Liposomal Nicotinamide Riboside+ Ingredients & Drug Interactions
by Codeage
What is this page for?
First and foremost: checking Liposomal Nicotinamide Riboside+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liposomal Nicotinamide Riboside+ is a dietary supplement by Codeage with 3 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liposomal Nicotinamide Riboside+ by Codeage
Ask about any prescription or over-the-counter medication and we check it for interactions with Liposomal Nicotinamide Riboside+ by Codeage — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liposomal Nicotinamide Riboside+ by Codeage
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has three active ingredients. Nicotinamide riboside is a form of vitamin B3 that your body converts to NAD+, a coenzyme involved in energy and cellular health.
Trans-pterostilbene and betaine anhydrous are included as supporting ingredients. The capsule itself contains methylcellulose and sunflower oil as inactive ingredients.
Does it work?
Moderate evidence
The evidence for nicotinamide riboside is still emerging. For age-related macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, and heart failure, we don't have enough reliable evidence to rate how well it works.
Betaine anhydrous is effective for a rare condition called homocystinuria, and possibly effective for elevated homocysteine levels, but evidence is insufficient for depression, fatty liver disease, reflux, or colon polyp prevention. We hold no effectiveness data for trans-pterostilbene.
How safe is it?
Well-documented data
Nicotinamide riboside appears well tolerated in short-term studies, though long-term safety isn't fully established. The most common side effects reported in trials include bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements.
A small number of trial participants reported leg cramps or mild muscle soreness. Betaine anhydrous is generally well tolerated at studied doses, with possible side effects including body odor, diarrhea, nausea, vomiting, and GI upset.
Rare cases of serious brain swelling have been reported, though this is uncommon. During pregnancy, the safety data for nicotinamide riboside is insufficient, so it's best to avoid it.
The same applies while breastfeeding. Betaine anhydrous has no data on file for pregnancy, and breastfeeding safety is not well established — talk with your doctor or pharmacist about personalized advice if either applies to you.
Meds to double-check
Minor interactions only
Before you start this product, check your exact blood pressure medications with the tool below — nicotinamide riboside may increase the blood-pressure-lowering effect, which could bring your levels too low. We couldn't check trans-pterostilbene for interactions, so run your full medication list through the checker as well.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
Nicotinamide riboside is an emerging NAD+ booster that's generally well tolerated short-term, but you should check with your pharmacist if you take blood pressure medication. If you're pregnant, breastfeeding, or have any chronic conditions, a quick conversation with your doctor or pharmacist before starting is a good idea.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liposomal Nicotinamide Riboside+, straight from the product label.
| Brand | Codeage |
|---|---|
| Barcode (UPC) | 850049609210 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 333430 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liposomal Nicotinamide Riboside+ by Codeage, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Nicotinamide Riboside | 500 mg | -- |
| trans-Pterostilbene | 100 mg | -- |
| Betaine Anhydrous | 102.5 mg | -- |
Other ingredients: Methylcellulose, Sunflower Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Nicotinamide Riboside Betaine Anhydrous Trans-Pterostilbene Essential Phospholipids
NR - TMG - Pterostilbene phospholipid complex
General Statements
2-month supply
Please recycle bottle & cap Please take off the label Questions? codeage.com Scan for info
Formulation
Vegan
Non-GMO Soy-free Dairy-free Gluten-free
cGMP Certified Manufacturing
External Bioavailable
Brand IP Statement(s)
Feel Different.
Copyright Codeage LLC. All rights reserved.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Adults take 1 capsule daily, or as recommended by your healthcare practitioner, with 8 ounces of water or your favorite beverage. May be taken with or without food.
Precautions
Caution: Do not exceed recommended dose. Discontinue use two weeks prior to surgery.
Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Please use caution if you have allergies or sensitivities to any of the listed ingredients.
Do not use if product has been opened or tampered with in any way.
Keep out of reach of children and pets.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liposomal Nicotinamide Riboside+ by Codeage label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liposomal Nicotinamide Riboside+ by Codeage
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Nicotinamide Riboside
Interacts with172 drugs
Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...
Nicotinamide Riboside monograph & interactionsTrans-Pterostilbene
Betaine Anhydrous
No knowninteractions
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...
Betaine Anhydrous monograph & interactionsOther (inactive) ingredients: Methylcellulose, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.
Liposomal Nicotinamide Riboside+ by Codeage Drug Interactions
HelloPharmacist Interaction Report
Codeage's Liposomal Nicotinamide Riboside+ contains nicotinamide riboside, which has a minor documented interaction with blood pressure medications.
Nicotinamide riboside may have additive effects when taken alongside antihypertensive drugs, potentially increasing the risk for low blood pressure (hypotension). One small clinical study suggested nicotinamide riboside can modestly reduce blood pressure in people with high blood pressure, though other research didn't find the same effect.
Read the full breakdown — every affected drug type, severity by severity
Betaine anhydrous, the third active ingredient, has no interactions documented in our data. Trans-pterostilbene, the second ingredient, could not be checked — we hold no data for it.
Additionally, you'll want to verify your exact blood pressure medications with the search tool on this page before starting, especially if your dose was recently adjusted.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liposomal Nicotinamide Riboside+?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liposomal Nicotinamide Riboside+ interact with 172 drugs. Click any drug to see the details.
1 of the 3 ingredients in Liposomal Nicotinamide Riboside+ interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside
AcebutololRhotral, Sectral
How Acebutolol interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bosentan interactionBumetanideBurinex
How Bumetanide interacts with Liposomal Nicotinamide Riboside+ — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide RibosideAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Bumetanide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liposomal Nicotinamide Riboside+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Nicotinamide Riboside
Antihypertensive Drugs
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.
Brand information
Manufacturer and brand details for Liposomal Nicotinamide Riboside+, from the product label.
Codeage
See all Codeage products- Name
- Codeage LLC
- Street Address
- 5628 Washington Blvd
- City
- Los Angeles
- State
- CA
- ZipCode
- 90016
- Web Address
- www.codeage.com
Liposomal Nicotinamide Riboside+ by Codeage: Common Questions
Does Liposomal Nicotinamide Riboside+ by Codeage interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What's nicotinamide riboside and what does it do?
Can I take this while pregnant or breastfeeding?
What side effects should I watch for?
Is this safe to take long-term?
Why does this product have three ingredients?
Will this affect my blood pressure medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Liposomal Nicotinamide Riboside+ is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liposomal Nicotinamide Riboside+’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Nicotinamide Riboside
Interacts with 172 drugsNicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...
Read the full Nicotinamide Riboside monograph → Herb & supplement monographBetaine Anhydrous
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...
Read the full Betaine Anhydrous monograph →Sources & How We Checked
Liposomal Nicotinamide Riboside+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Nicotinamide Riboside 7 references
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
- Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
- Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
- Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
- Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
- EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.
See these in context on the Nicotinamide Riboside monograph →
Betaine Anhydrous 11 references
- Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
- Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
- Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
- McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
- Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
- Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
- Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
- Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
- Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
- Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
- Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC