Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Advanced Multi-Billion Dophilus Ingredients & Drug Interactions

by Solgar

Advanced Multi-Billion Dophilus label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Multi-Billion Dophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Multi-Billion Dophilus is a dietary supplement by Solgar with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus, LA-5. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Multi-Billion Dophilus by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Multi-Billion Dophilus by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Multi-Billion Dophilus by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Advanced Multi-Billion Dophilus Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains four active probiotic (beneficial bacteria) strains: L. acidophilus LA-5, B. lactis BB-12, L. paracasei L. CASEI 431, and L. rhamnosus GG.

They're grouped together as the Advanced Multi-Billion Dophilus Complex. The capsule itself is made of vegetable cellulose, which acts as a plant-based shell to hold the probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain healthy intestinal flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Radiation-induced diarrhea, Lactose intolerance, Necrotizing enterocolitis (NEC).

L. acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's possibly ineffective for atopic disease (allergic conditions), and the evidence isn't strong enough to rate it for acute respiratory distress syndrome.

We don't have effectiveness data on file for the other three strains in this blend, so we can't tell you how they perform on their own or together.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children. That said, since these are live organisms, there's a small theoretical risk they could cause infection in certain people — cases of bacteremia, sepsis, and other serious infections have been reported, though most happen in people where the bacteria may have moved from somewhere else in the body.

Some people taking L. acidophilus with other probiotics report mild gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea, but these are uncommon. One trial noted a couple of cases of rash and itching, though it's unclear whether those were due to the L. acidophilus or another ingredient.

Pregnancy: L. acidophilus is rated possibly safe in pregnancy. Lactation: we don't have safety data on file for this ingredient during breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, don't take them at the same time as this product — the antibiotic may reduce how well the L. acidophilus works. We don't have interaction data for the other three strains, so check your exact medications on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic blend may help with IBS, antibiotic-associated diarrhea, or bacterial vaginosis. If you take antibiotics, space them out from this product so the antibiotics don't kill the live bacteria.

Check your medications with the tool on this page, and talk to your pharmacist before starting, especially if you're immunocompromised or have a serious illness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Multi-Billion Dophilus, straight from the product label.

Brand Solgar
Barcode (UPC) 033984000391
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79324
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Multi-Billion Dophilus by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
033984000391
IngredientAmount% DV
Advanced Multi-Billion Dophilus Complex0 NP--
L. acidophilus, LA-50 NP--
B. lactis, BB-120 NP--
L. paracasei, L. CASEI 4310 NP--
L. rhamnosus GG, LGG0 NP--

Other ingredients: Advanced Multi-Billion Dophilus Complex, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Solgar Advanced Multi-Billion Dophilus Vegetable Capsules are a source of L. acidophilus, B. lactis, L. paracasei and L. rhamnosus, beneficial microorganisms that help maintain a healthy intestinal flora. This product is formulated with the well known strains LA-5, BB-12, L. casei 431 and LGG and promotes the healthy functioning of the intestinal system.

Brand IP Statement(s)

BB-12, LA-5 and L. CASEI 431 are registered trademarks of Chr. Hansen.

LGG is a trademark of Valio Ltd.

2014 Solgar, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

SOLGB70038 03B

General Statements

Since 1947 Enhanced series 5 billions microorganisms per serving

Storage

Refrigeration optional

Store at room temperature or refrigerate. Although it is not required, refrigeration helps to further preserve the probiotic microorganisms.

Formulation

100% dairy, lactose & milk free Contains no casein

Suitable for vegetarians

Contains no major allergens.

Free Of: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Artificial Flavor, Sweetener, Preservatives and Color.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) vegetable capsule one to two times daily, preferably with meals or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Multi-Billion Dophilus by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Multi-Billion Dophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Multi-Billion Dophilus by Solgar

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Advanced Multi-Billion Dophilus Complex

0 NP per serving
  • › L. acidophilus, LA-5
  • › B. lactis, BB-12
  • › L. paracasei, L. CASEI 431
  • › L. rhamnosus GG, LGG

Other (inactive) ingredients: Advanced Multi-Billion Dophilus Complex, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Multi-Billion Dophilus by Solgar Drug Interactions

Want to check YOUR meds against Advanced Multi-Billion Dophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. acidophilus, LA-5 182

Individual Drug Interactions

The ingredients in Advanced Multi-Billion Dophilus interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in Advanced Multi-Billion Dophilus interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus, LA-5

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Multi-Billion Dophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus, LA-51 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus, LA-5 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Multi-Billion Dophilus, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Advanced Multi-Billion Dophilus by Solgar: Common Questions

Does Advanced Multi-Billion Dophilus by Solgar interact with any medications?
Yes. Based on its ingredients, Advanced Multi-Billion Dophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Multi-Billion Dophilus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
You can take both, but not at the same time. Antibiotics can kill the live bacteria in this product and make it less effective. Ask your pharmacist about the best timing — usually spacing them a few hours apart helps.
What does L. acidophilus do?
L. acidophilus is a beneficial bacteria that may help with irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and H. pylori infection. The evidence is strong enough to call it possibly effective for those uses.
Are there any side effects?
Most people tolerate it well. A small number of people report mild bloating, gas, abdominal pain, or diarrhea when taking probiotics. Rash and itching have been reported in rare cases, though it's not clear whether they were due to this ingredient.
Is it safe during pregnancy?
L. acidophilus is rated possibly safe in pregnancy, but talk with your doctor or pharmacist about whether it's right for you in your specific situation.
What are the other strains in this blend for?
We don't have effectiveness data on file for B. lactis BB-12, L. paracasei L. CASEI 431, or L. rhamnosus GG, so I can't tell you what they're designed to do on their own.
Is this safe if I have a weakened immune system?
Since these are live organisms, there's a small theoretical risk in people who are immunocompromised. Check with your doctor before starting, especially if you have a serious illness or take immunosuppressant medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Multi-Billion Dophilus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Multi-Billion Dophilus label
Go deeper

The Full Monographs Behind Advanced Multi-Billion Dophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Advanced Multi-Billion Dophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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