervirens, bois D'artois, bois Béni, +15 more Possible
What it is: Boxwood is an evergreen shrub whose leaves have been used in folk medicine, most notably in some early studies looking at HIV.
Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.
Read the full Boxwood + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBreadfruit Possible
What it is: Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high bloo...
Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).
Read the full Breadfruit + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBroccoli Possible
What it is: Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific int...
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBuchuAgathosma Betulina, anysboegoe, barasmae Folium, +12 more Possible
What it is: Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic.
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBulbine Natalensis Possible
What it is: Bulbine natalensis is a South African plant marketed mainly as a testosterone-boosting and libido supplement, but the human evidence is esse...
Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Bulbine Natalensis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionButcher's BroomRuscus Aculeatus, balai Du Boucher, box Holly, +17 more Possible
What it is: Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some ev...
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCajeput OilMelaleuca Leucadendra, aceite De Cajeput, cajeputi Aetheroleum, +10 more Possible
What it is: Cajeput oil is an aromatic essential oil traditionally used for aches, congestion, and minor skin complaints, but solid human evidence for t...
Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.
Read the full Cajeput Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalamusAcorus Calamus, acore Calame, acore Odorant, +20 more Possible
What it is: Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complain...
Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.
Read the full Calamus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalcium D-glucarate Possible
What it is: Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and help...
Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
Read the full Calcium D-glucarate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalifornia PoppyEschscholzia Californica, amapola De California, pavot D'amérique, +4 more Possible
What it is: California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs.
Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Read the full California Poppy + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCamphor Possible
What it is: Camphor is a strong-smelling compound from the camphor tree (or made synthetically) that is used in many topical rub-on products for muscle...
Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.
Read the full Camphor + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCannabichromene (cbc)Cannabichrome, pentylcannabichromene, cannabinochromene Possible
What it is: Cannabichromene (CBC) is a non-intoxicating cannabinoid found in the cannabis plant that is being studied for possible pain, anti-inflammato...
Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.
Read the full Cannabichromene (cbc) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCannabinol (cbn) Possible
What it is: Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limit...
Theoretically, cannabinol might increase the levels and clinical effects of CYP2E1 substrates.
Read the full Cannabinol (cbn) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCannabisCannabis Sativa, anashca, banji, +25 more Possible
What it is: Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not).
Theoretically, cannabis might have additive effects if used with other CNS depressants.
Read the full Cannabis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCarawayCarum Carvi, alcaravea, anis Canadien, +20 more Possible
What it is: Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion.
Theoretically, caraway might increase the effects and adverse effects of CNS depressants.
Read the full Caraway + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCassia CinnamonCinnamomum Aromaticum, bastard Cinnamon, chinese Cinnamon, +1 more Possible
What it is: Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar suppor...
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia Cinnamon + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCat's ClawGriffe Du Chat, hawk's Claw, liane Du Pérou, +4 more Possible
What it is: Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support.
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCatechuBlack Catechu, acacia Catechu: Acacia à Cachou, acacia Catechu Heartwood Extract, +17 more Possible
What it is: Catechu is an astringent extract made from the heartwood of the Acacia (Senegalia) catechu tree, used traditionally for mouth sores, sore th...
Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.
Read the full Catechu + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCatnipNepeta Cataria, cataire, catmint, +8 more Possible
What it is: Catnip is a mint-family herb most often used as a calming tea for sleep, anxiety, and minor digestive upset, but solid human research suppor...
Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Read the full Catnip + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCauliflower Possible
What it is: Cauliflower is a nutritious cruciferous vegetable that provides vitamin C, fiber, and plant compounds called glucosinolates.
Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabbage, can increase cytochrome P450 1A2 (CYP1A2) activity by 14% to 27%.
Read the full Cauliflower + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCeleryApium Graveolens, ache Des Marais, ajamoda, +13 more Possible
What it is: Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint d...
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCeylon Leadwort Possible
What it is: Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin pr...
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Ceylon Leadwort + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChanca PiedraPhyllanthus Niruri, amli, arranca-pedras, +16 more Possible
What it is: Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health.
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Chanca Piedra + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChaparralLarrea Divaricata, creosote Bush, créosotier, +4 more Possible
What it is: Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition.
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChlorellaChlorella Pyrenoidosa, algue Verte D'eau Douce, bulgarian Chlorella, +12 more Possible
What it is: Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small stud...
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChokeberryAronia Arbutifolia, aronia Melanocarpa, aronia Nigra, +1 more Possible
What it is: Chokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements.
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCilantro Possible
What it is: Cilantro is the leafy part of the Coriandrum sativum plant and is widely eaten as a food, where it is considered safe for most people.
Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.
Read the full Cilantro + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCinchonaCinchona Calisaya, arbol De La Quina, bois Aux Fièvres, +14 more Possible
What it is: Cinchona bark is the natural source of quinine and has been used for centuries to treat malaria and fever, but the bark itself is not standa...
Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.
Read the full Cinchona + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCloveSyzygium Aromaticum, bourgeon Floral De Clou De Girofle, bouton Floral De Clou De Girofle, +12 more Possible
What it is: Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to it...
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionClubmossLycopodium Clavatum, club Moss, common Clubmoss, +12 more Possible
What it is: Clubmoss (Lycopodium clavatum) is a primitive plant with a long history in folk medicine and homeopathy, but there is very little reliable h...
Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.
Read the full Clubmoss + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCnidiumCnidium Monnieri, cnidii Fructus, cnidii Monnieri Fructus, +10 more Possible
What it is: Cnidium is the dried fruit of an Asian plant long used in traditional Chinese medicine, mostly for skin problems and sexual health.
In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.
Read the full Cnidium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionColeus6beta, 17beta-acetoxy-8, 13-epoxy-1alpha, +15 more Possible
What it is: Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart he...
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Coleus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionComfreySymphytum Officinale, ass Ear, beinwellwurzel, +15 more Possible
What it is: Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit fo...
Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Comfrey + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCorianderCoriandrum Sativum, coriander Essential Oil, coriandre, +5 more Possible
What it is: Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints...
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Coriander + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCorkwood Tree Possible
What it is: Corkwood Tree (Duboisia myoporoides) is an Australian plant best known as a commercial source of powerful tropane alkaloids like scopolamine...
Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.
Read the full Corkwood Tree + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCorn PoppyPapaver Rhoeas, amapola, common Poppy, +18 more Possible
What it is: Corn poppy is a red-flowered plant traditionally used in teas and syrups for cough, sleep, and mild pain.
Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.
Read the full Corn Poppy + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCorydalis Yanhusuo Possible
What it is: Corydalis yanhusuo is a traditional Chinese herb used mainly for pain.
Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.
Read the full Corydalis Yanhusuo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCranberryVaccinium Macrocarpon, agrio, american Cranberry, +16 more Possible
What it is: Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate bu...
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCubebsPiper Cubeba, cubeb, cubeb Berries, +14 more Possible
What it is: Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, a...
Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Cubebs + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDandelionTaraxacum Officinale, blowball, cankerwort, +17 more Possible
What it is: Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid.
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDanshenSalvia Bowleyana, ch'ih Shen, chinese Red Sage, +15 more Possible
What it is: Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems.
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Danshen + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDelta-9-tetrahydrocannabinol (thc)Bho, black Glass, budder, +9 more Possible
What it is: THC is the main mind-altering compound in cannabis and is best known for causing a 'high.' A prescription form (dronabinol) is approved for...
Theoretically, THC might have additive effects if used with other CNS depressants.
Read the full Delta-9-tetrahydrocannabinol (thc) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDendrobium Possible
What it is: Dendrobium is a group of orchids long used in traditional Chinese medicine, often to moisten the body and as a general tonic.
The dendrobium constituent dendrobine is reported to have convulsant effects.
Read the full Dendrobium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDevil's ClawHarpagophytum Procumbens, devils Claw, devil's Claw Root, +9 more Possible
What it is: Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of d...
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDhea3b-hydroxy-androst-5-ene-17-one, 3betahydroxy-androst-5-ene-17-one, androstenolone, +4 more Possible
What it is: DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits.
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDimethylhexylamine (dmha) Possible
What it is: DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often false...
Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.
Read the full Dimethylhexylamine (dmha) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDiosmin Possible
What it is: Diosmin is a citrus-derived flavonoid most often used for vein-related problems such as chronic venous insufficiency and hemorrhoids, and it...
Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.
Read the full Diosmin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEchinaceaAmerican Cone Flower, black Sampson, black Susans, +7 more Possible
What it is: Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears sm...
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionElecampaneAlant, aunée, aunée Officinale, +17 more Possible
What it is: Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion.
Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Read the full Elecampane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEleutheroEleutherococcus Senticosus, acanthopanax Obovatus, ciwujia Root, +13 more Possible
What it is: Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress.
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEnglish IvyHedera Helix, common Ivy, gum Ivy, +9 more Possible
What it is: English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredie...
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEpistane Possible
What it is: Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been s...
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionErgotClaviceps Purpurea, cockspur Rye, cornezuelo, +7 more Possible
What it is: Ergot is a toxic fungus that grows on rye and contains powerful chemicals (ergot alkaloids) that strongly narrow blood vessels and squeeze t...
Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.
Read the full Ergot + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEucalyptusEucalyptus Globulus, blue Gum, blue Mallee, +13 more Possible
What it is: Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion.
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEuropean BarberryBerberis Vulgaris, agracejo, barberry, +15 more Possible
What it is: European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolat...
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full European Barberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFalse UnicornChamaelirium Luteum, alétris, blazing Star, +9 more Possible
What it is: False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concern...
In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.
Read the full False Unicorn + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFennelFoeniculum Vulgare, adas, almindelig Fennikel, +20 more Possible
What it is: Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramp...
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFermented Wheat Germ Extract Possible
What it is: Fermented wheat germ extract is a supplement made by fermenting wheat germ with yeast, and it is most often marketed for people going throug...
Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse effects.
Read the full Fermented Wheat Germ Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFeverfewTanacetum Parthenium, altamisa, bachelor's Buttons, +13 more Possible
What it is: Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occ...
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFig Possible
What it is: Fig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally...
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFo-ti Possible
What it is: Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair.
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Fo-ti + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGalphimia GlaucaGalphimia Glauca, calderona Amarilla, flor Estrella, +2 more Possible
What it is: Galphimia glauca is a shrub from Mexico and Central America that has been studied mainly for anxiety, with some small clinical trials sugges...
Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.
Read the full Galphimia Glauca + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGamma Butyrolactone (gbl)2-3 Dihydro Furanone Possible
What it is: Gamma butyrolactone (GBL) is a toxic industrial solvent, not a dietary supplement, and the body converts it into GHB, a powerful and dangero...
Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.
Read the full Gamma Butyrolactone (gbl) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGarciniaGarcinia Gummi-gutta, acide Hydroxycitrique, ahc, +11 more Possible
What it is: Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control.
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGerman ChamomileMatricaria Recutita, blue Chamomile, camomèle, +12 more Possible
What it is: German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints.
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full German Chamomile + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGingerZingiber Officinale, african Ginger, ardraka, +21 more Possible
What it is: Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nause...
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGinkgoGinkgo Biloba, abricot Argenté Japonais, adiantifolia, +13 more Possible
What it is: Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation.
Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Read the full Ginkgo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGojiLycium Chinense, lycium Barbarum, barberry Matrimony Vine, +15 more Possible
What it is: Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food.
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Goji + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGoldthreadCoptis Chinensis, cankerroot, chinese Coptis, +13 more Possible
What it is: Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholester...
There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Goldthread + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGotu KolaCentella Asiatica, asiatic Pennywort, brahma-buti, +12 more Possible
What it is: Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memor...
Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
Read the full Gotu Kola + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGrapeVitis Vinifera, activin, black Grape Raisins, +10 more Possible
What it is: Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support h...
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Read the full Grape + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGreater CelandineChelidonium Majus, bai Qu Cai, celandine, +9 more Possible
What it is: Greater celandine is a traditional herb most often promoted for digestive and gallbladder complaints, but solid human evidence for any use i...
Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.
Read the full Greater Celandine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGriffonia SimplicifoliaBandeiraea Simplicifolia Possible
What it is: Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin.
Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.
Read the full Griffonia Simplicifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGuar GumDietary Fiber, farine De Guar, fibre Alimentaire, +10 more Possible
What it is: Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity.
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGuaranaPaullinia Cupana, brazilian Cocoa, cacao Brésilien, +3 more Possible
What it is: Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGuarumoCecropia Obtusifolia, chancarro, grayumbo, +9 more Possible
What it is: Guarumo (Cecropia obtusifolia) is a tropical tree used in Latin American traditional medicine, most often as a leaf tea for diabetes and hig...
In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle relaxant activity.
Read the full Guarumo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGum ArabicAcacia, acacia Gum, arabic Gum, +16 more Possible
What it is: Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplemen...
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Gum Arabic + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGymnemaGymnema Sylvestre, gimnema, gur-mar, +14 more Possible
What it is: Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue.
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHawaiian Baby WoodroseArgyreia Nervosa, baby Hawaiian Woodrose, baby Woodrose, +11 more Possible
What it is: Hawaiian Baby Woodrose seeds contain LSD-like compounds and are most often used recreationally to cause hallucinations, not as a safe or pro...
Theoretically, concomitant use may increase the risk for serotonergic adverse effects.
Read the full Hawaiian Baby Woodrose + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHemp AgrimonyEupatorium Cannabinum, alpenkraut, cañamazo, +15 more Possible
What it is: Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little relia...
Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).
Read the full Hemp Agrimony + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHesperidinAlpha-glucosyl Hesperidin, alpha-glucosylhesperidin, bioflavonoid, +8 more Possible
What it is: Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrh...
Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Read the full Hesperidin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHigenamine Possible
What it is: Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidenc...
Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Higenamine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHopsHumulus Lupulus, asperge Sauvage, common Hops, +13 more Possible
What it is: Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very stron...
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Read the full Hops + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHordenineAnhalinine Possible
What it is: Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid hu...
Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.
Read the full Hordenine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHorny Goat WeedEpimedium Grandiflorum, barrenwort, Épimède, +10 more Possible
What it is: Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence...
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHu Zhang Possible
What it is: Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin.
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Hu Zhang + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHuperzine AHupa, huperzina A, huperzine, +3 more Possible
What it is: Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some pres...
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIbogaTabernanthe Iboga, bois Sacré, eboka Possible
What it is: Iboga is a Central African shrub whose root bark contains ibogaine, a powerful hallucinogenic compound studied mainly for addiction.
Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drugs.
Read the full Iboga + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIndian Long PepperPiper Longum, bi Ba, bi Bo, +17 more Possible
What it is: Indian long pepper (pippali) is a spice long used in Ayurvedic medicine and is best known for its piperine content, which may increase how w...
Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.
Read the full Indian Long Pepper + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIndian SnakerootRauvolfia Serpentina, ajmaline, alseroxylon, +16 more Possible
What it is: Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects...
Theoretically, taking Indian snakeroot might cause additive sedative effects.
Read the full Indian Snakeroot + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIndole-3-carbinol Possible
What it is: Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement m...
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIpriflavone7-isopropoxyisoflavone, ipriflavona Possible
What it is: Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it relia...
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIsopropylnorsynephrine Possible
What it is: Isopropylnorsynephrine is a synthetic stimulant chemically related to synephrine, marketed mainly in weight-loss and pre-workout supplements...
Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effects.
