Aloe Vera 5,000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Aloe Vera 5,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Aloe Vera 5,000 mg is a dietary supplement by Nature's Truth with 1 active ingredient. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe vera. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Aloe Vera 5,000 mg by Nature's Truth
Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe Vera 5,000 mg by Nature's Truth — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Aloe Vera 5,000 mg by Nature's Truth
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: aloe vera inner leaf gel concentrate in fresh form, delivering 5,000 mg per softgel. The inactive ingredients are sunflower oil, safflower oil, gelatin, glycerin, and white beeswax — these are the capsule and carrier materials.
Does it work?
Moderate evidence
Aloe vera has research supporting possible effectiveness for several uses: acne, weight management (obesity), diabetes, psoriasis, minor burns, and constipation. The evidence for each is preliminary, so results aren't guaranteed, but the data suggests it's worth considering if you're exploring natural options for one of these concerns.
Talk with your pharmacist about whether it fits your situation.
How safe is it?
Well-documented data
Oral aloe gel from this product is generally well tolerated in typical doses. However, aloe latex — a bitter yellow compound — carries greater risks, especially with high doses or long-term use.
Most common side effects from oral use are abdominal pain, cramps, and diarrhea. Rare serious effects include severe potassium loss, muscle weakness, and irregular heartbeat, mostly from overuse or abuse.
The safety data advises against taking aloe by mouth during pregnancy because the latex may stimulate the uterus and act as a strong laxative. The same caution applies to breastfeeding — there isn't enough safety data, and the laxative effects could affect your baby.
If you're pregnant or nursing, talk with your pharmacist or doctor before taking this.
Meds to double-check
Major interaction found
Before you take this, check your medications against digoxin and other heart drugs (cardiac glycosides), blood thinners (anticoagulants) and warfarin, diabetes medications, water pills (diuretics), and stimulant laxatives. These carry the highest risks.
Also mention any drugs your liver processes, as aloe may weaken their effect.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
Aloe vera may help with acne, burns, constipation, and a few other conditions, though the evidence is preliminary. If you take heart medications like digoxin, blood thinners, diabetes drugs, or diuretics, you need to check with your pharmacist first — the interactions can be serious.
Pregnant or breastfeeding? Skip it unless your doctor approves.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Aloe Vera 5,000 mg, straight from the product label.
| Brand | Nature's Truth |
|---|---|
| Barcode (UPC) | 840093109811 |
| Net contents | 100 Quick Release Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2024 |
| DSLD ID | 306619 |
| Product type | Botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Aloe Vera 5,000 mg by Nature's Truth, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Aloe vera | 5000 mg | -- |
| Aloe vera Inner Leaf Gel Concentrate, Fresh | 25 mg | -- |
Other ingredients: Sunflower Oil, Safflower Oil, Gelatin, Glycerin, White Beeswax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
100% quality satisfaction guarantee
DNA tested
Gluten free Non GMO
DNA tested botanicals Certified authentic Tru-ID
No gluten, wheat, yeast, milk, lactose, soy, artificial color, artificial flavor, artificial sweetener, preservatives. Non-GMO Our Non-GMO pledge Visit our website
General Statements
Vitamins
Seals/Symbols
Certified authentic Tru-ID
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) quick release softgel three times daily, preferably with meals.
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
If any adverse reactions occur, immediately stop using this product and consult your doctor. If seal under cap is damaged or missing, do not use.
Not intended for use by persons under the age of 18. Keep out of reach of children.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Copyright 2021 Nature's Truth LLC
Formula
Traditional herb equivalent of 5,000mg of fresh aloe vera Potent Aloe vera 5,000 mg equivalent from 25 mg of 200:1 concentrate.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Aloe Vera 5,000 mg by Nature's Truth label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Aloe Vera 5,000 mg by Nature's Truth
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Quick Release Softgel(s) Dosage formSoftgel Capsule Servings per container100 Amounts shown are per serving.
Aloe vera
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Aloe vera monograph & interactionsOther (inactive) ingredients: Sunflower Oil, Safflower Oil, Gelatin, Glycerin, White Beeswax. These complete the product’s ingredient list but are not active constituents.
Aloe Vera 5,000 mg by Nature's Truth Drug Interactions
HelloPharmacist Interaction Report
Aloe Vera 5,000 mg from Nature's Truth does interact with several medication types, and some of those interactions are serious.
The most serious concern is digoxin (Lanoxin), a heart medication — overuse of aloe latex can deplete potassium and raise the risk of toxicity with this drug.
Read the full breakdown — every affected drug type, severity by severity
Aloe also carries Moderate-severity interactions with blood thinners (anticoagulants) and warfarin, which increase bleeding risk; diabetes medications, which may lower blood sugar too much; water pills (diuretics), which can compound potassium loss; and stimulant laxatives, which may cause excessive fluid and electrolyte loss. There's also a Minor interaction with certain medications processed by CYP1A2 enzymes in your liver — aloe may reduce their effectiveness.
Altogether, these interactions span 460 individual medications. Use the medication checker below with your exact prescriptions before you start this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Aloe Vera 5,000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Aloe Vera 5,000 mg interact with 461 drugs. Click any drug to see the details.
1 of the 1 ingredient in Aloe Vera 5,000 mg interact with drugs. Each result below shows which ingredient is responsible. Aloe vera
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshDigoxin (lanoxin) Major
Interaction Summary
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Digoxin interactionAbciximabReoPro
How Abciximab interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Aloe Vera 5,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera Inner Leaf Gel Concentrate, FreshStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Aloe Vera Inner Leaf Gel Concentrate, Fresh + Armodafinil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Aloe Vera 5,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aloe vera
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Aloe Vera 5,000 mg, from the product label.
Nature's Truth
See all Nature's Truth products- Name
- Nature's Truth LLC
- City
- Ronkonkoma
- State
- NY
- ZipCode
- 11779
- Phone Number
- 1-844-544-1030
- Web Address
- NaturesTruth.com
Aloe Vera 5,000 mg by Nature's Truth: Common Questions
Does Aloe Vera 5,000 mg by Nature's Truth interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on a blood thinner like warfarin?
Will this help my constipation?
Is this safe to take for a long time?
What's the difference between aloe gel and aloe latex?
Can I use this while pregnant?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Aloe Vera 5,000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Aloe Vera 5,000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Aloe Vera 5,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
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