Medication interaction hub

What Supplements Interact with Erythromycin Ethylsuccinate, Sulfisoxazole?

Erythromycin Ethylsuccinate, Sulfisoxazole brand name: Pediazole. Every interaction below applies to the brands too.

224 Interactions 12 Major 171 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Erythromycin Ethylsuccinate, Sulfisoxazole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Erythromycin Ethylsuccinate, Sulfisoxazole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Pediazole (erythromycin ethylsuccinate with sulfisoxazole), an antibiotic often given for children's ear infections, deserves real care around supplements. Erythromycin slows the liver enzyme that clears over half the ingredients on this page, so their levels can climb during treatment, and grapefruit can push the antibiotic's own levels up the same way. A second cluster can stretch the heart's electrical rhythm, called the QT interval, a risk erythromycin already carries. And PABA, found in some B-complex products, can directly blunt the sulfa half of this medicine.

St. John's wort works in the opposite direction, speeding this drug's breakdown and lowering its levels. Probiotics are gentler; the antibiotic can kill their live organisms, so space the two well apart. About twenty ingredients add sun sensitivity. All told the page lists 224 ingredients, 12 of them rated major (171 moderate, 41 minor), and those dozen are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 12 Moderate 171 Minor 41 No known interaction 1,228

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Erythromycin Ethylsuccinate, Sulfisoxazole: Top Interactions at a Glance

The most significant Erythromycin Ethylsuccinate, Sulfisoxazole supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 224 interacting ingredients — plus 1,228 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Erythromycin Ethylsuccinate, Sulfisoxazole + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Erythromycin Ethylsuccinate, Sulfisoxazolei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Para-aminobenzoic Acid (paba) + Erythromycin Ethylsuccinate, Sulfisoxazolei

Theoretically, concomitant use of PABA and sulfonamide antibiotics inhibits the antibacterial effects of sulfonamide.

Read the full interaction Major Likelihood Probable Activated Charcoal + Erythromycin Ethylsuccinate, Sulfisoxazolei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Erythromycin Ethylsuccinate, Sulfisoxazolei

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Beer + Erythromycin Ethylsuccinate, Sulfisoxazolei

Concomitant use may increase blood alcohol levels and adverse effects.

Read the full interaction Major Likelihood Probable Cesium + Erythromycin Ethylsuccinate, Sulfisoxazolei

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction
The complete list

Every Supplement Checked Against Erythromycin Ethylsuccinate, Sulfisoxazole

All 1,452 ingredients in our database, ranked by severity — 224 with a Erythromycin Ethylsuccinate, Sulfisoxazole interaction on file and 1,228 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Erythromycin Ethylsuccinate, Sulfisoxazole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Neem with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Pomegranate with Erythromycin Ethylsuccinate, Sulfisoxazole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Dhea with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Black Hellebore with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of macrolide antibiotics and black hellebore might increase risk of cardiac glycoside toxicity.

Full Black Hellebore + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Black Pepper with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Black Tea with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Black Tea + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Bog Labrador Tea with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Boswellia Serrata with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Bulbine Natalensis with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Calamus with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Cannabinol (cbn) with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Full Cannabinol (cbn) + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Cannabis with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of cannabis.

Full Cannabis + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Cat's Claw with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Ceylon Leadwort with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Chanca Piedra with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Chlorella with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Chokeberry with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Cilantro with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Cinchona with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Erythromycin Ethylsuccinate, Sulfisoxazole answer

Can you take Clove with Erythromycin Ethylsuccinate, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Erythromycin Ethylsuccinate, Sulfisoxazole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Erythromycin Ethylsuccinate, Sulfisoxazole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Erythromycin Ethylsuccinate, Sulfisoxazole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Erythromycin Ethylsuccinate, Sulfisoxazole sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Sulfonamide Antibiotics 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Erythromycin 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate, Sulfisoxazole through this category.

Related: does Erythromycin Ethylsuccinate, Sulfisoxazole deplete any nutrients?

Erythromycin Ethylsuccinate, Sulfisoxazole has 7 reported nutrient associations in the research literature — see the Erythromycin Ethylsuccinate, Sulfisoxazole nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Erythromycin Ethylsuccinate, Sulfisoxazole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Erythromycin Ethylsuccinate, Sulfisoxazole.

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Products that contain Erythromycin Ethylsuccinate, Sulfisoxazole-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Erythromycin Ethylsuccinate, Sulfisoxazole.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Erythromycin Ethylsuccinate, Sulfisoxazole & Supplements: Common Questions

What supplements interact with Erythromycin Ethylsuccinate, Sulfisoxazole?
In our interaction database, 224 supplement and herbal ingredients have an interaction with Erythromycin Ethylsuccinate, Sulfisoxazole on file — 12 rated major, 171 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Para-aminobenzoic Acid (paba), Activated Charcoal.
Which Erythromycin Ethylsuccinate, Sulfisoxazole supplement interactions are the most serious?
Focus on the major group: Grapefruit, Para-aminobenzoic Acid (paba), Activated Charcoal, Arsenic and Beer, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Erythromycin Ethylsuccinate, Sulfisoxazole?
That depends entirely on which supplement. The honest answer for Erythromycin Ethylsuccinate, Sulfisoxazole is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Pediazole have the same supplement interactions as Erythromycin Ethylsuccinate, Sulfisoxazole?
Yes — Pediazole all contain Erythromycin Ethylsuccinate, Sulfisoxazole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Erythromycin Ethylsuccinate, Sulfisoxazole deplete any vitamins or nutrients?
It might — Erythromycin Ethylsuccinate, Sulfisoxazole has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Erythromycin Ethylsuccinate, Sulfisoxazole nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Erythromycin Ethylsuccinate, Sulfisoxazole and my other medications?
This page covers Erythromycin Ethylsuccinate, Sulfisoxazole against supplements and herbal ingredients. Checking Erythromycin Ethylsuccinate, Sulfisoxazole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.