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Dietary supplement

NR 1000 Ingredients & Drug Interactions

by Renue By Science

NR 1000 label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NR 1000 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

NR 1000 is a dietary supplement by Renue By Science with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside Chloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NR 1000 by Renue By Science

Ask about any prescription or over-the-counter medication and we check it for interactions with NR 1000 by Renue By Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NR 1000 by Renue By Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

NR 1000 contains one active ingredient: nicotinamide riboside chloride, a compound related to the B vitamin niacin. It's included in the capsule along with inactive ingredients (hypromellose, microcrystalline cellulose, and rice flour) that serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Nicotinamide Riboside product and its label doesn't state a use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for nicotinamide riboside in age-related cognitive decline, macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, and heart failure is insufficient to rate. We don't yet have enough reliable data to say whether it works for these conditions.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears well tolerated in the short term, but long-term safety isn't fully known yet. The most common side effects in trials are bloating, muscle pain, nausea, itching, sweating, and temporary changes in stool.

A few people reported leg cramps or mild muscle soreness, and some experienced stomach discomfort or diarrhea — though in combination products it's unclear whether nicotinamide riboside alone was responsible. Regarding pregnancy and breastfeeding, safety data is limited.

The available evidence is not conclusive, so it's best to avoid NR 1000 during pregnancy and breastfeeding unless you've discussed it with your doctor or pharmacist. Talk with your healthcare provider if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NR 1000, double-check any blood pressure medications (antihypertensives) you're on — nicotinamide riboside may add to their blood-pressure-lowering effect. Use the medication checker on this page to verify your exact drug, and confirm with your doctor or pharmacist that it's okay to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

NR 1000 might appeal to people interested in supporting long-term cellular health, though evidence for specific age-related conditions is still developing. If you take blood pressure medication, check your exact drug with the tool on this page before starting — nicotinamide riboside may enhance its effect.

Anyone pregnant, breastfeeding, or taking other medications should chat with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NR 1000, straight from the product label.

Brand Renue By Science
Barcode (UPC) 850055685109
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 319005
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NR 1000 by Renue By Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
850055685109
IngredientAmount% DV
Nicotinamide Riboside Chloride1000 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Take two (2) capsules daily with or without food. May be taken with or without food.

Precautions

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using.

Do not use if safety seal is broken or missing.

Formula

Ultrapure Nicotinamide Riboside in delayed release, enteric-coated capsules.

Nicotinamide riboside

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

This product is manufactured in the United States at a FDA registered facility under strict GMP standards.

Enteric capsules

No artificial colors, flavors or preservatives. Non-GMO.

Suitable for vegans.

Enteric capsules resist degradation in the highly acidic environment of the stomach to protect the payload from digestion.

Seals/Symbols

GMP Good Manufacturing Practice Certified

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NR 1000 by Renue By Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NR 1000 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NR 1000 by Renue By Science

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Nicotinamide Riboside Chloride

Interacts with
172 drugs
1000 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside Chloride monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

NR 1000 by Renue By Science Drug Interactions

Want to check YOUR meds against NR 1000?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Nicotinamide Riboside Chloride 172

Individual Drug Interactions

The ingredients in NR 1000 interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in NR 1000 interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside Chloride

Each ingredient & the kinds of drugs it affects

For each ingredient in NR 1000 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside Chloride1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside Chloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NR 1000, from the product label.

Renue By Science

See all Renue By Science products
Name
Renue By Science
City
Jacksonville
State
FL
ZipCode
32204
Phone Number
1-800-810-1935
Web Address
renuebyscience.com
Pharmacist Counseling Corner

NR 1000 by Renue By Science: Common Questions

Does NR 1000 by Renue By Science interact with any medications?
Yes. Based on its ingredients, NR 1000 has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NR 1000 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nicotinamide riboside and what does it do?
Nicotinamide riboside is a compound related to the B vitamin niacin. Your body converts it to NAD+, a molecule involved in cellular energy and repair, but the evidence for its effects on specific age-related conditions is still being studied.
Is NR 1000 safe to take long-term?
Short-term studies show it's well tolerated, but long-term safety isn't fully established yet. If you're thinking about taking it regularly, discuss that timeline with your doctor or pharmacist.
Can I take this while I'm pregnant or breastfeeding?
There isn't enough safety data to say it's okay during pregnancy or breastfeeding. Talk with your doctor or pharmacist before using NR 1000 if you're pregnant, planning to become pregnant, or nursing.
What side effects might I experience?
The most common are bloating, muscle pain, nausea, itching, and temporary changes in stool. Some people have also reported mild muscle soreness or, rarely, leg cramps. If you experience any of these, mention them to your pharmacist.
Does nicotinamide riboside actually work for anti-aging or cognitive health?
The evidence isn't established yet — we don't have enough reliable data to say whether it helps with age-related cognitive decline, macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, or heart failure.
I'm on a blood pressure medication. Is NR 1000 safe for me?
Nicotinamide riboside may add to your blood pressure drug's effect, potentially lowering your blood pressure more than intended. Before starting, run your exact medication through the checker on this page and confirm with your doctor or pharmacist that it's safe to combine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NR 1000 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NR 1000 label
Go deeper

The Full Monographs Behind NR 1000’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

NR 1000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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