Medication interaction hub

What Supplements Interact with Heparin?

Heparin brand name: Heparin. Every interaction below applies to the brands too.

202 Interactions 2 Major 183 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Heparin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Heparin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Heparin exists to keep clots from forming, and all 202 supplements on this list touch that same clotting machinery, so treat these pairings with real care. Nearly all lean the same way, adding antiplatelet or anticoagulant activity that can push a therapeutic dose toward bruising and bleeding. Danshen and piracetam carry the two major ratings, backed by human and animal evidence of platelet inhibition, and they are the entries to rule out first.

The 183 moderate and 17 minor entries rest mostly on lab or animal findings rather than documented human harm, but the pattern is uniform enough to respect, especially since heparin is often used around surgery, when bleeding already looms. Bismuth is the odd one out, possibly speeding clotting and dulling heparin's effect instead. Watch for easy bruising, nosebleeds, pink urine, or dark stools while taking any of these.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 183 Minor 17 No known interaction 1,250

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Heparin: Top Interactions at a Glance

The Heparin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 202 interacting ingredients — plus 1,250 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Heparin Combinations Today

The Heparin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin E + Heparini

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Aloe + Heparini

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Unlikely Panax Ginseng + Heparini

Although Panax ginseng has shown antiplatelet effects in the laboratory, it is unlikely to increase the risk of bleeding if used with anticoagulant or antiplate...

Read the full interaction Moderate Likelihood Probable Willow Bark + Heparini

Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Heparini

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Rose Hip + Heparini

Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Heparin

All 1,452 ingredients in our database, ranked by severity — 202 with a Heparin interaction on file and 1,250 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Heparin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin E with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Vitamin E + Heparin answer

Can you take Aloe with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Aloe + Heparin answer

Can you take Panax Ginseng with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Although Panax ginseng has shown antiplatelet effects in the laboratory, it is unlikely to increase the risk of bleeding if used with antico...

Full Panax Ginseng + Heparin answer

Can you take Willow Bark with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Willow Bark + Heparin answer

Can you take Reishi Mushroom with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of reishi mushroom might increase the risk of bleeding.

Full Reishi Mushroom + Heparin answer

Can you take Black Tea with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Heparin answer

Can you take Blood Irradiation Therapy with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Heparin answer

Can you take Boldo with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Boldo + Heparin answer

Can you take Borage with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Heparin answer

Can you take Breadfruit with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Breadfruit + Heparin answer

Can you take Bromelain with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Heparin answer

Can you take Buchu with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu may have antiplatelet effects.

Full Buchu + Heparin answer

Can you take Bulbine Natalensis with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining Bulbine natalensis leaf with drugs that have anticoagulant or antiplatelet activity might increase the risk of brui...

Full Bulbine Natalensis + Heparin answer

Can you take Bupleurum with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Heparin answer

Can you take Burdock with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Burdock + Heparin answer

Can you take Caffeine with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Caffeine + Heparin answer

Can you take Canadian Fleabane with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Full Canadian Fleabane + Heparin answer

Can you take Cannabis with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Cannabis + Heparin answer

Can you take Capsicum with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Heparin answer

Can you take Carrageenan with Heparin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, carrageenan may increase the risk of bleeding in patients taking anticoagulant or antiplatelet drugs.

Full Carrageenan + Heparin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Heparin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Heparin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Heparin sits in 1 interaction category. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Heparin through this category.

About Heparin

Heparin Injection is an anticoagulant (blood thinner) used to prevent and treat blood clots, including deep vein thrombosis, pulmonary embolism, and clotting related to atrial fibrillation, surgery, and dialysis.

Generic name: Heparin  ·  Brand name: Heparin.

See the full Heparin Injection drug information

Related: does Heparin deplete any nutrients?

Heparin has 2 reported nutrient associations in the research literature — see the Heparin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Heparin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Heparin.

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Pharmacist Counseling Corner

Heparin & Supplements: Common Questions

What supplements interact with Heparin?
More than you might expect — 202 in total, though they are far from equal: 2 are rated major, 183 moderate, and 17 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Danshen, Piracetam, Bridelia.
Which Heparin supplement interactions are the most serious?
Focus on the major group: Danshen and Piracetam. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Heparin?
Usually yes — most people on Heparin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Heparin have the same supplement interactions as Heparin?
Yes — Heparin all contain Heparin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Heparin deplete any vitamins or nutrients?
It might — Heparin has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Heparin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Heparin and my other medications?
This page covers Heparin against supplements and herbal ingredients. Checking Heparin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Heparin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.