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Dietary supplement

Akkermansia Ingredients & Drug Interactions

by Codeage

Akkermansia label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Akkermansia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Akkermansia is a dietary supplement by Codeage with 2 active ingredients. Its ingredients are commonly taken for constipation and digestive health, source of prebiotic fiber (inulin), coffee substitute.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chicory. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Akkermansia by Codeage

Ask about any prescription or over-the-counter medication and we check it for interactions with Akkermansia by Codeage — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Akkermansia by Codeage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: chicory and Akkermansia muciniphila, a live beneficial bacterium studied for its role in gut health. The capsule also contains inactive ingredients—methylcellulose, microcrystalline cellulose, and an enteric coating (a protective layer that helps the contents survive stomach acid and dissolve in the small intestine).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: gut health and digestive support.
  • We looked for evidence on: Constipation, Dyspepsia, Diabetes, Hyperlipidemia, Nonalcoholic fatty liver disease (NAFLD), Microbiome composition — and 2 related terms.
  • The closest evidence on file: Chicory is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD) (Natural Medicines).
  • Also on file: Chicory is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diabetes, Dyspepsia, Hyperlipidemia.

The evidence we hold doesn't establish that chicory is effective for neonatal jaundice, nonalcoholic fatty liver disease, osteoarthritis, indigestion (dyspepsia), or high cholesterol (hyperlipidemia)—the data we have rates it insufficient. For Akkermansia muciniphila, we hold no effectiveness ratings in our system, so we can't speak to whether it works for any condition.

The evidence, ingredient by ingredient Chicory Akkermansia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chicory is generally well tolerated in food amounts but may cause gas, bloating, belching, and abdominal pain in some people. It can also trigger allergies in those sensitive to the ragweed family (Asteraceae/Compositae)—including people who react to ragweed, chrysanthemums, marigolds, and daisies.

Traditional sources warn that chicory may stimulate the uterus, so it's best avoided in medicinal amounts during pregnancy. Safety data for medicinal amounts while breastfeeding are not reliable enough, so it's best avoided then too.

Akkermansia muciniphila appears generally well tolerated in short-term use based on small human studies, but long-term safety data are limited.

Side effects, ingredient by ingredient Chicory Akkermansia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Chicory.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs—including insulin, metformin, sulfonylureas, or other blood sugar medications—check your exact medication in the tool below before starting. Chicory may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product may be worth asking your pharmacist about if you're interested in probiotics and can tolerate chicory. If you take any diabetes medication, check with your pharmacist first—chicory could affect your blood sugar.

Avoid during pregnancy or while breastfeeding, since safety data don't support use in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Akkermansia, straight from the product label.

Brand Codeage
Barcode (UPC) 850049609050
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333402
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Akkermansia by Codeage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
850049609050
IngredientAmount% DV
Chicory435 mg--
Akkermansia muciniphila1 mg--

Other ingredients: Methylcellulose, Microcrystalline Cellulose, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Daily Synbiotic Akkermansia Probiotic

Akkermansia Muciniphila Probiotic - Prebiotic 100 Million AFU

General Statements

3-Month supply

Feel Different.

Please recycle bottle & cap Please take off the label Scan for info Questions? codeage.com

Formulation

Vegan

Non-GMO Soy-free Dairy-free Gluten-free

cGMP Certified Manufacturing

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule daily, or as recommended by your healthcare practitioner, with 8 ounces of water or your favorite beverage. May be taken with or without food.

Brand IP Statement(s)

Copyright Codeage LLC. All rights reserved.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Discontinue use two weeks prior to surgery.

Please use caution if you have allergies or sensitivities to any of the listed ingredients.

Do not use if product has been opened or tampered with in any way.

Keep out of reach of children and pets.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Akkermansia by Codeage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Akkermansia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Akkermansia by Codeage

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chicory

Interacts with
86 drugs
435 mg per serving Form: Inulin

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regular...

Chicory monograph & interactions

Akkermansia muciniphila

No known
interactions
1 mg per serving

Akkermansia muciniphila is a gut bacterium sold as a next-generation probiotic. Early research in animals and small human studies looks promising for...

Akkermansia muciniphila monograph & interactions

Other (inactive) ingredients: Methylcellulose, Microcrystalline Cellulose, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Akkermansia by Codeage Drug Interactions

Want to check YOUR meds against Akkermansia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Chicory 86

Individual Drug Interactions

The ingredients in Akkermansia interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Akkermansia interact with drugs. Each result below shows which ingredient is responsible. Chicory

Each ingredient & the kinds of drugs it affects

For each ingredient in Akkermansia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chicory1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Akkermansia, from the product label.

Codeage

See all Codeage products
Name
Codeage LLC
Street Address
5628 Washington Blvd
City
Los Angeles
State
CA
ZipCode
90016
Web Address
www.codeage.com
Pharmacist Counseling Corner

Akkermansia by Codeage: Common Questions

Does Akkermansia by Codeage interact with any medications?
Yes. Based on its ingredients, Akkermansia has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Akkermansia contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Akkermansia muciniphila do?
Akkermansia muciniphila is a probiotic bacterium—a type of beneficial gut microorganism. We don't have effectiveness data on file for it, so we can't tell you what conditions it's intended to treat or prevent based on our data alone.
Will this cause gas or bloating?
Chicory commonly causes gas, bloating, belching, and abdominal pain in some people. If you're sensitive to it, you may want to start with a smaller dose or talk to your pharmacist about whether this is the right product for you.
Can I take this if I'm allergic to ragweed?
Chicory may cause an allergic reaction in people sensitive to the ragweed family of plants, which includes ragweed, chrysanthemums, marigolds, and daisies. If you have allergies to any of these, check with your pharmacist before using this product.
Is it safe to use during pregnancy or while breastfeeding?
No. Traditional sources warn that chicory may stimulate the uterus in pregnancy, and there isn't enough reliable safety data for medicinal amounts while breastfeeding. Both should be avoided during these times—talk to your doctor or pharmacist for personalized advice.
Why do I need the enteric coating?
The enteric coating protects the capsule contents from stomach acid so they can reach and dissolve in your small intestine, where they're meant to work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Akkermansia label
Go deeper

The Full Monographs Behind Akkermansia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph → Herb & supplement monograph

Akkermansia

Akkermansia muciniphila is a gut bacterium sold as a next-generation probiotic. Early research in animals and small human studies looks promising for metabolic and gut health, but the eviden...

Read the full Akkermansia monograph →
Sources

Sources & How We Checked

Akkermansia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chicory 13 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5. PubMed
  3. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  4. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  5. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  6. Cadot, P., Kochuyt, A. M., van Ree, R., and Ceuppens, J. L. Oral allergy syndrome to chicory associated with birch pollen allergy. Int.Arch.Allergy Immunol. 2003;131(1):19-24. PubMed
  7. Friis, B., Hjorth, N., Vail, J. T., Jr., and Mitchell, J. C. Occupational contact dermatitis from Cichorium (chicory, endive) and Lactuca (lettuce). Contact Dermatitis 1975;1(5):311-313.
  8. Nemery, B. and Demedts, M. Occupational asthma in a chicory grower. Lancet 3-25-1989;1(8639):672-673. PubMed
  9. Pirson F, Detry B, Pilette C. Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with bet v 1-related protein. J Investig Allergol Clin Immunol 2009;19(4):306-10.
  10. Willi R, Pfab F, Huss-Marp J, et al. Contact anaphylaxis and protein contact dermatitis in a cook handling chicory leaves. Contact Dermatitis 2009;60(4):226-7. PubMed
  11. Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
  12. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  13. Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9. PubMed

See these in context on the Chicory monograph →

Akkermansia 2 references
  1. Probiotics: What You Need To Know — NIH NCCIH Source
  2. Probiotics — MedlinePlus Source

See these in context on the Akkermansia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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