5-HTP 200 mg Maximum Strength Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking 5-HTP 200 mg Maximum Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
5-HTP 200 mg Maximum Strength is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-5 HTP. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 5-HTP 200 mg Maximum Strength by Swanson
Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP 200 mg Maximum Strength by Swanson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 5-HTP 200 mg Maximum Strength by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has a single active ingredient: L-5 HTP (5-hydroxytryptophan), a naturally occurring amino acid that your body uses to make serotonin, a brain chemical involved in mood and sleep. The capsules also contain inactive ingredients—gelatin, magnesium stearate, and rice flour—which are standard binders and fillers.
Does it work?
Not established
5-HTP is rated possibly effective for depression based on the evidence we hold. For other uses tested—down syndrome, Alzheimer disease, panic disorder, and cerebellar ataxia—either the evidence is insufficient to rate it or it appears possibly ineffective.
Talk with your pharmacist or doctor about whether it's a fit for what you're considering it for.
How safe is it?
Well-documented data
Orally, 5-HTP is generally well tolerated in the short term. The most common side effects are abdominal pain, loss of appetite, dizziness, diarrhea, drowsiness, fatigue, headache, insomnia, nausea, and vomiting—and how bad they are may depend on dose.
Rare but serious side effects include aggression, hallucinations, mania, and severe stomach complaints. Gastrointestinal upset may ease with continued use, and taking it more slowly when you start may help.
The safety data advises against using 5-HTP during pregnancy and while breastfeeding. There isn't enough information to know whether it's safe at these times, so talk with your doctor or pharmacist for personalized guidance.
Meds to double-check
Moderate interaction found
Before taking this product, double-check your medications with the search tool below if you take serotonergic drugs (antidepressants and similar), any sedating medication (sleep aids, anti-anxiety drugs, opioids, antihistamines), or carbidopa (a Parkinson's drug). These are Moderate-severity interactions with 5-HTP.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
5-HTP might be worth considering if you're exploring options for depression and have talked with your pharmacist or doctor. If you take any antidepressant, sleep aid, pain reliever, anti-anxiety drug, or antihistamine, check your exact medications with the tool on this page before you start.
It can cause drowsiness and stomach upset, especially when you first begin. Don't use it if you're pregnant or breastfeeding without professional guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 5-HTP 200 mg Maximum Strength, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 5-HTP 200 mg Maximum Strength by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-5 HTP | 200 mg | -- |
Other ingredients: Gelatin, Magnesium Stearate, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take one capsule per day with water on an empty stomach.
Precautions
Warning: For adults only.
Do not take this product if you are taking a prescription antidepressant or if you are pregnant or nursing. Consult your healthcare provider before use if you have a medical condition or if you are taking any prescription medications.
Keep out of reach of children.
Do not use if seal is broken.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Sleep Support Maximum Strength
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
5-HTP 200 mg Maximum Strength by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 5-HTP 200 mg Maximum Strength by Swanson
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-5 HTP
Interacts with398 drugs
5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...
L-5 HTP monograph & interactionsOther (inactive) ingredients: Gelatin, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.
5-HTP 200 mg Maximum Strength by Swanson Drug Interactions
HelloPharmacist Interaction Report
Swanson's 5-HTP 200 mg Maximum Strength contains L-5 HTP, which interacts with medications in several important ways.
The most serious concern is with serotonergic drugs — antidepressants (SSRIs, SNRIs, tricyclics), tramadol, and similar medications that work on serotonin. Combining them with 5-HTP can add up serotonergic effects and may raise the risk of serotonin syndrome (a serious condition with confusion, rapid heart rate, high blood pressure, and muscle rigidity) and other serotonergic side effects.
Read the full breakdown — every affected drug type, severity by severity
5-HTP also pairs with sedating medications (CNS depressants) — sleep aids, anti-anxiety drugs, opioids, antihistamines — and could make drowsiness or sedation worse. The data shows 5-HTP itself causes drowsiness and fatigue in trials.
There's also a Moderate interaction with carbidopa (Lodosyn), a Parkinson's medication, which can heighten serotonergic side effects and raise the risk of restlessness, anxiety, insomnia, and other psychiatric effects.
Alone among the ingredients we checked, 5-HTP shows documented interactions. Altogether, these interactions span 398 individual medications.
If you take any prescription or over-the-counter medication—especially an antidepressant, sleep aid, pain reliever, or antihistamine—use the checker on this page to verify your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against 5-HTP 200 mg Maximum Strength?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 5-HTP 200 mg Maximum Strength interact with 398 drugs. Click any drug to see the details.
1 of the 1 ingredient in 5-HTP 200 mg Maximum Strength interact with drugs. Each result below shows which ingredient is responsible. L-5 HTP
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Oxycodone interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Alfentanil interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Alosetron interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Aminophylline, Amobarbital, Ephedrine interactionAmitriptylineElavil
How Amitriptyline interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Amitriptyline, Perphenazine interactionAmobarbitalAmytal
How Amobarbital interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Amobarbital, Secobarbital interactionAmoxapineAsendin
How Amoxapine interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5 Htp + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with 5-HTP 200 mg Maximum Strength — through 1 ingredient. Tap an ingredient for the detail:
L-5 HtpCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5 Htp + Aprobarbital, Butabarbital, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 5-HTP 200 mg Maximum Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-5 HTP
Carbidopa (Lodosyn)
Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.
Cns Depressants
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.
Serotonergic Drugs
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.
Brand information
Manufacturer and brand details for 5-HTP 200 mg Maximum Strength, from the product label.
Swanson
See all Swanson products- Name
- Swanson Health Products
- City
- Fargo
- State
- ND
- ZipCode
- 58104
- Phone Number
- 1-800-437-4148
- Web Address
- swanson.com
5-HTP 200 mg Maximum Strength by Swanson: Common Questions
Does 5-HTP 200 mg Maximum Strength by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-5 HTP and what does it do?
Can I take this with my antidepressant?
Will this make me drowsy?
What stomach side effects should I expect?
Is 5-HTP safe during pregnancy or while breastfeeding?
Does this really work for depression?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if 5-HTP 200 mg Maximum Strength is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 5-HTP 200 mg Maximum Strength’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
5-HTP 200 mg Maximum Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
5-htp 32 references
- Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
- Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
- Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
- U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
- Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
- Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
- Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
- U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
- Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
- Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
- Takahashi S, Kondo H, Kato N. Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. J Psychiatr Res 1975;12:177-87. PubMed
- Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. PubMed
- den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
- Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr 2013;6:29-34. PubMed
- Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76:109-17. PubMed
- Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 1977;224:175-86. DOI
- Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25:327-9. PubMed
- De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985;29:239-48.
- Van Woert, M. H., Rosenbaum, D., Howieson, J., and Bowers, M. B., Jr. Long-term therapy of myoclonus and other neurologic disorders with L-5- hydroxytryptophan and carbidopa. N Engl J Med 1-13-1977;296(2):70-75. PubMed
- Wyatt, R. J., Vaughan, T., Galanter, M., Kaplan, J., and Green, R. Behavioral changes of chronic schizophrenic patients given L-5- hydroxytryptophan. Science 9-22-1972;177(54):1124-1126. PubMed
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