Aconite - Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine Interaction
Herbal: Aconite
Also Known As: Aconitum napellus, Aconitum, Aconitum Angustifolium, Atis, Ativisha, Autumn Monkshood, Bachnag, Bikhma, Caowu, Chuanwu, Chuan-wu, Fu Zi, Futzu, Helmet Flower, Monkshood, Prativisha, Radix Aconiti, Vachnag, Vatsnabh, Visha, Wild Aconitum, Wolfsbane, Wutou
Drug: Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine
Brand names:
Colrex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine is classified as belonging to the following category: Stimulant Drugs
Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovascular toxicity.
Aconite and its constituents have stimulant effects due to agonist activity at beta-2-adrenoreceptors. In cardiac muscle, aconite appears to have a positive inotropic effect and increases heart rate and blood pressure. However, some constituents of aconite can reduce heart rate and blood pressure.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Yeih DF, Chiang FT, Huang SKS. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone. Heart 2000;84:E8.
- Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9.
- Telang, B. V. and Ng'ang'a, J. N. Involvement of Central adrenergic mechanisms in the induction of cardiac arrhythmias by aconitine nitrate administered intraventricularly. Indian J Physiol Pharmacol. 1975;19(1):1-10.
- Kimura, I., Takada, M., and Nojima, H. Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice. Biol.Pharm Bull. 1997;20(8):856-860.
- Zhao D, Wang J, Cui Y, Wu X. Pharmacological effects of Chinese herb aconite (fuzi) on cardiovascular system. J Tradit Chin Med. 2012 Sep;32(3):308-13.
Aconite Overview
Aconitum, also commonly known as aconite or Wolfsbane, is a plant species that belongs to the buttercup (Ranunculaceae) family. It is native to Asia and Europe and is known for its blue or purple flowers and poisonous roots.
Aconitum has a long history of use in traditional medicine and has been used to treat a wide range of health conditions, including fever, pain, and respiratory problems. It is also used as a sedative and to treat heart problems. However, aconite is extremely poisonous as it contains toxic alkaloids. It can cause serious side effects, including nausea, vomiting, difficulty breathing, and even death. Handling aconite is considered dangerous as well some toxins may be absorbed through the skin. Although some heavily processed preparations of aconite are available, it is most commonly used in homeopathic preparations that are highly diluted.
Aconite - More Interactions
Aconite interacts with 276 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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