Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Allicin Ingredients & Drug Interactions

by VolDox HeartLife

Allicin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Allicin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Allicin is a dietary supplement by VolDox HeartLife with 5 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 804 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flax, Sesame, L-Arginine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Allicin by VolDox HeartLife

Ask about any prescription or over-the-counter medication and we check it for interactions with Allicin by VolDox HeartLife — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Allicin by VolDox HeartLife

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

VolDox HeartLife Allicin contains five active ingredients: L-arginine, cayenne pepper extract, sesame, flax, and allicin. L-arginine is an amino acid that increases nitric oxide and supports blood vessel function.

Cayenne pepper extract contains capsaicin, a compound that may help with certain types of nerve pain. Sesame and flax are plant-based ingredients; sesame may support blood pressure and blood sugar control, while flax contains lignans and omega-3 fatty acids linked to heart and cholesterol health.

The capsule also contains inactive ingredients (cellulose and corn starch) used as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain cholesterol levels, blood pressure and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Hypertension, Metabolic syndrome — and 4 related terms.
  • The strongest evidence on file: Flaxseed is rated "Possibly Effective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Flaxseed is rated "Possibly Effective" for Hypertension.
  • Also on file: Sesame is rated "Possibly Effective" for Hypertension.

For cayenne pepper extract, the data supports it as likely effective for postherpetic neuralgia (nerve pain after shingles) and diabetic neuropathy (nerve damage from diabetes). It's rated possibly effective for cluster headache, back pain, and postoperative nausea and vomiting.

Sesame is rated possibly effective for high blood pressure but possibly ineffective for cough; evidence for other uses (liver disease, HIV wasting, Alzheimer's, anemia) is insufficient to rate. Flax is possibly effective for high cholesterol, diabetes, breast pain, and high blood pressure, plus possibly effective for constipation.

We have no effectiveness ratings on file for L-arginine or allicin.

The evidence, ingredient by ingredient L-arginine Capsicum Sesame Flaxseed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is often well tolerated short-term but can lower blood pressure and may not be safe for everyone — use only under medical supervision, as safety for self-treatment is not established. Most common side effects are abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

Cayenne pepper extract is generally safe in food and approved topical products but commonly causes burning and irritation; oral amounts in food are likely fine, but concentrated supplements are not well studied. The most frequent side effects are belching, bloating, burning, diarrhea, gas, headache, nausea, and sweating.

Sesame is a major allergen and can trigger allergic reactions ranging from skin swelling to breathing problems; concentrated supplements are less studied than food amounts. Flax is usually well tolerated as a food but causes bloating, diarrhea, and gastrointestinal complaints, especially at higher doses.

L-arginine is rated possibly safe in pregnancy; sesame is rated likely to possibly safe in pregnancy and likely safe while breastfeeding; flax is rated possibly unsafe in pregnancy. For cayenne pepper extract and sesame, safety data during breastfeeding with concentrated supplements is not well established.

Pregnancy and breastfeeding safety data are not on file for flax lactation or for allicin.

Side effects, ingredient by ingredient L-arginine Capsicum Sesame Flaxseed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — L-arginine, Capsicum, Flaxseed, Sesame.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take antihypertensive drugs (blood pressure medications), ACE inhibitors, ARBs, blood thinners (anticoagulants or antiplatelets), diabetes medications, or potassium-sparing diuretics — these all carry Moderate interactions. Also flag any use of sildenafil (Viagra), theophylline, aspirin, tamoxifen, ciprofloxacin, or estrogen-containing products.

Minor interactions exist with ACE inhibitors and ciprofloxacin. We could not check interaction data for allicin itself.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with some evidence for heart and circulatory support, but several of them interact with common blood pressure, blood thinner, and diabetes medications. If you take any prescription drugs — especially for blood pressure, heart health, or blood sugar control — talk with your pharmacist or doctor before starting.

The ingredients are generally well tolerated, but L-arginine requires medical supervision and sesame is a known allergen.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Allicin, straight from the product label.

Brand VolDox HeartLife
Barcode (UPC) 7426968122098
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 335635
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Allicin by VolDox HeartLife, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
7426968122098
IngredientAmount% DV
L-Arginine100 mg--
Cayenne Pepper extract20 mg--
Sesame75 mg--
Flax75 mg--
Allicin180 mg--

Other ingredients: Cellulose, Corn Starch

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Food Supplement - HeartLife 500 mg capsule contains 180mg of 100% stabilised Allicin (Garlic) which with all other unique ingredients of HeartLife capsule may help to maintain cholesterol levels, blood pressure and a healthy heart.

100% Stabilised powder capsules

Allicin x 500 mg

Precautions

You must follow a healthy lifestyle and balanced diet.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Pregnant or trying to conceive, consult your healthcare provider for advice.

If you are allergic to any of the ingredients in HeartLife please stop taking the capsules and consult your doctor.

Suggested/Recommended/Usage/Directions

Recommended Use: 2 capsules daily with a meal or as directed by your health care physician. Maximum daily intake must not exceed 6 capsules.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Sugar Free

Made with Non-GMO Ingredients

Seals/Symbols

Safe Natural Effective

100% Stabilized Allicin Patented Active Ingredient GRAS Generally Recognized as Safe GMP Good Manufacturing Processes Quality Product Made with Non-GMO Ingredients

FDA Statement of Identity

Dietary Supplement

General Statements

VolDox Worldwide Distribution Company

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Allicin by VolDox HeartLife label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Allicin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Allicin by VolDox HeartLife

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Arginine

Interacts with
403 drugs
100 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

Cayenne Pepper extract

Interacts with
239 drugs
20 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Cayenne Pepper extract monograph & interactions

Sesame

Interacts with
528 drugs
75 mg per serving

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds ca...

Sesame monograph & interactions

Flax

Interacts with
597 drugs
75 mg per serving

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...

Flax monograph & interactions

Allicin

180 mg per serving Form: Garlic Bulb Extract

Other (inactive) ingredients: Cellulose, Corn Starch. These complete the product’s ingredient list but are not active constituents.

Interaction report

Allicin by VolDox HeartLife Drug Interactions

Want to check YOUR meds against Allicin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
804Drugs
673 Moderate 131 Minor

Ingredients driving the most interactions

Flax 597
Sesame 528
L-Arginine 403
Cayenne Pepper extract 239

Individual Drug Interactions

The ingredients in Allicin interact with 804 drugs. Click any drug to see the details.

4 of the 5 ingredients in Allicin interact with drugs. Each result below shows which ingredient is responsible. Flax Sesame L-Arginine Cayenne Pepper extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Allicin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Flax5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Flax full monograph & interactions

Sesame5 drug types · 528 drugs

Antidiabetes Drugs

Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical studies show that sesame oil can decrease plasma glucose and glycated hemoglobin (HbA1c) levels. Some clinical research in patients taking glibenclamide shows that using sesame oil or a blend of sesame oil and rice bran oil in place of other oil for cooking reduces plasma glucose more than glibenclamide alone. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that replacing other cooking oil with sesame oil can lower systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with or without hypertension. There is also some evidence that sesame oil has additive effects in patients also taking atenolol, nifedipine, and/or hydrochlorothiazide. In patients using nifedipine, using a blend of sesame oil and rice bran oil for cooking reduces both SBP and DBP more than nifedipine alone.

Likelihood Probable Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.
In vitro, sesame inhibits CYP2C9. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, sesame might interfere with tamoxifen.
In animal research, sesame seed reduces the tumor-inhibitory effect of tamoxifen by reducing apoptosis and increasing proliferation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sesame might alter the transport of P-glycoprotein substrates.
In vitro research suggests that sesamin, a constituent of sesame, can inhibit the multi-drug transporter protein, P-glycoprotein. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sesame full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Cayenne Pepper extract6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Cayenne Pepper extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Allicin, from the product label.

VolDox HeartLife

See all VolDox HeartLife products
Name
VolDox Ltd,
Street Address
63/66 Hatton Garden 5th Floor, Suite 23
State
London
ZipCode
EC1N 8LE
Pharmacist Counseling Corner

Allicin by VolDox HeartLife: Common Questions

Does Allicin by VolDox HeartLife interact with any medications?
Yes. Based on its ingredients, Allicin has a known interaction with 804 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Allicin contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
L-arginine is rated possibly safe in pregnancy, and sesame is likely to possibly safe during pregnancy and likely safe while breastfeeding. For cayenne pepper extract and sesame, we don't have enough data on concentrated supplement doses during breastfeeding. Flax is rated possibly unsafe in pregnancy. Talk with your doctor or pharmacist about your specific situation before starting.
What's allicin, and why is it in this product?
Allicin is a compound from garlic with potential heart-health benefits, but we don't have detailed interaction or effectiveness data on file for it. It's the product's namesake ingredient, though four other active ingredients are also present.
Will this help my high cholesterol or high blood pressure?
Flax is rated possibly effective for both high cholesterol and high blood pressure. Sesame is rated possibly effective for high blood pressure. L-arginine, cayenne, and allicin don't have effectiveness ratings in our data, so we can't comment on those.
What are the most common side effects?
L-arginine commonly causes abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing. Cayenne pepper extract often causes belching, bloating, burning, diarrhea, gas, headache, and nausea. Flax frequently triggers bloating, diarrhea, and digestive complaints. All three improve if you drink plenty of water and start with small amounts.
Is sesame safe if I have a food allergy?
Sesame is a major allergen. Up to 0.5% of the U.S. population reports a sesame allergy, and allergic reactions can range from skin swelling and itching to breathing problems. If you have any known sesame allergy or suspect one, avoid this product.
Can I take this with my diabetes medication?
Multiple ingredients in this product — L-arginine, cayenne pepper extract, sesame, and flax — all carry Moderate interactions with diabetes medications because they may lower blood sugar. Combined use could increase the risk of low blood sugar (hypoglycemia). Talk with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Allicin label
Go deeper

The Full Monographs Behind Allicin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Sesame

Interacts with 528 drugs

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds called lignans. Some early research sugges...

Read the full Sesame monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph →
Sources

Sources & How We Checked

Allicin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 245 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
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See these in context on the L-arginine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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