Read the full Isopropylnorsynephrine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionJackfruitArtocarpus Heterophyllus, arbol Del Pan, baramil, +21 more Possible
What it is: Jackfruit is a large tropical fruit that is nutritious and safe to eat as a food, offering fiber, vitamin C, potassium, and antioxidants.
Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.
Read the full Jackfruit + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionJamaican Dogwood Possible
What it is: Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking.
Jamaican dogwood may potentiate sedative effects.
Read the full Jamaican Dogwood + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionJimson Weed Possible
What it is: Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning,...
Theoretically, jimson weed may increase anticholinergic effects and adverse effects.
Read the full Jimson Weed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKhatCatha Edulis, abessinischer Tea, abyssinian Tea, +23 more Possible
What it is: Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problem...
Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.
Read the full Khat + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKhellaAmmi Visnaga, ammi Daucoides, daucus Visnaga, +13 more Possible
What it is: Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels.
Theoretically, concomitant use might result in increased photosensitivity.
Read the full Khella + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKratomMitragyna Speciosa, biak-biak, cratom, +16 more Possible
What it is: Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effec...
Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.
Read the full Kratom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKudzuPueraria Montana, bidarikand, bilaikanda, +18 more Possible
What it is: Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol in...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLemon BalmMelissa Officinalis, balm, balm Mint, +15 more Possible
What it is: Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically f...
Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Read the full Lemon Balm + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLemongrassCymbopogon Citratus, abafado, cana Santa, +17 more Possible
What it is: Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil.
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Lemongrass + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLentinanBeta-glucan Lentinan, lentinane, lentinus Edodes Polysaccharide, +4 more Possible
What it is: Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherap...
Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2D6 (CYP2D6).
Read the full Lentinan + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLicoriceGlycyrrhiza Echinate, alcacuz, bois Doux, +17 more Possible
What it is: Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most...
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Licorice + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLigandrol Possible
What it is: Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement.
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Ligandrol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLight Therapy Possible
What it is: Light therapy uses controlled exposure to bright artificial light and is best supported for seasonal affective disorder, where it is a recog...
Light therapy may increase the risk for photosensitization.
Read the full Light Therapy + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLimeCitrus Aurantifolia, adam's Apple, bara Nimbu, +11 more Possible
What it is: Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants.
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMace Possible
What it is: Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg.
Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedative effects.
Read the full Mace + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMagnoliaMagnolia Biondii, beaver Tree, bourgeon Floral De Magnolia, +13 more Possible
What it is: Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion.
Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
Read the full Magnolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionManchurian Thorn Possible
What it is: Manchurian Thorn (Aralia elata) is a thorny shrub or small tree used in traditional East Asian medicine, mainly for blood sugar, joint pain,...
Animal research suggests that high doses of Manchurian thorn can induce liver damage.
Read the full Manchurian Thorn + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMarjoramOriganum Majorana, essence De Marjolaine, garden Marjoram, +12 more Possible
What it is: Marjoram is a Mediterranean kitchen herb related to oregano that is widely used in food and traditional medicine for digestive, sleep, and r...
In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.
Read the full Marjoram + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMarsh Labrador TeaRhododendron Tomentosum, james' Tea, lède Des Marais, +13 more Possible
What it is: Marsh Labrador tea is a bog-growing shrub used in folk medicine for coughs, colds, and skin problems, but high-quality human evidence for an...
Marsh Labrador tea can potentiate effects of barbiturates and alcohol.
Read the full Marsh Labrador Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMethoxylated Flavones Possible
What it is: Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substance...
Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.
Read the full Methoxylated Flavones + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMethylene Blue3, 7-bis (dimethylamino)-phenazathionium Chloride, Azul De Metileno, +8 more Possible
What it is: Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it i...
Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.
Read the full Methylene Blue + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMethylsynephrine Possible
What it is: Methylsynephrine (also called oxilofrine) is a synthetic stimulant sometimes added to weight-loss and pre-workout products, but it is not a...
Methylsynephrine has cardiac stimulant effects.
Read the full Methylsynephrine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMilk ThistleSilybum Marianum, artichaut Sauvage, blessed Milk Thistle, +12 more Possible
What it is: Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called s...
Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.
Read the full Milk Thistle + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMoringaMoringa Oleifera Possible
What it is: Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition...
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Moringa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMotherwortLeonurus Cardiac, agripalma, agripaume, +16 more Possible
What it is: Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but soli...
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Motherwort + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMountain AshSorbus Aucuparia, arbre Aux Grives, corbier D'europe, +12 more Possible
What it is: Mountain ash (rowan) is a northern-hemisphere tree whose bright red berries are traditionally cooked into jams, syrups, and teas.
Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.
Read the full Mountain Ash + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionN,n-dmpea Possible
What it is: N,N-DMPEA (N,N-dimethylphenethylamine) is a synthetic relative of phenethylamine sometimes marketed in stimulant or pre-workout supplements.
In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).
Read the full N,n-dmpea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionNeemAzadirachta Indica, arishta, arishtha, +18 more Possible
What it is: Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes.
Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Neem + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionNiacin3-pyridinecarboxylic Acid, vitamin B3 Possible
What it is: Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countri...
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionNoniMorinda Citrifolia, ba Ji Tian, bois Douleur, +17 more Possible
What it is: Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claime...
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Noni + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionNutmegMyristica Fragrans, buah Pala, jaatipatree, +14 more Possible
What it is: Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little so...
Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.
Read the full Nutmeg + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOnionAllium Cepa, allii Cepae Bulbus, cebolla, +9 more Possible
What it is: Onion is a common food with a long history in traditional medicine, and it contains antioxidants like quercetin and sulfur compounds.
Theoretically, taking onion might increase the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Onion + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOregon GrapeMahonia Aquifolium, barberry, berberis, +13 more Possible
What it is: Oregon grape is a shrub whose root contains berberine and related compounds.
Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Read the full Oregon Grape + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOstarine Possible
What it is: Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not...
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPadang Cassia Possible
What it is: Padang Cassia is a type of cinnamon (Indonesian or Korintje cinnamon) grown mainly in Indonesia and used widely as a kitchen spice.
There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.
Read the full Padang Cassia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPanax GinsengAsian Ginseng, asiatic Ginseng, chinese Ginseng, +12 more Possible
What it is: Panax ginseng is a popular traditional herb used to boost energy, ease stress, and support overall wellness, though scientific evidence is m...
Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.
Read the full Panax Ginseng + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPanax NotoginsengPanax Notoginseng, field Seven, noto-gin, +15 more Possible
What it is: Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation.
Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Panax Notoginseng + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionParsleyPetroselinum Crispum, common Parsley, garden Parsley, +16 more Possible
What it is: Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C.
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPassion FlowerPassiflora Incarnata, apricot Vine, burucuya, +18 more Possible
What it is: Passion flower is a traditional calming herb that many people use for anxiety and sleep.
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passion Flower + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPennyroyal Possible
What it is: Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to...
Concomitant use of pennyroyal essential oil and acetaminophen might increase the risk of acetaminophen-induced hepatotoxicity.
Read the full Pennyroyal + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPeonyPaeonia Lactiflora, bai Shao, chi Shao, +17 more Possible
What it is: Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combina...
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Peony + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPeppermintMentha X Piperita, black Peppermint, brandy Mint, +12 more Possible
What it is: Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms.
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhellodendronPhellodendron Amurense, amur Cork Bark, amur Cork Tree, +7 more Possible
What it is: Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and an...
Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Read the full Phellodendron + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhenethylamine (pea)2-phenylethanamine, methylphenylethylamine, pea Possible
What it is: Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and...
Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Read the full Phenethylamine (pea) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhenibutBeta-phenyl-gamma-aminobutyric Acid, 4-amino-3-phenylbutyric Acid, b-(aminomethyl)-benzenepropanoic Acid, +7 more Possible
What it is: Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it ca...
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Read the full Phenibut + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhenpromethamine Possible
What it is: Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement.
Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effects.
Read the full Phenpromethamine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPhosphatidylserine Possible
What it is: Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory...
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPinellia Ternata Possible
What it is: Pinellia ternata is a tuber used in traditional Chinese medicine, most often for nausea, vomiting, and phlegmy coughs, and almost always as...
Evidence from animal research shows that a Pinellia ternata preparation decreases activity and increases sleeping time.
Read the full Pinellia Ternata + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPomegranatePunica Granatum, anardana, dadim, +14 more Possible
What it is: Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice.
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPoria Mushroom Possible
What it is: Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid.
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Mushroom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPropolisAcide De Cire D'abeille, baume De Propolis, bee Glue, +12 more Possible
What it is: Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies.
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPurple Nut Sedge Possible
What it is: Purple nut sedge (Cyperus rotundus) is a common weed whose tubers have a long history in Ayurvedic, Chinese, and other traditional medicine...
In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).
Read the full Purple Nut Sedge + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionQuercetin7-pentahydroxyflavone, bioflavonoid, bioflavonoid Complex, +9 more Possible
What it is: Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement.
Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Quercetin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRabdosia RubescensRabdosia Rubescens, bing Ling Cao, blushred Rabdosia, +5 more Possible
What it is: Rabdosia rubescens is a Chinese herb traditionally used for sore throats, inflammation, and infections, and its compound oridonin has drawn...
In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Rabdosia Rubescens + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRaspberry Ketone Possible
What it is: Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human e...
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketone + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRauwolscine Possible
What it is: Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout su...
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRed Yeast RiceMonascus Purpureus, cholestin, hong Qu, +19 more Possible
What it is: Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') chole...
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRhubarbRheum Officinale, chinese Rhubarb, da Huang, +13 more Possible
What it is: Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food.
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Rhubarb + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRooibosAspalathus Linearis, green Red Bush, infusion Rooibos, +9 more Possible
What it is: Rooibos is a caffeine-free herbal tea from South Africa that is rich in antioxidants and generally considered safe as a beverage.
Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.
Read the full Rooibos + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRueRuta Graveolens, aruta, arvada, +17 more Possible
What it is: Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to...
Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Read the full Rue + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSaffronCrocus Sativus, autumn Crocus, azafrán, +16 more Possible
What it is: Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most r...
Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Read the full Saffron + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSageSalvia Officinalis, broadleaf Sage, common Sage, +14 more Possible
What it is: Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and me...
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Sage + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSaigon Cinnamon Possible
What it is: Saigon cinnamon is a flavorful spice from a Cinnamomum tree grown mainly in Vietnam, and it is a type of 'cassia' cinnamon.
Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Saigon Cinnamon + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSameS-adenosyl-l-methionine, ademetionine, adomet, +8 more Possible
What it is: SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis.
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Same + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSassafrasSassafras Albidum, ague Tree, bois De Cannelle, +7 more Possible
What it is: Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole,...
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSceletium Possible
What it is: Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood.
Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Read the full Sceletium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSchizonepeta Possible
What it is: Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and...
Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6.
Read the full Schizonepeta + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSecurinega Suffruticosa Possible
What it is: Securinega suffruticosa is a shrub used in traditional East Asian medicine, best known for an alkaloid called securinine that strongly stimu...
Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.
Read the full Securinega Suffruticosa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionShepherd's PurseCapsella Bursa-pastoris, blind Weed, bolsa Del Pastor, +14 more Possible
What it is: Shepherd's purse is a traditional herb most often used to help slow heavy menstrual bleeding and other minor bleeding, but solid human resea...
Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Read the full Shepherd's Purse + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionShiitake Mushroom Possible
What it is: Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people.
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSkullcapScutellaria Lateriflora, american Skullcap, blue Pimpernel, +15 more Possible
What it is: American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited.
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSlippery ElmIndian Elm, moose Elm, olmo Americano, +7 more Possible
What it is: Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and ir...
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSpearmintMentha Spicata, curled Mint, fish Mint, +16 more Possible
What it is: Spearmint is a common culinary mint that is generally safe in food and tea amounts.
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Read the full Spearmint + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSulforaphane Possible
What it is: Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflamma...
Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Read the full Sulforaphane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSweet AnnieArtemisia Annua, absinthe Sauvage, ajenjo Silvestre, +11 more Possible
What it is: Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs.
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Annie + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionSweet CloverMelilotus Officinalis, angipars, casse Lunettes, +14 more Possible
What it is: Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limit...
Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.
Read the full Sweet Clover + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTarragonArtemisia Dracunculus, armoise Âcre, dragonne, +8 more Possible
What it is: Tarragon is a flavorful culinary herb that has been used in traditional medicine for digestion, sleep, and other complaints, but solid human...
Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneally at a dose of 1 mL/kg.
Read the full Tarragon + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTeazleDipsacus Fullonum, baignoire De Vénus, barber's Brush, +11 more Possible
What it is: Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and...
In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.
Read the full Teazle + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTerminaliaTerminalia Arjuna, abhaya, amandier Indien, +19 more Possible
What it is: Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness...
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Terminalia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTestolone Possible
What it is: Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Testolone + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTheacrine Possible
What it is: Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood.
Theoretically, theacrine might alter the effects of CNS depressants.
Read the full Theacrine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionThuja Possible
What it is: Thuja, also called northern white cedar or arborvitae, is a tree whose leaf and oil have a long history in folk and homeopathic medicine, es...
Thuja products can contains significant amounts of thujone, a neurotoxin.
Read the full Thuja + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionThunder God VineTripterygium Wilfordii, huang-t'eng Ken, lei Gong Teng, +8 more Possible
What it is: Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited...
Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Thunder God Vine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionThymeThymus Vulgaris, farigoule, farigoulette, +14 more Possible
What it is: Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints.
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTianeptine Possible
What it is: Tianeptine is a prescription antidepressant in some countries, but it is NOT approved by the FDA in the United States and is illegally sold...
Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.
Read the full Tianeptine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTinospora Cordifolia Possible
What it is: Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat...
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Tinospora Cordifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionToothed ClubmossHuperzia Serrata, chinese Club Moss, huperazon, +4 more Possible
What it is: Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's...
In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine.
Read the full Toothed Clubmoss + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTragacanthAdragante, astragale Adragant, astragale De Marseille, +14 more Possible
What it is: Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the thro...
Theoretically, tragacanth might alter absorption of oral drugs.
Read the full Tragacanth + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTurmericCurcuma Longa, curcuma, curcumae Longa, +17 more Possible
What it is: Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain.
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionUva UrsiArctostaphylos Uva-ursi, arberry, arbousier, +16 more Possible
What it is: Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have anti...
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionValerianValeriana Officinalis, all-heal, amantilla, +10 more Possible
What it is: Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves.
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionVitamin A Possible
What it is: Vitamin A is an essential nutrient important for vision, skin, immune function, and growth.
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full Vitamin A + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionVitamin EAlpha-tocopherol, beta-tocopherol, delta-tocopherol, +1 more Possible
What it is: Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet.
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Vitamin E + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWheatgrassTriticum Aestivum, agropyre, blé En Herbe, +7 more Possible
What it is: Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and pl...
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWhite Pepper Possible
What it is: White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice.
In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).
Read the full White Pepper + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWild CherryPrunus Serotine, american Black Cherry, bird Cherry, +12 more Possible
What it is: Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific...
In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Wild Cherry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWild LettuceLactuca Virosa, acrid Lettuce, allubbyne, +13 more Possible
What it is: Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited.
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Wild Lettuce + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWinter Cherry Possible
What it is: Winter Cherry is another name for ashwagandha (Withania somnifera), an herb long used in Ayurvedic medicine, most often for stress, sleep, a...
In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).
Read the full Winter Cherry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionYin ChenArmoise à Balais, armoise Capillaire, artemisia Officinalis, +11 more Possible
What it is: Yin Chen is a traditional Chinese medicine herb used mainly for liver and gallbladder complaints and jaundice.
Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Read the full Yin Chen + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionZedoary Possible
What it is: Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice.
Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.
Read the full Zedoary + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionZizyphusZiziphus Jujuba, anèbe, annab, +20 more Possible
What it is: Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion.
Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.
Read the full Zizyphus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionLavenderLavandula Angustifolia, alhucema, common Lavender, +14 more Unlikely
What it is: Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for...
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionThyroid Extract Likely
What it is: Thyroid extract supplements are made from dried animal thyroid gland and may contain real thyroid hormones (T3 and T4), but the amounts in o...
Food and medications can interfere with thyroid hormone absorption.
Read the full Thyroid Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHibiscus SabdariffaHibiscus Sabdariffa, agua De Jamaica, ambashthaki, +16 more Probable
What it is: Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood...
Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.
Read the full Hibiscus Sabdariffa + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionVitamin C Probable
What it is: Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements.
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAegeline Possible
What it is: Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-los...
Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.
Read the full Aegeline + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAgarAgar-agar, agarose, agarose Gel, +17 more Possible
What it is: Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber.
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAlginAlginate, alginate De Calcium, alginate De Magnésium, +12 more Possible
What it is: Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines.
Theoretically, algin can alter the absorption of oral drugs.
Read the full Algin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAloeAloe Vera, aloe Capensis, aloe Gel, +18 more Possible
What it is: Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help.
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAtractylodesAtractylodes Lancea, amk, atr, +9 more Possible
What it is: Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue,...
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Atractylodes + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBaelAegle Marmelos, arbre De Bael, bael Tree, +16 more Possible
What it is: Bael is a fruit-bearing tree long used in traditional Indian (Ayurvedic) medicine, mostly for digestive problems like diarrhea and indigesti...
Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.
Read the full Bael + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlack PsylliumAfrican Plantain, brown Psyllium, dietary Fiber, +16 more Possible
What it is: Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive...
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Black Psyllium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBlond PsylliumPlantago Ovata, balle De Psyllium, blond Plantago, +14 more Possible
What it is: Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements.
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Blond Psyllium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBroccoli Sprout Possible
What it is: Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammat...
Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Sprout + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalea Zacatechichi Possible
What it is: Calea zacatechichi, often called 'dream herb,' is a Mexican plant traditionally used to encourage vivid dreams and to treat digestive compla...
Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.
Read the full Calea Zacatechichi + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCarobCeratonia Siliqua, algarrobo, carob Flour, +16 more Possible
What it is: Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum...
Theoretically, carob might also impair the absorption of oral drugs.
Read the full Carob + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCascara SagradaFrangula Purshiana, rhamnus Purshiana, bitter Bark, +13 more Possible
What it is: Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipati...
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEurycoma LongifoliaAkar Pasak Bumi, ali's Umbrella, ali's Walking Stick, +17 more Possible
What it is: Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some...
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFucus VesiculosusBlack Tang, bladder Fucus, bladder Wrack, +14 more Possible
What it is: Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin.
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
Read the full Fucus Vesiculosus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGlucosamine Possible
What it is: Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, espe...
Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Read the full Glucosamine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHempCannabis Sativa, cheungsam, fiber Hemp, +14 more Possible
What it is: Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generall...
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHoneyBeri Honey, blossom Honey, buckwheat Honey, +13 more Possible
What it is: Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade...
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionKaraya GumBassora Tragacanth, goma Karaya, gomme Karaya, +14 more Possible
What it is: Karaya gum is a natural plant gum from the Sterculia tree that is mostly used as a bulk-forming laxative and as a thickener or adhesive in f...
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.
Read the full Karaya Gum + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMarshmallowAlthaea Officinalis, altea, alteia, +16 more Possible
What it is: Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sor...
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionN-methyltyramine Possible
What it is: N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added t...
N-methyltyramine is thought to have stimulant effects.
Read the full N-methyltyramine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionOctopamine Possible
What it is: Octopamine is a stimulant-like compound found in small amounts in some plants (such as bitter orange) and made naturally in the body.
Octopamine is thought to have stimulant effects.
Read the full Octopamine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPuravive Possible
What it is: Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no pub...
Puravive contains Panax ginseng.
Read the full Puravive + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRhodiolaRhodiola Rosea, arctic Root, golden Root, +12 more Possible
What it is: Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress.
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTyramine Possible
What it is: Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and s...
Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.
Read the full Tyramine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionVitamin DErgocalciferol, cholecalciferol Possible
What it is: Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function.
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionXanthan GumBacterial Polysaccharide, corn Sugar Gum, goma Xantana, +7 more Possible
What it is: Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing diffic...
Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.
Read the full Xanthan Gum + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAsian Water PlantainAlisma Plantago-aquatica, dong Fang Ze Xie, jilgyeongitaegsa, +6 more Unlikely
What it is: Asian water plantain (Ze Xie) is a rhizome long used in traditional Chinese medicine, mainly as a diuretic and for fluid retention.
Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does not cause harm to the body.
Read the full Asian Water Plantain + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalabar BeanPhysostigma Venenosum, chop Nut, esere Nut, +7 more Unlikely
What it is: Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor.
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Calabar Bean + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCalendulaCalendula Officinalis, caléndula, calendule, +13 more Unlikely
What it is: Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound...
Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Read the full Calendula + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChrysin Unlikely
What it is: Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies hav...
Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
Read the full Chrysin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDeanol2-dimethyl Aminoethanol, cyclohexylpropionate De Déanol, deaner, +9 more Unlikely
What it is: Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses...
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Deanol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDiindolylmethaneDim Unlikely
What it is: Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone b...
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full Diindolylmethane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionGamma-aminobutyric Acid (gaba)Acide Bêta-phényl-gamma-amino-butyrique, acide Gamma-aminobutyrique, Ácido Gama-aminobutríco, +3 more Unlikely
What it is: GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety,...
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHumann Superbeets Heart Chews Unlikely
What it is: SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric ox...
Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).
Read the full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionJequirityAbrus Precatorius, bead Vine, black-eyed Susan, +19 more Unlikely
What it is: Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins k...
In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.
Read the full Jequirity + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMommy's Bliss Gripe Water Unlikely
What it is: Mommy's Bliss Gripe Water is a sugar-free, alcohol-free liquid made with fennel and ginger that parents use to soothe gassy, colicky, or fus...
Mommy's Bliss Gripe Water contains fennel seed.
Read the full Mommy's Bliss Gripe Water + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPolypodium Leucotomos Unlikely
What it is: Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain lig...
Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
Read the full Polypodium Leucotomos + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRed CloverTrifolium Pratense, beebread, clovone, +17 more Unlikely
What it is: Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms...
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionRosemaryRosmarinus Officinalis, alecrim, compass Plant, +14 more Unlikely
What it is: Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts.
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTangerine Unlikely
What it is: Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food.
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTheanine Unlikely
What it is: Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without...
Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Theanine + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTurpentine OilPinus Palustris, aceite De Trementina, essence De Térébenthine, +9 more Unlikely
What it is: Turpentine oil is a strong-smelling pine resin product used mostly in tiny amounts in topical rubs for muscle aches and congestion.
There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP activity.
Read the full Turpentine Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionCan You Take It With Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.
Can you take Vitamin A with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...
Full Vitamin A + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Vitamin D with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Full Vitamin D + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Ginger with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.
Full Ginger + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Ashwagandha with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Full Ashwagandha + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Black Pepper with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Full Black Pepper + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Beta-methylphenethylamine (bmpea) with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Full Beta-methylphenethylamine (bmpea) + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Bilberry with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Full Bilberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Biofeedback with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.
Full Biofeedback + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Bishop's Weed with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.
Full Bishop's Weed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Bitter Almond with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.
Full Bitter Almond + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Bitter Orange with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.
Full Bitter Orange + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Black Cohosh with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Full Black Cohosh + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Black Hoof Mushroom with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
Full Black Hoof Mushroom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Black Seed with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Full Black Seed + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Bog Labrador Tea with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...
Full Bog Labrador Tea + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Boldo with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Full Boldo + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Boswellia Serrata with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Full Boswellia Serrata + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Boxwood with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.
Full Boxwood + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Breadfruit with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).
Full Breadfruit + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerCan you take Broccoli with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Full Broccoli + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine answerWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
How Does Our Interaction Checker Work?
Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).
So the check works in three steps: (1) Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine sits in 21 interaction categories. Open any one to see what the group means:
Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
121 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
79 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cns Depressants 78 ingredients
Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.
78 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
60 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Stimulant Drugs 44 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
44 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Hepatotoxic Drugs 38 ingredients
Medications with known liver considerations. Supplements that can stress the liver add to the load.
38 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Anticholinergic Drugs 30 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
30 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
24 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Photosensitizing Drugs 20 ingredients
Medications that make skin more sun-sensitive. Supplements with the same property can compound it.
20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Serotonergic Drugs 20 ingredients
Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.
20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Oral Drugs 17 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
17 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Glucuronidated Drugs 12 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
12 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Acetaminophen (Tylenol, Others) 8 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
8 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Nephrotoxic Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Seizure Threshold Lowering Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Narcotic Drugs 5 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
5 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
3 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Alpha-Adrenergic Agonists 1 ingredient
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Codeine 1 ingredient
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Serotonergic Drugs 1 ingredient
Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.
1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine through this category.
Related: does Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine deplete any nutrients?
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine has 1 reported nutrient association in the research literature — see the Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine nutrient depletion report.
Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine
Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine.
Search a supplement product
Type a product name, brand, or UPC — smart search across our full catalog.
Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI
Or scan the bottle
Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.
Prefer typing? The interaction checker looks up products by name too.
Products that contain Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine-interacting ingredients
Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine.
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine & Supplements: Common Questions
What supplements interact with Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Which Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine supplement interactions are the most serious?
Can I take vitamins or supplements while on Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Do brands like Colrex have the same supplement interactions as Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine?
Where do these interaction ratings come from?
Does Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine deplete any vitamins or nutrients?
What about Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine and my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
More Free Pharmacist Tools
Where This Data Comes From — and Why You Can Trust It
🧪 Licensed clinical database
Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.
🧑⚕️ Pharmacist review
This page is curated and coded by Dr. Brian Staiger, PharmD, BCPS, Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.
🔄 Kept current
Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.
🔍 Full transparency
How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.
Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.